Illinois vs Indiana Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 20)

Updated: 2025-09-13T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Indiana is opening as a 4.5-point favorite at home over Illinois for this Big Ten matchup, with the projected over/under around 55.5 points. Both teams come in riding momentum—Indiana after a dominant 73-0 win over Indiana State and Illinois after a convincing 38-0 shutout of Western Michigan—making this primetime showdown one with high expectations.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 20, 2025

Start Time: 7:30 PM EST​

Venue: Memorial Stadium​

Hoosiers Record: (3-0)

Fighting Illini Record: (3-0)

OPENING ODDS

ILL Moneyline: +162

IND Moneyline: -195

ILL Spread: +4.5

IND Spread: -4.5

Over/Under: 52.5

ILL
Betting Trends

  • Illinois is listed 2-0 ATS so far in 2025, meaning both of their games to date have resulted in covering the spread. Their large nonconference wins have helped build confidence among bettors that they perform well relative to expectations when favored or matched reasonably.

IND
Betting Trends

  • Indiana is also 1-1 ATS through their first two games this season. While they have shown ability to win big (as in the blowout over Indiana State), covering at home in higher-expectation games remains an open question, especially given potential injuries or opponent adjustments.

MATCHUP TRENDS

  • The 4.5-point spread in favor of Indiana suggests oddsmakers expect a competitive game, not a blowout. Given both teams’ defensive strong performances recently (both had shutouts), an under seems plausible if neither offense breaks quickly. Illinois’ early success ATS gives them some value as underdogs, especially if they avoid turnovers. Indiana’s recent performance suggests they might overshoot expectations or have the possibility of a letdown under pressure in a home primetime spot. The over/under near 55.5 allows for both the possibility of scoring if offenses get into rhythm or a lower-scoring, defensive struggle if both defenses continue their strong early-season form.

ILL vs. IND
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: L. Altmyer under 224.5 Passing Yards.

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Illinois vs Indiana Prediction & Odds:
Free CFB Betting Insights for 9/20/25

The September 20, 2025, Big Ten showdown between the Illinois Fighting Illini and the Indiana Hoosiers has the makings of a gritty early-season conference battle, with both programs entering on the back of commanding nonconference performances and eager to test themselves against stronger competition. Illinois has impressed so far with consecutive shutouts, including a 38-0 win over Western Michigan, a result that underscored the discipline of its defense and the progress of quarterback Luke Altmeyer in directing an efficient, balanced offense. Running back Kaden Feagin has been an important part of their early success, providing a physical presence that allows the Illini to control tempo and set up the passing game, while defensively Illinois has swarmed to the ball and eliminated explosive plays, showing the kind of physicality that will be necessary against a conference rival. Indiana, however, comes in with momentum of its own after a 73-0 demolition of Indiana State that showcased an offense firing on all cylinders and a defense that smothered every attempt at resistance. Quarterback Fernando Mendoza has given the Hoosiers consistency in the passing game, connecting comfortably with receivers while the rushing attack, led by Khobie Martin, has bulldozed opponents and created balance that keeps defenses guessing.

The Hoosiers’ offensive line has also stepped up, both in run blocking and pass protection, which will be crucial against an Illinois front that prides itself on generating pressure. For Indiana, playing at home in Bloomington adds another layer of confidence, as the crowd will expect them to seize control early and maintain it throughout. Key to this matchup will be whether Illinois’ defense can replicate its early success against a more dynamic opponent, forcing the Hoosiers into long third downs and limiting chunk plays, while also giving their own offense enough possessions and field position to stay within reach. Indiana will seek to build on its rhythm, leveraging home-field advantage to wear down Illinois’ defense and test the Illini secondary with a mix of short, efficient passes and explosive shots downfield. From a betting perspective, Indiana is favored by about 4.5 points, a modest spread that indicates the expectation of a competitive game, and the total sits around 55.5, suggesting moderate scoring potential. Illinois’ 2-0 ATS record makes them an attractive underdog for bettors who believe their defense can translate against stronger competition, while Indiana’s explosiveness and comfort at home appeal to those backing the favorite to cover. Ultimately, this game will hinge on execution in the trenches and red-zone efficiency, as both teams’ defenses have shown the ability to shut down weaker opposition, and now it will come down to which side can carry that form into conference play. The rivalry element adds an extra layer of intensity, and while Indiana has the momentum and home-field edge, Illinois has the resilience and balance to make this a tight, hard-fought contest that could be decided late in the fourth quarter.

Illinois Fighting Illini CFB Preview

The Illinois Fighting Illini head into their September 20, 2025, Big Ten matchup against the Indiana Hoosiers with growing confidence after an opening stretch that has seen them dominate weaker opponents and set a strong defensive tone. Their 38-0 shutout of Western Michigan was a statement win that highlighted the maturity of quarterback Luke Altmeyer, who has managed the offense with poise, avoided costly mistakes, and shown an ability to spread the ball effectively when the ground game sets the table. Running back Kaden Feagin has been central to Illinois’ offensive success, providing a power-running option that wears down defenses and opens up opportunities for play action, giving Altmeyer favorable looks downfield. The offensive line has been solid, creating holes for Feagin and keeping Altmeyer upright, but the challenge now is stepping up against a Hoosiers defense that is faster and more physical than anything they have seen in nonconference play. Defensively, Illinois has been the story of the season so far, smothering opponents by closing down rushing lanes, tackling cleanly, and eliminating big plays; but this unit will now be tasked with containing Fernando Mendoza and Indiana’s balanced offense that has already proven it can strike quickly and often.

The Illini secondary, which has looked sharp against overmatched opponents, will need to show it can hold up against more skilled receivers, while the front seven must generate enough pressure to prevent Mendoza from sitting comfortably in the pocket. Turnovers could prove critical, as Illinois’ margin for error on the road will be slim, and flipping field position could be the difference between competing and being overwhelmed. Special teams will also be vital for Illinois, as they cannot afford to give Indiana short fields in a hostile environment where momentum can swing quickly. From a betting perspective, Illinois enters with a perfect ATS record early in the year, a sign that they have played up to or exceeded expectations, and their underdog status around +4.5 points could provide value for bettors who trust their defense to keep the game close. To not only cover but potentially win outright, the Illini must play clean football, sustain drives to control possession, and prevent Indiana’s explosive offense from finding rhythm early. For Illinois, this matchup is about proving that their early dominance was more than just a product of weak opponents and showing they can go on the road in conference play and stand toe-to-toe with a rival. If they succeed in maintaining defensive discipline and getting steady contributions from Feagin and Altmeyer, Illinois has every chance to push Indiana to the limit and make this one of the weekend’s most competitive Big Ten battles.

Indiana is opening as a 4.5-point favorite at home over Illinois for this Big Ten matchup, with the projected over/under around 55.5 points. Both teams come in riding momentum—Indiana after a dominant 73-0 win over Indiana State and Illinois after a convincing 38-0 shutout of Western Michigan—making this primetime showdown one with high expectations. Illinois vs Indiana AI Prediction: Free CFB Betting Insights for Sep 20. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Indiana Hoosiers CFB Preview

The Indiana Hoosiers return to Bloomington on September 20, 2025, eager to carry the momentum of their explosive early-season performances into their Big Ten clash with Illinois, and the home crowd at Memorial Stadium will expect nothing less than a continuation of the dominance they displayed in their 73-0 rout of Indiana State. That game highlighted the potential of this Indiana team, with quarterback Fernando Mendoza orchestrating the offense efficiently, spreading the ball to multiple receivers, and showing the poise of a leader who can handle pressure while maintaining rhythm. Complementing him, running back Khobie Martin has been the workhorse in the ground game, punishing defenses with physical runs and creating balance that forces opponents to respect both phases of the Hoosiers’ attack. Indiana’s offensive line deserves equal credit for paving lanes and protecting Mendoza, giving him the time to dissect coverages and allowing Martin to exploit mismatches at the line of scrimmage. On defense, the Hoosiers have looked sharp, particularly against the run, flying to the football with confidence and generating turnovers that have flipped momentum decisively in their favor. Against Illinois, however, Indiana knows it will face a sterner test, as the Illini defense has proven itself disciplined and stingy, and their offense is capable of controlling tempo with the bruising runs of Kaden Feagin and the efficient game management of quarterback Luke Altmeyer.

For Indiana to maintain its edge, the defense must disrupt Illinois’ offensive line, shut down Feagin’s ability to churn out consistent yardage, and force Altmeyer into passing situations where pressure can lead to mistakes. Special teams could also be a hidden factor, as Indiana has been consistent in field position battles and will look to use that edge against an Illinois team that thrives when given short fields. From a betting standpoint, Indiana is favored by about 4.5 points, reflecting the market’s belief in their offensive firepower and home-field advantage, and their 1-1 ATS mark early in the season shows that while they can dominate, they need to carry that same intensity into conference play to consistently meet expectations. To cover, Indiana must avoid sloppy starts, convert red-zone chances into touchdowns, and lean on the energy of their crowd to keep Illinois on its heels. The Hoosiers’ formula for success lies in continuing to push tempo, mixing the pass and run effectively, and letting their defensive front dictate matchups, and if they execute that plan, they not only have the tools to win but also to make a statement in their conference opener. For Indiana, this game is about proving that their nonconference dominance translates into Big Ten play and setting the tone for the rest of the season with a convincing home victory.

Illinois vs. Indiana Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each line. In fact, anytime the Fighting Illini and Hoosiers play there’s always several intriguing observations to key in on. Not to mention games played at Memorial Stadium in Sep rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: L. Altmyer under 224.5 Passing Yards.

Illinois vs. Indiana Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every past game between the Fighting Illini and Hoosiers and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most fixated on the trending factor emotional bettors often put on Indiana’s strength factors between a Fighting Illini team going up against a possibly strong Hoosiers team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Illinois vs Indiana picks, computer picks Fighting Illini vs Hoosiers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Fighting Illini Betting Trends

Illinois is listed 2-0 ATS so far in 2025, meaning both of their games to date have resulted in covering the spread. Their large nonconference wins have helped build confidence among bettors that they perform well relative to expectations when favored or matched reasonably.

Hoosiers Betting Trends

Indiana is also 1-1 ATS through their first two games this season. While they have shown ability to win big (as in the blowout over Indiana State), covering at home in higher-expectation games remains an open question, especially given potential injuries or opponent adjustments.

Fighting Illini vs. Hoosiers Matchup Trends

The 4.5-point spread in favor of Indiana suggests oddsmakers expect a competitive game, not a blowout. Given both teams’ defensive strong performances recently (both had shutouts), an under seems plausible if neither offense breaks quickly. Illinois’ early success ATS gives them some value as underdogs, especially if they avoid turnovers. Indiana’s recent performance suggests they might overshoot expectations or have the possibility of a letdown under pressure in a home primetime spot. The over/under near 55.5 allows for both the possibility of scoring if offenses get into rhythm or a lower-scoring, defensive struggle if both defenses continue their strong early-season form.

Illinois vs. Indiana Game Info

Illinois vs Indiana starts on September 20, 2025 at 7:30 PM EST.

Spread: Indiana -4.5
Moneyline: Illinois +162, Indiana -195
Over/Under: 52.5

Illinois: (3-0)  |  Indiana: (3-0)

Remi's searched hard and found the best prop for this matchup: L. Altmyer under 224.5 Passing Yards.. Prices move—always shop for the best number.

The 4.5-point spread in favor of Indiana suggests oddsmakers expect a competitive game, not a blowout. Given both teams’ defensive strong performances recently (both had shutouts), an under seems plausible if neither offense breaks quickly. Illinois’ early success ATS gives them some value as underdogs, especially if they avoid turnovers. Indiana’s recent performance suggests they might overshoot expectations or have the possibility of a letdown under pressure in a home primetime spot. The over/under near 55.5 allows for both the possibility of scoring if offenses get into rhythm or a lower-scoring, defensive struggle if both defenses continue their strong early-season form.

ILL trend: Illinois is listed 2-0 ATS so far in 2025, meaning both of their games to date have resulted in covering the spread. Their large nonconference wins have helped build confidence among bettors that they perform well relative to expectations when favored or matched reasonably.

IND trend: Indiana is also 1-1 ATS through their first two games this season. While they have shown ability to win big (as in the blowout over Indiana State), covering at home in higher-expectation games remains an open question, especially given potential injuries or opponent adjustments.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Illinois vs. Indiana Odds

AI algorithm Remi is pouring through tons of stats on each line. In fact, anytime the Illinois vs Indiana trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable patterns.

Illinois vs Indiana Opening Odds

ILL Moneyline: +162
IND Moneyline: -195
ILL Spread: +4.5
IND Spread: -4.5
Over/Under: 52.5

Illinois vs Indiana Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+188
-6.5 (-110)
+6.5 (-110)
O 56.5 (-106)
U 56.5 (-114)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1500
-27.5 (-102)
+27.5 (-120)
O 60.5 (-115)
U 60.5 (-105)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+160
-190
+4.5 (-110)
-4.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+980
-21.5 (-105)
+21.5 (-115)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+168
-5.5 (-110)
+5.5 (-110)
O 63.5 (-106)
U 63.5 (-114)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7.5 (-118)
-7.5 (-104)
O 42.5 (-120)
U 42.5 (-102)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-450
+340
-12.5 (-110)
+12.5 (-110)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+140
-3.5 (-108)
+3.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+610
-950
+17.5 (-115)
-17.5 (-105)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-610
 
-14.5 (-105)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+172
-210
+4.5 (-105)
-4.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+122
-146
+2.5 (+100)
-2.5 (-122)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-110
-110
+1.5 (-115)
-1.5 (-105)
O 57.5 (-105)
U 57.5 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-375
+9.5 (-102)
-9.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-400
+310
-10.5 (-110)
+10.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+122
-146
+2.5 (-102)
-2.5 (-120)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-350
+8.5 (-110)
-8.5 (-110)
O 38.5 (-115)
U 38.5 (-105)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-520
+385
-11.5 (-118)
+11.5 (-104)
O 47.5 (-105)
U 47.5 (-115)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+122
-146
+2.5 (+100)
-2.5 (-122)
O 48.5 (-115)
U 48.5 (-105)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+188
-5.5 (-120)
+5.5 (-102)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+176
-215
+5.5 (-110)
-5.5 (-110)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
+104
-125
+1.5 (-105)
-1.5 (-115)
O 46.5 (-114)
U 46.5 (-106)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+480
-670
+15.5 (-110)
-15.5 (-110)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+146
-176
+4.5 (-115)
-4.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-720
 
-15.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-146
+122
-2.5 (-122)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-138
+2.5 (-106)
-2.5 (-114)
O 52.5 (-110)
U 52.5 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+195
-240
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+106
 
+2.5 (-115)
 
O 41.5 (-110)
U 41.5 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+310
 
+11.5 (-115)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+37.5 (-108)
-37.5 (-112)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+152
-184
+4.5 (-115)
-4.5 (-105)
O 67.5 (-105)
U 67.5 (-115)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-285
+230
-7.5 (-102)
+7.5 (-120)
O 44.5 (-120)
U 44.5 (-102)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+470
-15.5 (-112)
+15.5 (-108)
O 55.5 (-106)
U 55.5 (-114)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-106)
-33.5 (-114)
O 44.5 (-108)
U 44.5 (-112)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
+9.5 (-110)
-9.5 (-110)
O 47.5 (-112)
U 47.5 (-108)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-104)
U 45.5 (-118)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+106
-128
+1.5 (-105)
-1.5 (-115)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-630
+450
-14.5 (-105)
+14.5 (-115)
O 48.5 (-105)
U 48.5 (-115)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-144
+120
-2.5 (-120)
+2.5 (-102)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 55.5 (-104)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+184
-225
+5.5 (-104)
-5.5 (-118)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+270
-9.5 (-110)
+9.5 (-110)
O 53.5 (-118)
U 53.5 (-104)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+220
-275
+7.5 (-120)
-7.5 (-102)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+375
-500
+13.5 (-110)
-13.5 (-110)
O 49.5 (-115)
U 49.5 (-105)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Illinois Fighting Illini vs. Indiana Hoosiers on September 20, 2025 at Memorial Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN