Blue Devils vs. Orange
Prediction, Odds & Props
Sep 27 | CFB AI Picks

Updated: 2025-09-20T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Duke Blue Devils travel to the JMA Wireless Dome on September 27, 2025, for an ACC clash with the Syracuse Orange in a game that could have early implications in the conference standings. Both teams have shown flashes of offensive promise, making this matchup a test of consistency and execution on both sides of the ball.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 27, 2025

Start Time: 12:00 PM EST​

Venue: JMA Wireless Dome​

Orange Record: (3-1)

Blue Devils Record: (2-2)

OPENING ODDS

DUKE Moneyline: -222

CUSE Moneyline: +182

DUKE Spread: -5.5

CUSE Spread: +5.5

Over/Under: 60.5

DUKE
Betting Trends

  • Duke has been competitive against the spread in recent contests, covering in two of its last three games as an underdog.

CUSE
Betting Trends

  • Syracuse has been streaky ATS at home, alternating covers and misses, with inconsistency tied to its defense’s ability to limit big plays.

MATCHUP TRENDS

  • This game presents a contrast in betting profiles, as Duke has shown more reliability on the road ATS compared to Syracuse’s home volatility, suggesting value in the underdog keeping it close. Additionally, early totals action leans toward the over, with bettors anticipating a faster pace and the possibility of explosive plays on both sides.

DUKE vs. CUSE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Collins under 233.5 Passing Yards.

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Duke vs Syracuse Prediction & Odds:
Free CFB Betting Insights for 9/27/25

The September 27, 2025 ACC matchup between the Duke Blue Devils and the Syracuse Orange at the JMA Wireless Dome offers an intriguing clash of teams trying to solidify their place in the conference pecking order, with Duke entering as the steadier and more disciplined side while Syracuse leans on home-field advantage and offensive explosiveness to make up for its inconsistency. Duke has built its early-season reputation on efficient quarterback play, a balanced attack that combines steady rushing production with smart passing, and a defense that may not dominate statistically but forces opponents into mistakes by staying disciplined and opportunistic. Their ability to avoid turnovers and play situational football at a high level—particularly on third downs and in the red zone—has given them a chance to cover spreads consistently, even as underdogs, and that reliability has made them one of the ACC’s trickier opponents despite not having the same level of star power as some of their conference peers. Syracuse, meanwhile, comes into this contest needing to establish rhythm on both sides of the ball, as their offense has shown the ability to score quickly and stretch defenses vertically but has often been undone by turnovers, poor pass protection, and inconsistent execution in long-yardage situations.

The Orange defense has also been a liability at times, alternating between stretches of disruptive pressure and breakdowns in coverage that lead to big plays, and their inability to stay off the field has led to fatigue that opponents have capitalized on in second halves. For this matchup, Syracuse’s key will be sustaining drives and finishing red-zone trips with touchdowns while forcing Duke out of its comfort zone by creating turnovers or winning field position battles through special teams. Betting trends highlight the contrast: Duke has been reliable on the road ATS, particularly in underdog spots, while Syracuse’s record at home has been far more erratic, with bettors often burned by their defensive lapses. The totals market also leans toward the over, with expectations that both offenses could find success against defenses that bend but do not always break, setting up the potential for a higher-scoring, entertaining contest. Ultimately, the game shapes up as a test of discipline versus volatility—if Duke continues its steady execution and mistake-free football, they have the edge to control tempo and potentially steal a road win, but if Syracuse can harness its home-field energy, protect its quarterback, and hit on a few explosive plays, the Orange could shift momentum and make this one of the weekend’s more entertaining battles in the ACC.

Duke Blue Devils CFB Preview

The Duke Blue Devils enter their September 27, 2025 showdown with Syracuse as a program that has quietly carved out a reputation for resilience, discipline, and consistency, traits that have served them well both on the field and at the betting window. Away from home, Duke has often performed better than expected, covering spreads by leaning on mistake-free football, balance on offense, and situational savvy on defense. Quarterback play has been the backbone of their success this season, with Duke’s signal-caller showing poise in the pocket, accuracy on intermediate throws, and the ability to spread the ball to multiple targets, which keeps opposing defenses guessing. The rushing game has complemented the passing attack, allowing the Blue Devils to stay balanced and control tempo, an especially important factor when playing in hostile road environments like the Dome. Their offensive line has been steady in pass protection and has created lanes for running backs to stay efficient, helping Duke sustain drives and wear down opposing defenses.

Defensively, Duke doesn’t overwhelm opponents with flash but executes a bend-but-don’t-break philosophy that forces long drives, creating chances for turnovers or red-zone stops. Against Syracuse, that approach could pay dividends, as the Orange have been prone to turnovers and inconsistent execution in extended possessions. Duke’s secondary will be tested against Syracuse’s vertical threats, but their pass rush has shown an ability to generate pressure without blitzing heavily, which could disrupt timing and lead to mistakes. Special teams have also been a steady contributor, with reliable kicking and coverage units helping Duke tilt the hidden yardage battle. From a betting perspective, Duke’s ability to consistently cover as a road underdog makes them a dangerous opponent, as they have shown the composure and toughness to stay within striking distance against higher-profile teams. For Duke, the keys will be to continue their balanced offensive attack, avoid turnovers, and execute in high-leverage situations like third downs and red-zone opportunities. If they can maintain their discipline and composure while capitalizing on Syracuse’s defensive lapses, the Blue Devils not only have a strong chance to cover but could walk out of the Dome with an outright ACC road victory that boosts their confidence and standing in the conference.

The Duke Blue Devils travel to the JMA Wireless Dome on September 27, 2025, for an ACC clash with the Syracuse Orange in a game that could have early implications in the conference standings. Both teams have shown flashes of offensive promise, making this matchup a test of consistency and execution on both sides of the ball. Duke vs Syracuse AI Prediction: Free CFB Betting Insights for Sep 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Syracuse Orange CFB Preview

The Syracuse Orange return to the JMA Wireless Dome on September 27, 2025 with an urgent need to steady their season and prove they can protect their home turf in ACC play, as inconsistency has defined their performance through the early schedule. Offensively, the Orange have the talent to test Duke’s disciplined defense, with a quarterback capable of stretching the field vertically and receivers who can create separation and turn short completions into chunk plays. Their ground game, when given proper blocking, has provided balance, but the offensive line has been a liability, allowing too much pressure and forcing the offense into long-yardage situations that stall drives. Cleaning up protection will be essential against a Duke defense that thrives on forcing opponents to sustain drives and capitalizing on mistakes. Defensively, Syracuse has been a rollercoaster, alternating between flashes of aggressive pressure and costly lapses in coverage or missed tackles that opponents have routinely turned into big plays. Their inability to get consistent stops has left them vulnerable to long stretches where the defense wears down, particularly if the offense cannot sustain drives.

Against Duke’s methodical, balanced attack, Syracuse must find a way to generate turnovers or at least create disruption to get the ball back in favorable situations. Special teams may provide a hidden edge for Syracuse if they can flip field position with a big return or pin Duke deep, as those opportunities could spark momentum in front of their home crowd. From a betting perspective, Syracuse has been shaky at home ATS, reflecting their volatility and tendency to alternate solid performances with disappointing ones, making it difficult for backers to trust them in spots like this. Still, the Dome has long been a challenging venue for visiting teams, and the energy of the home crowd could help mask some of their defensive issues. For Syracuse to prevail, they must protect the quarterback, take advantage of Duke’s willingness to grind out drives by forcing them into mistakes, and, most importantly, finish red-zone trips with touchdowns rather than field goals. If they execute cleanly and seize the emotional lift that comes with playing at home, the Orange have the tools to turn what looks like a disciplined Duke edge on paper into a tightly contested battle that could swing in their favor late.

Duke vs. Syracuse Prop Picks (AI)

Remi is pouring through tons of data on each line. In fact, anytime the Blue Devils and Orange play there’s always several intriguing observations to key in on. Not to mention games played at JMA Wireless Dome in Sep can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: R. Collins under 233.5 Passing Yards.

Duke vs. Syracuse Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Blue Devils and Orange and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

Interestingly enough, the data has been most focused on the growing weight emotional bettors often put on coaching factors between a Blue Devils team going up against a possibly improved Orange team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Duke vs Syracuse picks, computer picks Blue Devils vs Orange, best bets, model edges, confidence ratings.

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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Blue Devils Betting Trends

Duke has been competitive against the spread in recent contests, covering in two of its last three games as an underdog.

Orange Betting Trends

Syracuse has been streaky ATS at home, alternating covers and misses, with inconsistency tied to its defense’s ability to limit big plays.

Blue Devils vs. Orange Matchup Trends

This game presents a contrast in betting profiles, as Duke has shown more reliability on the road ATS compared to Syracuse’s home volatility, suggesting value in the underdog keeping it close. Additionally, early totals action leans toward the over, with bettors anticipating a faster pace and the possibility of explosive plays on both sides.

Duke vs. Syracuse Game Info

Duke vs Syracuse starts on September 27, 2025 at 12:00 PM EST.

Venue: JMA Wireless Dome.

Spread: Syracuse +5.5
Moneyline: Duke -222, Syracuse +182
Over/Under: 60.5

Duke: (2-2)  |  Syracuse: (3-1)

Remi's searched hard and found the best prop for this matchup: R. Collins under 233.5 Passing Yards.. Prices move—always shop for the best number.

This game presents a contrast in betting profiles, as Duke has shown more reliability on the road ATS compared to Syracuse’s home volatility, suggesting value in the underdog keeping it close. Additionally, early totals action leans toward the over, with bettors anticipating a faster pace and the possibility of explosive plays on both sides.

DUKE trend: Duke has been competitive against the spread in recent contests, covering in two of its last three games as an underdog.

CUSE trend: Syracuse has been streaky ATS at home, alternating covers and misses, with inconsistency tied to its defense’s ability to limit big plays.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Duke vs. Syracuse Odds

Remi is pouring through tons of data points on each line. In fact, anytime the Duke vs Syracuse trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.

Duke vs Syracuse Opening Odds

DUKE Moneyline: -222
CUSE Moneyline: +182
DUKE Spread: -5.5
CUSE Spread: +5.5
Over/Under: 60.5

Duke vs Syracuse Live Odds

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Western Kentucky Hilltoppers
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O 55.5 (-106)
U 55.5 (-114)
Oct 3, 2025 10:00PM EDT
New Mexico Lobos
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10/3/25 10PM
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+114
-137
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O 58.5 (-105)
U 58.5 (-115)
Oct 3, 2025 10:30PM EDT
Colorado State Rams
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10/3/25 10:30PM
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SDGST
+190
-235
+5.5 (+100)
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O 40.5 (-115)
U 40.5 (-105)
Oct 3, 2025 10:30PM EDT
West Virginia Mountaineers
BYU Cougars
10/3/25 10:30PM
WVU
BYU
+860
-1600
+18.5 (-104)
-18.5 (-118)
O 47.5 (-105)
U 47.5 (-115)
Oct 4, 2025 12:00PM EDT
Ohio Bobcats
Ball State Cardinals
10/4/25 12PM
OHIO
BALLST
-630
+450
-14.5 (-110)
+14.5 (-110)
O 51.5 (-105)
U 51.5 (-115)
Oct 4, 2025 12:00PM EDT
Illinois Fighting Illini
Purdue Boilermakers
10/4/25 12PM
ILL
PURDUE
-385
+300
-9.5 (-118)
+9.5 (-104)
O 55.5 (-110)
U 55.5 (-110)
Oct 4, 2025 12:00PM EDT
Kansas State Wildcats
Baylor Bears
10/4/25 12PM
KSTATE
BAYLOR
+190
-235
+6.5 (-108)
-6.5 (-112)
O 61.5 (-110)
U 61.5 (-110)
Oct 4, 2025 12:00PM EDT
Kentucky Wildcats
Georgia Bulldogs
10/4/25 12PM
UK
UGA
+890
-1700
+20.5 (-110)
-20.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 4, 2025 12:00PM EDT
Clemson Tigers
North Carolina Tar Heels
10/4/25 12PM
CLEM
UNC
-800
+540
-14.5 (-118)
+14.5 (-104)
O 46.5 (-110)
U 46.5 (-110)
Oct 4, 2025 12:00PM EDT
Wisconsin Badgers
Michigan Wolverines
10/4/25 12PM
WISC
MICH
+660
-1050
+16.5 (+102)
-16.5 (-124)
O 43.5 (-110)
U 43.5 (-110)
Oct 4, 2025 12:00PM EDT
Boston College Eagles
Pittsburgh Panthers
10/4/25 12PM
BC
PITT
+180
-220
+5.5 (-105)
-5.5 (-115)
O 58.5 (-110)
U 58.5 (-110)
Oct 4, 2025 12:00PM EDT
Air Force Falcons
Navy Midshipmen
10/4/25 12PM
AF
NAVY
+340
-450
+11.5 (-105)
-11.5 (-115)
O 51.5 (-115)
U 51.5 (-105)
Oct 4, 2025 12:00PM EDT
Iowa State Cyclones
Cincinnati Bearcats
10/4/25 12PM
IOWAST
CINCY
+105
-126
+1.5 (-105)
-1.5 (-115)
O 55.5 (-110)
U 55.5 (-110)
Oct 4, 2025 12:00PM EDT
Army Black Knights
UAB Blazers
10/4/25 12PM
ARMY
UAB
-265
+215
-7.5 (-102)
+7.5 (-120)
O 57.5 (-110)
U 57.5 (-110)
Oct 4, 2025 1:00PM EDT
Campbell Fighting Camels
NC State Wolfpack
10/4/25 1PM
CAMP
NCST
 
 
+42.5 (-110)
-42.5 (-110)
O 61.5 (-110)
U 61.5 (-110)
Oct 4, 2025 1:00PM EDT
Wake Forest Demon Deacons
Virginia Tech Hokies
10/4/25 1PM
WAKE
VATECH
+198
-245
+6.5 (-104)
-6.5 (-118)
O 50.5 (-110)
U 50.5 (-110)
Oct 4, 2025 1:00PM EDT
UTSA Roadrunners
Temple Owls
10/4/25 1PM
UTSA
TEMPLE
-235
+195
-6.5 (-110)
+6.5 (-110)
O 58.5 (-115)
U 58.5 (-105)
Oct 4, 2025 2:30PM EDT
Western Michigan Broncos
Umass Minutemen
10/4/25 2:30PM
WMICH
UMASS
-600
 
-13.5 (-115)
 
O 47.5 (-105)
U 47.5 (-115)
Oct 4, 2025 3:00PM EDT
Oklahoma State Cowboys
Arizona Wildcats
10/4/25 3PM
OKLAST
ARIZ
+680
-1200
+20.5 (-115)
-20.5 (-105)
O 55.5 (-110)
U 55.5 (-110)
Oct 4, 2025 3:30PM EDT
Vanderbilt Commodores
Alabama Crimson Tide
10/4/25 3:30PM
VANDY
BAMA
+330
-430
+10.5 (-105)
-10.5 (-115)
O 55.5 (-110)
U 55.5 (-110)
Oct 4, 2025 3:30PM EDT
Eastern Michigan Eagles
Buffalo Bulls
10/4/25 3:30PM
EMICH
BUFF
+285
-365
+10.5 (-118)
-10.5 (-104)
O 54.5 (-110)
U 54.5 (-110)
Oct 4, 2025 3:30PM EDT
Washington Huskies
Maryland Terrapins
10/4/25 3:30PM
WASH
MD
-250
+202
-6.5 (-114)
+6.5 (-106)
O 53.5 (-115)
U 53.5 (-105)
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Miami Ohio Redhawks
Northern Illinois Huskies
10/4/25 3:30PM
MIAOH
NILL
 
+168
 
+5.5 (-112)
O 37.5 (-114)
U 37.5 (-106)
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Central Michigan Chippewas
Akron Zips
10/4/25 3:30PM
CMICH
AKRON
-330
+260
-8.5 (-110)
+8.5 (-110)
O 45.5 (-105)
U 45.5 (-115)
Oct 4, 2025 3:30PM EDT
Virginia Cavaliers
Louisville Cardinals
10/4/25 3:30PM
UVA
LVILLE
+195
-240
+6.5 (-105)
-6.5 (-115)
O 62.5 (-102)
U 62.5 (-120)
Oct 4, 2025 3:30PM EDT
UL Monroe Warhawks
Northwestern Wildcats
10/4/25 3:30PM
MONROE
NWEST
+350
-465
+10.5 (-104)
-10.5 (-118)
O 40.5 (-110)
U 40.5 (-110)
Oct 4, 2025 3:30PM EDT
James Madison Dukes
Georgia State Panthers
10/4/25 3:30PM
JMAD
GAST
-1200
+720
-19.5 (-115)
+19.5 (-105)
O 53.5 (-115)
U 53.5 (-105)
Oct 4, 2025 3:30PM EDT
Syracuse Orange
SMU Mustangs
10/4/25 3:30PM
CUSE
SMU
+550
-820
+17.5 (-118)
-17.5 (-104)
O 58.5 (-105)
U 58.5 (-115)
Oct 4, 2025 3:30PM EDT
Boise State Broncos
Notre Dame Fighting Irish
10/4/25 3:30PM
BOISE
ND
+760
-1300
+20.5 (-110)
-20.5 (-110)
O 62.5 (-110)
U 62.5 (-110)
Oct 4, 2025 3:30PM EDT
Oregon State Beavers
App State Mountaineers
10/4/25 3:30PM
OREGST
APPST
+105
 
+1.5 (-105)
 
O 53.5 (-110)
U 53.5 (-110)
Oct 4, 2025 3:30PM EDT
FIU Panthers
UConn Huskies
10/4/25 3:30PM
FIU
UCONN
 
-265
 
-7.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 4, 2025 3:30PM EDT
Penn State Nittany Lions
UCLA Bruins
10/4/25 3:30PM
PSU
UCLA
-4000
+1400
-24.5 (-115)
+24.5 (-105)
O 50.5 (-106)
U 50.5 (-114)
Oct 4, 2025 3:30PM EDT
Texas Longhorns
Florida Gators
10/4/25 3:30PM
TEXAS
FLA
-275
+220
-6.5 (-122)
+6.5 (+100)
O 41.5 (-110)
U 41.5 (-110)
Oct 4, 2025 4:00PM EDT
Kent State Golden Flashes
Oklahoma Sooners
10/4/25 4PM
KENT
OKLA
 
 
+45.5 (-110)
-45.5 (-110)
O 53.5 (-115)
U 53.5 (-105)
Oct 4, 2025 4:00PM EDT
Michigan State Spartans
Nebraska Cornhuskers
10/4/25 4PM
MICHST
NEB
+350
-465
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O 48.5 (-115)
U 48.5 (-105)
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Texas State Bobcats
Arkansas State Red Wolves
10/4/25 4PM
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ARKST
-500
+375
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+13.5 (-110)
O 64.5 (-104)
U 64.5 (-118)
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Coastal Carolina Chanticleers
Old Dominion Monarchs
10/4/25 6PM
COAST
OLDDOM
+860
-1600
+20.5 (-106)
-20.5 (-114)
O 54.5 (-115)
U 54.5 (-105)
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UNLV Rebels
Wyoming Cowboys
10/4/25 7PM
UNLV
WYO
-166
+138
-3.5 (-110)
+3.5 (-110)
O 50.5 (-110)
U 50.5 (-110)
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Texas Tech Red Raiders
Houston Cougars
10/4/25 7PM
TXTECH
HOU
-420
+320
-10.5 (-112)
+10.5 (-108)
O 51.5 (-110)
U 51.5 (-110)
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South Alabama Jaguars
Troy Trojans
10/4/25 7PM
SBAMA
TROY
+108
-130
+2.5 (-110)
-2.5 (-110)
O 46.5 (-114)
U 46.5 (-106)
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Florida Atlantic Owls
Rice Owls
10/4/25 7PM
FAU
RICE
+150
-182
+4.5 (-112)
-4.5 (-108)
O 53.5 (-115)
U 53.5 (-105)
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Minnesota Golden Gophers
Ohio State Buckeyes
10/4/25 7:30PM
MINN
OHIOST
+1280
-3500
+23.5 (-110)
-23.5 (-110)
O 44.5 (-105)
U 44.5 (-115)
Oct 4, 2025 7:30PM EDT
Kansas Jayhawks
UCF Knights
10/4/25 7:30PM
KANSAS
UCF
-205
+168
-5.5 (-110)
+5.5 (-110)
O 54.5 (-110)
U 54.5 (-110)
Oct 4, 2025 7:30PM EDT
Colorado Buffaloes
TCU Horned Frogs
10/4/25 7:30PM
COLO
TCU
+400
-550
+13.5 (-104)
-13.5 (-118)
O 57.5 (-110)
U 57.5 (-110)
Oct 4, 2025 7:30PM EDT
Mississippi State Bulldogs
Texas A&M Aggies
10/4/25 7:30PM
MISSST
TEXAM
+470
-670
+14.5 (-114)
-14.5 (-106)
O 55.5 (-110)
U 55.5 (-110)
Oct 4, 2025 7:30PM EDT
Miami Hurricanes
Florida State Seminoles
10/4/25 7:30PM
MIAMI
FSU
-184
+150
-4.5 (-106)
+4.5 (-114)
O 53.5 (-115)
U 53.5 (-105)
Oct 4, 2025 8:00PM EDT
Tulsa Golden Hurricane
Memphis Tigers
10/4/25 8PM
TULSA
MEMP
+800
-1400
+20.5 (-114)
-20.5 (-106)
O 56.5 (-110)
U 56.5 (-110)
Oct 4, 2025 9:30PM EDT
Duke Blue Devils
California Golden Bears
10/4/25 9:30PM
DUKE
CAL
-155
+130
-3 (-110)
+3 (-110)
O 57.5 (-110)
U 57.5 (-110)
Oct 4, 2025 10:30PM EDT
Nevada Wolf Pack
Fresno State Bulldogs
10/4/25 10:30PM
NEVADA
FRESNO
+440
-610
+13.5 (-102)
-13.5 (-120)
O 44.5 (-115)
U 44.5 (-105)
Oct 9, 2025 7:30PM EDT
East Carolina Pirates
Tulane Green Wave
10/9/25 7:30PM
ECAR
TULANE
 
 
+7 (-110)
-7 (-110)
Oct 10, 2025 7:30PM EDT
South Florida Bulls
North Texas Mean Green
10/10/25 7:30PM
SFLA
NOTEX
 
 
+2.5 (-110)
-2.5 (-110)
Oct 11, 2025 12:00PM EDT
Florida Gators
Texas A&M Aggies
10/11/25 12PM
FLA
TEXAM
 
 
+9.5 (-110)
-9.5 (-110)
Oct 11, 2025 12:00PM EDT
Alabama Crimson Tide
Missouri Tigers
10/11/25 12PM
BAMA
MIZZOU
-205
+168
-6.5 (-102)
+6.5 (-120)
O 55.5 (-108)
U 55.5 (-112)
Oct 11, 2025 12:00PM EDT
Ohio State Buckeyes
Illinois Fighting Illini
10/11/25 12PM
OHIOST
ILL
-780
+530
-15.5 (-110)
+15.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 11, 2025 12:45PM EDT
Georgia Bulldogs
Auburn Tigers
10/11/25 12:45PM
UGA
AUBURN
-172
+142
-3.5 (-114)
+3.5 (-106)
O 47.5 (-110)
U 47.5 (-110)
Oct 11, 2025 3:30PM EDT
Indiana Hoosiers
Oregon Ducks
10/11/25 3:30PM
IND
OREG
+300
-385
+10.5 (-112)
-10.5 (-108)
O 52.5 (-110)
U 52.5 (-110)
Oct 11, 2025 3:30PM EDT
Oklahoma Sooners
Texas Longhorns
10/11/25 3:30PM
OKLA
TEXAS
 
 
+3.5 (-110)
-3.5 (-110)
Oct 11, 2025 4:15PM EDT
Arkansas Razorbacks
Tennessee Volunteers
10/11/25 4:15PM
ARK
TENN
+350
-465
+12.5 (-110)
-12.5 (-110)
O 67.5 (-110)
U 67.5 (-110)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Duke Blue Devils vs. Syracuse Orange on September 27, 2025 at JMA Wireless Dome.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN
UNC@UCF UCF -6.5 54.4% 4 WIN
ARKST@KENSAW KENSAW +4.5 54.5% 4 WIN
ILL@IND IND -6 53.2% 3 WIN
SELOU@LSU LSU -47.5 55.3% 5 LOSS
TNMART@MIZZST MIZZST -14.5 56.2% 6 WIN
FRESNO@HAWAII HAWAII +3 56.6% 6 WIN
MRSHL@MTSU MTSU +2.5 56.8% 6 LOSS
MICH@NEB NEB +1.5 57.3% 7 LOSS
WASH@WASHST DENZEL BOSTON UNDER 69.5 RECV YDS 56.2% 6 LOSS
IOWA@RUT ANTWAN RAYMOND OVER 0.5 TOUCHDOWNS 54.4% 4 WIN
GEORGIA@TENN UNDER 50.5 55.5% 6 LOSS
ARK@OLEMISS MISS -225 72.0% 9 WIN
DUKE@TULANE TULANE -120 56.5% 4 WIN
ARK@OLEMISS MISS -6.5 53.9% 3 LOSS
AKRON@UAB UAB -11 54.7% 4 LOSS
UCONN@DEL DEL +9.5 55.0% 5 WIN
APLST@USM USM +4 55.3% 6 WIN
MERIMK@KENSAW KENSAW -13.5 56.2% 7 WIN
UMASS@IOWA IOWA -34.5 56.4% 7 WIN
UMASS@IOWA JAZIUN PATTERSON UNDER 0.5 RUSH TDS 54.8% 4 WIN
NMEX@UCLA NICO IAMALEAVA UNDER 31.5 PASS ATT 53.4% 3 LOSS
KSTATE@ARIZ ARIZ +1.5 56.1% 6 WIN
BC@MICHST NICK MARSH OVER 47.5 RCV YDS 53.6% 3 WIN
ARIZST@MISSST MISSST +7 54.2% 4 WIN
TULSA@NMEXST NMEXST +3.5 56.9% 6 WIN
UCLA@UNLV OVER 54.5 56.2% 6 LOSS
FRESNO@OREGST FRESNO +1.5 54.7% 4 WIN
VANDY@VATECH VANDY +2.5 55.8% 5 WIN
JMAD@LVILLE LVILLE -14.5 54.0% 3 LOSS
TCU@UNC JOSEPH MANJACK OVER 37.5 RECV YDS 53.8% 3 LOSS
ND@MIAMI MIAMI +3 55.2% 6 WIN
MISSST@USM USM +14.5 56.0% 6 LOSS
UTAH@UCLA UCLA +5.5 56.2% 6 LOSS
CAL@OREGST OREGST +1.5 55.1% 5 LOSS
FAU@MD MD -13.5 55.2% 5 WIN
GAS@FRESNO FRESNO +2 55.2% 5 WIN
TOLEDO@UK UK -9.5 56.2% 6 LOSS
AUSTPEAY@MTSU PEAY +12.5 56.2% 6 WIN