Purdue vs Notre Dame Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 20)

Updated: 2025-09-13T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Notre Dame hosts Purdue in South Bend as the Fighting Irish look to bounce back from a narrow season-opening loss, while Purdue enters 2025 with low external expectations after a difficult 2024, hoping to show improvement early under its new regime. This matchup carries high rivalry stakes and may serve as a litmus test for both programs—Notre Dame to reaffirm its status, Purdue to prove it can compete at a higher level than the previous year.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 20, 2025

Start Time: 3:30 PM EST​

Venue: Notre Dame Stadium​

Fighting Irish Record: (0-2)

Boilermakers Record: (2-1)

OPENING ODDS

PURDUE Moneyline: +1800

ND Moneyline: -5882

PURDUE Spread: +26.5

ND Spread: -26.5

Over/Under: 52.5

PURDUE
Betting Trends

  • Purdue’s ATS (against the spread) metrics for 2025 are not fully public, but early season results suggest mixed performance: strong in games they win, especially at home, but vulnerable in blowouts or when facing teams with superior firepower. Predictions and previews place Purdue as underdogs or modestly challenged in many key games, and bettors seem cautious about expecting them to cover large spreads, especially on the road.

ND
Betting Trends

  • Notre Dame’s early games reflect a program that often meets or slightly under‐performs against expectations in tight games, though they benefit from home field and history in rivalry matchups. After losing the opener at Miami in a close game, they have faced high expectations from both fans and bettors, which influences how people view their ability to cover: the spread is likely to favor Notre Dame, but large margins could be tempered if the opponent plays well.

MATCHUP TRENDS

  • Because Purdue is coming off a historically bad 1-11 season, many line‐makers and bettors will likely assume Notre Dame has the talent and momentum edge; however, Purdue’s early season wins have shown flashes and given hope to those looking for undervalued underdogs. The rivalry history is heavily tilted toward Notre Dame, especially at home; their winning streak in recent meetings adds psychological weight, but also raises expectations that sometimes lead to overconfidence. The Over/Under line might draw attention: gone are games where either team can be expected to be passive—both sides have shown capacity for scoring, though Notre Dame’s defensive lapses in close games could open up scoring avenues. The key ATS angles: whether Purdue can cover + points if the spread becomes large; whether Notre Dame can not only win but dominate enough to cover; and whether bettors believe Notre Dame might ease up late if the game gets out of hand, opening backdoor cover opportunities.

PURDUE vs. ND
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: E. Raridon under 47.5 Receiving Yards.

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Purdue vs Notre Dame Prediction & Odds:
Free CFB Betting Insights for 9/20/25

The September 20, 2025, matchup between the Notre Dame Fighting Irish and the Purdue Boilermakers in South Bend is a clash steeped in history and tradition, with both programs entering the game with something to prove at different stages of their trajectories. Notre Dame comes in looking to rebound from a season-opening setback and demonstrate that its aspirations of national relevance remain intact, while Purdue, after a historically rough 2024 campaign, seeks to show progress and credibility under its rebuilding effort. For Notre Dame, the emphasis will be on playing a complete game; their offense has shown the ability to move the ball efficiently with a balanced attack that mixes strong quarterback play and explosive skill position talent, but lapses in execution and untimely turnovers have prevented them from turning drives into comfortable wins. Defensively, the Irish need to clean up mistakes in coverage and improve red-zone stops, as they were tested in their opener and looked vulnerable to big plays, something Purdue will surely try to exploit. The Boilermakers, on the other hand, enter with a chip on their shoulder, eager to distance themselves from the 1-11 nightmare of last year and showcase that their roster has both the discipline and toughness to compete against higher-caliber opponents.

While their talent level may not match Notre Dame’s across the board, Purdue has shown flashes of improvement early in the year, with a running game that can move the chains and an offense that, when clicking, is capable of stringing together scoring drives. Their defense, however, has been inconsistent, particularly against more athletic opponents, and in this matchup they will need to be opportunistic, forcing turnovers and pressuring Notre Dame’s quarterback into mistakes to keep the game within striking distance. The rivalry aspect cannot be ignored either, as Purdue always views Notre Dame as a measuring stick, and close games in the past have been decided by small margins or late swings in momentum. From a betting perspective, Notre Dame will likely be favored by double digits, but covering the spread depends on their ability to control tempo, limit mistakes, and dominate in the trenches, while Purdue’s potential as an underdog lies in keeping the game competitive into the second half and exploiting any lapses in Irish execution. The Over/Under may draw significant interest, as Notre Dame’s offense is capable of scoring quickly but Purdue’s ability to slow the game and chew clock could keep totals down if they succeed in controlling tempo. Ultimately, this game shapes up as a barometer for both programs—Notre Dame aiming to reassert its strength and show it can put away lesser opponents convincingly, and Purdue looking to prove it has turned a corner by standing tall in a hostile road environment against a team with far greater expectations.

Purdue Boilermakers CFB Preview

The Purdue Boilermakers travel to South Bend on September 20, 2025, seeking not only to compete with the storied Notre Dame Fighting Irish but also to demonstrate that their program is steadily climbing out of the struggles that defined their 2024 campaign. Coming off a 1-11 season that marked one of the lowest points in program history, Purdue has entered 2025 with a renewed sense of urgency under its coaching staff, focusing on instilling discipline, balance, and a commitment to improvement in all phases of the game. Offensively, the Boilermakers have leaned on a run-first approach to establish rhythm, using the ground game to set up manageable passing situations while trying to build confidence for their quarterback in an attack that has struggled to find consistency. Against Notre Dame’s defense, which has had its own lapses in coverage and tackling, Purdue’s best path lies in sustaining long drives, limiting turnovers, and converting red-zone opportunities into touchdowns rather than settling for field goals. Their offensive line will need to hold its own against a physical Irish front, as constant pressure on the quarterback or a stifled run game could spell trouble early and force the Boilermakers out of their comfort zone.

Defensively, Purdue will be tasked with slowing down a Notre Dame attack that has speed and versatility at multiple positions, and while the Boilermakers have shown flashes of defensive intensity, they will need to be sharper than ever in gap discipline and tackling to avoid being exploited by explosive plays. Forcing turnovers and creating short fields will be critical if Purdue hopes to stay competitive, as trading long drives with the Irish may not be sustainable over four quarters. Special teams execution will also be important, as flipping field position and avoiding mistakes could give the Boilermakers a chance to build momentum in what is likely to be a hostile atmosphere. From a betting perspective, Purdue is almost certain to enter as a heavy underdog, but that role suits them in a rivalry game where motivation and energy can sometimes keep the margin closer than expected. If they can stay within striking distance through the first half and force Notre Dame to work harder than anticipated, the Boilermakers have a chance to reward those who back them to cover. While an outright upset would require near-perfect execution and Notre Dame underperforming, Purdue can use this matchup to showcase its resilience, measure its progress against elite competition, and set a tone for the rest of its season that the program is on its way back to respectability.

Notre Dame hosts Purdue in South Bend as the Fighting Irish look to bounce back from a narrow season-opening loss, while Purdue enters 2025 with low external expectations after a difficult 2024, hoping to show improvement early under its new regime. This matchup carries high rivalry stakes and may serve as a litmus test for both programs—Notre Dame to reaffirm its status, Purdue to prove it can compete at a higher level than the previous year. Purdue vs Notre Dame AI Prediction: Free CFB Betting Insights for Sep 20. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Notre Dame Fighting Irish CFB Preview

The Notre Dame Fighting Irish return to the friendly confines of South Bend on September 20, 2025, to host the Purdue Boilermakers in a game that offers the chance to regain momentum, reinforce their standing as a top national program, and remind rivals that Notre Dame Stadium is one of the toughest environments for visitors in college football. After a disappointing early-season setback that revealed both strengths and flaws, the Irish enter this matchup knowing that controlling tempo, executing cleanly, and playing disciplined football will be key to avoiding the kind of nervous, down-to-the-wire finishes that have tripped them up before. Offensively, Notre Dame boasts balance, with a quarterback who has shown the ability to lead sustained drives and stretch the field with timely throws, paired with a rushing attack that can punish defenses behind a physical offensive line. The receiving corps has the speed to create mismatches, and if the Irish get into rhythm early, they have the firepower to overwhelm a Purdue defense that has been prone to giving up chunk plays. Defensively, Notre Dame’s front seven will be tasked with shutting down the Boilermakers’ run game and forcing them into predictable passing situations where the Irish secondary can look to generate turnovers and clamp down on explosive plays.

This unit has been inconsistent at times, particularly in third-down situations, but against Purdue they will look to impose their will with physicality and depth. At home, the Irish also have the added edge of a crowd that expects dominance in a rivalry game and can provide a lift during momentum swings. Special teams have been reliable, particularly in the kicking game, and with solid return units, Notre Dame has the tools to tilt field position in their favor and make life even harder for the visitors. From a betting perspective, Notre Dame will be favored by a significant margin, likely in the double digits, reflecting both their superior talent and Purdue’s rebuilding status, though the question will be whether the Irish can sustain focus and intensity long enough to cover. If they start fast, limit turnovers, and finish drives in the red zone with touchdowns, Notre Dame has the potential to win comfortably and reaffirm their place in the national conversation. If they allow Purdue to hang around, however, the spread could become tricky, even in a game that never feels in doubt outright. Ultimately, this is an opportunity for the Irish to show that they can take care of business against a rival at home, assert dominance across all three phases, and send a message that despite early setbacks, they are a program that still expects to compete on the highest stage.

Purdue vs. Notre Dame Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each line. In fact, anytime the Boilermakers and Fighting Irish play there’s always several intriguing angles to key in on. Not to mention games played at Notre Dame Stadium in Sep seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: E. Raridon under 47.5 Receiving Yards.

Purdue vs. Notre Dame Prediction (AI)

Remi Robot Icon

Remi, our AI sports genius, has been pouring over tons of data from every angle between the Boilermakers and Fighting Irish and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the linear correlation of emphasis emotional bettors often put on player performance factors between a Boilermakers team going up against a possibly improved Fighting Irish team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Purdue vs Notre Dame picks, computer picks Boilermakers vs Fighting Irish, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Boilermakers Betting Trends

Purdue’s ATS (against the spread) metrics for 2025 are not fully public, but early season results suggest mixed performance: strong in games they win, especially at home, but vulnerable in blowouts or when facing teams with superior firepower. Predictions and previews place Purdue as underdogs or modestly challenged in many key games, and bettors seem cautious about expecting them to cover large spreads, especially on the road.

Fighting Irish Betting Trends

Notre Dame’s early games reflect a program that often meets or slightly under‐performs against expectations in tight games, though they benefit from home field and history in rivalry matchups. After losing the opener at Miami in a close game, they have faced high expectations from both fans and bettors, which influences how people view their ability to cover: the spread is likely to favor Notre Dame, but large margins could be tempered if the opponent plays well.

Boilermakers vs. Fighting Irish Matchup Trends

Because Purdue is coming off a historically bad 1-11 season, many line‐makers and bettors will likely assume Notre Dame has the talent and momentum edge; however, Purdue’s early season wins have shown flashes and given hope to those looking for undervalued underdogs. The rivalry history is heavily tilted toward Notre Dame, especially at home; their winning streak in recent meetings adds psychological weight, but also raises expectations that sometimes lead to overconfidence. The Over/Under line might draw attention: gone are games where either team can be expected to be passive—both sides have shown capacity for scoring, though Notre Dame’s defensive lapses in close games could open up scoring avenues. The key ATS angles: whether Purdue can cover + points if the spread becomes large; whether Notre Dame can not only win but dominate enough to cover; and whether bettors believe Notre Dame might ease up late if the game gets out of hand, opening backdoor cover opportunities.

Purdue vs. Notre Dame Game Info

Purdue vs Notre Dame starts on September 20, 2025 at 3:30 PM EST.

Venue: Notre Dame Stadium.

Spread: Notre Dame -26.5
Moneyline: Purdue +1800, Notre Dame -5882
Over/Under: 52.5

Purdue: (2-1)  |  Notre Dame: (0-2)

Remi's searched hard and found the best prop for this matchup: E. Raridon under 47.5 Receiving Yards.. Prices move—always shop for the best number.

Because Purdue is coming off a historically bad 1-11 season, many line‐makers and bettors will likely assume Notre Dame has the talent and momentum edge; however, Purdue’s early season wins have shown flashes and given hope to those looking for undervalued underdogs. The rivalry history is heavily tilted toward Notre Dame, especially at home; their winning streak in recent meetings adds psychological weight, but also raises expectations that sometimes lead to overconfidence. The Over/Under line might draw attention: gone are games where either team can be expected to be passive—both sides have shown capacity for scoring, though Notre Dame’s defensive lapses in close games could open up scoring avenues. The key ATS angles: whether Purdue can cover + points if the spread becomes large; whether Notre Dame can not only win but dominate enough to cover; and whether bettors believe Notre Dame might ease up late if the game gets out of hand, opening backdoor cover opportunities.

PURDUE trend: Purdue’s ATS (against the spread) metrics for 2025 are not fully public, but early season results suggest mixed performance: strong in games they win, especially at home, but vulnerable in blowouts or when facing teams with superior firepower. Predictions and previews place Purdue as underdogs or modestly challenged in many key games, and bettors seem cautious about expecting them to cover large spreads, especially on the road.

ND trend: Notre Dame’s early games reflect a program that often meets or slightly under‐performs against expectations in tight games, though they benefit from home field and history in rivalry matchups. After losing the opener at Miami in a close game, they have faced high expectations from both fans and bettors, which influences how people view their ability to cover: the spread is likely to favor Notre Dame, but large margins could be tempered if the opponent plays well.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Purdue vs. Notre Dame Odds

AI algorithm Remi is pouring through loads of data points on each team. In fact, anytime the Purdue vs Notre Dame trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable betting trends.

Purdue vs Notre Dame Opening Odds

PURDUE Moneyline: +1800
ND Moneyline: -5882
PURDUE Spread: +26.5
ND Spread: -26.5
Over/Under: 52.5

Purdue vs Notre Dame Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+185
-6.5 (-110)
+6.5 (-110)
O 55.5 (-112)
U 55.5 (-108)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1600
-26.5 (-112)
+26.5 (-108)
O 61.5 (-105)
U 61.5 (-115)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+164
-198
+4.5 (-108)
-4.5 (-112)
O 49.5 (-115)
U 49.5 (-105)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+1000
-21 (-115)
+21 (-105)
O 50.5 (-112)
U 50.5 (-108)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-395
+310
-10.5 (-108)
+10.5 (-112)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-290
+235
-7.5 (-105)
+7.5 (-115)
O 48.5 (-108)
U 48.5 (-112)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+114
-2.5 (-115)
+2.5 (-105)
O 58.5 (-112)
U 58.5 (-108)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+170
-4.5 (-112)
+4.5 (-108)
O 63.5 (-108)
U 63.5 (-112)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1400
-3200
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7 (-105)
-7 (-115)
O 43.5 (-110)
U 43.5 (-110)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-500
+380
-12.5 (-108)
+12.5 (-112)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-180
+150
-3.5 (-108)
+3.5 (-112)
O 53.5 (-115)
U 53.5 (-105)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+600
-900
+17.5 (-110)
-17.5 (-110)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-625
 
-14.5 (-108)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+180
-218
+4.5 (-105)
-4.5 (-115)
O 54.5 (-108)
U 54.5 (-112)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+130
-155
+3 (-112)
-3 (-108)
O 56.5 (-115)
U 56.5 (-105)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-105
-115
+1.5 (-115)
-1.5 (-105)
O 56.5 (-112)
U 56.5 (-108)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+310
-395
+9.5 (-110)
-9.5 (-110)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-410
+320
-10.5 (-110)
+10.5 (-110)
O 49.5 (-105)
U 49.5 (-115)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+130
-155
+3 (-112)
-3 (-108)
O 61.5 (-112)
U 61.5 (-108)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-345
+9.5 (-112)
-9.5 (-108)
O 39.5 (-108)
U 39.5 (-112)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-485
+370
-12.5 (-110)
+12.5 (-110)
O 47.5 (-108)
U 47.5 (-112)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+124
-148
+2.5 (-102)
-2.5 (-118)
O 48.5 (-112)
U 48.5 (-108)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-238
+195
-6 (-112)
+6 (-108)
O 53.5 (-112)
U 53.5 (-108)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+180
-218
+5.5 (-112)
-5.5 (-108)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
-102
-118
+1.5 (-115)
-1.5 (-105)
O 46.5 (-108)
U 46.5 (-112)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+455
-625
+15.5 (-108)
-15.5 (-112)
O 62.5 (-112)
U 62.5 (-108)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+164
-198
+4.5 (-110)
-4.5 (-110)
O 53.5 (-115)
U 53.5 (-105)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-700
 
-16.5 (-108)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-155
+130
-3 (-110)
+3 (-110)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+114
-135
+2.5 (-110)
-2.5 (-110)
O 51.5 (-115)
U 51.5 (-105)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+205
-250
+6.5 (-108)
-6.5 (-112)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+102
 
+1.5 (-110)
 
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+340
 
+10.5 (-105)
 
O 50.5 (-112)
U 50.5 (-108)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+38.5 (-115)
-38.5 (-105)
O 56.5 (-108)
U 56.5 (-112)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+154
-185
+4.5 (-110)
-4.5 (-110)
O 66.5 (-115)
U 66.5 (-105)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-270
+220
-7 (-105)
+7 (-115)
O 44.5 (-115)
U 44.5 (-105)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-650
+470
-15.5 (-110)
+15.5 (-110)
O 54.5 (-118)
U 54.5 (-102)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-108)
-33.5 (-112)
O 44.5 (-112)
U 44.5 (-108)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+280
-355
+8.5 (-108)
-8.5 (-112)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-105)
U 45.5 (-115)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+100
-120
+1.5 (-110)
-1.5 (-110)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-625
+455
-14.5 (-105)
+14.5 (-115)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-142
+120
-2.5 (-115)
+2.5 (-105)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1400
-3200
+25.5 (-110)
-25.5 (-110)
O 55.5 (-102)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+180
-218
+5.5 (-110)
-5.5 (-110)
O 46.5 (-112)
U 46.5 (-108)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+275
-9.5 (-108)
+9.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+230
-285
+7.5 (-115)
-7.5 (-105)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+410
-550
+13.5 (-110)
-13.5 (-110)
O 49.5 (-112)
U 49.5 (-108)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Purdue Boilermakers vs. Notre Dame Fighting Irish on September 20, 2025 at Notre Dame Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN