South Carolina vs LSU Prediction — AI Finds CAN'T MISS CFB Lines & Props (Oct 11)
Updated: 2025-10-04T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
LSU (4–1) hosts South Carolina (3–2) on October 11 in Baton Rouge, as the Tigers aim to stay in pace in the SEC West and the Gamecocks look to pull off a major road upset. LSU enters as a solid favorite, with betting markets centering on their strong defense and improved offensive balance.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 11, 2025
Start Time: 7:45 PM EST
Venue: Tiger Stadium
Tigers Record: (4-1)
Gamecocks Record: (3-2)
OPENING ODDS
SC Moneyline: +298
LSU Moneyline: -379
SC Spread: +9.5
LSU Spread: -9.5
Over/Under: 43.5
SC
Betting Trends
- South Carolina has covered the spread in 60% of its games this season, showing a modest edge as an underdog or in away matchups.
LSU
Betting Trends
- LSU has had some uneven results against the spread at home, partially due to high expectations and occasional underperformance relative to big spreads.
MATCHUP TRENDS
- LSU’s red-zone success rate sits at 84.21%, while the Tigers convert on third down roughly 42.42% of the time — both figures suggest that when drives move into scoring range, LSU is efficient, but sustaining those drives remains a challenge at times.
SC vs. LSU
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: Z. Thomas under 36.5 Receiving Yards.
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South Carolina vs LSU Prediction & Odds:
Free CFB Betting Insights for 10/11/25
The October 11, 2025, SEC matchup between the South Carolina Gamecocks and the LSU Tigers at Tiger Stadium brings together two programs trending in different directions but both searching for defining conference victories. LSU enters the contest at 4–1, ranked inside the top 15 nationally, and riding the confidence of a defense that has quietly become one of the stingiest in the SEC. The Tigers are allowing just 12.2 points per game and 4.6 yards per play through five games, showcasing a level of discipline and physicality that has anchored their early-season success. Head coach Brian Kelly’s offense has complemented that defense with improved balance and efficiency, averaging 27 points per game and 5.5 yards per play while limiting turnovers and capitalizing in the red zone at an 84.2% clip. Quarterback Garrett Nussmeier has shown steady command of the system, throwing for over 1,200 yards and eight touchdowns with just three interceptions. His connection with wide receiver Kyren Lacy has emerged as a reliable big-play weapon, while the run game, powered by Logan Diggs and Kaleb Jackson, provides toughness between the tackles. LSU’s offensive line, which struggled with consistency last season, has begun to gel, allowing Nussmeier more time to operate and creating better balance between the run and pass. Defensively, LSU remains one of the most complete units in the SEC, with linebacker Harold Perkins Jr. continuing to terrorize opposing backfields and defensive tackle Mekhi Wingo anchoring the interior with dominance against the run. The Tigers have also excelled in situational football, holding opponents to just 30% on third downs and forcing turnovers in key moments that shift field position.
On the other sideline, Shane Beamer’s South Carolina team enters at 3–2, scrappy as ever, and looking to prove it can contend with the SEC’s upper echelon. The Gamecocks have averaged 24.8 points per game while giving up 18.8, showing flashes of progress but still lacking consistency on both sides of the ball. Quarterback LaNorris Sellers has been dynamic when given time, displaying strong arm talent and mobility, but South Carolina’s offensive line has struggled to hold up against elite pass rushes, which could spell trouble against LSU’s ferocious front. Running back Raheim “Rocket” Sanders, a transfer from Arkansas, has added needed power to the run game, but the offense’s rhythm often depends on Sellers’ ability to extend plays and find Xavier Legette and Nyck Harbor downfield. Defensively, the Gamecocks are competitive but vulnerable to tempo and precision passing — exactly what LSU excels at. Linebacker Stone Blanton and safety Nick Emmanwori have been standouts, but South Carolina’s secondary has given up chunk plays that could haunt them against Nussmeier’s arm. The key for the Gamecocks will be disrupting LSU’s timing, winning the turnover battle, and forcing long drives instead of quick scores. Expect South Carolina to use creative blitz packages and coverage disguises to test LSU’s offensive line early, while LSU will try to impose its will on both lines of scrimmage and take advantage of mismatches outside. With the Tiger Stadium crowd roaring, LSU’s defensive depth, efficiency, and superior talent should eventually tilt the game in their favor. South Carolina’s resilience will keep it competitive early, but LSU’s ability to execute in the red zone and control tempo likely propels the Tigers to another solid SEC victory under the lights in Baton Rouge.
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https://t.co/5ZsTtlq9LC pic.twitter.com/Ow8UagleCv
— South Carolina Football (@GamecockFB) October 6, 2025
South Carolina Gamecocks CFB Preview
The South Carolina Gamecocks enter their October 11, 2025, trip to Baton Rouge looking to make a statement against an LSU team that has been one of the SEC’s most complete squads through the first half of the season. At 3–2 under head coach Shane Beamer, South Carolina has continued to show flashes of toughness and development, but inconsistency on offense and lapses in protection have kept them from turning potential into sustained success. The Gamecocks average 24.8 points per game and 5.3 yards per play, and while their offensive balance has improved, the line of scrimmage remains their biggest question mark — an area that will be tested heavily by LSU’s aggressive front seven. Quarterback LaNorris Sellers has given this team new life with his combination of arm strength, mobility, and leadership. Sellers has thrown for over 1,000 yards and nine touchdowns this season while adding valuable rushing production in short-yardage situations. His ability to extend plays outside the pocket has masked some of the offensive line’s pass-blocking issues, but against LSU’s elite pass rush featuring Harold Perkins Jr. and Mekhi Wingo, he’ll need to make quick decisions and avoid costly turnovers. Running back Raheim “Rocket” Sanders, a transfer from Arkansas, has been a stabilizing force for the Gamecocks’ offense, rushing for over 400 yards and averaging close to 4.8 yards per carry, giving South Carolina a dependable option to grind out first downs and open up play-action opportunities.
Wideouts Xavier Legette and Nyck Harbor headline a dynamic receiving group capable of creating explosive plays downfield, but they’ll face a disciplined LSU secondary that thrives at closing passing lanes and limiting yards after the catch. For South Carolina to stay competitive, establishing early rhythm and neutralizing LSU’s defensive line through quick passes, misdirection, and motion will be critical. Defensively, the Gamecocks will rely heavily on a unit that’s held opponents to just 18.8 points per game, with linebackers Stone Blanton and Debo Williams serving as the emotional anchors of the defense. Safety Nick Emmanwori continues to play at an All-SEC level, providing crucial support against the run while making plays in coverage. However, the challenge of containing LSU quarterback Garrett Nussmeier and his arsenal of receivers will test South Carolina’s secondary depth and communication. Expect defensive coordinator Clayton White to mix in pressure looks and disguised coverages to try to force Nussmeier into hurried throws and capitalize on turnovers. Special teams could be a deciding factor — punter Kai Kroeger and kicker Mitch Jeter have both been reliable weapons, capable of flipping field position or turning drives into points. Still, the road environment at Tiger Stadium presents its own challenge; communication, composure, and discipline will all be vital if the Gamecocks are to pull off the upset. For South Carolina, the formula for success is clear: win the turnover battle, sustain drives to keep LSU’s offense off the field, and capitalize on every scoring opportunity. The Gamecocks have shown resilience under Beamer, and while the odds are steep, a focused, mistake-free effort could keep this game competitive deep into the second half.
Credit: USA TODAY/IMAGN
LSU Tigers CFB Preview
The LSU Tigers return to Tiger Stadium on October 11, 2025, with the momentum of a 4–1 start and the confidence of a team that has reestablished itself as one of the most balanced forces in the SEC. Head coach Brian Kelly has guided LSU into the heart of conference play with a formula built on defensive dominance, efficient quarterback play, and a more physical brand of football on both lines of scrimmage. Through five games, the Tigers are averaging 27 points per game while allowing just 12.2, making them one of the toughest teams to score against in the nation. Quarterback Garrett Nussmeier has evolved into a steady, confident leader for this offense, passing for over 1,200 yards with eight touchdowns and only three interceptions. His connection with wideouts Kyren Lacy and Chris Hilton Jr. has provided LSU with reliable playmaking on the perimeter, while tight end Mason Taylor continues to be a key target in the red zone and on third down. In the backfield, running backs Logan Diggs and Kaleb Jackson have formed a bruising duo, combining for more than 500 rushing yards and bringing balance to an attack that averages 5.5 yards per play. The offensive line, once a liability, has developed into a cohesive unit capable of dictating tempo and protecting Nussmeier from pressure. Against South Carolina’s disciplined but bendable defense, LSU will look to establish the run early, use tempo to create mismatches, and exploit the Gamecocks’ secondary with play-action and quick strikes.
Defensively, LSU has been outstanding — giving up just 4.6 yards per play and holding opponents to a mere 30% third-down conversion rate. Defensive coordinator Blake Baker has built a unit defined by speed, depth, and controlled aggression. Linebacker Harold Perkins Jr. remains the centerpiece, a nightmare for opposing quarterbacks with his ability to rush off the edge or drop into coverage, while defensive tackle Mekhi Wingo continues to plug the middle and collapse pockets. The secondary, anchored by Sage Ryan and Zy Alexander, has improved its communication and discipline, allowing LSU to limit explosive plays that hurt them in prior seasons. Against South Carolina, LSU’s defense will focus on containing quarterback LaNorris Sellers, whose mobility can extend drives, and shutting down transfer running back Raheim “Rocket” Sanders before he can find open lanes. The Tigers’ ability to win on first down and force third-and-long situations will be critical, as South Carolina’s offense struggles when behind schedule. Special teams have also been a strength, with kicker Damian Ramos consistent inside 45 yards and the return units providing LSU with favorable field position. With Death Valley at full volume under the lights, LSU will look to seize momentum early, force South Carolina into mistakes, and lean on its defensive front to close the door late. The blueprint for the Tigers is clear — start fast, stay efficient, and let their depth and discipline carry them through. If they execute, LSU has the firepower and composure to control the game from start to finish and keep themselves firmly in the hunt for the SEC West crown.
BT‼️#KCvsJAX on ESPN
— LSU Football (@LSUfootball) October 7, 2025
pic.twitter.com/unTuQCUH4K
South Carolina vs LSU Prop Picks (AI)
AI algorithm Remi is pouring through mountains of datapoints on each team. In fact, anytime the Gamecocks and Tigers play there’s always several intriguing trends to key in on. Not to mention games played at Tiger Stadium in Oct rarely follow normal, predictable betting trends.
South Carolina vs LSU Prediction (AI)
Remi, our AI sports genius, has been pouring over millions of data from every past game between the Gamecocks and Tigers and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the growing factor knucklehead sportsbettors tend to put on player performance factors between a Gamecocks team going up against a possibly strong Tigers team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.
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Below is our current AI South Carolina vs LSU picks, computer picks Gamecocks vs Tigers, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
South Carolina Betting Trends
South Carolina has covered the spread in 60% of its games this season, showing a modest edge as an underdog or in away matchups.
LSU Betting Trends
LSU has had some uneven results against the spread at home, partially due to high expectations and occasional underperformance relative to big spreads.
Gamecocks vs. Tigers Matchup Trends
LSU’s red-zone success rate sits at 84.21%, while the Tigers convert on third down roughly 42.42% of the time — both figures suggest that when drives move into scoring range, LSU is efficient, but sustaining those drives remains a challenge at times.
South Carolina vs. LSU Game Info
South Carolina vs LSU starts on October 11, 2025 at 7:45 PM EST.
Venue: Tiger Stadium.
Spread: LSU -9.5
Moneyline: South Carolina +298, LSU -379
Over/Under: 43.5
South Carolina: (3-2) | LSU: (4-1)
Remi's searched hard and found the best prop for this matchup: Z. Thomas under 36.5 Receiving Yards.. Prices move—always shop for the best number.
LSU’s red-zone success rate sits at 84.21%, while the Tigers convert on third down roughly 42.42% of the time — both figures suggest that when drives move into scoring range, LSU is efficient, but sustaining those drives remains a challenge at times.
SC trend: South Carolina has covered the spread in 60% of its games this season, showing a modest edge as an underdog or in away matchups.
LSU trend: LSU has had some uneven results against the spread at home, partially due to high expectations and occasional underperformance relative to big spreads.
See our latest CFB picks and odds pages for 2025 to compare prices before you bet.
South Carolina vs. LSU Odds
Remi is pouring through loads of stats on each line. In fact, anytime the South Carolina vs LSU trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude can often follow normal, predictable patterns.
| SC Moneyline | +298 |
|---|---|
| LSU Moneyline | -379 |
| SC Spread | +9.5 |
| LSU Spread | -9.5 |
| Over / Under | 43.5 |
South Carolina vs LSU Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
|
–
–
|
+1258
-5049
|
+23.5 (-110)
-23.5 (-110)
|
O 47 (-110)
U 47 (-110)
|
|
|
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
|
–
–
|
-135
+110
|
-2.5 (-110)
+2.5 (-110)
|
O 60.5 (-110)
U 60.5 (-110)
|
|
|
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
|
–
–
|
-136
+111
|
-2.5 (-110)
+2.5 (-110)
|
O 66.5 (-110)
U 66.5 (-110)
|
|
|
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
|
–
–
|
+170
-212
|
+5 (-110)
-5 (-110)
|
O 59 (-110)
U 59 (-110)
|
|
|
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
|
–
–
|
-128
|
-2 (-110)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
|
–
–
|
+380
-526
|
+12.5 (-110)
-12.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
|
–
–
|
-130
+106
|
-2 (-110)
+2 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
|
–
–
|
+151
-187
|
+4 (-110)
-4 (-110)
|
O 58 (-110)
U 58 (-110)
|
|
|
Dec 6, 2025 8:01PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8:01PM
IND
OHIOST
|
–
–
|
+165
-200
|
+4 (-105)
-4 (-115)
|
O 47.5 (-115)
U 47.5 (-105)
|
|
|
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
|
–
–
|
+172
-216
|
+4.5 (-105)
-4.5 (-115)
|
O 38 (-110)
U 38 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers South Carolina Gamecocks vs. LSU Tigers on October 11, 2025 at Tiger Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| COLO@KSTATE | COLO +17.5 | 54.0% | 4 | WIN |
| PSU@RUT | RUT +14 | 52.8% | 1 | WIN |
| OHIOST@MICH | MICH +10.5 | 56.4% | 6 | LOSS |
| VATECH@UVA | VATECH +8 | 57.8% | 7 | LOSS |
| NWEST@ILL | LUKE ALTMYER UNDER 19.5 PASS COMP | 54.3% | 4 | WIN |
| ORE@WAS | DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS | 55.2% | 5 | WIN |
| MIAMI@VATECH | VATECH +18.5 | 54.2% | 4 | WIN |
| GAST@TROY | TROY -9.5 | 55.7% | 5 | WIN |
| DEL@WAKE | DEL +18 | 56.7% | 6 | LOSS |
| NMEX@AF | NMEX -3.5 | 56.1% | 5 | WIN |
| WASHST@JMAD | WASHST +14.5 | 55.3% | 5 | WIN |
| ILL@WISC | WISC +9 | 55.1% | 5 | WIN |
| WKY@LSU | WKY +23.5 | 56.3% | 6 | WIN |
| WASH@UCLA | DEMOND WILLIAMS UNDER 27.5 PASS ATT | 56.3% | 6 | WIN |
| TCU@HOU | AMARE THOMAS OVER 69.5 RECV YDS | 55.2% | 5 | WIN |
| TEX@UGA | NATE FRAZIER UNDER 65.5 RUSH + REC YDS | 55.5% | 5 | WIN |
| PUR@WASH | ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS | 54.1% | 4 | WIN |
| OKLA@BAMA | UNDER 46 | 52.4% | 2 | WIN |
| UVA@DUKE | DUKE -3.5 | 54.7% | 3 | LOSS |
| OKLA@BAMA | BAMA -6 | 54.5% | 3 | LOSS |
| OREGST@TULSA | OREGST -120 | 55.6% | 5 | LOSS |
| UTEP@MIZZST | MIZZST -5 | 54.3% | 4 | WIN |
| COLOST@NMEX | NMEX -14 | 57.1% | 6 | LOSS |
| PSU@MICHST | MICHST +7.5 | 56.5% | 6 | LOSS |
| MISSST@MIZZOU | MISSST +7.5 | 57.2% | 7 | LOSS |
| FAU@TULANE | FAU +17.5 | 56.0% | 6 | WIN |
| NCST@MIAMI | NCST +15.5 | 57.1% | 7 | LOSS |
| KENTST@AKRON | AKRON -6.5 | 55.4% | 5 | LOSS |
| JAXST@UTEP | JAXST -105 | 57.0% | 7 | WIN |
| FSU@CLEM | CLEM -118 | 57.1% | 5 | WIN |
| UNLV@COLOST | UNLV -4 | 55.2% | 5 | WIN |
| OREG@IOWA | IOWA +6.5 | 53.3% | 2 | WIN |
| NEB@UCLA | NEB +1.5 | 55.8% | 5 | WIN |
| KENSAW@NMEXST | NMEXST +10 | 56.5% | 6 | WIN |
| STNFRD@UNC | STNFRD +7.5 | 53.8% | 3 | WIN |
| DUKE@UCONN | UCONN +8.5 | 57.9% | 7 | WIN |
| NEVADA@UTAHST | NEVADA +9.5 | 55.9% | 5 | LOSS |
| SAMST@OREGST | SAMST +21 | 57.7% | 7 | WIN |
| NEB@UCLA | NICO IAMALEAVA UNDER 180.5 PASS YDS | 56.6% | 6 | LOSS |
| HOU@UCF | HOU -112 | 58.0% | 6 | WIN |
| GASTHRN@APPST | GASTHRN +180 | 36.5% | 2 | WIN |
| KENTST@BALLST | BALLST -2.5 | 54.5% | 4 | WIN |
| WAKE@FSU | WAKE +10.5 | 56.4% | 6 | LOSS |
| WYO@SDGST | SDGST -10.5 | 56.7% | 7 | WIN |
| OKLA@TENN | TENN -130 | 58.3% | 5 | LOSS |
| GATECH@NCST | GATECH -5 | 56.4% | 6 | LOSS |
| MIAMI@SMU | MIAMI -10 | 54.3% | 4 | LOSS |
| IND@MD | MD +21.5 | 54.6% | 4 | LOSS |
| CINCY@UTAH | CINCY +11 | 57.6% | 7 | LOSS |
| OLDDOM@LAMON | LAMON +17 | 58.4% | 8 | LOSS |
| VANDY@TEXAS | OVER 46.5 | 53.7% | 2 | WIN |