The September 6, 2025 Cy-Hawk rivalry clash between the Iowa Hawkeyes and the Iowa State Cyclones at Jack Trice Stadium in Ames is set to be one of the premier early-season games on the college football calendar, a matchup defined not only by its history but also by its immediate implications for two programs eager to prove themselves, and oddsmakers have made Iowa State a slim three-point favorite with the total hovering around the mid-40s, signaling expectations for the type of physical, low-scoring contest that has often characterized this series. Iowa comes into the game 0-1 ATS after failing to cover in their season opener despite a commanding victory that featured 310 rushing yards, their best output in a season opener since 2002, underscoring both their dominance in the trenches and their lingering limitations in the passing game. Iowa State, meanwhile, enters 2-0 ATS after opening with consecutive covers, a mark that reflects a program that has learned how to meet expectations early in the season under head coach Matt Campbell, and they do so behind an offense that has begun to show more explosiveness through the air while pairing that growth with a stout run defense. The key battleground will be the line of scrimmage, as Iowa looks to impose its traditional power run game behind a veteran offensive line and a stable of backs who can wear down defenses, while Iowa State will counter with a defensive front that has grown more physical and has already proven it can handle opposing ground attacks. Iowa’s transfer quarterback Mark Gronowski has the mobility and play-action ability to give the Hawkeyes a wrinkle that has been missing from recent offenses, but he must show composure against a Cyclones secondary that will look to capitalize on any mistakes, particularly if the Hawkeyes are forced into long passing downs.

On the other side, Iowa State’s balanced attack will test an Iowa defense that, while still disciplined and strong in the front seven, has some inexperience in the back end, creating potential opportunities for chunk plays that could tilt the game. Special teams are always a defining factor in the Cy-Hawk series, and Iowa’s reputation under Kirk Ferentz for elite punting and disciplined coverage could help them flip field position in a tight game, while Iowa State will look to their kicking game and return units to prevent the Hawkeyes from finding an edge. Turnovers will almost certainly swing momentum, as neither team is built to chase from behind with explosive scoring drives, making ball security paramount. From a betting standpoint, Iowa State’s ATS perfection through two games combined with the heavy lean of public money toward the Cyclones reflects confidence in their ability to protect home field, but the rivalry’s history suggests Iowa cannot be discounted, particularly with a ground game capable of controlling tempo and silencing the crowd if successful early. Ultimately, the game may come down to which quarterback can make the fewest mistakes and deliver one or two critical third-down conversions, and whether Iowa State’s home crowd can rattle the Hawkeyes enough to prevent them from dictating their physical style of play, with the winner not only claiming the Cy-Hawk Trophy but also seizing valuable momentum heading into the heart of the September schedule.