Syracuse vs Clemson Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 20)

Updated: 2025-09-13T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Clemson hosts Syracuse at Death Valley, with Syracuse entering this matchup as a significant underdog—Clemson opened as heavy favorites. Despite the long odds, Syracuse is riding momentum after a dominant offensive showing vs. Colgate that featured Steve Angeli throwing for over 400 yards, while Clemson has not yet covered a spread so far this season and has shown some defensive vulnerabilities.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 20, 2025

Start Time: 12:00 PM EST​

Venue: Memorial Stadium​

Tigers Record: (1-2)

Orange Record: (2-1)

OPENING ODDS

CUSE Moneyline: +514

CLEM Moneyline: -735

CUSE Spread: +17

CLEM Spread: -17.0

Over/Under: 55.5

CUSE
Betting Trends

  • Syracuse is 2-1 ATS this season, having covered the spread in two of their three games so far; that includes their blowout win over Colgate, where they vastly outperformed expectations. The Orange have also been noted to benefit from betting markets perhaps overlooking them, which has created some value when they are priced as underdogs.

CLEM
Betting Trends

  • Clemson is 0-3 ATS this season, having failed to cover in all three of its games, including losses or narrow wins in matchups where the expectations were higher. Even when winning, Clemson’s margins have been tighter than the spread or their performance hasn’t met spread expectations, suggesting bettors have been cautious about laying large spreads with them.

MATCHUP TRENDS

  • Given Clemson’s poor ATS record and Syracuse’s success covering as underdogs, there may be value in backing Syracuse with the points. The over/under is set around 55.5, which might be considered low given Syracuse’s fast pace when their offense clicks, and Clemson’s occasional defensive breakdowns could lead to some scoring. Also, Syracuse performed well in their recent explosive offensive performance, showing they can force turnovers and sustain drives, which could pressure Clemson more than they have been tested for. Betting line movement (if Syracuse gains money) could narrow the spread. History matters too: Syracuse has lost frequently to Clemson, but with their current form and Clemson’s ATS struggles, this year may present an opportunity for a closer game or even an upset.

CUSE vs. CLEM
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: T.J. Moore over 37.5 Receiving Yards.

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Syracuse vs Clemson Prediction & Odds:
Free CFB Betting Insights for 9/20/25

The September 20, 2025, showdown between the Syracuse Orange and the Clemson Tigers at Memorial Stadium is an ACC contest filled with intrigue because it features a Clemson team still trying to assert dominance after a shaky start against a Syracuse squad that has shown offensive explosiveness and the ability to cover spreads as an underdog. Clemson comes into this matchup with a 0-3 record against the spread despite being heavily favored in each of its first three games, a trend that suggests the Tigers have not yet found their usual rhythm on either side of the ball, and that has left bettors hesitant to trust them with big numbers. Their defense, traditionally a strength, has been prone to lapses this season, giving up more explosive plays than expected and struggling to consistently impose its will in the red zone. Offensively, Cade Klubnik has had moments of sharp play but has also lacked consistency, and Clemson’s running game has not been able to fully carry the load, leaving the Tigers needing more balance if they want to separate from opponents. On the other side, Syracuse enters this matchup with confidence after a dominant 600-yard offensive explosion against Colgate in which quarterback Steve Angeli threw for over 400 yards and showcased his ability to orchestrate a fast-paced, high-powered offense. The Orange have covered in two of their first three games, proving themselves to be a value play for bettors in underdog roles, and their blend of quick-strike capability and turnover creation on defense makes them a dangerous opponent for a Clemson team still looking for stability.

The betting line opened with Clemson as heavy favorites, but their inability to cover spreads combined with Syracuse’s proven ability to outperform expectations as an underdog has narrowed the public’s perception of this contest, creating intrigue around whether Syracuse can once again keep the game closer than oddsmakers predict. The total, hovering around 55.5, adds another layer of complexity, as Syracuse’s tempo and Clemson’s defensive issues suggest the potential for more points, while Clemson’s preference for controlling tempo at home could lean the game under if their defense rises to the occasion. History leans heavily toward Clemson, as they have dominated the head-to-head series in recent years, but there have been occasions where Syracuse has pushed the Tigers deeper into games than expected, and their current form suggests they could make this more competitive than a typical Clemson home game. Ultimately, the matchup will hinge on whether Clemson can finally put together a complete performance—offense executing cleanly, defense limiting big plays, and special teams holding firm—because if they continue to play inconsistently, Syracuse has the firepower to exploit mistakes, force the Tigers into uncomfortable situations, and possibly turn the contest into a fourth-quarter battle. For Clemson, this is about regaining control of their narrative and reassuring fans and bettors that they are still a dominant force, while for Syracuse it is an opportunity to prove their early-season offensive success can translate against elite opposition and that they are a program capable of more than just playing spoiler.

Syracuse Orange CFB Preview

The Syracuse Orange enter their September 20, 2025, matchup against the Clemson Tigers with a blend of confidence and determination, knowing that while they will be heavy underdogs in Death Valley, they have the offensive firepower and recent form to make this a far more competitive game than oddsmakers may suggest. Syracuse’s season has been highlighted by the emergence of quarterback Steve Angeli, who lit up Colgate with over 400 passing yards in a 600-yard offensive performance that demonstrated the Orange’s ability to sustain drives and hit explosive plays downfield. That type of production is what gives Syracuse hope of breaking through against a Clemson defense that has been vulnerable to big plays and has yet to live up to its reputation as one of the nation’s elite units. The Orange will look to strike quickly and put the Tigers under pressure, using tempo, spacing, and playmakers on the outside to stretch the field and test Clemson’s secondary. Defensively, Syracuse understands they will not win this game by shutting down Clemson entirely, but rather by making timely stops, forcing turnovers, and giving their offense extra possessions, especially if they can capitalize on any inconsistency from Cade Klubnik and the Tigers’ passing game. Special teams and field position will be crucial as well, since short fields can tilt momentum in Syracuse’s favor and help offset the advantages Clemson enjoys at home.

From a betting standpoint, Syracuse has been reliable in the underdog role, covering in two of their first three games this season, and with Clemson sitting at 0-3 ATS, there is significant value in backing the Orange to keep things close. The key for Syracuse will be discipline—limiting penalties, protecting the football, and staying composed in one of college football’s most intimidating road environments—because mental mistakes and turnovers could quickly turn a competitive game into a runaway. Their path to success lies in executing their offensive game plan early, keeping the pressure on Clemson, and forcing the Tigers to play from behind, something they have not done well so far this year. While history shows Syracuse has often come up short against Clemson, there have been several matchups in recent seasons where they have pushed the Tigers deeper into the game than expected, and with their current offensive form, they are capable of repeating that. If the Orange can combine their offensive explosiveness with opportunistic defense and avoid giving Clemson extra possessions, they have every reason to believe they can not only cover the spread but potentially make this one of the most competitive and surprising results of the weekend.

Clemson hosts Syracuse at Death Valley, with Syracuse entering this matchup as a significant underdog—Clemson opened as heavy favorites. Despite the long odds, Syracuse is riding momentum after a dominant offensive showing vs. Colgate that featured Steve Angeli throwing for over 400 yards, while Clemson has not yet covered a spread so far this season and has shown some defensive vulnerabilities. Syracuse vs Clemson AI Prediction: Free CFB Betting Insights for Sep 20. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Clemson Tigers CFB Preview

The Clemson Tigers return to Memorial Stadium on September 20, 2025, for a high-stakes ACC showdown with Syracuse that carries more weight than usual given Clemson’s underwhelming start to the season against the spread and their need to reassert themselves as one of the conference’s premier teams. Despite opening the year 3-0 straight up, the Tigers have failed to cover in all three games, a trend that reflects inconsistent play on both sides of the ball and has raised concerns about whether this team has the balance and execution to dominate opponents as it once did. Offensively, Cade Klubnik has been steady at times but also streaky, with stretches where the passing game sputters and leaves the offense leaning too heavily on the ground attack to move the chains. Against Syracuse, Clemson will need Klubnik to be more decisive, take advantage of the Tigers’ speed at receiver, and avoid the costly turnovers that have plagued some of their early possessions. Their offensive line will also be under pressure to control the trenches, both to open running lanes and to provide Klubnik with the time he needs to operate, because Syracuse’s defense has shown a knack for forcing mistakes and swinging momentum with timely takeaways.

On defense, Clemson must play up to its reputation by containing Steve Angeli and Syracuse’s vertical passing game, which torched Colgate for over 400 yards and has been one of the ACC’s early storylines. Limiting explosive plays will be paramount, as Clemson cannot afford to let Syracuse build confidence in a hostile road setting where one or two big strikes could shift the tone of the game. Special teams will also be a point of emphasis, as Clemson will look to use field position and returns to tilt the game in their favor and keep pressure on Syracuse throughout. From a betting perspective, Clemson remains the favorite because of their talent, depth, and home-field advantage at Death Valley, but their inability to cover spreads so far makes them a risky side to back with a large number, especially against a Syracuse team that has proven capable of exceeding expectations as an underdog. To change that narrative, Clemson must seize control early, feed off the energy of their crowd, and ensure that Syracuse never feels comfortable in the game. The Tigers’ path to a convincing win lies in executing with discipline, dominating possession, and proving that their defensive unit can smother an opponent’s rhythm, and if they succeed, they could finally deliver the kind of statement victory that both their fans and bettors have been waiting for.

Syracuse vs. Clemson Prop Picks (AI)

Remi is pouring through mountains of datapoints on each team. In fact, anytime the Orange and Tigers play there’s always several intriguing observations to key in on. Not to mention games played at Memorial Stadium in Sep rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: T.J. Moore over 37.5 Receiving Yards.

Syracuse vs. Clemson Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every facet between the Orange and Tigers and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most fixated on the growing factor emotional bettors tend to put on player performance factors between a Orange team going up against a possibly tired Tigers team. It appears the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Syracuse vs Clemson picks, computer picks Orange vs Tigers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Orange Betting Trends

Syracuse is 2-1 ATS this season, having covered the spread in two of their three games so far; that includes their blowout win over Colgate, where they vastly outperformed expectations. The Orange have also been noted to benefit from betting markets perhaps overlooking them, which has created some value when they are priced as underdogs.

Tigers Betting Trends

Clemson is 0-3 ATS this season, having failed to cover in all three of its games, including losses or narrow wins in matchups where the expectations were higher. Even when winning, Clemson’s margins have been tighter than the spread or their performance hasn’t met spread expectations, suggesting bettors have been cautious about laying large spreads with them.

Orange vs. Tigers Matchup Trends

Given Clemson’s poor ATS record and Syracuse’s success covering as underdogs, there may be value in backing Syracuse with the points. The over/under is set around 55.5, which might be considered low given Syracuse’s fast pace when their offense clicks, and Clemson’s occasional defensive breakdowns could lead to some scoring. Also, Syracuse performed well in their recent explosive offensive performance, showing they can force turnovers and sustain drives, which could pressure Clemson more than they have been tested for. Betting line movement (if Syracuse gains money) could narrow the spread. History matters too: Syracuse has lost frequently to Clemson, but with their current form and Clemson’s ATS struggles, this year may present an opportunity for a closer game or even an upset.

Syracuse vs. Clemson Game Info

Syracuse vs Clemson starts on September 20, 2025 at 12:00 PM EST.

Spread: Clemson -17.0
Moneyline: Syracuse +514, Clemson -735
Over/Under: 55.5

Syracuse: (2-1)  |  Clemson: (1-2)

Remi's searched hard and found the best prop for this matchup: T.J. Moore over 37.5 Receiving Yards.. Prices move—always shop for the best number.

Given Clemson’s poor ATS record and Syracuse’s success covering as underdogs, there may be value in backing Syracuse with the points. The over/under is set around 55.5, which might be considered low given Syracuse’s fast pace when their offense clicks, and Clemson’s occasional defensive breakdowns could lead to some scoring. Also, Syracuse performed well in their recent explosive offensive performance, showing they can force turnovers and sustain drives, which could pressure Clemson more than they have been tested for. Betting line movement (if Syracuse gains money) could narrow the spread. History matters too: Syracuse has lost frequently to Clemson, but with their current form and Clemson’s ATS struggles, this year may present an opportunity for a closer game or even an upset.

CUSE trend: Syracuse is 2-1 ATS this season, having covered the spread in two of their three games so far; that includes their blowout win over Colgate, where they vastly outperformed expectations. The Orange have also been noted to benefit from betting markets perhaps overlooking them, which has created some value when they are priced as underdogs.

CLEM trend: Clemson is 0-3 ATS this season, having failed to cover in all three of its games, including losses or narrow wins in matchups where the expectations were higher. Even when winning, Clemson’s margins have been tighter than the spread or their performance hasn’t met spread expectations, suggesting bettors have been cautious about laying large spreads with them.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Syracuse vs. Clemson Odds

Remi is pouring through mountains of stats on each player. In fact, anytime the Syracuse vs Clemson trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.

Syracuse vs Clemson Opening Odds

CUSE Moneyline: +514
CLEM Moneyline: -735
CUSE Spread: +17
CLEM Spread: -17.0
Over/Under: 55.5

Syracuse vs Clemson Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+188
-6.5 (-110)
+6.5 (-110)
O 56.5 (-106)
U 56.5 (-114)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1500
-27.5 (-102)
+27.5 (-120)
O 60.5 (-115)
U 60.5 (-105)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+160
-190
+4.5 (-110)
-4.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+980
-21.5 (-105)
+21.5 (-115)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+168
-5.5 (-110)
+5.5 (-110)
O 63.5 (-106)
U 63.5 (-114)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7.5 (-118)
-7.5 (-104)
O 42.5 (-120)
U 42.5 (-102)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-450
+340
-12.5 (-110)
+12.5 (-110)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+140
-3.5 (-108)
+3.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+610
-950
+17.5 (-115)
-17.5 (-105)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-610
 
-14.5 (-105)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+172
-210
+4.5 (-105)
-4.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+122
-146
+2.5 (+100)
-2.5 (-122)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-110
-110
+1.5 (-115)
-1.5 (-105)
O 57.5 (-105)
U 57.5 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-375
+9.5 (-102)
-9.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-400
+310
-10.5 (-110)
+10.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+122
-146
+2.5 (-102)
-2.5 (-120)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-350
+8.5 (-110)
-8.5 (-110)
O 38.5 (-115)
U 38.5 (-105)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-520
+385
-11.5 (-118)
+11.5 (-104)
O 47.5 (-105)
U 47.5 (-115)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+122
-146
+2.5 (+100)
-2.5 (-122)
O 48.5 (-115)
U 48.5 (-105)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+188
-5.5 (-120)
+5.5 (-102)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+176
-215
+5.5 (-110)
-5.5 (-110)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
+104
-125
+1.5 (-105)
-1.5 (-115)
O 46.5 (-114)
U 46.5 (-106)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+480
-670
+15.5 (-110)
-15.5 (-110)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+146
-176
+4.5 (-115)
-4.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-720
 
-15.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-146
+122
-2.5 (-122)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-138
+2.5 (-106)
-2.5 (-114)
O 52.5 (-110)
U 52.5 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+195
-240
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+106
 
+2.5 (-115)
 
O 41.5 (-110)
U 41.5 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+310
 
+11.5 (-115)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+37.5 (-108)
-37.5 (-112)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+152
-184
+4.5 (-115)
-4.5 (-105)
O 67.5 (-105)
U 67.5 (-115)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-285
+230
-7.5 (-102)
+7.5 (-120)
O 44.5 (-120)
U 44.5 (-102)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+470
-15.5 (-112)
+15.5 (-108)
O 55.5 (-106)
U 55.5 (-114)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-106)
-33.5 (-114)
O 44.5 (-108)
U 44.5 (-112)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
+9.5 (-110)
-9.5 (-110)
O 47.5 (-112)
U 47.5 (-108)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-104)
U 45.5 (-118)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+106
-128
+1.5 (-105)
-1.5 (-115)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-630
+450
-14.5 (-105)
+14.5 (-115)
O 48.5 (-105)
U 48.5 (-115)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-144
+120
-2.5 (-120)
+2.5 (-102)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 55.5 (-104)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+184
-225
+5.5 (-104)
-5.5 (-118)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+270
-9.5 (-110)
+9.5 (-110)
O 53.5 (-118)
U 53.5 (-104)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+220
-275
+7.5 (-120)
-7.5 (-102)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+375
-500
+13.5 (-110)
-13.5 (-110)
O 49.5 (-115)
U 49.5 (-105)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Syracuse Orange vs. Clemson Tigers on September 20, 2025 at Memorial Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN