Virginia vs Louisville Prediction — AI Finds CAN'T MISS CFB Lines & Props (Oct 04)

Updated: 2025-09-27T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Virginia Cavaliers travel to Louisville on October 4, 2025 to face the Cardinals in a pivotal ACC showdown that carries serious implications for each team’s conference trajectory. Virginia is riding momentum from a dramatic double-overtime win over No. 8 Florida State, while Louisville enters with the aura of a rising contender under Jeff Brohm.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Oct 04, 2025

Start Time: 3:30 PM EST​

Venue: L&N Federal Credit Union Stadium​

Cardinals Record: (4-0)

Cavaliers Record: (4-1)

OPENING ODDS

UVA Moneyline: +188

LVILLE Moneyline: -231

UVA Spread: +6.5

LVILLE Spread: -6.5

Over/Under: 62.5

UVA
Betting Trends

  • Virginia enters this matchup with a strong underlying profile: they rank among the more efficient scorers and have outperformed projections in several games this season, suggesting they may have value as an underdog on the road.

LVILLE
Betting Trends

  • Louisville is frequently installed as a favorite at home in 2025, and while they’ve had success, their ATS track record has shown variability—especially in games involving ranked or tough opponents on home turf.

MATCHUP TRENDS

  • Louisville opened as a 7-point favorite over Virginia, later drifting to 7.5, a line that illustrates the market’s expectation of a competitive game. That margin sets up a classic test—can Virginia cover as a road underdog against a confident Louisville squad that’s built to dominate at home?

UVA vs. LVILLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Twitty under 28.5 Receiving Yards.

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Virginia vs Louisville Prediction & Odds:
Free CFB Betting Insights for 10/4/25

The October 4, 2025 matchup between the Virginia Cavaliers and the Louisville Cardinals at Cardinal Stadium sets up as one of the more compelling conference clashes of the weekend, with both teams entering in strong form and looking to make a statement in the ACC, and the outcome could hinge on tempo, turnovers, and execution in the trenches. Virginia comes into this contest riding the emotional high of a double-overtime victory against Florida State, a win that not only boosted their confidence but also showcased their offensive versatility and resilience under pressure, and their profile this season has been built on efficiency across all phases, as they are averaging nearly 46 points per game while holding opponents to just over 23. The Cavaliers have leaned on a balanced attack, with their rushing game churning out more than five and a half yards per attempt and their passing game producing over 1,400 yards and 11 touchdowns through five games, making them difficult to defend because they can pivot between pounding the ground game and striking through the air when defenses overcommit. Quarterback play has been steady, with quick decision-making and smart distribution keeping the chains moving, while the offensive line has created both running lanes and protection pockets to sustain long drives, and their third-down conversion rate of nearly 57 percent is among the best in the country, evidence of their ability to extend possessions and wear down defenses.

Louisville, meanwhile, enters undefeated at 4–0 under Jeff Brohm, with the kind of energy and momentum that has reenergized the program and made Cardinal Stadium a tough place for opponents to escape with wins, and their offense has been equally dynamic, leaning on explosive plays and balance to keep defenses guessing. The Cardinals have shown an ability to strike quickly but also to grind out methodical drives, and their home crowd gives them a powerful edge in moments when games hang in the balance, as noise and energy have consistently made communication difficult for opposing offenses. Defensively, Louisville will be tested by Virginia’s balance, as they must commit to stopping the run without leaving themselves vulnerable to deep shots, and their ability to get pressure on the quarterback without overextending will be critical to forcing mistakes. On the other side, Virginia’s defense will look to continue its opportunistic ways by generating turnovers and winning situational downs, particularly in the red zone, where Louisville will want to finish drives with touchdowns to avoid allowing the Cavaliers to stay close. Special teams may also play a crucial role, as both programs understand the value of field position in a game expected to be competitive, and one return or mistake could provide the swing that tips momentum. From a betting perspective, Louisville has opened as more than a touchdown favorite, but Virginia’s efficiency metrics and recent upset suggest they carry value as an underdog capable of covering if not winning outright, making this a high-stakes clash both on the field and in wagering circles. Ultimately, this game is likely to come down to who imposes their style: if Virginia can maintain balance, control the tempo, and avoid turnovers, they can push Louisville deep into the fourth quarter, while the Cardinals will aim to ride their home-field advantage, offensive explosiveness, and defensive disruption to continue their undefeated run and bolster their claim as an ACC contender.

Virginia Cavaliers CFB Preview

The Virginia Cavaliers travel to Louisville on October 4, 2025 riding the wave of their season-defining double-overtime upset of Florida State, and they will enter this matchup not just with confidence but with the statistical backing of one of the most efficient offenses in the ACC, making them a dangerous underdog in a hostile environment where discipline and balance will be critical. Virginia has been among the most productive teams in the country, averaging nearly 46 points per game and combining a ground game that churns out over 5.5 yards per carry with a passing attack that has already accounted for more than 1,400 yards and 11 touchdowns, and their offensive identity has been shaped by consistency in execution, as evidenced by a third-down conversion rate pushing 57 percent and red-zone efficiency over 80 percent. The Cavaliers’ offensive line has been one of their most underrated strengths, creating holes for their backs while also giving their quarterback time to make smart reads and spread the ball around, and if they can win in the trenches at Louisville, their attack should once again be difficult to slow down. The quarterback has managed games with poise, avoiding unnecessary risks and leaning on playmakers at receiver who have consistently created separation, giving the offense a layered approach that makes it hard for defenses to force predictable play-calling.

Defensively, Virginia has allowed just over 23 points per game, which is respectable given the tempo at which they play, and they have been opportunistic, generating turnovers and timely stops that often swing field position in their favor, a trait that will be essential against a Louisville team that thrives on explosive plays. The Cavaliers’ front seven must focus on gap discipline to contain the Cardinals’ rushing attack while also applying pressure on the quarterback to prevent him from finding rhythm in the passing game, and their secondary will be tasked with avoiding breakdowns that could lead to quick scores. Special teams will also be pivotal for Virginia, as playing on the road requires clean execution in coverage, avoiding costly penalties, and potentially flipping momentum with a big return or blocked kick, all of which could help neutralize the Cardinals’ home-field advantage. From a betting perspective, Virginia has already outperformed expectations by not only beating Florida State but also consistently exceeding efficiency metrics that make them appealing as an underdog, and their recent trajectory suggests they can keep this game within reach deep into the fourth quarter if they avoid turnovers and maintain balance. Their blueprint for success is clear: start fast to prevent Louisville from building early momentum, use their offensive versatility to control tempo, and force the Cardinals into mistakes that create scoring chances. If the Cavaliers execute that plan and continue their sharp situational football, they have every chance to not only cover the spread but also contend for a second straight statement victory that would thrust them into the heart of the ACC race.

The Virginia Cavaliers travel to Louisville on October 4, 2025 to face the Cardinals in a pivotal ACC showdown that carries serious implications for each team’s conference trajectory. Virginia is riding momentum from a dramatic double-overtime win over No. 8 Florida State, while Louisville enters with the aura of a rising contender under Jeff Brohm. Virginia vs Louisville AI Prediction: Free CFB Betting Insights for Oct 04. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Louisville Cardinals CFB Preview

The Louisville Cardinals return to Cardinal Stadium on October 4, 2025 with the confidence of a 4–0 start under Jeff Brohm and the knowledge that a primetime home test against Virginia offers both the opportunity to validate their contender status in the ACC and the challenge of stopping one of the hottest teams in the league after the Cavaliers’ upset of Florida State. Louisville’s offensive identity has been built on explosiveness and balance, with their quarterback distributing effectively to a deep group of receivers while the ground game provides enough consistency to keep defenses from selling out against the pass, and their offensive line has done a strong job of creating lanes while keeping pressure off the backfield, which will be critical against a Virginia front that has thrived on disrupting rhythm. The Cardinals have been particularly strong at home, where their crowd has fueled fast starts and forced opponents into mistakes, and they will aim to replicate that energy by jumping on Virginia early and forcing the Cavaliers to play from behind. Defensively, Louisville’s challenge will be containing an offense averaging nearly 46 points per game and converting more than 55 percent of its third downs, meaning their ability to win on early downs and put Virginia into uncomfortable situations will be paramount.

Their secondary will be tested by Virginia’s passing attack, but if their defensive front can collapse pockets and generate consistent pressure, they will have a chance to disrupt timing and create turnovers that can swing momentum. Special teams will also be a key factor, as Louisville has historically excelled in field position battles at home, and against a Virginia team capable of scoring in bunches, every hidden yard will matter. From a betting perspective, Louisville opened as a touchdown favorite, reflecting confidence in their undefeated start and home-field advantage, but they will need to deliver four quarters of focused football to cover that number against a Virginia squad that has already proven it can outperform expectations. The blueprint for Louisville is clear: establish the run early to control tempo, lean on the passing game to punish overcommitments, force Virginia to grind out long drives rather than giving up explosive plays, and capitalize on red-zone trips with touchdowns. If the Cardinals execute that plan and feed off their home environment, they not only have a strong chance to stay unbeaten but also to deliver the type of statement performance that cements them as legitimate contenders in the ACC race.

Virginia vs. Louisville Prop Picks (AI)

AI algorithm Remi is pouring through mountains of stats on each line. In fact, anytime the Cavaliers and Cardinals play there’s always several intriguing angles to key in on. Not to mention games played at L&N Federal Credit Union Stadium in Oct seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: D. Twitty under 28.5 Receiving Yards.

Virginia vs. Louisville Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every facet between the Cavaliers and Cardinals and using recursive machine learning and impressive AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the unproportionally assigned emphasis emotional bettors regularly put on Virginia’s strength factors between a Cavaliers team going up against a possibly deflated Cardinals team. In reality, the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Virginia vs Louisville picks, computer picks Cavaliers vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Cavaliers Betting Trends

Virginia enters this matchup with a strong underlying profile: they rank among the more efficient scorers and have outperformed projections in several games this season, suggesting they may have value as an underdog on the road.

Cardinals Betting Trends

Louisville is frequently installed as a favorite at home in 2025, and while they’ve had success, their ATS track record has shown variability—especially in games involving ranked or tough opponents on home turf.

Cavaliers vs. Cardinals Matchup Trends

Louisville opened as a 7-point favorite over Virginia, later drifting to 7.5, a line that illustrates the market’s expectation of a competitive game. That margin sets up a classic test—can Virginia cover as a road underdog against a confident Louisville squad that’s built to dominate at home?

Virginia vs. Louisville Game Info

Virginia vs Louisville starts on October 04, 2025 at 3:30 PM EST.

Venue: L&N Federal Credit Union Stadium.

Spread: Louisville -6.5
Moneyline: Virginia +188, Louisville -231
Over/Under: 62.5

Virginia: (4-1)  |  Louisville: (4-0)

Remi's searched hard and found the best prop for this matchup: D. Twitty under 28.5 Receiving Yards.. Prices move—always shop for the best number.

Louisville opened as a 7-point favorite over Virginia, later drifting to 7.5, a line that illustrates the market’s expectation of a competitive game. That margin sets up a classic test—can Virginia cover as a road underdog against a confident Louisville squad that’s built to dominate at home?

UVA trend: Virginia enters this matchup with a strong underlying profile: they rank among the more efficient scorers and have outperformed projections in several games this season, suggesting they may have value as an underdog on the road.

LVILLE trend: Louisville is frequently installed as a favorite at home in 2025, and while they’ve had success, their ATS track record has shown variability—especially in games involving ranked or tough opponents on home turf.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Virginia vs. Louisville Odds

Remi is pouring through loads of stats on each line. In fact, anytime the Virginia vs Louisville trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude can often follow normal, predictable patterns.

Virginia vs Louisville Opening Odds

UVA Moneyline: +188
LVILLE Moneyline: -231
UVA Spread: +6.5
LVILLE Spread: -6.5
Over/Under: 62.5

Virginia vs Louisville Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+188
-6.5 (-110)
+6.5 (-110)
O 56.5 (-106)
U 56.5 (-114)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1500
-27.5 (-102)
+27.5 (-120)
O 60.5 (-115)
U 60.5 (-105)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+160
-190
+4.5 (-110)
-4.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+980
-21.5 (-105)
+21.5 (-115)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+168
-5.5 (-110)
+5.5 (-110)
O 63.5 (-106)
U 63.5 (-114)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7.5 (-118)
-7.5 (-104)
O 42.5 (-120)
U 42.5 (-102)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-450
+340
-12.5 (-110)
+12.5 (-110)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+140
-3.5 (-108)
+3.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+610
-950
+17.5 (-115)
-17.5 (-105)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-610
 
-14.5 (-105)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+172
-210
+4.5 (-105)
-4.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+122
-146
+2.5 (+100)
-2.5 (-122)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-110
-110
+1.5 (-115)
-1.5 (-105)
O 57.5 (-105)
U 57.5 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-375
+9.5 (-102)
-9.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-400
+310
-10.5 (-110)
+10.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+122
-146
+2.5 (-102)
-2.5 (-120)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-350
+8.5 (-110)
-8.5 (-110)
O 38.5 (-115)
U 38.5 (-105)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-520
+385
-11.5 (-118)
+11.5 (-104)
O 47.5 (-105)
U 47.5 (-115)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+122
-146
+2.5 (+100)
-2.5 (-122)
O 48.5 (-115)
U 48.5 (-105)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+188
-5.5 (-120)
+5.5 (-102)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+176
-215
+5.5 (-110)
-5.5 (-110)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
+104
-125
+1.5 (-105)
-1.5 (-115)
O 46.5 (-114)
U 46.5 (-106)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+480
-670
+15.5 (-110)
-15.5 (-110)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+146
-176
+4.5 (-115)
-4.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-720
 
-15.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-146
+122
-2.5 (-122)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-138
+2.5 (-106)
-2.5 (-114)
O 52.5 (-110)
U 52.5 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+195
-240
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+106
 
+2.5 (-115)
 
O 41.5 (-110)
U 41.5 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+310
 
+11.5 (-115)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+37.5 (-108)
-37.5 (-112)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+152
-184
+4.5 (-115)
-4.5 (-105)
O 67.5 (-105)
U 67.5 (-115)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-285
+230
-7.5 (-102)
+7.5 (-120)
O 44.5 (-120)
U 44.5 (-102)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+470
-15.5 (-112)
+15.5 (-108)
O 55.5 (-106)
U 55.5 (-114)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-106)
-33.5 (-114)
O 44.5 (-108)
U 44.5 (-112)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
+9.5 (-110)
-9.5 (-110)
O 47.5 (-112)
U 47.5 (-108)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-104)
U 45.5 (-118)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+106
-128
+1.5 (-105)
-1.5 (-115)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-630
+450
-14.5 (-105)
+14.5 (-115)
O 48.5 (-105)
U 48.5 (-115)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-144
+120
-2.5 (-120)
+2.5 (-102)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 55.5 (-104)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+184
-225
+5.5 (-104)
-5.5 (-118)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+270
-9.5 (-110)
+9.5 (-110)
O 53.5 (-118)
U 53.5 (-104)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+220
-275
+7.5 (-120)
-7.5 (-102)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+375
-500
+13.5 (-110)
-13.5 (-110)
O 49.5 (-115)
U 49.5 (-105)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Virginia Cavaliers vs. Louisville Cardinals on October 04, 2025 at L&N Federal Credit Union Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN