The October 4, 2025 matchup between Minnesota and Ohio State at Ohio Stadium is one of the Big Ten’s most intriguing games of the week, as it features a Golden Gophers team eager to prove it can compete against elite competition and a Buckeyes squad aiming to showcase its dominance and defend its national championship pedigree. Ohio State enters the contest 4–0 with one of the most suffocating defenses in the country, giving up just 5.5 points per game and not allowing a single red zone touchdown through the first month of the season, while also boasting an efficient offense led by freshman quarterback Julian Sayin, who has completed nearly 79 percent of his passes for 987 yards and 10 touchdowns with only two interceptions. Wide receiver Jeremiah Smith has emerged as one of the premier playmakers in college football, and his ability to stretch the field adds explosiveness to an offense that complements its defensive strength. Minnesota, on the other hand, comes in at 3–1 with plenty of grit, having edged Rutgers 31–28 in their last outing thanks to the steady play of quarterback Drake Lindsey, who has thrown for 958 yards, seven touchdowns, and only two interceptions this season, but they face concerns in the run game as injuries to Darius Taylor and A.J. Turner have forced them to lean more heavily on the passing attack.

Defensively, the Golden Gophers flashed potential against Rutgers, producing seven sacks and an interception, and they will need similar disruptive energy if they hope to slow down Sayin and Ohio State’s rhythm. The key matchup lies in the trenches: Ohio State’s depth and talent across the offensive line will be tested by Minnesota’s aggressive front seven, while on the other side, the Buckeyes’ defensive line will look to collapse the pocket and keep Lindsey uncomfortable all afternoon. Special teams could also play a pivotal role, as Minnesota may need a momentum-swinging play in the return game or a key field goal to stay within striking distance, while Ohio State will look to remain steady and avoid giving the Gophers cheap opportunities. From a betting perspective, Ohio State is favored by more than three touchdowns, a number that reflects both their defensive dominance and Minnesota’s inconsistency, as the Gophers are just 1–3 ATS this season compared to the Buckeyes’ stronger 3–1 ATS mark. For Minnesota to hang around, they must win the turnover battle, capitalize on red-zone chances, and keep Ohio State from building an early double-digit lead, while the Buckeyes simply need to play to their standard—limit mistakes, convert in the red zone, and let their defense dictate terms. Ultimately, this matchup feels like another opportunity for Ohio State to showcase its depth and balance, but Minnesota’s resilience and opportunism could at least make the game more competitive than the spread suggests if they execute with discipline and force Ohio State into uncomfortable situations.