The September 20, 2025, showdown between the Michigan State Spartans and the USC Trojans at the Los Angeles Memorial Coliseum promises to be one of the more compelling matchups of the weekend, pitting a disciplined Big Ten program against one of the most explosive offenses in the country. USC comes in having overwhelmed its early opponents with a high-octane passing attack that ranks among the nation’s best, moving the ball efficiently while striking for explosive plays that break games open in an instant. Quarterback play has been outstanding, with receivers consistently finding separation and punishing defenses downfield, while the run game has been strong enough to prevent defenses from selling out to stop the pass. Michigan State, by contrast, is undefeated and has carved out its success with a more balanced and methodical approach, relying on a sturdy defense that excels at generating pressure and a steady offense that avoids turnovers and maximizes possessions. The Spartans understand that the key to competing in this game is to control tempo, sustain long drives, and keep USC’s offense off the field, because a track meet would favor the Trojans’ superior speed and depth. On defense, Michigan State will look to collapse the pocket and disrupt USC’s timing before their receivers can break into open space, while in the secondary they must remain disciplined to prevent explosive plays that can tilt momentum.

Special teams could play a pivotal role as well, as flipping field position and limiting USC’s return opportunities will be critical in slowing the Trojans’ rhythm. For USC, the formula is straightforward: start fast, pile on points early, and make Michigan State play from behind, where the Spartans’ less dynamic offense is more likely to stall. The Trojans will aim to push tempo, exploit mismatches in the secondary, and rely on their playmakers to create separation, while their defense will focus on bottling up Michigan State’s ground game and forcing third-and-long situations. From a betting perspective, USC is favored by around two touchdowns, reflecting the perception that their offensive firepower will be too much for Michigan State to handle, but the Spartans’ 2-0 start and consistent ATS performance make them a dangerous underdog if they can execute their game plan and keep the contest within reach into the second half. The over/under will likely trend high given USC’s scoring potential, but Michigan State’s emphasis on tempo control and defense could tilt the game toward the under if they succeed in slowing the pace. Ultimately, this clash will hinge on whether Michigan State can drag USC into a grind-it-out style game or whether the Trojans impose their will with explosive plays and depth. Either way, it will be an early litmus test for both programs, with USC seeking to confirm its national contender status and Michigan State aiming to prove that its disciplined, physical style can travel and compete in one of college football’s toughest venues.