The September 6, 2025 matchup between the Tulane Green Wave and the South Alabama Jaguars at Hancock Whitney Stadium in Mobile stands out as one of the more intriguing early-season non-conference games because it brings together two programs that both impressed in Week 1 but in very different ways, with Tulane announcing itself as a defensive powerhouse in a 23–3 dismantling of Big Ten opponent Northwestern while South Alabama handled its business in a 38–21 victory over Morgan State that allowed them to tune up against an FCS foe. For Tulane, the story coming out of opening week was all about the defense, which forced five turnovers, swarmed the backfield with relentless pressure, and suffocated Northwestern’s offensive line, while quarterback Jake Retzlaff looked every bit the dual-threat weapon the Green Wave envisioned when they brought him in, mixing efficient throws with timely scrambles to keep drives alive. Head coach Jon Sumrall’s team looked organized, disciplined, and confident, and they will arrive in Mobile with the intention of continuing that momentum by using speed and pressure to force South Alabama into mistakes and set up favorable field position. The Jaguars, meanwhile, are trying to build on the steady leadership of quarterback Bishop Davenport, who commanded the offense with poise and balance in the opener, while running back Kentrel Bullock provided the ground game stability necessary to control tempo and keep the defense rested.

Their defense, led by safety Ty Goodwill, flew to the football and created opportunities, but the real test now comes against a Tulane team that has both the offensive balance and defensive intensity to punish any lapses. Strategically, Tulane will want to dictate tempo with its quick-strike offense and pressure defense, forcing Davenport into passing situations where turnovers could swing momentum, while South Alabama will focus on sustaining long drives, leaning on Bullock to keep the chains moving, and trying to neutralize Tulane’s pass rush with quick releases and misdirection plays. Special teams will be critical as well, since flipping the field in what could be a tight contest early will help whichever team gains the upper hand in hidden yardage. From a betting perspective, both programs are 1–0 ATS, but Tulane’s strong showing against a Power Five team has them installed as the favorite, while South Alabama’s home-field advantage and balanced play make them a trendy underdog pick capable of hanging around longer than expected. Ultimately, the game is likely to come down to which side executes its identity more cleanly: Tulane’s defense suffocating and opportunistic, or South Alabama’s offense steady and resilient. If Retzlaff continues to deliver efficient quarterback play and the Green Wave defense maintains its turnover-forcing form, Tulane should control the game and walk away with a statement road win, but if South Alabama can establish Bullock on the ground, limit turnovers, and ride the emotion of the home crowd, this matchup could be much tighter than the opening lines suggest and provide one of Week 2’s more competitive surprises.