Oregon vs Penn State Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 27)

Updated: 2025-09-20T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Oregon Ducks travel east to face the Penn State Nittany Lions on September 27, 2025, in a matchup that has major College Football Playoff implications. Both teams boast elite defenses and explosive playmakers, setting up a high-stakes showdown under the lights in Happy Valley.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 27, 2025

Start Time: 7:30 PM EST​

Venue: West Shore Home Field at Beaver Stadium​

Nittany Lions Record: (3-0)

Ducks Record: (4-0)

OPENING ODDS

OREG Moneyline: +140

PSU Moneyline: -168

OREG Spread: +3.5

PSU Spread: -3.5

Over/Under: 51.5

OREG
Betting Trends

  • Oregon has covered the spread in four of its last five road games, showing resilience against tough defensive opponents.

PSU
Betting Trends

  • Penn State has gone 5-1 ATS in its last six games at Beaver Stadium, consistently rewarding backers with strong home performances.

MATCHUP TRENDS

  • In their last 10 combined games, Oregon and Penn State have gone over the total in seven matchups, suggesting that despite strong defenses, their offenses often rise to the occasion in big spots.

OREG vs. PSU
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: N. Singleton over 62.5 Rushing Yards.

LIVE CFB ODDS

CFB ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
325-240
VAULT
NET UNITS
(INCL VIG)
+395.4
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$39,540
EXECUTIVE
VS. SPREAD
1593-1364
EXECUTIVE
NET UNITS
(INCL VIG)
+371.9
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$37,192

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

Oregon vs Penn State Prediction & Odds:
Free CFB Betting Insights for 9/27/25

The matchup between the Oregon Ducks and the Penn State Nittany Lions on September 27, 2025, is shaping up to be one of the most pivotal contests of the college football season, featuring two programs with national championship aspirations and rosters built to compete at the highest level. Oregon comes into this clash with its trademark blend of speed, tempo, and offensive efficiency, powered by a quarterback who has grown into one of the most reliable decision-makers in the nation and a backfield that consistently churns out yards with both finesse and power. Their offensive line, which has been the backbone of the Ducks’ recent success, will face arguably its toughest test of the season against a Penn State defensive front loaded with future NFL talent, particularly edge rushers who specialize in collapsing pockets and forcing hurried throws. The Ducks’ receivers, who bring a mix of speed and route-running precision, could stretch Penn State’s secondary vertically, which would be a key factor if Oregon wants to loosen up what is traditionally a stout run defense. On the other side, Penn State counters with a balanced offensive approach that has leaned heavily on a dominant ground game led by a dynamic stable of running backs while also showcasing a quarterback who has displayed both composure and big-play ability. Their offensive line thrives on physicality, and the matchup against Oregon’s defensive front, which prides itself on speed and gap discipline, will be crucial in determining whether Penn State can control the pace and keep the Ducks’ offense on the sidelines.

Defensively, Oregon has developed a reputation for generating turnovers and creating disruptive plays in the backfield, but this game will test their ability to withstand a physical, grind-it-out style of play that Penn State embraces. Special teams could also play an outsized role, as both squads feature reliable kickers and explosive return units capable of flipping momentum in a game that projects to be tightly contested. Beyond the X’s and O’s, the atmosphere of Beaver Stadium at night looms large, with the raucous White Out crowd creating one of the most intimidating environments in all of college football, which could challenge Oregon’s ability to operate its up-tempo offense without costly mistakes. Both teams have an opportunity to solidify their playoff résumés with a statement victory, and the outcome may ultimately come down to which team executes better in situational football—red zone efficiency, third down conversions, and turnover margin are likely to determine the winner. With Oregon’s speed and balance clashing against Penn State’s physicality and defensive toughness, this game is not just a test of talent but also of willpower, execution, and adaptability, making it one of the defining contests of the 2025 season and a possible preview of a playoff rematch down the line.

Oregon Ducks CFB Preview

The Oregon Ducks enter their September 27, 2025 showdown against Penn State as one of the most explosive and versatile teams in college football, carrying an identity built on tempo, balance, and a roster loaded with speed at every level. Their offense has been the centerpiece of their success, with a quarterback who has shown steady leadership, strong decision-making, and the ability to hit receivers on both quick-timing routes and deep shots down the field. Oregon’s running game remains just as vital, featuring a blend of power and speed backs capable of exploiting creases behind an offensive line that excels in space and has developed into one of the more cohesive units in the country. The wide receiver corps is deep and athletic, headlined by playmakers who can stretch defenses vertically and force opponents to defend the entire field, while the tight ends have provided steady production in short-yardage and red zone scenarios. The Ducks’ defense has taken steps forward, embracing a philosophy rooted in aggression and speed, with pass rushers who consistently disrupt the pocket and linebackers that fly sideline to sideline to erase big plays. The secondary has the athleticism and depth to compete against top-tier passing attacks, though their ability to hold up physically against Penn State’s downhill run game will be tested.

Oregon also benefits from disciplined special teams, with a kicker who has been reliable in pressure moments and returners who can swing momentum with a single big play. The biggest challenge for the Ducks will be adapting their offensive rhythm to a hostile environment like Beaver Stadium, where crowd noise and Penn State’s defensive intensity could force mistakes if they fail to stay composed. Oregon’s recent track record against physical teams shows they can compete, but they will need to prove that their offensive line can neutralize elite pass rushers and their defensive front can withstand four quarters of punishing runs. A victory here would not only bolster their playoff résumé but also validate their ability to win against the kind of opponent they will inevitably need to beat in December and January. For Oregon, this is not just another test—it’s a chance to show that speed, versatility, and offensive ingenuity can stand toe-to-toe with physicality, discipline, and a raucous atmosphere, and that they are every bit the contender they’re believed to be heading into the heart of the season.

The Oregon Ducks travel east to face the Penn State Nittany Lions on September 27, 2025, in a matchup that has major College Football Playoff implications. Both teams boast elite defenses and explosive playmakers, setting up a high-stakes showdown under the lights in Happy Valley. Oregon vs Penn State AI Prediction: Free CFB Betting Insights for Sep 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Penn State Nittany Lions CFB Preview

The Penn State Nittany Lions come into their September 27, 2025 matchup against Oregon with all the confidence and momentum of a program that has become a consistent force in the Big Ten and a regular contender in the College Football Playoff conversation, and they know that protecting Beaver Stadium in a high-profile game under the White Out atmosphere gives them a massive psychological advantage. Penn State’s identity this season has revolved around their balance on offense, anchored by a bruising offensive line that has consistently opened holes for one of the deepest and most dynamic running back rooms in the country, capable of grinding out tough yards between the tackles or bouncing outside for explosive plays. Their quarterback, who has grown more poised and efficient as the season has progressed, adds another dimension with his ability to make throws on the run and extend plays under pressure, something that will be critical against Oregon’s fast and aggressive defense. The wide receiver group has been emerging as well, with several reliable possession targets and at least one speed threat who can stretch the field and test the Ducks’ secondary. On defense, Penn State continues to pride itself on dominance in the trenches, with a front four that thrives on collapsing the pocket and forcing quarterbacks into hurried throws, while their linebackers maintain the program’s long tradition of athleticism and instincts, often dictating the pace of a game with timely stops.

The secondary is physical and disciplined, capable of holding their own in coverage but also aggressive enough to jump routes and create turnovers, something that could swing this game if Oregon is forced into obvious passing situations. Special teams remain a steady strength, with reliable kicking, a strong punting game, and returners who can change momentum in a flash. Perhaps the biggest edge for Penn State is the White Out environment, where the sheer noise and energy of over 100,000 fans often rattle visiting offenses, particularly those like Oregon that depend on rhythm and tempo to maximize efficiency. If Penn State can control the line of scrimmage, limit Oregon’s explosive plays, and impose their brand of physical football, they could turn what many expect to be a shootout into a methodical, grind-it-out game that suits their strengths. For head coach James Franklin, this is a defining opportunity to solidify his team’s playoff positioning and to prove once again that the Nittany Lions are not just contenders within the Big Ten but one of the most complete teams in all of college football. Ultimately, for Penn State, this game is about defending home turf, proving that discipline and physicality can prevail against speed and versatility, and sending a statement to the rest of the nation that they remain a premier force built to thrive in the toughest moments of the season.

Oregon vs. Penn State Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each player. In fact, anytime the Ducks and Nittany Lions play there’s always several intriguing observations to key in on. Not to mention games played at West Shore Home Field at Beaver Stadium in Sep almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: N. Singleton over 62.5 Rushing Yards.

Oregon vs. Penn State Prediction (AI)

Remi Robot Icon

Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Ducks and Nittany Lions and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Remi has been most fixated on the trending emphasis knucklehead sportsbettors often put on Oregon’s strength factors between a Ducks team going up against a possibly deflated Nittany Lions team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Oregon vs Penn State picks, computer picks Ducks vs Nittany Lions, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
ACTIVE PICKS LOCKED - SEE NOW

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Ducks Betting Trends

Oregon has covered the spread in four of its last five road games, showing resilience against tough defensive opponents.

Nittany Lions Betting Trends

Penn State has gone 5-1 ATS in its last six games at Beaver Stadium, consistently rewarding backers with strong home performances.

Ducks vs. Nittany Lions Matchup Trends

In their last 10 combined games, Oregon and Penn State have gone over the total in seven matchups, suggesting that despite strong defenses, their offenses often rise to the occasion in big spots.

Oregon vs. Penn State Game Info

Oregon vs Penn State starts on September 27, 2025 at 7:30 PM EST.

Venue: West Shore Home Field at Beaver Stadium.

Spread: Penn State -3.5
Moneyline: Oregon +140, Penn State -168
Over/Under: 51.5

Oregon: (4-0)  |  Penn State: (3-0)

Remi's searched hard and found the best prop for this matchup: N. Singleton over 62.5 Rushing Yards.. Prices move—always shop for the best number.

In their last 10 combined games, Oregon and Penn State have gone over the total in seven matchups, suggesting that despite strong defenses, their offenses often rise to the occasion in big spots.

OREG trend: Oregon has covered the spread in four of its last five road games, showing resilience against tough defensive opponents.

PSU trend: Penn State has gone 5-1 ATS in its last six games at Beaver Stadium, consistently rewarding backers with strong home performances.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Oregon vs. Penn State Odds

Remi is pouring through mountains of stats on each line. In fact, anytime the Oregon vs Penn State trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable patterns.

Oregon vs Penn State Opening Odds

OREG Moneyline: +140
PSU Moneyline: -168
OREG Spread: +3.5
PSU Spread: -3.5
Over/Under: 51.5

Oregon vs Penn State Live Odds

Games PTS ML SPR O/U
Oct 21, 2025 7:00PM EDT
Kennesaw State Owls
FIU Panthers
10/21/25 7PM
KENSAW
FIU
-155
 
-3 (-115)
 
O 49.5 (-110)
U 49.5 (-110)
Oct 21, 2025 7:30PM EDT
Western Kentucky Hilltoppers
Louisiana Tech Bulldogs
10/21/25 7:30PM
WKY
LATECH
+146
-170
+3.5 (-117)
-3.5 (-103)
O 50 (-110)
U 50 (-110)
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-340
 
-9 (-110)
O 55 (-110)
U 55 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-120
+100
-1.5 (-110)
+1.5 (-110)
O 50.5 (-110)
U 50.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-235
+200
-6.5 (-110)
+6.5 (-110)
O 56 (-110)
U 56 (-110)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-3000
+1500
-26.5 (-110)
+26.5 (-110)
O 61.5 (-110)
U 61.5 (-110)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+170
-200
+4.5 (-110)
-4.5 (-110)
O 50 (-110)
U 50 (-110)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+1000
-21.5 (-110)
+21.5 (-110)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-395
+317
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-300
+250
-7.5 (-110)
+7.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-190
+163
-4.5 (-110)
+4.5 (-110)
O 63.5 (-110)
U 63.5 (-110)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1400
-2800
+25 (-105)
-25 (-115)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+238
-285
+7 (-105)
-7 (-115)
O 43.5 (-110)
U 43.5 (-110)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-480
+378
-12.5 (-110)
+12.5 (-110)
O 59 (-110)
U 59 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-175
+150
-3.5 (-110)
+3.5 (-110)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+600
-900
+17.5 (-110)
-17.5 (-110)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-550
 
-14.5 (-110)
O 63 (-105)
U 63 (-115)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+180
-210
+5 (-110)
-5 (-110)
O 54 (-110)
U 54 (-110)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+129
-150
+3 (-110)
-3 (-110)
O 57 (-110)
U 57 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-105
-115
+1 (-110)
-1 (-110)
O 57 (-110)
U 57 (-110)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-360
+9.5 (-110)
-9.5 (-110)
O 47 (-110)
U 47 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-395
+317
-11 (-110)
+11 (-110)
O 49 (-110)
U 49 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+129
-150
+3 (-110)
-3 (-110)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-340
+9 (-110)
-9 (-110)
O 39 (-110)
U 39 (-110)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-470
+370
-12 (-110)
+12 (-110)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+125
-145
+2.5 (-105)
-2.5 (-115)
O 49 (-105)
U 49 (-115)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+190
-6 (-110)
+6 (-110)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+175
-205
+5.5 (-110)
-5.5 (-110)
O 41 (-110)
U 41 (-110)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
-105
-115
+1 (-110)
-1 (-110)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+485
-670
+16 (-110)
-16 (-110)
O 62.5 (-110)
U 62.5 (-110)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+163
-190
+4.5 (-110)
-4.5 (-110)
O 54 (-110)
U 54 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-725
 
-16 (-110)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-155
+134
-3 (-115)
+3 (-105)
O 48 (-110)
U 48 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+120
-140
+2.5 (-105)
-2.5 (-115)
O 52 (-110)
U 52 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+210
-250
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+105
 
+1.5 (-110)
 
O 41 (-115)
U 41 (-105)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+355
 
+11 (-110)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+3500
-10000
+38 (-110)
-38 (-110)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+163
-190
+4.5 (-110)
-4.5 (-110)
O 67.5 (-110)
U 67.5 (-110)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-260
+218
-7 (-110)
+7 (-110)
O 45 (-110)
U 45 (-110)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+485
-16 (-110)
+16 (-110)
O 55.5 (-105)
U 55.5 (-115)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-105)
-33.5 (-115)
O 44.5 (-110)
U 44.5 (-110)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-330
+9.5 (-110)
-9.5 (-110)
O 48 (-110)
U 48 (-110)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-20000
+30 (-110)
-30 (-110)
O 45 (-115)
U 45 (-105)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+100
-120
+1.5 (-110)
-1.5 (-110)
O 62.5 (-110)
U 62.5 (-110)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-650
+475
-14.5 (-110)
+14.5 (-110)
O 48 (-110)
U 48 (-110)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-145
+125
-3 (-105)
+3 (-115)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1300
-2500
+25.5 (-110)
-25.5 (-110)
O 55 (-110)
U 55 (-110)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+183
-215
+5 (-110)
-5 (-110)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-350
+280
-9.5 (-110)
+9.5 (-110)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+250
-300
+7.5 (-110)
-7.5 (-110)
O 47 (-110)
U 47 (-110)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+425
-550
+14 (-115)
-14 (-105)
O 49.5 (-110)
U 49.5 (-110)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-320
+255
-8.5 (-110)
+8.5 (-110)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-280
+225
-7.5 (+100)
+7.5 (-122)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Oregon Ducks vs. Penn State Nittany Lions on September 27, 2025 at West Shore Home Field at Beaver Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN