South Carolina vs Missouri Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 20)

Updated: 2025-09-13T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Missouri enters this Week 4 SEC clash undefeated (2-0), riding a wave of offensive momentum, including a commanding 52-10 victory over Louisiana that featured a dominant rushing performance. South Carolina (1-2) will look to bounce back from a tough 31-7 home loss to Vanderbilt and the loss of starting quarterback LaNorris Sellers due to injury.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 20, 2025

Start Time: 7:00 PM EST​

Venue: Memorial Stadium at Faurot Field​

Tigers Record: (3-0)

Gamecocks Record: (2-1)

OPENING ODDS

SC Moneyline: +400

MIZZOU Moneyline: -546

SC Spread: +13.5

MIZZOU Spread: -13.5

Over/Under: 46.5

SC
Betting Trends

  • Publicly available ATS data for the Gamecocks in 2025 is sparse, but their struggles in recent outings—particularly a lopsided loss at home—suggest they’ve had difficulty covering, especially when expectations were higher. Even though historical trends for South Carolina against Missouri in Columbia have been competitive, recent performance indicates they may have struggled to meet spread expectations.

MIZZOU
Betting Trends

  • Missouri’s blowout win against Louisiana and solid early-season appearances suggest they’ve likely covered spreads as favorites, especially at home. Their ability to control tempo and dominate on the ground implies an upward trend in morst佳 recent ATS results, though ATS records are not confirmed for all games.

MATCHUP TRENDS

  • The betting market likely favors Missouri as home favorites, given their offensive firepower and South Carolina’s recent struggles and injuries. If Missouri continues its trend of covering at home, they might be a strong play. Temple’s (sorry, South Carolina’s) road underdog status and history of competitive games in SEC matchups might entice bettors to look at the spread for value, especially if Missouri’s line becomes large. Additionally, with Missouri’s balanced offense and South Carolina’s injury-induced instability, the Over/Under may draw attention based on whether bettors expect a high-scoring or more controlled pace game.

SC vs. MIZZOU
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: B. Pribula under 237.5 Passing Yards.

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South Carolina vs Missouri Prediction & Odds:
Free CFB Betting Insights for 9/20/25

The September 20, 2025, SEC matchup between the South Carolina Gamecocks and the Missouri Tigers is shaping up as a pivotal early-season contest for two teams trending in very different directions, with Missouri riding a wave of momentum at 2-0 and South Carolina searching for answers after a rough start to the year and the loss of their starting quarterback. Missouri has looked every bit the part of a contender so far, highlighted by a dominant 52-10 victory over Louisiana in which their offense rolled up huge yardage behind a relentless ground attack led by Ahmad Hardy, who exploded for 250 rushing yards in that game, while their defense remained disciplined and opportunistic, limiting explosive plays and tightening in the red zone. They appear to be building balance on both sides of the ball, combining explosive offensive capability with enough defensive stability to control games, and they will be eager to carry that form into their SEC opener at home. South Carolina, meanwhile, is coming off a humbling 31-7 home loss to Vanderbilt, a setback that not only underscored their offensive struggles but also raised concerns about depth and execution after the injury to quarterback LaNorris Sellers left the team scrambling for answers. Their offensive inconsistency has put extra pressure on the defense, which has been asked to shoulder more than it can manage when the offense fails to sustain drives, and against a Missouri squad that thrives on creating rhythm and finishing possessions with points, that imbalance could prove costly.

The key for South Carolina will be whether their backup quarterback and offensive playmakers can generate enough consistency to keep pace and whether their defense can force Missouri into mistakes early to create confidence and field position. For Missouri, the challenge will be to avoid complacency and maintain sharp execution against an opponent that, while reeling, still has SEC-level athletes and the ability to disrupt if overlooked. From a betting perspective, Missouri’s strong start suggests they will enter as solid home favorites, with a line likely to reflect their offensive dominance and South Carolina’s offensive injuries, though South Carolina’s historical competitiveness as a road underdog might entice some bettors if the spread grows too large. The total points market could be influenced by the uncertainty around South Carolina’s offense; if they cannot move the ball, the under might come into play despite Missouri’s ability to score quickly. Ultimately, this game feels like Missouri’s to control, with their balanced offense, depth, and confidence setting them up to secure another statement win at home, while South Carolina’s only path to keeping it competitive lies in playing mistake-free, slowing the tempo, and finding unexpected sparks on both sides of the ball.

South Carolina Gamecocks CFB Preview

The South Carolina Gamecocks head into their September 20, 2025, matchup against Missouri with urgency and plenty of questions, as they look to rebound from a difficult start to the season and find stability in the wake of injuries and inconsistency. Their most recent outing, a disappointing 31-7 home loss to Vanderbilt, highlighted not only offensive struggles but also the pressing challenge of replacing quarterback LaNorris Sellers, whose injury has forced the coaching staff to recalibrate the offense and put greater responsibility on backups and skill players. Without Sellers’ mobility and leadership, South Carolina will need to simplify its game plan, leaning on the running game to establish tempo and shorten the contest, while asking their receivers to make plays in tight windows to keep drives alive. Defensively, the Gamecocks will have to shoulder an even heavier burden, as they cannot afford to allow Missouri’s offense, which looked dominant in its 52-10 rout of Louisiana, to dictate the pace of play. Their front seven must focus on limiting Ahmad Hardy, who exploded for 250 rushing yards in that game, by controlling the line of scrimmage and forcing Missouri into long passing situations where turnovers can be created.

Special teams execution will also be critical, as South Carolina cannot afford mistakes that shorten the field for Missouri or leave points on the board in what projects to be a challenging environment on the road. From a betting perspective, South Carolina’s ATS form has been shaky, reflecting their struggles to meet expectations in both wins and losses, but their role as a heavy underdog could offer value if their defense can keep them within striking distance. The formula for the Gamecocks is straightforward: avoid turnovers, find a way to grind out possessions, and hope the defense can create momentum-shifting plays that frustrate Missouri’s rhythm. While an outright upset in Columbia would be a tall order, South Carolina has historically had the grit to rise in tough situations, and if their players respond to the adversity of losing their starting quarterback, they could make this game more competitive than many expect. For South Carolina, this is as much a test of character as it is of football execution, and their ability to play disciplined, mistake-free football on the road will determine whether they can cover the spread and restore some confidence in a season that has already hit adversity.

Missouri enters this Week 4 SEC clash undefeated (2-0), riding a wave of offensive momentum, including a commanding 52-10 victory over Louisiana that featured a dominant rushing performance. South Carolina (1-2) will look to bounce back from a tough 31-7 home loss to Vanderbilt and the loss of starting quarterback LaNorris Sellers due to injury. South Carolina vs Missouri AI Prediction: Free CFB Betting Insights for Sep 20. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Missouri Tigers CFB Preview

The Missouri Tigers enter their September 20, 2025, clash with South Carolina brimming with confidence, having opened the season 2-0 and flashing the kind of balanced, explosive football that makes them a dangerous SEC contender. Their most recent performance, a 52-10 dismantling of Louisiana, showcased everything head coach Eli Drinkwitz has been building toward, with a dominant ground game led by Ahmad Hardy’s monster 250-yard rushing effort, a passing attack that spread the ball efficiently, and a defense that set the tone by limiting big plays and capitalizing on mistakes. Playing at home in Columbia, Missouri will have the added advantage of crowd energy, which could prove crucial in pushing them to start fast and avoid the kind of sluggishness that sometimes plagues favorites in early-season conference matchups. Offensively, the Tigers’ strength lies in their ability to strike balance: Hardy has been nearly unstoppable running behind an experienced offensive line, but their quarterback has also demonstrated poise and accuracy, making it difficult for defenses to load the box without being punished through the air. Defensively, Missouri will face a South Carolina team scrambling after the injury to quarterback LaNorris Sellers, and this presents an opportunity for the Tigers’ front seven to dominate the line of scrimmage, pressure the backup quarterback into mistakes, and limit the Gamecocks’ ability to control tempo with the run.

Missouri’s secondary has shown improved discipline, and if they force South Carolina into obvious passing downs, turnovers could quickly turn this game into a rout. Special teams has been another strength, with reliable kicking and solid coverage that has kept opponents from finding easy yardage, further cementing their edge in hidden aspects of the game. From a betting perspective, Missouri has been a strong play so far, not only winning but covering spreads with authority, and oddsmakers are likely to set them as comfortable home favorites given South Carolina’s offensive struggles and injury concerns. For Missouri to continue rewarding bettors, the key will be keeping focus, avoiding unnecessary penalties, and putting the game out of reach by halftime rather than letting South Carolina hang around with defensive grit. The path is clear: lean on Hardy and the rushing attack to set the tone, mix in efficient passing to stretch the field, and trust their defense to suffocate a shorthanded South Carolina squad. If they execute at the level they’ve shown through two weeks, the Tigers should not only win but do so convincingly, sending a message to the SEC that their early dominance is no fluke and that they are ready to compete at the top of the conference.

South Carolina vs. Missouri Prop Picks (AI)

Remi is pouring through tons of data on each team. In fact, anytime the Gamecocks and Tigers play there’s always several intriguing angles to key in on. Not to mention games played at Memorial Stadium at Faurot Field in Sep can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: B. Pribula under 237.5 Passing Yards.

South Carolina vs. Missouri Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every facet between the Gamecocks and Tigers and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

Remi has been most fixated on the unproportionally assigned factor human bettors often put on Missouri’s strength factors between a Gamecocks team going up against a possibly strong Tigers team. In reality, the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI South Carolina vs Missouri picks, computer picks Gamecocks vs Tigers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Gamecocks Betting Trends

Publicly available ATS data for the Gamecocks in 2025 is sparse, but their struggles in recent outings—particularly a lopsided loss at home—suggest they’ve had difficulty covering, especially when expectations were higher. Even though historical trends for South Carolina against Missouri in Columbia have been competitive, recent performance indicates they may have struggled to meet spread expectations.

Tigers Betting Trends

Missouri’s blowout win against Louisiana and solid early-season appearances suggest they’ve likely covered spreads as favorites, especially at home. Their ability to control tempo and dominate on the ground implies an upward trend in morst佳 recent ATS results, though ATS records are not confirmed for all games.

Gamecocks vs. Tigers Matchup Trends

The betting market likely favors Missouri as home favorites, given their offensive firepower and South Carolina’s recent struggles and injuries. If Missouri continues its trend of covering at home, they might be a strong play. Temple’s (sorry, South Carolina’s) road underdog status and history of competitive games in SEC matchups might entice bettors to look at the spread for value, especially if Missouri’s line becomes large. Additionally, with Missouri’s balanced offense and South Carolina’s injury-induced instability, the Over/Under may draw attention based on whether bettors expect a high-scoring or more controlled pace game.

South Carolina vs. Missouri Game Info

South Carolina vs Missouri starts on September 20, 2025 at 7:00 PM EST.

Venue: Memorial Stadium at Faurot Field.

Spread: Missouri -13.5
Moneyline: South Carolina +400, Missouri -546
Over/Under: 46.5

South Carolina: (2-1)  |  Missouri: (3-0)

Remi's searched hard and found the best prop for this matchup: B. Pribula under 237.5 Passing Yards.. Prices move—always shop for the best number.

The betting market likely favors Missouri as home favorites, given their offensive firepower and South Carolina’s recent struggles and injuries. If Missouri continues its trend of covering at home, they might be a strong play. Temple’s (sorry, South Carolina’s) road underdog status and history of competitive games in SEC matchups might entice bettors to look at the spread for value, especially if Missouri’s line becomes large. Additionally, with Missouri’s balanced offense and South Carolina’s injury-induced instability, the Over/Under may draw attention based on whether bettors expect a high-scoring or more controlled pace game.

SC trend: Publicly available ATS data for the Gamecocks in 2025 is sparse, but their struggles in recent outings—particularly a lopsided loss at home—suggest they’ve had difficulty covering, especially when expectations were higher. Even though historical trends for South Carolina against Missouri in Columbia have been competitive, recent performance indicates they may have struggled to meet spread expectations.

MIZZOU trend: Missouri’s blowout win against Louisiana and solid early-season appearances suggest they’ve likely covered spreads as favorites, especially at home. Their ability to control tempo and dominate on the ground implies an upward trend in morst佳 recent ATS results, though ATS records are not confirmed for all games.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

South Carolina vs. Missouri Odds

AI algorithm Remi is pouring through tons of stats on each player. In fact, anytime the South Carolina vs Missouri trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps rarely follow normal, predictable patterns.

South Carolina vs Missouri Opening Odds

SC Moneyline: +400
MIZZOU Moneyline: -546
SC Spread: +13.5
MIZZOU Spread: -13.5
Over/Under: 46.5

South Carolina vs Missouri Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+188
-6.5 (-110)
+6.5 (-110)
O 56.5 (-106)
U 56.5 (-114)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1500
-27.5 (-102)
+27.5 (-120)
O 60.5 (-115)
U 60.5 (-105)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+160
-190
+4.5 (-110)
-4.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+980
-21.5 (-105)
+21.5 (-115)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+168
-5.5 (-110)
+5.5 (-110)
O 63.5 (-106)
U 63.5 (-114)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7.5 (-118)
-7.5 (-104)
O 42.5 (-120)
U 42.5 (-102)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-450
+340
-12.5 (-110)
+12.5 (-110)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+140
-3.5 (-108)
+3.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+610
-950
+17.5 (-115)
-17.5 (-105)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-610
 
-14.5 (-105)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+172
-210
+4.5 (-105)
-4.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+122
-146
+2.5 (+100)
-2.5 (-122)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-110
-110
+1.5 (-115)
-1.5 (-105)
O 57.5 (-105)
U 57.5 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-375
+9.5 (-102)
-9.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-400
+310
-10.5 (-110)
+10.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+122
-146
+2.5 (-102)
-2.5 (-120)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-350
+8.5 (-110)
-8.5 (-110)
O 38.5 (-115)
U 38.5 (-105)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-520
+385
-11.5 (-118)
+11.5 (-104)
O 47.5 (-105)
U 47.5 (-115)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+122
-146
+2.5 (+100)
-2.5 (-122)
O 48.5 (-115)
U 48.5 (-105)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+188
-5.5 (-120)
+5.5 (-102)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+176
-215
+5.5 (-110)
-5.5 (-110)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
+104
-125
+1.5 (-105)
-1.5 (-115)
O 46.5 (-114)
U 46.5 (-106)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+480
-670
+15.5 (-110)
-15.5 (-110)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+146
-176
+4.5 (-115)
-4.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-720
 
-15.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-146
+122
-2.5 (-122)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-138
+2.5 (-106)
-2.5 (-114)
O 52.5 (-110)
U 52.5 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+195
-240
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+106
 
+2.5 (-115)
 
O 41.5 (-110)
U 41.5 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+310
 
+11.5 (-115)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+37.5 (-108)
-37.5 (-112)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+152
-184
+4.5 (-115)
-4.5 (-105)
O 67.5 (-105)
U 67.5 (-115)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-285
+230
-7.5 (-102)
+7.5 (-120)
O 44.5 (-120)
U 44.5 (-102)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+470
-15.5 (-112)
+15.5 (-108)
O 55.5 (-106)
U 55.5 (-114)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-106)
-33.5 (-114)
O 44.5 (-108)
U 44.5 (-112)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
+9.5 (-110)
-9.5 (-110)
O 47.5 (-112)
U 47.5 (-108)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-104)
U 45.5 (-118)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+106
-128
+1.5 (-105)
-1.5 (-115)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-630
+450
-14.5 (-105)
+14.5 (-115)
O 48.5 (-105)
U 48.5 (-115)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-144
+120
-2.5 (-120)
+2.5 (-102)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 55.5 (-104)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+184
-225
+5.5 (-104)
-5.5 (-118)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+270
-9.5 (-110)
+9.5 (-110)
O 53.5 (-118)
U 53.5 (-104)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+220
-275
+7.5 (-120)
-7.5 (-102)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+375
-500
+13.5 (-110)
-13.5 (-110)
O 49.5 (-115)
U 49.5 (-105)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers South Carolina Gamecocks vs. Missouri Tigers on September 20, 2025 at Memorial Stadium at Faurot Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN