Illinois vs Duke Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 06)

Updated: 2025-08-30T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Illinois visits Duke on September 6, 2025, in a Week 2 non-conference clash that promises both high stakes and high-speed offensive action. Illinois enters as a slight 3-point favorite, with early betting trends showing mixed support and expectations for a tightly contested game.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 06, 2025

Start Time: 12:00 PM EST​

Venue: Brooks Field at Wallace Wade Stadium​

Blue Devils Record: (1-0)

Fighting Illini Record: (1-0)

OPENING ODDS

ILL Moneyline: -151

DUKE Moneyline: +127

ILL Spread: -3

DUKE Spread: +3

Over/Under: 49.5

ILL
Betting Trends

  • Illinois is 1–0 ATS, having comfortably covered in a dominant 52–3 opener over Western Illinois.

DUKE
Betting Trends

  • Duke stands at 0–1 ATS, failing to cover in their opener despite a solid 45–17 win over Elon.

MATCHUP TRENDS

  • Despite Illinois being the favorite, early projections list them at 440 yards of offense per game and a stout defense, suggesting bettors may expect offensive fireworks and choose to support Duke’s upside.

ILL vs. DUKE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Hagans under 42.5 Receiving Yards.

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Illinois vs Duke Prediction & Odds:
Free CFB Betting Insights for 9/6/25

The September 6, 2025 meeting between the Illinois Fighting Illini and the Duke Blue Devils at Wallace Wade Stadium in Durham offers one of the more intriguing non-conference showdowns of Week 2, as Illinois travels south following a dominant opening performance while Duke looks to use its home field to deliver a statement win against a Big Ten opponent, and oddsmakers have made the Illini a slim three-point favorite with the total set around the low fifties, reflecting expectations of a balanced, competitive contest where both offenses should find opportunities but defensive adjustments will ultimately decide the outcome. Illinois enters this game riding the high of a 52–3 blowout of Western Illinois in which quarterback Luke Altmyer showed poise and distribution skills by completing passes to nine different receivers, most notably connecting with Hank Beatty for 100 yards and a punt return touchdown that highlighted the explosiveness Illinois has been searching for, while the defense dominated behind linebacker Gabe Jacas, who recorded two sacks and forced a fumble, setting the tone for a unit that prides itself on toughness and discipline. Head coach Bret Bielema has built Illinois on physicality, establishing the run behind a veteran offensive line while allowing Altmyer the freedom to diversify the passing game, and this contest provides an opportunity to showcase growth against a Power Five opponent with a strong defensive pedigree.

Duke counters with its own momentum after a 45–17 victory over Elon, where transfer quarterback Darian Mensah made a strong impression by throwing for nearly 400 yards and three touchdowns while displaying chemistry with a retooled receiving corps led by Cooper Barkate, Sahmir Hagans, and Que’Sean Brown, giving the Blue Devils confidence that they can push the ball vertically against any opponent. The battle in the trenches looms as a deciding factor, with Illinois aiming to assert its physical advantage through line play and ball control while Duke will look to use tempo, play-action, and spacing to wear down the Illini defense and open lanes for explosive plays. Special teams could also swing momentum, as Illinois demonstrated game-changing ability in the return game in Week 1, but Duke has long prided itself on efficiency and opportunism in that phase, meaning a single miscue could shift field position in a tight contest. From a betting perspective, Illinois holds the ATS edge after covering in Week 1, while Duke failed to do so despite winning comfortably, and the early money leaning toward Illinois suggests bettors trust Bielema’s physical brand of football to travel. Still, Duke’s home-field advantage and offensive explosiveness cannot be discounted, especially given the Illini’s occasional struggles to keep pace when opponents are able to generate quick scoring drives. Ultimately, the outcome will hinge on whether Illinois can establish its run game, control time of possession, and keep Altmyer in manageable passing situations, or whether Duke’s aerial attack, buoyed by Mensah’s arm and a speedy receiving corps, can stretch the field and force Illinois into a shootout they may not be built to win. This game not only carries significance for bragging rights between conferences but also serves as an early measuring stick for two programs with aspirations of postseason breakthroughs, and whichever side emerges victorious will leave the field with validation and momentum heading deeper into September.

Illinois Fighting Illini CFB Preview

The Illinois Fighting Illini head into their September 6, 2025 clash with the Duke Blue Devils carrying momentum and confidence after a dominant 52–3 season-opening win, and though they are only three-point road favorites, the way they dismantled Western Illinois offers optimism that head coach Bret Bielema’s team may have both the balance and depth to compete against stronger competition, and the challenge now is proving it against an ACC foe with enough offensive firepower to test every level of their defense. Illinois’ offensive identity begins up front with a veteran offensive line that opened holes for a ground game designed to wear down opponents, while quarterback Luke Altmyer continues to settle into his role as the distributor of a more diversified attack that showed promise when he connected with nine different receivers in Week 1. Wideout Hank Beatty delivered his first career 100-yard receiving performance and added a punt return touchdown, signaling the type of playmaking explosiveness that has often eluded the Illini in recent years, and with supporting options like Isaiah Williams providing experience in the slot, the receiving corps looks deeper than before. Defensively, Illinois relies on a front seven led by linebacker Gabe Jacas, who tallied two sacks and forced a fumble in the opener, and their ability to pressure quarterbacks while maintaining gap discipline has been the foundation of Bielema’s system, giving the Illini the tools to disrupt Duke’s timing and force mistakes.

The key for Illinois will be maintaining discipline in the secondary, as Duke’s quarterback Darian Mensah showed immediate chemistry with a group of receivers capable of stretching the field, and while the Illini defensive backs are physical, they have at times been vulnerable to explosive passing plays that can flip momentum. Special teams could again play a vital role, as Illinois has already shown game-breaking potential with Beatty’s punt return, and in a close road game, hidden yardage and momentum swings could make the difference between covering the spread and suffering a frustrating loss. From a betting perspective, Illinois has already rewarded backers at 1–0 ATS and has generated support as a slight road favorite, though the line reflects the uncertainty of whether their offensive improvement can hold against a Power Five defense and whether their depth will travel effectively. The formula for Illinois will be to establish the run early, control time of possession, and let Altmyer build confidence through efficient, high-percentage passes, while defensively they must generate pressure without overcommitting, as blown assignments against Duke’s speedy receivers could prove costly. The Illini know that a win in Durham would not only extend their momentum but also solidify belief that Bielema’s system is delivering sustainable progress, and given the narrow spread, execution in high-leverage moments—third downs, red-zone trips, and turnover battles—will likely decide the outcome. For Illinois, this game represents more than just a non-conference road test; it is a chance to validate their early dominance, to prove their offense has evolved into a more balanced and dangerous unit, and to demonstrate that their defense, long their calling card, can withstand a legitimate challenge and carry them toward a season where postseason aspirations remain firmly on the table.

Illinois visits Duke on September 6, 2025, in a Week 2 non-conference clash that promises both high stakes and high-speed offensive action. Illinois enters as a slight 3-point favorite, with early betting trends showing mixed support and expectations for a tightly contested game.  Illinois vs Duke AI Prediction: Free CFB Betting Insights for Sep 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Duke Blue Devils CFB Preview

The Duke Blue Devils enter their September 6, 2025 matchup against the Illinois Fighting Illini with cautious optimism and the weight of proving that their early-season offensive fireworks can translate against a stronger Big Ten opponent, as they return to Wallace Wade Stadium after a convincing 45–17 opening win over Elon but face an Illinois team coming off a dominant performance of its own, and oddsmakers have installed the Blue Devils as narrow three-point underdogs despite the advantage of playing at home. Duke’s new-look offense is led by transfer quarterback Darian Mensah, who immediately showcased his ability by throwing for nearly 400 yards and three touchdowns in his debut, connecting seamlessly with a retooled receiving corps that includes Harvard transfer Cooper Barkate and reliable targets like Sahmir Hagans and Que’Sean Brown, and the ability to push the ball downfield gives Duke a dimension that has been inconsistent in recent years. Their offensive line, while still developing cohesion, showed enough protection to keep Mensah comfortable in Week 1, and they will need to replicate that performance against an Illinois front seven that thrives on pressure and physicality. On defense, Duke has emphasized speed and discipline under head coach Manny Diaz, and their ability to clog rushing lanes will be tested immediately by an Illinois ground game that racked up over 300 yards in its opener and prides itself on controlling tempo.

The secondary, led by veterans who excel at reading quarterbacks and closing quickly on receivers, will be tasked with preventing Luke Altmyer from building on his efficient Week 1 performance in which he spread the ball to nine different targets and showcased emerging chemistry with Hank Beatty, who turned in a 100-yard receiving day and added a punt return touchdown. Special teams could also be critical for Duke, as Illinois has already demonstrated its ability to swing momentum with explosive returns, and field position in what could be a lower-possession game might prove decisive. From a betting perspective, Duke enters 0–1 ATS after failing to cover despite a comfortable win over Elon, but they remain confident that home-field advantage and the offensive spark provided by Mensah will allow them to test Illinois in ways their first opponent could not. The formula for Duke’s success will be to start fast offensively, protect Mensah long enough to hit deep throws, and maintain defensive discipline to avoid being worn down by Illinois’ punishing style, while turnovers and third-down execution will likely decide whether they can spring an upset or fall short. This game also carries larger implications for Duke’s trajectory under Diaz, as a win over a Big Ten opponent would not only boost national credibility but also reinforce the idea that their transfer-heavy roster and offensive restructuring can pay immediate dividends. Ultimately, the Blue Devils know that stopping Illinois’ run and forcing Altmyer into high-pressure passing situations will give them their best chance to prevail, and if Mensah can replicate his Week 1 poise under tougher circumstances, Duke could turn a September showcase into a defining early-season statement that shapes their path forward in the ACC.

Illinois vs. Duke Prop Picks (AI)

Remi is pouring through mountains of datapoints on each line. In fact, anytime the Fighting Illini and Blue Devils play there’s always several intriguing angles to key in on. Not to mention games played at Brooks Field at Wallace Wade Stadium in Sep seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: S. Hagans under 42.5 Receiving Yards.

Illinois vs. Duke Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every simulation between the Fighting Illini and Blue Devils and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Remi has been most fixated on the unproportionally assigned factor human bettors often put on Duke’s strength factors between a Fighting Illini team going up against a possibly unhealthy Blue Devils team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Illinois vs Duke picks, computer picks Fighting Illini vs Blue Devils, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Fighting Illini Betting Trends

Illinois is 1–0 ATS, having comfortably covered in a dominant 52–3 opener over Western Illinois.

Blue Devils Betting Trends

Duke stands at 0–1 ATS, failing to cover in their opener despite a solid 45–17 win over Elon.

Fighting Illini vs. Blue Devils Matchup Trends

Despite Illinois being the favorite, early projections list them at 440 yards of offense per game and a stout defense, suggesting bettors may expect offensive fireworks and choose to support Duke’s upside.

Illinois vs. Duke Game Info

Illinois vs Duke starts on September 06, 2025 at 12:00 PM EST.

Venue: Brooks Field at Wallace Wade Stadium.

Spread: Duke +3
Moneyline: Illinois -151, Duke +127
Over/Under: 49.5

Illinois: (1-0)  |  Duke: (1-0)

Remi's searched hard and found the best prop for this matchup: S. Hagans under 42.5 Receiving Yards.. Prices move—always shop for the best number.

Despite Illinois being the favorite, early projections list them at 440 yards of offense per game and a stout defense, suggesting bettors may expect offensive fireworks and choose to support Duke’s upside.

ILL trend: Illinois is 1–0 ATS, having comfortably covered in a dominant 52–3 opener over Western Illinois.

DUKE trend: Duke stands at 0–1 ATS, failing to cover in their opener despite a solid 45–17 win over Elon.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Illinois vs. Duke Odds

AI algorithm Remi is pouring through tons of data points on each line. In fact, anytime the Illinois vs Duke trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.

Illinois vs Duke Opening Odds

ILL Moneyline: -151
DUKE Moneyline: +127
ILL Spread: -3
DUKE Spread: +3
Over/Under: 49.5

Illinois vs Duke Live Odds

Games PTS ML SPR O/U
Oct 21, 2025 7:00PM EDT
Kennesaw State Owls
FIU Panthers
10/21/25 7PM
KENSAW
FIU
-155
 
-3 (-115)
 
O 49.5 (-110)
U 49.5 (-110)
Oct 21, 2025 7:30PM EDT
Western Kentucky Hilltoppers
Louisiana Tech Bulldogs
10/21/25 7:30PM
WKY
LATECH
+146
-170
+3.5 (-117)
-3.5 (-103)
O 50 (-110)
U 50 (-110)
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-340
 
-9 (-110)
O 55 (-110)
U 55 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-120
+100
-1.5 (-110)
+1.5 (-110)
O 50.5 (-110)
U 50.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-235
+200
-6.5 (-110)
+6.5 (-110)
O 56 (-110)
U 56 (-110)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-3000
+1500
-26.5 (-110)
+26.5 (-110)
O 61.5 (-110)
U 61.5 (-110)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+170
-200
+4.5 (-110)
-4.5 (-110)
O 50 (-110)
U 50 (-110)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+1000
-21.5 (-110)
+21.5 (-110)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-395
+317
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-300
+250
-7.5 (-110)
+7.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-190
+163
-4.5 (-110)
+4.5 (-110)
O 63.5 (-110)
U 63.5 (-110)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1400
-2800
+25 (-105)
-25 (-115)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+238
-285
+7 (-105)
-7 (-115)
O 43.5 (-110)
U 43.5 (-110)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-480
+378
-12.5 (-110)
+12.5 (-110)
O 59 (-110)
U 59 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-175
+150
-3.5 (-110)
+3.5 (-110)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+600
-900
+17.5 (-110)
-17.5 (-110)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-550
 
-14.5 (-110)
O 63 (-105)
U 63 (-115)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+180
-210
+5 (-110)
-5 (-110)
O 54 (-110)
U 54 (-110)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+129
-150
+3 (-110)
-3 (-110)
O 57 (-110)
U 57 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-105
-115
+1 (-110)
-1 (-110)
O 57 (-110)
U 57 (-110)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-360
+9.5 (-110)
-9.5 (-110)
O 47 (-110)
U 47 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-395
+317
-11 (-110)
+11 (-110)
O 49 (-110)
U 49 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+129
-150
+3 (-110)
-3 (-110)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-340
+9 (-110)
-9 (-110)
O 39 (-110)
U 39 (-110)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-470
+370
-12 (-110)
+12 (-110)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+125
-145
+2.5 (-105)
-2.5 (-115)
O 49 (-105)
U 49 (-115)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+190
-6 (-110)
+6 (-110)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+175
-205
+5.5 (-110)
-5.5 (-110)
O 41 (-110)
U 41 (-110)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
-105
-115
+1 (-110)
-1 (-110)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+485
-670
+16 (-110)
-16 (-110)
O 62.5 (-110)
U 62.5 (-110)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+163
-190
+4.5 (-110)
-4.5 (-110)
O 54 (-110)
U 54 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-725
 
-16 (-110)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-155
+134
-3 (-115)
+3 (-105)
O 48 (-110)
U 48 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+120
-140
+2.5 (-105)
-2.5 (-115)
O 52 (-110)
U 52 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+210
-250
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+105
 
+1.5 (-110)
 
O 41 (-115)
U 41 (-105)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+355
 
+11 (-110)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+3500
-10000
+38 (-110)
-38 (-110)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+163
-190
+4.5 (-110)
-4.5 (-110)
O 67.5 (-110)
U 67.5 (-110)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-260
+218
-7 (-110)
+7 (-110)
O 45 (-110)
U 45 (-110)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+485
-16 (-110)
+16 (-110)
O 55.5 (-105)
U 55.5 (-115)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-105)
-33.5 (-115)
O 44.5 (-110)
U 44.5 (-110)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-330
+9.5 (-110)
-9.5 (-110)
O 48 (-110)
U 48 (-110)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-20000
+30 (-110)
-30 (-110)
O 45 (-115)
U 45 (-105)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+100
-120
+1.5 (-110)
-1.5 (-110)
O 62.5 (-110)
U 62.5 (-110)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-650
+475
-14.5 (-110)
+14.5 (-110)
O 48 (-110)
U 48 (-110)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-145
+125
-3 (-105)
+3 (-115)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1300
-2500
+25.5 (-110)
-25.5 (-110)
O 55 (-110)
U 55 (-110)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+183
-215
+5 (-110)
-5 (-110)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-350
+280
-9.5 (-110)
+9.5 (-110)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+250
-300
+7.5 (-110)
-7.5 (-110)
O 47 (-110)
U 47 (-110)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+425
-550
+14 (-115)
-14 (-105)
O 49.5 (-110)
U 49.5 (-110)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-320
+255
-8.5 (-110)
+8.5 (-110)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-280
+225
-7.5 (+100)
+7.5 (-122)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Illinois Fighting Illini vs. Duke Blue Devils on September 06, 2025 at Brooks Field at Wallace Wade Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN