Louisville vs Pittsburgh Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 27)

Updated: 2025-09-20T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Louisville Cardinals travel to Acrisure Stadium on September 27, 2025, to face the Pittsburgh Panthers in an ACC clash with significant implications for both programs’ positioning in the conference race. Louisville brings an explosive offense, while Pitt looks to defend its home turf with a physical brand of football, setting up a battle of tempo versus toughness.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 27, 2025

Start Time: 12:00 PM EST​

Venue: Acrisure Stadium​

Panthers Record: (2-1)

Cardinals Record: (3-0)

OPENING ODDS

LVILLE Moneyline: -187

PITT Moneyline: +156

LVILLE Spread: -4.5

PITT Spread: +4.5

Over/Under: 57.5

LVILLE
Betting Trends

  • Louisville has been strong ATS on the road, covering in three of its last four away games by leaning on offensive efficiency and explosive playmaking.

PITT
Betting Trends

  • Pittsburgh has struggled ATS at home recently, covering only once in its last four games, largely due to late-game collapses and offensive inconsistency.

MATCHUP TRENDS

  • Louisville has excelled in matchups against ACC opponents with shaky offenses, covering in five of its last six in that scenario, while Pitt has failed to cover in three straight ACC home games. Early totals movement leans toward the over, as bettors expect Louisville’s pace to force Pitt into a higher-scoring affair than usual.

LVILLE vs. PITT
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Moss under 290.5 Passing Yards.

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Louisville vs Pittsburgh Prediction & Odds:
Free CFB Betting Insights for 9/27/25

The September 27, 2025 matchup between the Louisville Cardinals and the Pittsburgh Panthers at Acrisure Stadium is a classic ACC clash of contrasting styles, with Louisville bringing one of the league’s most explosive and up-tempo offenses against a Pittsburgh program built on defensive toughness and physical play. Louisville enters this game with momentum, boasting a quarterback who has emerged as a star, combining poise, arm strength, and mobility to extend plays and punish defenses with both short precision throws and deep strikes. His connection with a versatile receiving corps has made the Cardinals a nightmare for opposing secondaries, while the rushing attack has been effective enough to maintain balance and force defenses into difficult decisions about where to allocate resources. Their offensive line has held up admirably, limiting sacks and allowing the passing game to flourish, and their red-zone efficiency has been one of the keys to their success, turning possessions into touchdowns rather than field goals. Defensively, Louisville is not dominant but opportunistic, creating turnovers and stiffening in the red zone to compensate for their occasional vulnerability against physical rushing teams, which makes the matchup against Pitt particularly compelling. The Panthers, by contrast, will look to slow the game down and turn it into a battle of attrition, leaning on their defensive front to pressure Louisville’s quarterback and disrupt rhythm, while offensively relying on their own rushing attack to control tempo and keep the Cardinals’ offense on the sideline.

Pitt’s defensive line is among the most aggressive in the conference, and if they can generate consistent pressure, they may force Louisville into mistakes that swing momentum, though their secondary has been prone to lapses that Louisville will target relentlessly. Offensively, Pitt has struggled with consistency at quarterback, alternating between efficient stretches and costly turnovers, and their lack of explosive plays has often left them unable to keep pace in higher-scoring contests. For Pitt to compete here, they must avoid mistakes, win on third down, and capitalize on every red-zone chance, as trading field goals for Louisville touchdowns will not be a sustainable formula. Special teams could also play a pivotal role, as Pitt will need to maximize hidden yardage and potentially deliver a spark with a big return, while Louisville’s consistent kicking game and disciplined coverage units give them a slight edge in that department. From a betting standpoint, Louisville’s strong ATS record on the road contrasts sharply with Pitt’s struggles to cover at home, making the Cardinals the more trustworthy side on paper, especially if the game plays into their preferred fast pace. Still, home-field advantage and the physicality of Pitt’s defense cannot be dismissed, as they have historically managed to drag more talented teams into ugly, low-scoring battles. Ultimately, this matchup will be decided by which team dictates tempo—if Louisville’s offense can get rolling early and force Pitt into a shootout, the Cardinals have the weapons to win comfortably, but if the Panthers control the clock, create pressure, and force turnovers, they have a chance to grind out an upset and shift the trajectory of their season.

Louisville Cardinals CFB Preview

The Louisville Cardinals head into their September 27, 2025 road test against the Pittsburgh Panthers with confidence and momentum, knowing they have the offensive firepower to dictate the terms of this ACC clash if they execute their game plan cleanly, and their profile as a team that has consistently covered spreads away from home gives them a psychological edge as well. Louisville’s offensive identity is built around a quarterback who has emerged as one of the league’s most dynamic dual-threat playmakers, combining accuracy and vision in the passing game with the mobility to extend plays and punish defenses outside of structure, and his chemistry with a deep receiving corps has been a major reason the Cardinals have turned into an explosive scoring machine. Their offensive line, while not perfect, has been sturdy in pass protection, giving their quarterback time to attack vertically and forcing defenses to pick their poison against an attack that can stretch the field horizontally and vertically at will. The running game has also contributed balance, with backs capable of both grinding out yards in short-yardage situations and hitting the occasional big play when defenses are stretched thin, and this balance has kept Louisville from being predictable, a key to their success in road environments.

Defensively, the Cardinals are not flawless, but they’ve been opportunistic, using pressure to force hurried throws and capitalizing on turnovers that flip momentum, while also tightening up in the red zone to keep opponents from cashing in on long drives. Against Pitt, their defense will be tested against a team that thrives on physical play and clock control, but Louisville’s speed and aggressiveness on defense may allow them to force the Panthers into uncomfortable passing situations where they have struggled all season. Special teams are another steady area for Louisville, with consistent kicking and disciplined coverage units minimizing risk and giving them an edge in hidden yardage battles. From a betting perspective, Louisville’s road ATS record underscores their ability to travel well, and their tendency to thrive against ACC opponents who lack offensive explosiveness aligns perfectly with Pitt’s current profile. The keys for Louisville will be protecting their quarterback against Pitt’s ferocious pass rush, sustaining drives by staying efficient on third downs, and striking quickly when Pitt’s secondary shows its all-too-common lapses in coverage. If the Cardinals can neutralize the Panthers’ defensive front and avoid turnovers that give Pitt short fields, they have every chance to impose their pace and control the scoreboard, and their offensive versatility makes them particularly dangerous once they establish rhythm. Louisville knows the path to victory lies in forcing Pitt to chase points in a game script that does not fit their strengths, and if they succeed in doing so, the Cardinals not only solidify their place as one of the ACC’s most dangerous road teams but also send a message that their combination of balance, explosiveness, and discipline makes them a legitimate contender for the conference crown.

The Louisville Cardinals travel to Acrisure Stadium on September 27, 2025, to face the Pittsburgh Panthers in an ACC clash with significant implications for both programs’ positioning in the conference race. Louisville brings an explosive offense, while Pitt looks to defend its home turf with a physical brand of football, setting up a battle of tempo versus toughness. Louisville vs Pittsburgh AI Prediction: Free CFB Betting Insights for Sep 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Pittsburgh Panthers CFB Preview

The Pittsburgh Panthers return to Acrisure Stadium on September 27, 2025 to host the Louisville Cardinals with the weight of expectation on their shoulders, knowing that home-field advantage is only as strong as their ability to execute and avoid the costly lapses that have plagued them throughout the early season, and this game offers them the chance to reclaim momentum in the ACC. Pitt’s identity has always been rooted in physicality, especially on the defensive side of the ball, where their front seven has long been among the most aggressive in the league, generating steady pressure on quarterbacks and disrupting opponents’ run games, and against Louisville’s explosive offense, that unit will be tasked with setting the tone early by collapsing the pocket and forcing mistakes. The Panthers’ pass rush will be critical, as Louisville’s quarterback thrives when given time to scan the field and connect with a deep, versatile receiving corps, so Pitt’s edge defenders and linebackers must close space quickly and limit those opportunities. The secondary, however, has been a vulnerability, with breakdowns in coverage leading to big plays, and the group must be disciplined and communicate effectively to avoid letting Louisville dictate pace with explosive strikes. Offensively, Pitt’s production has been inconsistent, hinging heavily on a quarterback whose performance has swung between efficient game management and costly turnovers, and they’ll need him to play with poise against a Louisville defense that, while not dominant, has been opportunistic in creating turnovers and capitalizing in the red zone.

The Panthers’ run game is a strength when the offensive line establishes control, as their backs are capable of grinding out yards and sustaining drives, which also serves the critical purpose of keeping Louisville’s high-octane offense on the sideline, and this formula of ball control and physicality is their clearest path to victory. Special teams could be a hidden weapon, as Pitt will look for field position edges and perhaps a momentum-shifting play from the return game to spark their home crowd and tilt the flow of the contest. From a betting perspective, Pitt’s poor ATS record at home has been a frustration for backers, but history shows they have the ability to drag more talented, explosive opponents into low-scoring, physical contests that favor their style, and they’ll be hoping to replicate that approach against the Cardinals. The keys for Pitt will be avoiding turnovers, winning third down on both sides of the ball, and capitalizing on every red-zone opportunity, because field goals will not be enough to match Louisville’s scoring pace. The home crowd will be a critical factor, providing energy and noise to disrupt Louisville’s communication, and the Panthers must feed off that momentum to stay competitive for four quarters. If they can pressure Louisville’s quarterback into mistakes, run the ball effectively, and keep the game in a low-possession grind, the Panthers have every chance to flip the script, cover the spread, and potentially pull off the upset that could reset the trajectory of their season and restore faith in their rugged, physical brand of football.

Louisville vs. Pittsburgh Prop Picks (AI)

Remi is pouring through loads of stats on each team. In fact, anytime the Cardinals and Panthers play there’s always several intriguing trends to key in on. Not to mention games played at Acrisure Stadium in Sep almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: M. Moss under 290.5 Passing Yards.

Louisville vs. Pittsburgh Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the Cardinals and Panthers and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

The Algorithm has been most focused on the growing weight knucklehead sportsbettors regularly put on player performance factors between a Cardinals team going up against a possibly rested Panthers team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Louisville vs Pittsburgh picks, computer picks Cardinals vs Panthers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Cardinals Betting Trends

Louisville has been strong ATS on the road, covering in three of its last four away games by leaning on offensive efficiency and explosive playmaking.

Panthers Betting Trends

Pittsburgh has struggled ATS at home recently, covering only once in its last four games, largely due to late-game collapses and offensive inconsistency.

Cardinals vs. Panthers Matchup Trends

Louisville has excelled in matchups against ACC opponents with shaky offenses, covering in five of its last six in that scenario, while Pitt has failed to cover in three straight ACC home games. Early totals movement leans toward the over, as bettors expect Louisville’s pace to force Pitt into a higher-scoring affair than usual.

Louisville vs. Pittsburgh Game Info

Louisville vs Pittsburgh starts on September 27, 2025 at 12:00 PM EST.

Spread: Pittsburgh +4.5
Moneyline: Louisville -187, Pittsburgh +156
Over/Under: 57.5

Louisville: (3-0)  |  Pittsburgh: (2-1)

Remi's searched hard and found the best prop for this matchup: M. Moss under 290.5 Passing Yards.. Prices move—always shop for the best number.

Louisville has excelled in matchups against ACC opponents with shaky offenses, covering in five of its last six in that scenario, while Pitt has failed to cover in three straight ACC home games. Early totals movement leans toward the over, as bettors expect Louisville’s pace to force Pitt into a higher-scoring affair than usual.

LVILLE trend: Louisville has been strong ATS on the road, covering in three of its last four away games by leaning on offensive efficiency and explosive playmaking.

PITT trend: Pittsburgh has struggled ATS at home recently, covering only once in its last four games, largely due to late-game collapses and offensive inconsistency.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Louisville vs. Pittsburgh Odds

AI algorithm Remi is pouring through loads of data points on each team. In fact, anytime the Louisville vs Pittsburgh trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.

Louisville vs Pittsburgh Opening Odds

LVILLE Moneyline: -187
PITT Moneyline: +156
LVILLE Spread: -4.5
PITT Spread: +4.5
Over/Under: 57.5

Louisville vs Pittsburgh Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+185
-6.5 (-110)
+6.5 (-110)
O 55.5 (-112)
U 55.5 (-108)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1600
-26.5 (-112)
+26.5 (-108)
O 61.5 (-105)
U 61.5 (-115)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+164
-198
+4.5 (-108)
-4.5 (-112)
O 49.5 (-115)
U 49.5 (-105)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+1000
-21 (-115)
+21 (-105)
O 50.5 (-112)
U 50.5 (-108)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-395
+310
-10.5 (-108)
+10.5 (-112)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-290
+235
-7.5 (-105)
+7.5 (-115)
O 48.5 (-108)
U 48.5 (-112)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+114
-2.5 (-115)
+2.5 (-105)
O 58.5 (-112)
U 58.5 (-108)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+170
-4.5 (-112)
+4.5 (-108)
O 63.5 (-108)
U 63.5 (-112)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1400
-3200
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7 (-105)
-7 (-115)
O 43.5 (-110)
U 43.5 (-110)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-500
+380
-12.5 (-108)
+12.5 (-112)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-180
+150
-3.5 (-108)
+3.5 (-112)
O 53.5 (-115)
U 53.5 (-105)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+600
-900
+17.5 (-110)
-17.5 (-110)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-625
 
-14.5 (-108)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+180
-218
+4.5 (-105)
-4.5 (-115)
O 54.5 (-108)
U 54.5 (-112)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+130
-155
+3 (-112)
-3 (-108)
O 56.5 (-115)
U 56.5 (-105)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-105
-115
+1.5 (-115)
-1.5 (-105)
O 56.5 (-112)
U 56.5 (-108)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+310
-395
+9.5 (-110)
-9.5 (-110)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-410
+320
-10.5 (-110)
+10.5 (-110)
O 49.5 (-105)
U 49.5 (-115)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+130
-155
+3 (-112)
-3 (-108)
O 61.5 (-112)
U 61.5 (-108)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-345
+9.5 (-112)
-9.5 (-108)
O 39.5 (-108)
U 39.5 (-112)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-485
+370
-12.5 (-110)
+12.5 (-110)
O 47.5 (-108)
U 47.5 (-112)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+124
-148
+2.5 (-102)
-2.5 (-118)
O 48.5 (-112)
U 48.5 (-108)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-238
+195
-6 (-112)
+6 (-108)
O 53.5 (-112)
U 53.5 (-108)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+180
-218
+5.5 (-112)
-5.5 (-108)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
-102
-118
+1.5 (-115)
-1.5 (-105)
O 46.5 (-108)
U 46.5 (-112)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+455
-625
+15.5 (-108)
-15.5 (-112)
O 62.5 (-112)
U 62.5 (-108)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+164
-198
+4.5 (-110)
-4.5 (-110)
O 53.5 (-115)
U 53.5 (-105)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-700
 
-16.5 (-108)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-155
+130
-3 (-110)
+3 (-110)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+114
-135
+2.5 (-110)
-2.5 (-110)
O 51.5 (-115)
U 51.5 (-105)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+205
-250
+6.5 (-108)
-6.5 (-112)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+102
 
+1.5 (-110)
 
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+340
 
+10.5 (-105)
 
O 50.5 (-112)
U 50.5 (-108)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+38.5 (-115)
-38.5 (-105)
O 56.5 (-108)
U 56.5 (-112)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+154
-185
+4.5 (-110)
-4.5 (-110)
O 66.5 (-115)
U 66.5 (-105)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-270
+220
-7 (-105)
+7 (-115)
O 44.5 (-115)
U 44.5 (-105)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-650
+470
-15.5 (-110)
+15.5 (-110)
O 54.5 (-118)
U 54.5 (-102)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-108)
-33.5 (-112)
O 44.5 (-112)
U 44.5 (-108)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+280
-355
+8.5 (-108)
-8.5 (-112)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-105)
U 45.5 (-115)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+100
-120
+1.5 (-110)
-1.5 (-110)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-625
+455
-14.5 (-105)
+14.5 (-115)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-142
+120
-2.5 (-115)
+2.5 (-105)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1400
-3200
+25.5 (-110)
-25.5 (-110)
O 55.5 (-102)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+180
-218
+5.5 (-110)
-5.5 (-110)
O 46.5 (-112)
U 46.5 (-108)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+275
-9.5 (-108)
+9.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+230
-285
+7.5 (-115)
-7.5 (-105)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+410
-550
+13.5 (-110)
-13.5 (-110)
O 49.5 (-112)
U 49.5 (-108)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Louisville Cardinals vs. Pittsburgh Panthers on September 27, 2025 at Acrisure Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN