Michigan State vs USC Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 20)

Updated: 2025-09-13T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

USC enters this clash as a favorite at home, riding strong offensive numbers and showing productivity through their passing attack while Michigan State arrives undefeated and looking to prove its capability on the road in a tough environment. The betting market has given USC a spread in the neighborhood of -14.5, signaling confidence in their offense and perhaps doubts about Michigan State’s ability to contain USC in Los Angeles.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 20, 2025

Start Time: 11:00 PM EST​

Venue: United Airlines Field at the Los Angeles Memorial Coliseum​

Trojans Record: (3-0)

Spartans Record: (3-0)

OPENING ODDS

MICHST Moneyline: +495

USC Moneyline: -699

MICHST Spread: +15.5

USC Spread: -15.5

Over/Under: 56

MICHST
Betting Trends

  • Michigan State has started the season 2-0 and their ATS record is showing signs of reliability; the Spartans have covered in each of the games so far when matched up in favorable spotups or when expectations were manageable. Given their early performance and consistency, bettors view them as a team capable of meeting or exceeding the spread even when outsiders consider them underdogs.

USC
Betting Trends

  • USC is also 2-0 this season and has rewarded betting support in home games, especially when their offense is firing. The Trojans have posted strong offensive averages, particularly in total yards and points per game, which bolster confidence among bettors that they can dominate at home. Their coverage of spreads in favorable matchups, combined with home field advantage, suggests USC is expected not just to win but to do so emphatically.

MATCHUP TRENDS

  • With USC favored by around 14.5, the spread is wide enough that a couple of key turnovers, penalties, or special teams miscues by the Trojans could give Michigan State room to cover. Also, Michigan State’s early ATS success makes them dangerous as underdogs; if they protect the ball and play mistake-free, they might keep this closer than many expect. Over/Under totals will likely be pushed high, reflecting expectations of a shoot‐out or explosive offense from USC. Any deviation—USC starting slow or MSU forcing turnovers early—could tilt the value toward the Spartans + the points. Home crowd energy and tempo will also be angles bettors will watch closely.

MICHST vs. USC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: A. Chiles under 218.5 Passing Yards.

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Michigan State vs USC Prediction & Odds:
Free CFB Betting Insights for 9/20/25

The September 20, 2025, showdown between the Michigan State Spartans and the USC Trojans at the Los Angeles Memorial Coliseum promises to be one of the more compelling matchups of the weekend, pitting a disciplined Big Ten program against one of the most explosive offenses in the country. USC comes in having overwhelmed its early opponents with a high-octane passing attack that ranks among the nation’s best, moving the ball efficiently while striking for explosive plays that break games open in an instant. Quarterback play has been outstanding, with receivers consistently finding separation and punishing defenses downfield, while the run game has been strong enough to prevent defenses from selling out to stop the pass. Michigan State, by contrast, is undefeated and has carved out its success with a more balanced and methodical approach, relying on a sturdy defense that excels at generating pressure and a steady offense that avoids turnovers and maximizes possessions. The Spartans understand that the key to competing in this game is to control tempo, sustain long drives, and keep USC’s offense off the field, because a track meet would favor the Trojans’ superior speed and depth. On defense, Michigan State will look to collapse the pocket and disrupt USC’s timing before their receivers can break into open space, while in the secondary they must remain disciplined to prevent explosive plays that can tilt momentum.

Special teams could play a pivotal role as well, as flipping field position and limiting USC’s return opportunities will be critical in slowing the Trojans’ rhythm. For USC, the formula is straightforward: start fast, pile on points early, and make Michigan State play from behind, where the Spartans’ less dynamic offense is more likely to stall. The Trojans will aim to push tempo, exploit mismatches in the secondary, and rely on their playmakers to create separation, while their defense will focus on bottling up Michigan State’s ground game and forcing third-and-long situations. From a betting perspective, USC is favored by around two touchdowns, reflecting the perception that their offensive firepower will be too much for Michigan State to handle, but the Spartans’ 2-0 start and consistent ATS performance make them a dangerous underdog if they can execute their game plan and keep the contest within reach into the second half. The over/under will likely trend high given USC’s scoring potential, but Michigan State’s emphasis on tempo control and defense could tilt the game toward the under if they succeed in slowing the pace. Ultimately, this clash will hinge on whether Michigan State can drag USC into a grind-it-out style game or whether the Trojans impose their will with explosive plays and depth. Either way, it will be an early litmus test for both programs, with USC seeking to confirm its national contender status and Michigan State aiming to prove that its disciplined, physical style can travel and compete in one of college football’s toughest venues.

Michigan State Spartans CFB Preview

The Michigan State Spartans head to Los Angeles for their September 20, 2025, battle with USC knowing full well the challenge that awaits them, but also believing they have the ingredients to make this a far more competitive contest than oddsmakers anticipate. At 2-0, Michigan State has demonstrated discipline and balance early in the season, combining a physical defense that prides itself on creating pressure with an offense that plays within its limits, avoids turnovers, and sustains drives to wear down opponents. The Spartans’ formula hinges on establishing the run behind a capable offensive line and then using play-action to create manageable passing situations, ensuring that the quarterback is not forced into high-risk throws against faster, more athletic defenses. Against USC, this approach will be crucial, as trading explosive plays with the Trojans would almost certainly spell disaster; instead, Michigan State must aim to shrink the number of possessions by controlling tempo and keeping USC’s dynamic offense off the field. Defensively, the Spartans have the size and strength up front to at least challenge USC’s offensive line, and if they can collapse the pocket and limit time for the quarterback to find his receivers downfield, they could disrupt the Trojans’ rhythm and create opportunities for turnovers. The secondary will need to play a near-perfect game, tackling crisply to prevent short passes from turning into long gains and staying disciplined against double moves and vertical threats.

Special teams could also be a deciding factor for the Spartans, as flipping field position with strong punting and limiting USC’s return game would help tilt hidden yardage in their favor. Mentally, Michigan State must embrace the underdog role, understanding that as a two-touchdown underdog their job is to frustrate USC by keeping the game close into the second half and forcing the Trojans to execute under pressure. From a betting perspective, Michigan State’s strong early ATS record indicates they can be trusted to compete relative to expectations, and if they stick to their identity—defense, ball control, and mistake-free football—they offer real value against the spread even if an outright win is a long shot. For the Spartans to pull off an upset, they must capitalize on every scoring opportunity, avoid turnovers in their own half, and force USC to grind out long drives instead of hitting quick-strike touchdowns. Their ability to handle the atmosphere of the Coliseum, stay poised under early pressure, and execute their game plan with precision will ultimately determine whether they can make this a close contest or become another victim of USC’s offensive juggernaut.

USC enters this clash as a favorite at home, riding strong offensive numbers and showing productivity through their passing attack while Michigan State arrives undefeated and looking to prove its capability on the road in a tough environment. The betting market has given USC a spread in the neighborhood of -14.5, signaling confidence in their offense and perhaps doubts about Michigan State’s ability to contain USC in Los Angeles. Michigan State vs USC AI Prediction: Free CFB Betting Insights for Sep 20. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

USC Trojans CFB Preview

The USC Trojans enter their September 20, 2025, home clash with Michigan State as heavy favorites and with the expectation of showcasing once again why their offense is among the most feared in the nation. USC has opened the season on fire, putting up gaudy yardage and point totals behind a passing attack that can score in a flash, with their quarterback distributing the ball with precision to a deep and explosive receiving corps that regularly creates separation and turns short passes into big plays. The running game has been complementary rather than dominant, but it has done enough to force defenses to respect the threat, keeping them from selling out to stop the pass. At the Coliseum, USC enjoys one of the most significant home-field advantages in college football, with crowd energy and pace of play often overwhelming opponents who aren’t accustomed to that type of environment. Against Michigan State, the Trojans will aim to set the tone early by striking quickly and putting the Spartans in a hole that forces them to abandon their ground-and-pound identity in favor of higher-risk passing plays. USC’s defense, though not as consistent as the offense, has made strides in creating turnovers and limiting big plays, and their athletic front seven will look to disrupt Michigan State’s quarterback and bottle up the run game to take away the Spartans’ most reliable path to success.

The key for the Trojans will be to maintain intensity for four quarters, as lapses in focus could open the door for Michigan State to extend drives and hang around longer than expected. Special teams could also be a quiet advantage, as USC has the athletes to create field position swings that further tilt momentum in their favor. From a betting perspective, USC’s early-season dominance has made them reliable at home, but covering a spread around 14.5 will require efficiency, discipline, and the ability to avoid the kind of turnovers or penalties that keep an opponent like Michigan State within striking distance. If USC executes its game plan—hit explosive plays, pressure defensively, and feed off the crowd—they have the depth and talent to win by multiple scores and make a statement about their national aspirations. For Lincoln Riley’s team, this matchup is about more than just earning another victory; it is about proving that the Trojans can pair offensive firepower with consistent defense, handle a physical opponent, and continue to establish themselves as a program capable of contending deep into the season.

Michigan State vs. USC Prop Picks (AI)

Remi is pouring through tons of stats on each team. In fact, anytime the Spartans and Trojans play there’s always several intriguing angles to key in on. Not to mention games played at United Airlines Field at the Los Angeles Memorial Coliseum in Sep rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: A. Chiles under 218.5 Passing Yards.

Michigan State vs. USC Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every facet between the Spartans and Trojans and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

The Algorithm has been most fixated on the growing factor knucklehead sportsbettors often put on player performance factors between a Spartans team going up against a possibly unhealthy Trojans team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Michigan State vs USC picks, computer picks Spartans vs Trojans, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Spartans Betting Trends

Michigan State has started the season 2-0 and their ATS record is showing signs of reliability; the Spartans have covered in each of the games so far when matched up in favorable spotups or when expectations were manageable. Given their early performance and consistency, bettors view them as a team capable of meeting or exceeding the spread even when outsiders consider them underdogs.

Trojans Betting Trends

USC is also 2-0 this season and has rewarded betting support in home games, especially when their offense is firing. The Trojans have posted strong offensive averages, particularly in total yards and points per game, which bolster confidence among bettors that they can dominate at home. Their coverage of spreads in favorable matchups, combined with home field advantage, suggests USC is expected not just to win but to do so emphatically.

Spartans vs. Trojans Matchup Trends

With USC favored by around 14.5, the spread is wide enough that a couple of key turnovers, penalties, or special teams miscues by the Trojans could give Michigan State room to cover. Also, Michigan State’s early ATS success makes them dangerous as underdogs; if they protect the ball and play mistake-free, they might keep this closer than many expect. Over/Under totals will likely be pushed high, reflecting expectations of a shoot‐out or explosive offense from USC. Any deviation—USC starting slow or MSU forcing turnovers early—could tilt the value toward the Spartans + the points. Home crowd energy and tempo will also be angles bettors will watch closely.

Michigan State vs. USC Game Info

Michigan State vs USC starts on September 20, 2025 at 11:00 PM EST.

Venue: United Airlines Field at the Los Angeles Memorial Coliseum.

Spread: USC -15.5
Moneyline: Michigan State +495, USC -699
Over/Under: 56

Michigan State: (3-0)  |  USC: (3-0)

Remi's searched hard and found the best prop for this matchup: A. Chiles under 218.5 Passing Yards.. Prices move—always shop for the best number.

With USC favored by around 14.5, the spread is wide enough that a couple of key turnovers, penalties, or special teams miscues by the Trojans could give Michigan State room to cover. Also, Michigan State’s early ATS success makes them dangerous as underdogs; if they protect the ball and play mistake-free, they might keep this closer than many expect. Over/Under totals will likely be pushed high, reflecting expectations of a shoot‐out or explosive offense from USC. Any deviation—USC starting slow or MSU forcing turnovers early—could tilt the value toward the Spartans + the points. Home crowd energy and tempo will also be angles bettors will watch closely.

MICHST trend: Michigan State has started the season 2-0 and their ATS record is showing signs of reliability; the Spartans have covered in each of the games so far when matched up in favorable spotups or when expectations were manageable. Given their early performance and consistency, bettors view them as a team capable of meeting or exceeding the spread even when outsiders consider them underdogs.

USC trend: USC is also 2-0 this season and has rewarded betting support in home games, especially when their offense is firing. The Trojans have posted strong offensive averages, particularly in total yards and points per game, which bolster confidence among bettors that they can dominate at home. Their coverage of spreads in favorable matchups, combined with home field advantage, suggests USC is expected not just to win but to do so emphatically.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Michigan State vs. USC Odds

Remi is pouring through loads of stats on each player. In fact, anytime the Michigan State vs USC trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.

Michigan State vs USC Opening Odds

MICHST Moneyline: +495
USC Moneyline: -699
MICHST Spread: +15.5
USC Spread: -15.5
Over/Under: 56

Michigan State vs USC Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+188
-6.5 (-110)
+6.5 (-110)
O 56.5 (-106)
U 56.5 (-114)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1500
-27.5 (-102)
+27.5 (-120)
O 60.5 (-115)
U 60.5 (-105)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+160
-190
+4.5 (-110)
-4.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+980
-21.5 (-105)
+21.5 (-115)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+168
-5.5 (-110)
+5.5 (-110)
O 63.5 (-106)
U 63.5 (-114)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7.5 (-118)
-7.5 (-104)
O 42.5 (-120)
U 42.5 (-102)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-450
+340
-12.5 (-110)
+12.5 (-110)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+140
-3.5 (-108)
+3.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+610
-950
+17.5 (-115)
-17.5 (-105)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-610
 
-14.5 (-105)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+172
-210
+4.5 (-105)
-4.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+122
-146
+2.5 (+100)
-2.5 (-122)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-110
-110
+1.5 (-115)
-1.5 (-105)
O 57.5 (-105)
U 57.5 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-375
+9.5 (-102)
-9.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-400
+310
-10.5 (-110)
+10.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+122
-146
+2.5 (-102)
-2.5 (-120)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-350
+8.5 (-110)
-8.5 (-110)
O 38.5 (-115)
U 38.5 (-105)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-520
+385
-11.5 (-118)
+11.5 (-104)
O 47.5 (-105)
U 47.5 (-115)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+122
-146
+2.5 (+100)
-2.5 (-122)
O 48.5 (-115)
U 48.5 (-105)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+188
-5.5 (-120)
+5.5 (-102)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+176
-215
+5.5 (-110)
-5.5 (-110)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
+104
-125
+1.5 (-105)
-1.5 (-115)
O 46.5 (-114)
U 46.5 (-106)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+480
-670
+15.5 (-110)
-15.5 (-110)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+146
-176
+4.5 (-115)
-4.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-720
 
-15.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-146
+122
-2.5 (-122)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-138
+2.5 (-106)
-2.5 (-114)
O 52.5 (-110)
U 52.5 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+195
-240
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+106
 
+2.5 (-115)
 
O 41.5 (-110)
U 41.5 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+310
 
+11.5 (-115)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+37.5 (-108)
-37.5 (-112)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+152
-184
+4.5 (-115)
-4.5 (-105)
O 67.5 (-105)
U 67.5 (-115)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-285
+230
-7.5 (-102)
+7.5 (-120)
O 44.5 (-120)
U 44.5 (-102)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+470
-15.5 (-112)
+15.5 (-108)
O 55.5 (-106)
U 55.5 (-114)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-106)
-33.5 (-114)
O 44.5 (-108)
U 44.5 (-112)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
+9.5 (-110)
-9.5 (-110)
O 47.5 (-112)
U 47.5 (-108)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-104)
U 45.5 (-118)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+106
-128
+1.5 (-105)
-1.5 (-115)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-630
+450
-14.5 (-105)
+14.5 (-115)
O 48.5 (-105)
U 48.5 (-115)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-144
+120
-2.5 (-120)
+2.5 (-102)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 55.5 (-104)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+184
-225
+5.5 (-104)
-5.5 (-118)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+270
-9.5 (-110)
+9.5 (-110)
O 53.5 (-118)
U 53.5 (-104)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+220
-275
+7.5 (-120)
-7.5 (-102)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+375
-500
+13.5 (-110)
-13.5 (-110)
O 49.5 (-115)
U 49.5 (-105)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Michigan State Spartans vs. USC Trojans on September 20, 2025 at United Airlines Field at the Los Angeles Memorial Coliseum.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN