Indiana vs Iowa Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 27)

Updated: 2025-09-20T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Indiana Hoosiers will travel to Kinnick Stadium to take on the Iowa Hawkeyes on September 27, 2025, in a Big Ten showdown that pits Indiana’s improving offense against Iowa’s traditionally stout defense. Both teams are looking for a conference win to build momentum, with Iowa seeking to protect its home field while Indiana aims to prove it can compete on the road against one of the league’s most disciplined programs.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 27, 2025

Start Time: 3:30 PM EST​

Venue: Kinnick Stadium​

Hawkeyes Record: (3-1)

Hoosiers Record: (4-0)

OPENING ODDS

IND Moneyline: -299

IOWA Moneyline: +238

IND Spread: -7.5

IOWA Spread: +7.5

Over/Under: 48.5

IND
Betting Trends

  • Indiana has struggled to cover spreads consistently in Big Ten road games, often falling behind early and failing to recover against physical opponents.

IOWA
Betting Trends

  • Iowa has been solid ATS at home, especially in defensive-driven games where their ability to limit opponents and control tempo has paid off.

MATCHUP TRENDS

  • Historically, matchups between these two teams have leaned toward the under, as Iowa’s defense and methodical pace often suppress scoring while Indiana’s offense has struggled to break through in Iowa City.

IND vs. IOWA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Gronowski under 37.5 Rushing Yards.

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Indiana vs Iowa Prediction & Odds:
Free CFB Betting Insights for 9/27/25

The Indiana Hoosiers and Iowa Hawkeyes meeting at Kinnick Stadium on September 27, 2025, is a classic Big Ten matchup that embodies the league’s traditional trademarks of physical play, disciplined defense, and games often decided at the line of scrimmage, and both teams enter this contest eager to assert themselves early in conference play with a victory that could shape their momentum heading into October. Indiana arrives looking to prove that its offensive growth can carry over into hostile environments, as the Hoosiers have shown flashes of progress behind a quarterback who has grown more comfortable commanding the offense, distributing the ball quickly to receivers who can create separation, while leaning on a ground game that, while not always dominant, has produced steady contributions when the offensive line establishes rhythm. Their challenge will be immense against an Iowa defense that is annually among the Big Ten’s best at limiting explosive plays and forcing opponents into grinding, mistake-prone drives, with the Hawkeyes’ front seven excelling at stuffing the run and their secondary notorious for capitalizing on turnovers. For Indiana, avoiding costly mistakes and staying efficient on third downs will be critical, as falling behind early and being forced into obvious passing situations could allow Iowa’s defensive front to tee off and swing the game with pressure. On the other side, Iowa’s offense is not known for flash but for efficiency, leaning on a physical running game that sets up play-action opportunities and short-to-intermediate passes to tight ends and receivers who thrive in a system built around precision rather than explosiveness.

The Hawkeyes’ offensive line, long a strength of the program, will look to impose its will against Indiana’s defensive front, and if they can control the trenches, Iowa will dictate tempo, shorten the game, and wear down a Hoosiers defense that has struggled at times with depth. Indiana’s defense, meanwhile, will need to be opportunistic, generating negative plays and hoping to force Iowa’s offense into long-yardage situations where their lack of explosive firepower can be exposed, though doing so consistently against Iowa’s disciplined scheme will be difficult. Special teams could play an outsized role in this matchup, as Iowa’s kicking game and punting have historically been among the best in the nation, and field position could dictate scoring opportunities in what projects as a low-possession, grind-it-out game. The atmosphere at Kinnick Stadium will only magnify the challenge for Indiana, as the Hawkeyes’ home field is one of the most intimidating in the Big Ten, with a raucous crowd capable of disrupting communication and adding to the pressure on the visiting offense. Both coaching staffs will stress discipline and execution, knowing that turnovers and penalties in a game like this can swing momentum dramatically, and the battle of patience—between Indiana’s desire to generate offense and Iowa’s willingness to trust its defense and grind away—will define the narrative. Ultimately, this contest projects as another installment in Iowa’s familiar formula of defense, field position, and efficiency against an Indiana team searching for consistency, and whichever side can control the trenches and win critical third-down battles is likely to emerge with a win that carries significant weight for their Big Ten campaigns.

Indiana Hoosiers CFB Preview

The Indiana Hoosiers will enter their September 27, 2025, showdown at Kinnick Stadium knowing full well the challenge that awaits them, as winning on the road against Iowa requires both composure and execution, two qualities that have often eluded Indiana in recent Big Ten road trips. Offensively, the Hoosiers come into the game hoping to showcase the progress they’ve made under their current staff, with a quarterback who has steadily grown into his role, delivering accurate short-to-intermediate throws and occasionally taking shots downfield to keep defenses honest. His ability to protect the football will be crucial, as Iowa’s opportunistic defense has made a reputation out of turning careless passes into game-changing interceptions. Indiana’s receivers, while not as physically imposing as some of their conference counterparts, have shown the ability to find soft spots in zone coverage, and they will need to get open quickly given the relentless pressure Iowa’s front seven is likely to bring. The Hoosiers’ running game has been serviceable, leaning on a committee of backs who can churn out tough yards, but the offensive line has been inconsistent, sometimes struggling against aggressive defensive fronts, and that unit will face one of its toughest tests against an Iowa front built to win battles in the trenches. Defensively, Indiana will look to counter Iowa’s physical offensive style by stacking the box and relying on linebackers to fill gaps quickly, as slowing down the Hawkeyes’ rushing attack is critical to forcing them into uncomfortable passing situations where they are less effective.

The Hoosiers’ secondary will be tested not by volume but by precision, as Iowa quarterbacks thrive in play-action situations and targeting tight ends in mismatches, and discipline in coverage will be a must to avoid giving up back-breaking completions. On special teams, Indiana knows it cannot afford miscues, as field position will be paramount in a low-possession game, and a missed assignment on coverage or a missed field goal could tilt momentum irreversibly toward the Hawkeyes. More broadly, Indiana’s challenge will be mental as much as physical, as Kinnick Stadium is one of the most hostile environments in the Big Ten, and past Hoosier teams have faltered under that pressure, making it vital for this group to establish confidence early and avoid falling behind. The coaching staff will likely look to open the game with scripted plays designed to establish rhythm and settle nerves, while leaning on defensive aggressiveness to generate a turnover or two that could swing momentum. For Indiana, the path to victory is narrow but clear: protect the football, sustain drives with a balanced offensive approach, and force Iowa to abandon its comfort zone by creating long-yardage scenarios. If they can execute this formula while avoiding self-inflicted mistakes, the Hoosiers have a chance to be competitive deep into the fourth quarter, but if the offense sputters or turnovers pile up, it could quickly turn into another long afternoon in Iowa City that highlights the gap Indiana still needs to close to consistently compete in the Big Ten.

The Indiana Hoosiers will travel to Kinnick Stadium to take on the Iowa Hawkeyes on September 27, 2025, in a Big Ten showdown that pits Indiana’s improving offense against Iowa’s traditionally stout defense. Both teams are looking for a conference win to build momentum, with Iowa seeking to protect its home field while Indiana aims to prove it can compete on the road against one of the league’s most disciplined programs. Indiana vs Iowa AI Prediction: Free CFB Betting Insights for Sep 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Iowa Hawkeyes CFB Preview

The Iowa Hawkeyes will host the Indiana Hoosiers on September 27, 2025, at Kinnick Stadium with confidence in their tried-and-true formula of stingy defense, physicality, and home-field advantage, knowing that their brand of football has historically worn down opponents like Indiana who struggle to match their consistency in the trenches. Offensively, Iowa will look to establish its identity early by pounding the ball behind one of the most reliable offensive lines in the Big Ten, featuring road graders who open lanes for a stable of running backs capable of grinding out tough yards between the tackles and breaking the occasional run into the secondary. Their quarterback will be tasked with managing the game, making efficient throws on third down, and leveraging play-action opportunities that take advantage of defenses creeping up to stop the run, with tight ends often serving as the go-to weapons in Iowa’s passing attack. The wide receivers, while not typically explosive, are reliable enough to keep drives alive, and their ability to stretch the field just enough prevents defenses from fully keying on the run. Defensively, Iowa remains one of the nation’s most disciplined units, with a front seven that thrives on shutting down rushing lanes and linebackers who diagnose plays quickly and swarm to the football, while the secondary has developed a reputation for turning over even the most polished quarterbacks through sound coverage and ball-hawking instincts.

That opportunistic style will be critical against Indiana, whose quarterback has shown improvement but remains vulnerable to mistakes when pressured. On special teams, Iowa enjoys one of the strongest advantages in college football, with consistently strong punting, reliable kicking, and coverage units that flip field position and put pressure on opposing offenses to drive long fields, something Indiana has struggled with historically. The intangible edge of playing at Kinnick Stadium, where the crowd is both intimidating and disruptive, further tilts the balance in Iowa’s favor, as visiting teams often struggle to maintain communication and composure under the relentless noise and atmosphere. The coaching staff will emphasize patience and discipline, understanding that their defense and special teams are capable of dictating tempo even if the offense is not putting up gaudy numbers, and their strategy will likely revolve around wearing Indiana down physically and capitalizing on mistakes. For Iowa, the path to victory involves playing to their strengths: run the football effectively, dominate time of possession, prevent Indiana from generating explosive plays, and rely on their defense to create turnovers that shorten the field. If they succeed in executing that game plan, the Hawkeyes not only stand an excellent chance of defeating Indiana but also of reinforcing their position as one of the Big Ten’s most consistent and dangerous programs, particularly at home where their style of play becomes even more suffocating.

Indiana vs. Iowa Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each team. In fact, anytime the Hoosiers and Hawkeyes play there’s always several intriguing observations to key in on. Not to mention games played at Kinnick Stadium in Sep almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: M. Gronowski under 37.5 Rushing Yards.

Indiana vs. Iowa Prediction (AI)

Remi Robot Icon

Remi, our AI sports genius, has been pouring over tons of data from every angle between the Hoosiers and Hawkeyes and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most focused on the trending emphasis knucklehead sportsbettors tend to put on Indiana’s strength factors between a Hoosiers team going up against a possibly strong Hawkeyes team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Indiana vs Iowa picks, computer picks Hoosiers vs Hawkeyes, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Hoosiers Betting Trends

Indiana has struggled to cover spreads consistently in Big Ten road games, often falling behind early and failing to recover against physical opponents.

Hawkeyes Betting Trends

Iowa has been solid ATS at home, especially in defensive-driven games where their ability to limit opponents and control tempo has paid off.

Hoosiers vs. Hawkeyes Matchup Trends

Historically, matchups between these two teams have leaned toward the under, as Iowa’s defense and methodical pace often suppress scoring while Indiana’s offense has struggled to break through in Iowa City.

Indiana vs. Iowa Game Info

Indiana vs Iowa starts on September 27, 2025 at 3:30 PM EST.

Venue: Kinnick Stadium.

Spread: Iowa +7.5
Moneyline: Indiana -299, Iowa +238
Over/Under: 48.5

Indiana: (4-0)  |  Iowa: (3-1)

Remi's searched hard and found the best prop for this matchup: M. Gronowski under 37.5 Rushing Yards.. Prices move—always shop for the best number.

Historically, matchups between these two teams have leaned toward the under, as Iowa’s defense and methodical pace often suppress scoring while Indiana’s offense has struggled to break through in Iowa City.

IND trend: Indiana has struggled to cover spreads consistently in Big Ten road games, often falling behind early and failing to recover against physical opponents.

IOWA trend: Iowa has been solid ATS at home, especially in defensive-driven games where their ability to limit opponents and control tempo has paid off.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Indiana vs. Iowa Odds

Remi is pouring through tons of stats on each player. In fact, anytime the Indiana vs Iowa trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.

Indiana vs Iowa Opening Odds

IND Moneyline: -299
IOWA Moneyline: +238
IND Spread: -7.5
IOWA Spread: +7.5
Over/Under: 48.5

Indiana vs Iowa Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
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NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+188
-6.5 (-110)
+6.5 (-110)
O 56.5 (-106)
U 56.5 (-114)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1500
-27.5 (-102)
+27.5 (-120)
O 60.5 (-115)
U 60.5 (-105)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+160
-190
+4.5 (-110)
-4.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+980
-21.5 (-105)
+21.5 (-115)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+168
-5.5 (-110)
+5.5 (-110)
O 63.5 (-106)
U 63.5 (-114)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7.5 (-118)
-7.5 (-104)
O 42.5 (-120)
U 42.5 (-102)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-450
+340
-12.5 (-110)
+12.5 (-110)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+140
-3.5 (-108)
+3.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+610
-950
+17.5 (-115)
-17.5 (-105)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-610
 
-14.5 (-105)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+172
-210
+4.5 (-105)
-4.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+122
-146
+2.5 (+100)
-2.5 (-122)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-110
-110
+1.5 (-115)
-1.5 (-105)
O 57.5 (-105)
U 57.5 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-375
+9.5 (-102)
-9.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-400
+310
-10.5 (-110)
+10.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+122
-146
+2.5 (-102)
-2.5 (-120)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-350
+8.5 (-110)
-8.5 (-110)
O 38.5 (-115)
U 38.5 (-105)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-520
+385
-11.5 (-118)
+11.5 (-104)
O 47.5 (-105)
U 47.5 (-115)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+122
-146
+2.5 (+100)
-2.5 (-122)
O 48.5 (-115)
U 48.5 (-105)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+188
-5.5 (-120)
+5.5 (-102)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+176
-215
+5.5 (-110)
-5.5 (-110)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
+104
-125
+1.5 (-105)
-1.5 (-115)
O 46.5 (-114)
U 46.5 (-106)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+480
-670
+15.5 (-110)
-15.5 (-110)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+146
-176
+4.5 (-115)
-4.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-720
 
-15.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-146
+122
-2.5 (-122)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-138
+2.5 (-106)
-2.5 (-114)
O 52.5 (-110)
U 52.5 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+195
-240
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+106
 
+2.5 (-115)
 
O 41.5 (-110)
U 41.5 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+310
 
+11.5 (-115)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+37.5 (-108)
-37.5 (-112)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+152
-184
+4.5 (-115)
-4.5 (-105)
O 67.5 (-105)
U 67.5 (-115)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-285
+230
-7.5 (-102)
+7.5 (-120)
O 44.5 (-120)
U 44.5 (-102)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+470
-15.5 (-112)
+15.5 (-108)
O 55.5 (-106)
U 55.5 (-114)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-106)
-33.5 (-114)
O 44.5 (-108)
U 44.5 (-112)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
+9.5 (-110)
-9.5 (-110)
O 47.5 (-112)
U 47.5 (-108)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-104)
U 45.5 (-118)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+106
-128
+1.5 (-105)
-1.5 (-115)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-630
+450
-14.5 (-105)
+14.5 (-115)
O 48.5 (-105)
U 48.5 (-115)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-144
+120
-2.5 (-120)
+2.5 (-102)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 55.5 (-104)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+184
-225
+5.5 (-104)
-5.5 (-118)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+270
-9.5 (-110)
+9.5 (-110)
O 53.5 (-118)
U 53.5 (-104)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+220
-275
+7.5 (-120)
-7.5 (-102)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+375
-500
+13.5 (-110)
-13.5 (-110)
O 49.5 (-115)
U 49.5 (-105)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Indiana Hoosiers vs. Iowa Hawkeyes on September 27, 2025 at Kinnick Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN