Iowa vs Iowa State Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 06)

Updated: 2025-08-30T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The fierce rivalry known as the Cy‑Hawk Trophy games continues on September 6, 2025, as the Iowa Hawkeyes travel to Ames to face the Iowa State Cyclones in what promises to be another hard‑fought battle. Oddsmakers currently favor Iowa State by 3 points, while 69% of the point‑spread bets are backing the Cyclones, indicating strong confidence from bettors in their home advantage and recent performance trends.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 06, 2025

Start Time: 12:00 PM EST​

Venue: Jack Trice Stadium​

Cyclones Record: (2-0)

Hawkeyes Record: (1-0)

OPENING ODDS

IOWA Moneyline: +128

IOWAST Moneyline: -153

IOWA Spread: +3

IOWAST Spread: -3.0

Over/Under: 41.5

IOWA
Betting Trends

  • Iowa enters the matchup with a 0‑1 ATS record, having failed to cover in Week 1 despite a comfortable victory, signaling early-season inconsistency in meeting expectations.

IOWAST
Betting Trends

  • Iowa State stands at 2‑0 ATS, covering in both of their opening games, which highlights their effectiveness at managing expectations and capitalizing as favorites.

MATCHUP TRENDS

  • Even with Iowa State installed as home favorites, over two-thirds of spread wagers (approximately 69%) back the Cyclones, suggesting strong sharp and public confidence in their ability to cover.

IOWA vs. IOWAST
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Anderson under 25.5 Receiving Yards.

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Iowa vs Iowa State Prediction & Odds:
Free CFB Betting Insights for 9/6/25

The September 6, 2025 Cy-Hawk rivalry clash between the Iowa Hawkeyes and the Iowa State Cyclones at Jack Trice Stadium in Ames is set to be one of the premier early-season games on the college football calendar, a matchup defined not only by its history but also by its immediate implications for two programs eager to prove themselves, and oddsmakers have made Iowa State a slim three-point favorite with the total hovering around the mid-40s, signaling expectations for the type of physical, low-scoring contest that has often characterized this series. Iowa comes into the game 0-1 ATS after failing to cover in their season opener despite a commanding victory that featured 310 rushing yards, their best output in a season opener since 2002, underscoring both their dominance in the trenches and their lingering limitations in the passing game. Iowa State, meanwhile, enters 2-0 ATS after opening with consecutive covers, a mark that reflects a program that has learned how to meet expectations early in the season under head coach Matt Campbell, and they do so behind an offense that has begun to show more explosiveness through the air while pairing that growth with a stout run defense. The key battleground will be the line of scrimmage, as Iowa looks to impose its traditional power run game behind a veteran offensive line and a stable of backs who can wear down defenses, while Iowa State will counter with a defensive front that has grown more physical and has already proven it can handle opposing ground attacks. Iowa’s transfer quarterback Mark Gronowski has the mobility and play-action ability to give the Hawkeyes a wrinkle that has been missing from recent offenses, but he must show composure against a Cyclones secondary that will look to capitalize on any mistakes, particularly if the Hawkeyes are forced into long passing downs.

On the other side, Iowa State’s balanced attack will test an Iowa defense that, while still disciplined and strong in the front seven, has some inexperience in the back end, creating potential opportunities for chunk plays that could tilt the game. Special teams are always a defining factor in the Cy-Hawk series, and Iowa’s reputation under Kirk Ferentz for elite punting and disciplined coverage could help them flip field position in a tight game, while Iowa State will look to their kicking game and return units to prevent the Hawkeyes from finding an edge. Turnovers will almost certainly swing momentum, as neither team is built to chase from behind with explosive scoring drives, making ball security paramount. From a betting standpoint, Iowa State’s ATS perfection through two games combined with the heavy lean of public money toward the Cyclones reflects confidence in their ability to protect home field, but the rivalry’s history suggests Iowa cannot be discounted, particularly with a ground game capable of controlling tempo and silencing the crowd if successful early. Ultimately, the game may come down to which quarterback can make the fewest mistakes and deliver one or two critical third-down conversions, and whether Iowa State’s home crowd can rattle the Hawkeyes enough to prevent them from dictating their physical style of play, with the winner not only claiming the Cy-Hawk Trophy but also seizing valuable momentum heading into the heart of the September schedule.

Iowa Hawkeyes CFB Preview

The Iowa Hawkeyes enter their September 6, 2025 trip to Ames to face the Iowa State Cyclones with the determination to reclaim the Cy-Hawk Trophy and reinforce their identity as one of the Big Ten’s most disciplined and physically imposing programs, and while oddsmakers have installed them as narrow three-point underdogs, the Hawkeyes believe their formula of power running, suffocating defense, and special teams excellence can travel anywhere, even into one of the loudest environments in college football. Iowa opened its season with a comfortable win that saw them rush for 310 yards, their most in an opener since 2002, a performance that reaffirmed head coach Kirk Ferentz’s long-standing emphasis on dominating the trenches, controlling tempo, and wearing down opponents physically over four quarters. That ground game will again be the centerpiece, with a veteran offensive line paving the way for a committee of backs who have already shown they can generate explosive runs and punish defenses unprepared for their physicality. Quarterback Mark Gronowski, a transfer with mobility and a strong arm, offers a dimension that recent Iowa offenses have lacked, as he can extend plays outside the pocket and give the Hawkeyes a play-action threat to complement their rushing attack, but his efficiency and decision-making will be tested against an Iowa State defense that thrives on discipline and opportunism.

Defensively, Iowa brings its usual toughness, with a front seven anchored by size and experience that specializes in stopping the run, while the secondary is still adapting to turnover and will need to be sharp against a Cyclones offense that has shown early signs of increased explosiveness through the air. Iowa’s linebackers remain the heart of the unit, tasked with plugging gaps and limiting yards after contact, and their ability to pressure the quarterback without overcommitting will be critical in keeping Iowa State from hitting deep shots downfield. Special teams are often the hidden advantage in rivalry games, and Iowa’s consistent excellence in punting, coverage, and field position battles gives them an edge that could loom large in a contest projected to be decided by a single possession. From a betting perspective, Iowa has not covered yet this season, sitting at 0-1 ATS, but history suggests that under Ferentz they often thrive as underdogs, using the perceived slight as fuel for disciplined, mistake-free football. The key for Iowa will be to establish their running game early, force Iowa State into a grind-it-out battle, and avoid turnovers that could energize the home crowd and swing momentum, because while the Cyclones are capable of explosive stretches, the Hawkeyes’ ability to dictate tempo and force the game into their style remains their clearest path to victory. Ultimately, the Hawkeyes arrive in Ames as underdogs on paper, but with a proven formula of physical play, a resurgent running attack, and a coach who understands the stakes of this rivalry better than anyone, they have both the tools and the mindset to walk out of Jack Trice Stadium with the trophy and the satisfaction of spoiling their rival’s early-season optimism.

The fierce rivalry known as the Cy‑Hawk Trophy games continues on September 6, 2025, as the Iowa Hawkeyes travel to Ames to face the Iowa State Cyclones in what promises to be another hard‑fought battle. Oddsmakers currently favor Iowa State by 3 points, while 69% of the point‑spread bets are backing the Cyclones, indicating strong confidence from bettors in their home advantage and recent performance trends.  Iowa vs Iowa State AI Prediction: Free CFB Betting Insights for Sep 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Iowa State Cyclones CFB Preview

The Iowa State Cyclones host the Iowa Hawkeyes on September 6, 2025 at Jack Trice Stadium in what is once again the centerpiece game of their early season, and they enter the rivalry as narrow three-point favorites with momentum both on the field and in betting markets after covering in each of their first two games this year, a sign that head coach Matt Campbell’s squad is executing with consistency and efficiency. The Cyclones understand the magnitude of the Cy-Hawk Trophy matchup and will lean heavily on their balanced approach, which has already shown marked improvement through the air compared to recent seasons, with their quarterback distributing effectively to a versatile group of receivers and tight ends capable of stretching defenses both vertically and horizontally. Their offensive line has looked steadier in pass protection and their ground game, while not flashy, has been reliable enough to maintain balance, setting up play-action opportunities that will be critical against an Iowa defense built to smother straightforward rushing attacks. Defensively, Iowa State has stood out early by clogging run lanes and forcing opponents to become one-dimensional, and that emphasis will be paramount against a Hawkeyes team that just ran for 310 yards in its opener, their best rushing performance in over two decades.

The Cyclones’ front seven must win at the point of attack and prevent Iowa from controlling tempo, while the secondary will be tasked with limiting the damage from play-action passes when the Hawkeyes try to diversify their offense through transfer quarterback Mark Gronowski. Iowa State’s defensive discipline and ability to create turnovers could give them the edge in what is expected to be a tight, low-scoring game, especially with their home crowd providing one of the loudest atmospheres in the Big 12. Special teams will also be an emphasis, as rivalry games often swing on hidden yardage, field position, or a single explosive return, and the Cyclones have worked to ensure they are sound in coverage and efficient in the kicking game. From a betting standpoint, the public and sharp money alike are showing confidence in Iowa State, with nearly 70 percent of spread wagers backing the Cyclones, a reflection of both their strong ATS start and their ability to perform well at home in high-pressure situations. To win, Iowa State must continue to execute their formula: establish balance offensively, prevent Iowa from imposing their physical running game, and capitalize on scoring chances when they come, as possessions will be limited and every trip into the red zone will carry extra weight. Campbell’s group has the opportunity not only to keep the trophy in Ames but also to make an early-season statement that they are ready to contend at a higher level in the Big 12, and with confidence, home-field advantage, and an experienced core of playmakers, the Cyclones enter this rivalry believing they can seize control, satisfy bettors who have backed them heavily, and give their fanbase another reason to believe in their program’s continued rise.

Iowa vs. Iowa State Prop Picks (AI)

Remi is pouring through tons of stats on each line. In fact, anytime the Hawkeyes and Cyclones play there’s always several intriguing trends to key in on. Not to mention games played at Jack Trice Stadium in Sep seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: S. Anderson under 25.5 Receiving Yards.

Iowa vs. Iowa State Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every angle between the Hawkeyes and Cyclones and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Remi has been most focused on the linear correlation of factor human bettors tend to put on Iowa State’s strength factors between a Hawkeyes team going up against a possibly tired Cyclones team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Iowa vs Iowa State picks, computer picks Hawkeyes vs Cyclones, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Hawkeyes Betting Trends

Iowa enters the matchup with a 0‑1 ATS record, having failed to cover in Week 1 despite a comfortable victory, signaling early-season inconsistency in meeting expectations.

Cyclones Betting Trends

Iowa State stands at 2‑0 ATS, covering in both of their opening games, which highlights their effectiveness at managing expectations and capitalizing as favorites.

Hawkeyes vs. Cyclones Matchup Trends

Even with Iowa State installed as home favorites, over two-thirds of spread wagers (approximately 69%) back the Cyclones, suggesting strong sharp and public confidence in their ability to cover.

Iowa vs. Iowa State Game Info

Iowa vs Iowa State starts on September 06, 2025 at 12:00 PM EST.

Venue: Jack Trice Stadium.

Spread: Iowa State -3.0
Moneyline: Iowa +128, Iowa State -153
Over/Under: 41.5

Iowa: (1-0)  |  Iowa State: (2-0)

Remi's searched hard and found the best prop for this matchup: S. Anderson under 25.5 Receiving Yards.. Prices move—always shop for the best number.

Even with Iowa State installed as home favorites, over two-thirds of spread wagers (approximately 69%) back the Cyclones, suggesting strong sharp and public confidence in their ability to cover.

IOWA trend: Iowa enters the matchup with a 0‑1 ATS record, having failed to cover in Week 1 despite a comfortable victory, signaling early-season inconsistency in meeting expectations.

IOWAST trend: Iowa State stands at 2‑0 ATS, covering in both of their opening games, which highlights their effectiveness at managing expectations and capitalizing as favorites.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Iowa vs. Iowa State Odds

AI algorithm Remi is pouring through mountains of stats on each line. In fact, anytime the Iowa vs Iowa State trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

Iowa vs Iowa State Opening Odds

IOWA Moneyline: +128
IOWAST Moneyline: -153
IOWA Spread: +3
IOWAST Spread: -3.0
Over/Under: 41.5

Iowa vs Iowa State Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+185
-6.5 (-110)
+6.5 (-110)
O 55.5 (-112)
U 55.5 (-108)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1600
-26.5 (-112)
+26.5 (-108)
O 61.5 (-105)
U 61.5 (-115)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+164
-198
+4.5 (-108)
-4.5 (-112)
O 49.5 (-115)
U 49.5 (-105)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+1000
-21 (-115)
+21 (-105)
O 50.5 (-112)
U 50.5 (-108)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-395
+310
-10.5 (-108)
+10.5 (-112)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-290
+235
-7.5 (-105)
+7.5 (-115)
O 48.5 (-108)
U 48.5 (-112)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+114
-2.5 (-115)
+2.5 (-105)
O 58.5 (-112)
U 58.5 (-108)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+170
-4.5 (-112)
+4.5 (-108)
O 63.5 (-108)
U 63.5 (-112)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1400
-3200
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7 (-105)
-7 (-115)
O 43.5 (-110)
U 43.5 (-110)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-500
+380
-12.5 (-108)
+12.5 (-112)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-180
+150
-3.5 (-108)
+3.5 (-112)
O 53.5 (-115)
U 53.5 (-105)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+600
-900
+17.5 (-110)
-17.5 (-110)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-625
 
-14.5 (-108)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+180
-218
+4.5 (-105)
-4.5 (-115)
O 54.5 (-108)
U 54.5 (-112)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+130
-155
+3 (-112)
-3 (-108)
O 56.5 (-115)
U 56.5 (-105)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-105
-115
+1.5 (-115)
-1.5 (-105)
O 56.5 (-112)
U 56.5 (-108)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+310
-395
+9.5 (-110)
-9.5 (-110)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-410
+320
-10.5 (-110)
+10.5 (-110)
O 49.5 (-105)
U 49.5 (-115)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+130
-155
+3 (-112)
-3 (-108)
O 61.5 (-112)
U 61.5 (-108)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-345
+9.5 (-112)
-9.5 (-108)
O 39.5 (-108)
U 39.5 (-112)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-485
+370
-12.5 (-110)
+12.5 (-110)
O 47.5 (-108)
U 47.5 (-112)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+124
-148
+2.5 (-102)
-2.5 (-118)
O 48.5 (-112)
U 48.5 (-108)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-238
+195
-6 (-112)
+6 (-108)
O 53.5 (-112)
U 53.5 (-108)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+180
-218
+5.5 (-112)
-5.5 (-108)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
-102
-118
+1.5 (-115)
-1.5 (-105)
O 46.5 (-108)
U 46.5 (-112)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+455
-625
+15.5 (-108)
-15.5 (-112)
O 62.5 (-112)
U 62.5 (-108)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+164
-198
+4.5 (-110)
-4.5 (-110)
O 53.5 (-115)
U 53.5 (-105)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-700
 
-16.5 (-108)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-155
+130
-3 (-110)
+3 (-110)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+114
-135
+2.5 (-110)
-2.5 (-110)
O 51.5 (-115)
U 51.5 (-105)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+205
-250
+6.5 (-108)
-6.5 (-112)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+102
 
+1.5 (-110)
 
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+340
 
+10.5 (-105)
 
O 50.5 (-112)
U 50.5 (-108)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+38.5 (-115)
-38.5 (-105)
O 56.5 (-108)
U 56.5 (-112)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+154
-185
+4.5 (-110)
-4.5 (-110)
O 66.5 (-115)
U 66.5 (-105)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-270
+220
-7 (-105)
+7 (-115)
O 44.5 (-115)
U 44.5 (-105)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-650
+470
-15.5 (-110)
+15.5 (-110)
O 54.5 (-118)
U 54.5 (-102)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-108)
-33.5 (-112)
O 44.5 (-112)
U 44.5 (-108)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+280
-355
+8.5 (-108)
-8.5 (-112)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-105)
U 45.5 (-115)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+100
-120
+1.5 (-110)
-1.5 (-110)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-625
+455
-14.5 (-105)
+14.5 (-115)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-142
+120
-2.5 (-115)
+2.5 (-105)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1400
-3200
+25.5 (-110)
-25.5 (-110)
O 55.5 (-102)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+180
-218
+5.5 (-110)
-5.5 (-110)
O 46.5 (-112)
U 46.5 (-108)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+275
-9.5 (-108)
+9.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+230
-285
+7.5 (-115)
-7.5 (-105)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+410
-550
+13.5 (-110)
-13.5 (-110)
O 49.5 (-112)
U 49.5 (-108)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Iowa Hawkeyes vs. Iowa State Cyclones on September 06, 2025 at Jack Trice Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN