Wyoming vs Colorado Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 20)

Updated: 2025-09-13T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Colorado comes in with questions at quarterback after recently promoting Ryan Staub, following his efficient performance in relief duty, and they’ll look to stabilize the offense at home. Wyoming, meanwhile, has shown a strong defense early in 2025, playing a physical brand of football that leans on discipline and limiting mistakes, and might be able to keep this one closer than many expect.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 20, 2025

Start Time: 10:15 PM EST​

Venue: Folsom Field​

Buffaloes Record: (1-2)

Cowboys Record: (2-1)

OPENING ODDS

WYO Moneyline: +413

COLO Moneyline: -565

WYO Spread: +13.5

COLO Spread: -13.5

Over/Under: 44.5

WYO
Betting Trends

  • Wyoming’s recent behavior vs spreads is mixed; while they’ve won games by leaning on defense and ball control, they haven’t always done so in fashions that overwhelm expectations. Early in 2025, Wyoming has had solid performances but their margin of victory has not always been convincing, which makes covering large spreads more challenging for them.

COLO
Betting Trends

  • Colorado’s performance to cover spreads has been shaky this season; their reliance on multiple quarterbacks and changes in offensive flow have introduced uncertainty. While their talent is clear, the inconsistency, especially on offense, has made it difficult for bettors to fully trust them when they are heavy favorites.

MATCHUP TRENDS

  • Early preview odds suggest Colorado may be favored by around 13.5 points, a number that reflects both their home field and perceived talent; however, insiders are suggesting that might be too large a spread given Wyoming’s defensive strengths. Another angle: if Colorado’s offense struggles or if Staub’s command of the offense isn’t yet polished, Wyoming could find value as an underdog + points. Also, totals (Over/Under) might be lower than for some other Big 12 or P5 matchups, because Wyoming tends to play a slower tempo, emphasize defense, and avoid turnover-filled games — all of which suppress high scoring. The betting markets will likely weigh whether Colorado can avoid early miscues and whether Wyoming can force some stops or turnovers to stay competitive.

WYO vs. COLO
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Welch under 35.5 Rushing Yards.

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Wyoming vs Colorado Prediction & Odds:
Free CFB Betting Insights for 9/20/25

The September 20, 2025, meeting between the Wyoming Cowboys and the Colorado Buffaloes at Folsom Field is a fascinating early-season clash of styles, with Wyoming’s defense-first, grind-it-out approach colliding with Colorado’s effort to redefine its offensive identity under a new quarterback. Wyoming comes in with confidence after starting the year strong, continuing its tradition of disciplined play and physical defense, hallmarks of a program that thrives on limiting explosive plays and controlling tempo. The Cowboys’ front seven has been particularly stout, generating pressure at the line of scrimmage and forcing opponents to settle for field goals, while their secondary has played with discipline to minimize costly breakdowns. Offensively, Wyoming prefers to move methodically, relying on the ground game and controlled passing to eat clock and shorten games, a strategy designed to frustrate opponents who prefer to play fast and score often. Colorado, meanwhile, has been in transition, recently handing the reins of the offense to Ryan Staub after his promising performance off the bench against Delaware, where he displayed both efficiency and poise. Staub’s promotion underscores the need for stability at quarterback, something Colorado lacked earlier in the season, and his ability to get the ball out quickly and sustain drives could be a difference-maker against Wyoming’s stingy defense.

The Buffaloes’ receiving corps remains dangerous, featuring explosive playmakers who can stretch defenses vertically and create mismatches in space, while their running game, though not always dominant, provides just enough balance to prevent defenses from pinning their ears back. Defensively, Colorado has shown improvement, but consistency remains an issue, as they’ve been vulnerable to big plays and at times have struggled to get off the field on third down, something Wyoming will aim to exploit with sustained, clock-draining drives. From a betting perspective, Colorado is expected to be favored by nearly two touchdowns, reflecting their superior talent level and home-field advantage, but there is skepticism about whether they can win in dominant fashion against a disciplined Wyoming team that specializes in keeping games close. The over/under may hinge on whether Colorado can break Wyoming’s defensive structure early and force the Cowboys out of their comfort zone; if Colorado strikes quickly, the game could tilt toward the over, but if Wyoming controls tempo, the under looks more realistic. Ultimately, the matchup is about whether Colorado can impose its athleticism and offensive upside, or whether Wyoming’s physicality, ball control, and defensive execution can drag the game into a tight, low-possession contest. While the Buffaloes have the talent to win comfortably, Wyoming’s style is uniquely suited to frustrate a program still finding its offensive rhythm, making this a potential trap game that could remain closer than the spread suggests if the Cowboys execute their blueprint.

Wyoming Cowboys CFB Preview

The Wyoming Cowboys step into Boulder on September 20, 2025, prepared to embrace their underdog role against Colorado with the kind of disciplined, blue-collar football identity that has long defined the program. Wyoming comes in playing solid defense and showing early-season resilience, leaning on a front seven that consistently clogs running lanes and generates pressure while their secondary plays a bend-don’t-break style designed to prevent opponents from hitting explosive plays over the top. Offensively, the Cowboys don’t dazzle with fireworks but instead thrive on efficiency, emphasizing the ground game to chew up clock and shorten contests while sprinkling in safe, controlled passing to keep defenses honest. The offensive line is a key strength, physical and cohesive, allowing Wyoming to establish tempo against less physical opponents and giving their backs enough space to pick up steady yardage. Against Colorado, the Cowboys’ mission will be clear: control time of possession, keep the Buffaloes’ playmakers off the field, and turn this into a grind-it-out contest where every possession matters. The challenge, however, lies in finding enough offensive punch to capitalize on red-zone opportunities, as settling for field goals will make it difficult to keep pace if Colorado’s offense finds rhythm behind new starting quarterback Ryan Staub.

Wyoming’s defense will need to rattle Staub early, disguising coverages and dialing up timely pressure to test his poise and prevent him from establishing chemistry with his receivers. Special teams could also play a decisive role for the Cowboys, as hidden yards in field position battles and the ability to pin Colorado deep could help tilt momentum. From a betting perspective, Wyoming will likely enter as a double-digit underdog, but that is precisely where they have found value in past seasons, consistently playing disciplined enough football to cover against more talented opponents. Their path to an outright upset would require near-flawless execution: no turnovers, efficient red-zone production, and one or two momentum-swinging plays on defense or special teams. Even if pulling off a shock in Boulder proves difficult, Wyoming’s identity as a tough, physical, low-mistake team gives them a legitimate chance to keep the score within reach, frustrate the Buffaloes with long, grinding possessions, and make the underdog bet more appealing than the favorite. For the Cowboys, this game is as much about proving they can dictate their style against a Power Five opponent as it is about chasing a statement win, and if they execute their formula, they have every chance of making life uncomfortable for Colorado.

Colorado comes in with questions at quarterback after recently promoting Ryan Staub, following his efficient performance in relief duty, and they’ll look to stabilize the offense at home. Wyoming, meanwhile, has shown a strong defense early in 2025, playing a physical brand of football that leans on discipline and limiting mistakes, and might be able to keep this one closer than many expect. Wyoming vs Colorado AI Prediction: Free CFB Betting Insights for Sep 20. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Colorado Buffaloes CFB Preview

The Colorado Buffaloes return to Folsom Field on September 20, 2025, aiming to solidify their early-season identity and show that their offense under new quarterback Ryan Staub can deliver consistency as well as explosiveness against a disciplined Wyoming team. Staub’s promotion after his efficient showing in relief duty against Delaware has brought optimism that Colorado can stabilize its passing attack, and his poise combined with a talented receiving corps gives the Buffaloes the ability to stretch the field vertically and attack defenses with speed. The offense still has balance with a capable run game that, while not dominant, is effective enough to prevent defenses from overcommitting to stopping the pass, giving Colorado multiple avenues to move the ball. The offensive line remains a work in progress, occasionally vulnerable under heavy pressure, but if they give Staub time, the Buffaloes have the playmakers to produce quick scores and flip momentum. On defense, Colorado has shown flashes of strength, especially in creating turnovers and bringing pressure off the edge, though inconsistency has been a theme as breakdowns in coverage and struggles on third down have allowed opponents to hang around longer than expected.

Against Wyoming, the Buffaloes’ defense will be tasked with bottling up a ground-heavy attack and preventing the Cowboys from controlling tempo with long, clock-draining possessions. A quick start will be critical: if Colorado can build an early lead, they can force Wyoming out of its comfort zone and into passing situations where the Buffaloes’ athletic advantage should show. Special teams will also be a factor, as Colorado has the speed and skill in the return game to generate favorable field position, which could further frustrate Wyoming if the game tilts toward higher possession counts. From a betting perspective, Colorado will likely be favored by around two touchdowns, but to cover that number, they must prove they can string together four quarters of sharp execution without the lulls that plagued them in earlier games. The key will be capitalizing on red-zone trips with touchdowns rather than field goals and maintaining defensive discipline to deny Wyoming the kind of field-position advantages that often keep underdogs in the game. For the Buffaloes, this matchup is not just about earning a win but about showing they can handle a methodical, defensive-minded opponent with patience and efficiency, something that will be critical in the grind of their conference schedule. If Staub continues to grow into his role and the defense shores up its consistency, Colorado has every reason to believe it can not only win but do so in convincing fashion that validates its standing as a team on the rise.

Wyoming vs. Colorado Prop Picks (AI)

Remi is pouring through mountains of stats on each player. In fact, anytime the Cowboys and Buffaloes play there’s always several intriguing trends to key in on. Not to mention games played at Folsom Field in Sep seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: M. Welch under 35.5 Rushing Yards.

Wyoming vs. Colorado Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every angle between the Cowboys and Buffaloes and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the unproportionally assigned weight emotional bettors regularly put on Colorado’s strength factors between a Cowboys team going up against a possibly deflated Buffaloes team. It appears the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Wyoming vs Colorado picks, computer picks Cowboys vs Buffaloes, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Cowboys Betting Trends

Wyoming’s recent behavior vs spreads is mixed; while they’ve won games by leaning on defense and ball control, they haven’t always done so in fashions that overwhelm expectations. Early in 2025, Wyoming has had solid performances but their margin of victory has not always been convincing, which makes covering large spreads more challenging for them.

Buffaloes Betting Trends

Colorado’s performance to cover spreads has been shaky this season; their reliance on multiple quarterbacks and changes in offensive flow have introduced uncertainty. While their talent is clear, the inconsistency, especially on offense, has made it difficult for bettors to fully trust them when they are heavy favorites.

Cowboys vs. Buffaloes Matchup Trends

Early preview odds suggest Colorado may be favored by around 13.5 points, a number that reflects both their home field and perceived talent; however, insiders are suggesting that might be too large a spread given Wyoming’s defensive strengths. Another angle: if Colorado’s offense struggles or if Staub’s command of the offense isn’t yet polished, Wyoming could find value as an underdog + points. Also, totals (Over/Under) might be lower than for some other Big 12 or P5 matchups, because Wyoming tends to play a slower tempo, emphasize defense, and avoid turnover-filled games — all of which suppress high scoring. The betting markets will likely weigh whether Colorado can avoid early miscues and whether Wyoming can force some stops or turnovers to stay competitive.

Wyoming vs. Colorado Game Info

Wyoming vs Colorado starts on September 20, 2025 at 10:15 PM EST.

Spread: Colorado -13.5
Moneyline: Wyoming +413, Colorado -565
Over/Under: 44.5

Wyoming: (2-1)  |  Colorado: (1-2)

Remi's searched hard and found the best prop for this matchup: M. Welch under 35.5 Rushing Yards.. Prices move—always shop for the best number.

Early preview odds suggest Colorado may be favored by around 13.5 points, a number that reflects both their home field and perceived talent; however, insiders are suggesting that might be too large a spread given Wyoming’s defensive strengths. Another angle: if Colorado’s offense struggles or if Staub’s command of the offense isn’t yet polished, Wyoming could find value as an underdog + points. Also, totals (Over/Under) might be lower than for some other Big 12 or P5 matchups, because Wyoming tends to play a slower tempo, emphasize defense, and avoid turnover-filled games — all of which suppress high scoring. The betting markets will likely weigh whether Colorado can avoid early miscues and whether Wyoming can force some stops or turnovers to stay competitive.

WYO trend: Wyoming’s recent behavior vs spreads is mixed; while they’ve won games by leaning on defense and ball control, they haven’t always done so in fashions that overwhelm expectations. Early in 2025, Wyoming has had solid performances but their margin of victory has not always been convincing, which makes covering large spreads more challenging for them.

COLO trend: Colorado’s performance to cover spreads has been shaky this season; their reliance on multiple quarterbacks and changes in offensive flow have introduced uncertainty. While their talent is clear, the inconsistency, especially on offense, has made it difficult for bettors to fully trust them when they are heavy favorites.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Wyoming vs. Colorado Odds

Remi is pouring through mountains of data points on each team. In fact, anytime the Wyoming vs Colorado trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.

Wyoming vs Colorado Opening Odds

WYO Moneyline: +413
COLO Moneyline: -565
WYO Spread: +13.5
COLO Spread: -13.5
Over/Under: 44.5

Wyoming vs Colorado Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+188
-6.5 (-110)
+6.5 (-110)
O 56.5 (-106)
U 56.5 (-114)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1500
-27.5 (-102)
+27.5 (-120)
O 60.5 (-115)
U 60.5 (-105)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+160
-190
+4.5 (-110)
-4.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+980
-21.5 (-105)
+21.5 (-115)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+168
-5.5 (-110)
+5.5 (-110)
O 63.5 (-106)
U 63.5 (-114)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7.5 (-118)
-7.5 (-104)
O 42.5 (-120)
U 42.5 (-102)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-450
+340
-12.5 (-110)
+12.5 (-110)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+140
-3.5 (-108)
+3.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+610
-950
+17.5 (-115)
-17.5 (-105)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-610
 
-14.5 (-105)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+172
-210
+4.5 (-105)
-4.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+122
-146
+2.5 (+100)
-2.5 (-122)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-110
-110
+1.5 (-115)
-1.5 (-105)
O 57.5 (-105)
U 57.5 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-375
+9.5 (-102)
-9.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-400
+310
-10.5 (-110)
+10.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+122
-146
+2.5 (-102)
-2.5 (-120)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-350
+8.5 (-110)
-8.5 (-110)
O 38.5 (-115)
U 38.5 (-105)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-520
+385
-11.5 (-118)
+11.5 (-104)
O 47.5 (-105)
U 47.5 (-115)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+122
-146
+2.5 (+100)
-2.5 (-122)
O 48.5 (-115)
U 48.5 (-105)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+188
-5.5 (-120)
+5.5 (-102)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+176
-215
+5.5 (-110)
-5.5 (-110)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
+104
-125
+1.5 (-105)
-1.5 (-115)
O 46.5 (-114)
U 46.5 (-106)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+480
-670
+15.5 (-110)
-15.5 (-110)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+146
-176
+4.5 (-115)
-4.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-720
 
-15.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-146
+122
-2.5 (-122)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-138
+2.5 (-106)
-2.5 (-114)
O 52.5 (-110)
U 52.5 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+195
-240
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+106
 
+2.5 (-115)
 
O 41.5 (-110)
U 41.5 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+310
 
+11.5 (-115)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+37.5 (-108)
-37.5 (-112)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+152
-184
+4.5 (-115)
-4.5 (-105)
O 67.5 (-105)
U 67.5 (-115)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-285
+230
-7.5 (-102)
+7.5 (-120)
O 44.5 (-120)
U 44.5 (-102)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+470
-15.5 (-112)
+15.5 (-108)
O 55.5 (-106)
U 55.5 (-114)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-106)
-33.5 (-114)
O 44.5 (-108)
U 44.5 (-112)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
+9.5 (-110)
-9.5 (-110)
O 47.5 (-112)
U 47.5 (-108)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-104)
U 45.5 (-118)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+106
-128
+1.5 (-105)
-1.5 (-115)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-630
+450
-14.5 (-105)
+14.5 (-115)
O 48.5 (-105)
U 48.5 (-115)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-144
+120
-2.5 (-120)
+2.5 (-102)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 55.5 (-104)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+184
-225
+5.5 (-104)
-5.5 (-118)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+270
-9.5 (-110)
+9.5 (-110)
O 53.5 (-118)
U 53.5 (-104)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+220
-275
+7.5 (-120)
-7.5 (-102)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+375
-500
+13.5 (-110)
-13.5 (-110)
O 49.5 (-115)
U 49.5 (-105)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Wyoming Cowboys vs. Colorado Buffaloes on September 20, 2025 at Folsom Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN