Blue Devils vs. Orange
Prediction, Odds & Props
Sep 27 | CFB AI Picks
Updated: 2025-09-20T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Duke Blue Devils travel to the JMA Wireless Dome on September 27, 2025, for an ACC clash with the Syracuse Orange in a game that could have early implications in the conference standings. Both teams have shown flashes of offensive promise, making this matchup a test of consistency and execution on both sides of the ball.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 27, 2025
Start Time: 12:00 PM EST
Venue: JMA Wireless Dome
Orange Record: (3-1)
Blue Devils Record: (2-2)
OPENING ODDS
DUKE Moneyline: -222
CUSE Moneyline: +182
DUKE Spread: -5.5
CUSE Spread: +5.5
Over/Under: 60.5
DUKE
Betting Trends
- Duke has been competitive against the spread in recent contests, covering in two of its last three games as an underdog.
CUSE
Betting Trends
- Syracuse has been streaky ATS at home, alternating covers and misses, with inconsistency tied to its defense’s ability to limit big plays.
MATCHUP TRENDS
- This game presents a contrast in betting profiles, as Duke has shown more reliability on the road ATS compared to Syracuse’s home volatility, suggesting value in the underdog keeping it close. Additionally, early totals action leans toward the over, with bettors anticipating a faster pace and the possibility of explosive plays on both sides.
DUKE vs. CUSE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: R. Collins under 233.5 Passing Yards.
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Duke vs Syracuse Prediction & Odds:
Free CFB Betting Insights for 9/27/25
The Orange defense has also been a liability at times, alternating between stretches of disruptive pressure and breakdowns in coverage that lead to big plays, and their inability to stay off the field has led to fatigue that opponents have capitalized on in second halves. For this matchup, Syracuse’s key will be sustaining drives and finishing red-zone trips with touchdowns while forcing Duke out of its comfort zone by creating turnovers or winning field position battles through special teams. Betting trends highlight the contrast: Duke has been reliable on the road ATS, particularly in underdog spots, while Syracuse’s record at home has been far more erratic, with bettors often burned by their defensive lapses. The totals market also leans toward the over, with expectations that both offenses could find success against defenses that bend but do not always break, setting up the potential for a higher-scoring, entertaining contest. Ultimately, the game shapes up as a test of discipline versus volatility—if Duke continues its steady execution and mistake-free football, they have the edge to control tempo and potentially steal a road win, but if Syracuse can harness its home-field energy, protect its quarterback, and hit on a few explosive plays, the Orange could shift momentum and make this one of the weekend’s more entertaining battles in the ACC.
919 dubs >>> pic.twitter.com/VlZF3tSSzV
— Duke Football (@DukeFOOTBALL) September 23, 2025
Duke Blue Devils CFB Preview
The Duke Blue Devils enter their September 27, 2025 showdown with Syracuse as a program that has quietly carved out a reputation for resilience, discipline, and consistency, traits that have served them well both on the field and at the betting window. Away from home, Duke has often performed better than expected, covering spreads by leaning on mistake-free football, balance on offense, and situational savvy on defense. Quarterback play has been the backbone of their success this season, with Duke’s signal-caller showing poise in the pocket, accuracy on intermediate throws, and the ability to spread the ball to multiple targets, which keeps opposing defenses guessing. The rushing game has complemented the passing attack, allowing the Blue Devils to stay balanced and control tempo, an especially important factor when playing in hostile road environments like the Dome. Their offensive line has been steady in pass protection and has created lanes for running backs to stay efficient, helping Duke sustain drives and wear down opposing defenses.
Defensively, Duke doesn’t overwhelm opponents with flash but executes a bend-but-don’t-break philosophy that forces long drives, creating chances for turnovers or red-zone stops. Against Syracuse, that approach could pay dividends, as the Orange have been prone to turnovers and inconsistent execution in extended possessions. Duke’s secondary will be tested against Syracuse’s vertical threats, but their pass rush has shown an ability to generate pressure without blitzing heavily, which could disrupt timing and lead to mistakes. Special teams have also been a steady contributor, with reliable kicking and coverage units helping Duke tilt the hidden yardage battle. From a betting perspective, Duke’s ability to consistently cover as a road underdog makes them a dangerous opponent, as they have shown the composure and toughness to stay within striking distance against higher-profile teams. For Duke, the keys will be to continue their balanced offensive attack, avoid turnovers, and execute in high-leverage situations like third downs and red-zone opportunities. If they can maintain their discipline and composure while capitalizing on Syracuse’s defensive lapses, the Blue Devils not only have a strong chance to cover but could walk out of the Dome with an outright ACC road victory that boosts their confidence and standing in the conference.

Credit: USA TODAY/IMAGN
Syracuse Orange CFB Preview
The Syracuse Orange return to the JMA Wireless Dome on September 27, 2025 with an urgent need to steady their season and prove they can protect their home turf in ACC play, as inconsistency has defined their performance through the early schedule. Offensively, the Orange have the talent to test Duke’s disciplined defense, with a quarterback capable of stretching the field vertically and receivers who can create separation and turn short completions into chunk plays. Their ground game, when given proper blocking, has provided balance, but the offensive line has been a liability, allowing too much pressure and forcing the offense into long-yardage situations that stall drives. Cleaning up protection will be essential against a Duke defense that thrives on forcing opponents to sustain drives and capitalizing on mistakes. Defensively, Syracuse has been a rollercoaster, alternating between flashes of aggressive pressure and costly lapses in coverage or missed tackles that opponents have routinely turned into big plays. Their inability to get consistent stops has left them vulnerable to long stretches where the defense wears down, particularly if the offense cannot sustain drives.
Against Duke’s methodical, balanced attack, Syracuse must find a way to generate turnovers or at least create disruption to get the ball back in favorable situations. Special teams may provide a hidden edge for Syracuse if they can flip field position with a big return or pin Duke deep, as those opportunities could spark momentum in front of their home crowd. From a betting perspective, Syracuse has been shaky at home ATS, reflecting their volatility and tendency to alternate solid performances with disappointing ones, making it difficult for backers to trust them in spots like this. Still, the Dome has long been a challenging venue for visiting teams, and the energy of the home crowd could help mask some of their defensive issues. For Syracuse to prevail, they must protect the quarterback, take advantage of Duke’s willingness to grind out drives by forcing them into mistakes, and, most importantly, finish red-zone trips with touchdowns rather than field goals. If they execute cleanly and seize the emotional lift that comes with playing at home, the Orange have the tools to turn what looks like a disciplined Duke edge on paper into a tightly contested battle that could swing in their favor late.
Faith & Hard Work 🍊🎯 pic.twitter.com/LJGZMW6nxK
— Syracuse Football (@CuseFootball) September 24, 2025
Duke vs. Syracuse Prop Picks (AI)
Duke vs. Syracuse Prediction (AI)

Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Blue Devils and Orange and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most focused on the growing weight emotional bettors often put on coaching factors between a Blue Devils team going up against a possibly improved Orange team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI Duke vs Syracuse picks, computer picks Blue Devils vs Orange, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
Blue Devils Betting Trends
Duke has been competitive against the spread in recent contests, covering in two of its last three games as an underdog.
Orange Betting Trends
Syracuse has been streaky ATS at home, alternating covers and misses, with inconsistency tied to its defense’s ability to limit big plays.
Blue Devils vs. Orange Matchup Trends
This game presents a contrast in betting profiles, as Duke has shown more reliability on the road ATS compared to Syracuse’s home volatility, suggesting value in the underdog keeping it close. Additionally, early totals action leans toward the over, with bettors anticipating a faster pace and the possibility of explosive plays on both sides.
Duke vs. Syracuse Game Info
What time does Duke vs Syracuse start on September 27, 2025?
Duke vs Syracuse starts on September 27, 2025 at 12:00 PM EST.
Where is Duke vs Syracuse being played?
Venue: JMA Wireless Dome.
What are the opening odds for Duke vs Syracuse?
Spread: Syracuse +5.5
Moneyline: Duke -222, Syracuse +182
Over/Under: 60.5
What are the records for Duke vs Syracuse?
Duke: (2-2) | Syracuse: (3-1)
What is the AI best bet for Duke vs Syracuse?
Remi's searched hard and found the best prop for this matchup: R. Collins under 233.5 Passing Yards.. Prices move—always shop for the best number.
What are Duke vs Syracuse trending bets?
This game presents a contrast in betting profiles, as Duke has shown more reliability on the road ATS compared to Syracuse’s home volatility, suggesting value in the underdog keeping it close. Additionally, early totals action leans toward the over, with bettors anticipating a faster pace and the possibility of explosive plays on both sides.
What are Duke trending bets?
DUKE trend: Duke has been competitive against the spread in recent contests, covering in two of its last three games as an underdog.
What are Syracuse trending bets?
CUSE trend: Syracuse has been streaky ATS at home, alternating covers and misses, with inconsistency tied to its defense’s ability to limit big plays.
Where can I find AI Picks for Duke vs Syracuse?
See our latest CFB picks and odds pages for 2025 to compare prices before you bet.
Duke vs. Syracuse Odds
Remi is pouring through tons of data points on each line. In fact, anytime the Duke vs Syracuse trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.
Duke vs Syracuse Opening Odds
DUKE Moneyline:
-222 CUSE Moneyline: +182
DUKE Spread: -5.5
CUSE Spread: +5.5
Over/Under: 60.5
Duke vs Syracuse Live Odds
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O 50.5 (-110)
U 50.5 (-110)
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–
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-420
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O 51.5 (-110)
U 51.5 (-110)
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+108
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O 46.5 (-114)
U 46.5 (-106)
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+150
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O 53.5 (-115)
U 53.5 (-105)
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–
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+1280
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O 44.5 (-105)
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-205
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O 54.5 (-110)
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TCU Horned Frogs
10/4/25 7:30PM
COLO
TCU
|
–
–
|
+400
-550
|
+13.5 (-104)
-13.5 (-118)
|
O 57.5 (-110)
U 57.5 (-110)
|
|
Oct 4, 2025 7:30PM EDT
Mississippi State Bulldogs
Texas A&M Aggies
10/4/25 7:30PM
MISSST
TEXAM
|
–
–
|
+470
-670
|
+14.5 (-114)
-14.5 (-106)
|
O 55.5 (-110)
U 55.5 (-110)
|
|
Oct 4, 2025 7:30PM EDT
Miami Hurricanes
Florida State Seminoles
10/4/25 7:30PM
MIAMI
FSU
|
–
–
|
-184
+150
|
-4.5 (-106)
+4.5 (-114)
|
O 53.5 (-115)
U 53.5 (-105)
|
|
Oct 4, 2025 8:00PM EDT
Tulsa Golden Hurricane
Memphis Tigers
10/4/25 8PM
TULSA
MEMP
|
–
–
|
+800
-1400
|
+20.5 (-114)
-20.5 (-106)
|
O 56.5 (-110)
U 56.5 (-110)
|
|
Oct 4, 2025 9:30PM EDT
Duke Blue Devils
California Golden Bears
10/4/25 9:30PM
DUKE
CAL
|
–
–
|
-155
+130
|
-3 (-110)
+3 (-110)
|
O 57.5 (-110)
U 57.5 (-110)
|
|
Oct 4, 2025 10:30PM EDT
Nevada Wolf Pack
Fresno State Bulldogs
10/4/25 10:30PM
NEVADA
FRESNO
|
–
–
|
+440
-610
|
+13.5 (-102)
-13.5 (-120)
|
O 44.5 (-115)
U 44.5 (-105)
|
|
Oct 9, 2025 7:30PM EDT
East Carolina Pirates
Tulane Green Wave
10/9/25 7:30PM
ECAR
TULANE
|
–
–
|
|
+7 (-110)
-7 (-110)
|
|
|
Oct 10, 2025 7:30PM EDT
South Florida Bulls
North Texas Mean Green
10/10/25 7:30PM
SFLA
NOTEX
|
–
–
|
|
+2.5 (-110)
-2.5 (-110)
|
|
|
Oct 11, 2025 12:00PM EDT
Florida Gators
Texas A&M Aggies
10/11/25 12PM
FLA
TEXAM
|
–
–
|
|
+9.5 (-110)
-9.5 (-110)
|
|
|
Oct 11, 2025 12:00PM EDT
Alabama Crimson Tide
Missouri Tigers
10/11/25 12PM
BAMA
MIZZOU
|
–
–
|
-205
+168
|
-6.5 (-102)
+6.5 (-120)
|
O 55.5 (-108)
U 55.5 (-112)
|
|
Oct 11, 2025 12:00PM EDT
Ohio State Buckeyes
Illinois Fighting Illini
10/11/25 12PM
OHIOST
ILL
|
–
–
|
-780
+530
|
-15.5 (-110)
+15.5 (-110)
|
O 50.5 (-105)
U 50.5 (-115)
|
|
Oct 11, 2025 12:45PM EDT
Georgia Bulldogs
Auburn Tigers
10/11/25 12:45PM
UGA
AUBURN
|
–
–
|
-172
+142
|
-3.5 (-114)
+3.5 (-106)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
Oct 11, 2025 3:30PM EDT
Indiana Hoosiers
Oregon Ducks
10/11/25 3:30PM
IND
OREG
|
–
–
|
+300
-385
|
+10.5 (-112)
-10.5 (-108)
|
O 52.5 (-110)
U 52.5 (-110)
|
|
Oct 11, 2025 3:30PM EDT
Oklahoma Sooners
Texas Longhorns
10/11/25 3:30PM
OKLA
TEXAS
|
–
–
|
|
+3.5 (-110)
-3.5 (-110)
|
|
|
Oct 11, 2025 4:15PM EDT
Arkansas Razorbacks
Tennessee Volunteers
10/11/25 4:15PM
ARK
TENN
|
–
–
|
+350
-465
|
+12.5 (-110)
-12.5 (-110)
|
O 67.5 (-110)
U 67.5 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Duke Blue Devils vs. Syracuse Orange on September 27, 2025 at JMA Wireless Dome.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
EMICH@CMICH | CMICH -148 | 62.8% | 7 | WIN |
SDGST@NOILL | SDGST -118 | 55.7% | 3 | WIN |
BAMA@GEORGIA | GEORGIA -125 | 58.7% | 7 | LOSS |
TENN@MISSST | MISSST +7.5 | 54.3% | 4 | WIN |
UK@SC | SC -5.5 | 54.8% | 4 | WIN |
WKY@MIZZST | MIZZST +4.5 | 55.6% | 6 | LOSS |
JAXST@USM | USM -3.5 | 56.0% | 5 | WIN |
NMEXST@NMEX | NMEX -14.5 | 56.9% | 6 | WIN |
ARIZ@IOWAST | ROCCO BECHT UNDER 1.5 PASS TDS | 55.5% | 5 | WIN |
TCU@ARIZST | JOSH HOOVER PASS YDS UNDER 287.5 | 53.4% | 3 | WIN |
ARIZST@BAYLOR | BAYLOR -130 | 58.4% | 6 | LOSS |
WYO@COLO | WYO +13.5 | 54.1% | 3 | LOSS |
TULANE@OLEMISS | MISS -11.5 | 54.3% | 4 | WIN |
UNC@UCF | UCF -6.5 | 54.4% | 4 | WIN |
ARKST@KENSAW | KENSAW +4.5 | 54.5% | 4 | WIN |
ILL@IND | IND -6 | 53.2% | 3 | WIN |
SELOU@LSU | LSU -47.5 | 55.3% | 5 | LOSS |
TNMART@MIZZST | MIZZST -14.5 | 56.2% | 6 | WIN |
FRESNO@HAWAII | HAWAII +3 | 56.6% | 6 | WIN |
MRSHL@MTSU | MTSU +2.5 | 56.8% | 6 | LOSS |
MICH@NEB | NEB +1.5 | 57.3% | 7 | LOSS |
WASH@WASHST | DENZEL BOSTON UNDER 69.5 RECV YDS | 56.2% | 6 | LOSS |
IOWA@RUT | ANTWAN RAYMOND OVER 0.5 TOUCHDOWNS | 54.4% | 4 | WIN |
GEORGIA@TENN | UNDER 50.5 | 55.5% | 6 | LOSS |
ARK@OLEMISS | MISS -225 | 72.0% | 9 | WIN |
DUKE@TULANE | TULANE -120 | 56.5% | 4 | WIN |
ARK@OLEMISS | MISS -6.5 | 53.9% | 3 | LOSS |
AKRON@UAB | UAB -11 | 54.7% | 4 | LOSS |
UCONN@DEL | DEL +9.5 | 55.0% | 5 | WIN |
APLST@USM | USM +4 | 55.3% | 6 | WIN |
MERIMK@KENSAW | KENSAW -13.5 | 56.2% | 7 | WIN |
UMASS@IOWA | IOWA -34.5 | 56.4% | 7 | WIN |
UMASS@IOWA | JAZIUN PATTERSON UNDER 0.5 RUSH TDS | 54.8% | 4 | WIN |
NMEX@UCLA | NICO IAMALEAVA UNDER 31.5 PASS ATT | 53.4% | 3 | LOSS |
KSTATE@ARIZ | ARIZ +1.5 | 56.1% | 6 | WIN |
BC@MICHST | NICK MARSH OVER 47.5 RCV YDS | 53.6% | 3 | WIN |
ARIZST@MISSST | MISSST +7 | 54.2% | 4 | WIN |
TULSA@NMEXST | NMEXST +3.5 | 56.9% | 6 | WIN |
UCLA@UNLV | OVER 54.5 | 56.2% | 6 | LOSS |
FRESNO@OREGST | FRESNO +1.5 | 54.7% | 4 | WIN |
VANDY@VATECH | VANDY +2.5 | 55.8% | 5 | WIN |
JMAD@LVILLE | LVILLE -14.5 | 54.0% | 3 | LOSS |
TCU@UNC | JOSEPH MANJACK OVER 37.5 RECV YDS | 53.8% | 3 | LOSS |
ND@MIAMI | MIAMI +3 | 55.2% | 6 | WIN |
MISSST@USM | USM +14.5 | 56.0% | 6 | LOSS |
UTAH@UCLA | UCLA +5.5 | 56.2% | 6 | LOSS |
CAL@OREGST | OREGST +1.5 | 55.1% | 5 | LOSS |
FAU@MD | MD -13.5 | 55.2% | 5 | WIN |
GAS@FRESNO | FRESNO +2 | 55.2% | 5 | WIN |
TOLEDO@UK | UK -9.5 | 56.2% | 6 | LOSS |
AUSTPEAY@MTSU | PEAY +12.5 | 56.2% | 6 | WIN |