Central Michigan vs Pittsburgh Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 06)

Updated: 2025-08-30T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Central Michigan Chippewas make the short trip north to face the Pittsburgh Panthers at Acrisure Stadium on September 6, 2025, in what promises to be a notable early-season match-up between MAC and ACC programs. Pittsburgh enters as a heavy 21.5-point favorite, with the over/under set at 52.5, signaling expectations for a dominant Panthers win tempered by the possibility of offensive scoring throughout.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 06, 2025

Start Time: 12:00 PM EST​

Venue: Acrisure Stadium​

Panthers Record: (1-0)

Chippewas Record: (1-0)

OPENING ODDS

CMICH Moneyline: +1002

PITT Moneyline: -1961

CMICH Spread: +21.5

PITT Spread: -21.5

Over/Under: 52.5

CMICH
Betting Trends

  • Central Michigan starts the season 1–0 ATS, having covered as underdogs in their opener behind a disciplined and balanced performance that provided early-season confidence.

PITT
Betting Trends

  • Pittsburgh is also 1–0 ATS, earning a cover in their opener with a resounding 61–9 win over Duquesne, driven by explosive offense and opportunistic defense.

MATCHUP TRENDS

  • Despite Pittsburgh’s imposing favorite status, 39% of spread bets currently back Central Michigan—indicating that a sizable portion of bettors see value in the Chippewas keeping the game within reach.

CMICH vs. PITT
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Hicks under 49.5 Receiving Yards.

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Central Michigan vs Pittsburgh Prediction & Odds:
Free CFB Betting Insights for 9/6/25

The September 6, 2025 non-conference clash between the Central Michigan Chippewas and the Pittsburgh Panthers at Acrisure Stadium provides both teams with an important opportunity to build early-season momentum, though the context and expectations could not be more different, as Pittsburgh enters as a commanding 21.5-point favorite with the over/under set at 52.5, while Central Michigan arrives motivated to prove itself against a Power Five opponent and cover the spread for bettors who have already shown surprising confidence in the Chippewas’ ability to stay competitive. Pittsburgh wasted no time in asserting dominance in its season opener, throttling Duquesne 61–9 in a performance that highlighted not only the depth of talent on both sides of the ball but also the ability of their playmakers to turn games into routs quickly, and with quarterback Christian Veilleux distributing efficiently and their backfield producing consistently, the Panthers showcased an offensive rhythm that has them trending upward in early ACC power rankings. Their defense, equally dominant, suffocated Duquesne with relentless pressure and opportunism, creating turnovers and consistently forcing short drives, the type of blueprint they will aim to replicate against Central Michigan. The Chippewas, however, are no strangers to challenging environments, and under head coach Matt Drinkall they emphasize discipline, ball control, and execution, a philosophy that allows them to punch above their weight in matchups against superior rosters, and they enter at 1–0 ATS after delivering a performance in their opener that rewarded backers and gave players confidence that they can execute their plan.

Central Michigan’s offense must find ways to establish the run and sustain drives to keep Pittsburgh’s offense off the field, as a fast-paced, high-possession game will heavily favor the Panthers, and their offensive line will need to play mistake-free football against a defensive front that thrives on collapsing the pocket. Defensively, the Chippewas cannot afford breakdowns in coverage against Pittsburgh’s explosive receivers, as even a handful of chunk plays could put the game out of reach early, and turnovers will be critical if they want to keep within striking distance. Special teams may provide CMU its best chance at shifting momentum, with the potential for long returns or blocked kicks serving as equalizers against a more talented roster, but they must also avoid mistakes that hand the Panthers short fields. From a betting perspective, it is telling that despite Pittsburgh’s clear statistical and depth advantage, roughly 39 percent of spread wagers have landed on Central Michigan, suggesting some sharp bettors believe the Chippewas’ ball-control style could allow them to sneak inside the number. Ultimately, the game will likely hinge on whether Pittsburgh maintains focus and plays clean football or whether they allow complacency and penalties to create openings for Central Michigan to hang around, as the Panthers clearly have the tools to dominate, but the Chippewas’ resilience and opportunistic approach could test them longer than expected. For Pittsburgh, this is about reinforcing its strength as an ACC contender, while for Central Michigan, it is about seizing the chance to prove that disciplined execution and belief can close gaps even against one of the nation’s more formidable programs.

Central Michigan Chippewas CFB Preview

The Central Michigan Chippewas enter their September 6, 2025 matchup against the Pittsburgh Panthers with the mindset of embracing the underdog role and proving that they can compete with a Power Five opponent, even as oddsmakers have set them as heavy 21.5-point underdogs on the road, and their best chance to succeed lies in sticking to their core identity of discipline, physicality, and limiting mistakes. Under new head coach Matt Drinkall, Central Michigan has placed an emphasis on complementary football, with the offense designed to control tempo through a steady running game and high-percentage passing that keeps the chains moving while minimizing turnover opportunities, a strategy that not only shortens the game but also keeps their defense fresh. Their offensive line, which looked more organized in the opener, will need to deliver its best performance of the year, as Pittsburgh’s defensive front is physical, deep, and capable of disrupting the pocket, and protecting the quarterback will be paramount if the Chippewas want to stay within the spread. Quarterback play will be vital, and whether through steady short throws or timely deep attempts, CMU must find ways to stretch the Panthers’ defense vertically to prevent them from stacking the box against the run. Defensively, Central Michigan has historically prided itself on effort and discipline, and in this matchup they will need to bring that intensity to contain a Pittsburgh offense that hung 61 points on Duquesne in their opener and looks comfortable both pounding the football on the ground and attacking through the air with Christian Veilleux.

The Chippewas’ linebackers must be sharp in diagnosing play-action and misdirection, while the secondary cannot afford lapses against speedy receivers who can break the game open in a single play. Special teams, which already showed flashes of promise in the opener, will likely be leaned on heavily, as flipping field position and possibly generating a game-changing play through returns or blocks may be their only path to narrowing the talent gap. From a betting perspective, Central Michigan enters at 1-0 ATS after covering in their opener, and the fact that nearly 40 percent of spread bets are backing them against Pittsburgh suggests that many bettors believe their style of play and ability to hang tough against bigger programs could keep the game within the number. To make that confidence reality, CMU must avoid the costly errors that often doom underdogs in these settings, such as turnovers on their side of the field, penalties that extend drives, or special teams breakdowns that hand their opponent easy points. The formula is straightforward but unforgiving: win time of possession, prevent explosive plays, and capitalize on any mistakes Pittsburgh makes, because without that combination the gap in talent and depth could overwhelm them quickly. For the Chippewas, this game represents more than just a tough road test, as it is a chance to measure the program’s growth, instill belief in a new system, and show their players and fan base that they can compete with higher-profile opponents, even if pulling off the upset remains unlikely.

The Central Michigan Chippewas make the short trip north to face the Pittsburgh Panthers at Acrisure Stadium on September 6, 2025, in what promises to be a notable early-season match-up between MAC and ACC programs. Pittsburgh enters as a heavy 21.5-point favorite, with the over/under set at 52.5, signaling expectations for a dominant Panthers win tempered by the possibility of offensive scoring throughout. Central Michigan vs Pittsburgh AI Prediction: Free CFB Betting Insights for Sep 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Pittsburgh Panthers CFB Preview

The Pittsburgh Panthers enter their September 6, 2025 home matchup against the Central Michigan Chippewas with confidence and focus after beginning their season in emphatic fashion with a 61–9 dismantling of Duquesne, a result that not only demonstrated their offensive depth but also their defensive opportunism, and they now look to continue that momentum as 21.5-point favorites in a game where they will be expected to control every phase from start to finish. Head coach Pat Narduzzi has built this program on toughness, discipline, and physicality, and his current roster appears to reflect those values with a balanced offense that can attack on the ground or through the air and a defense that thrives on pressuring quarterbacks and forcing mistakes. Quarterback Christian Veilleux has settled into his role with improved command and decision-making, allowing the offense to flow through both quick, efficient passing and deep vertical shots that stretch defenses, while the backfield committee has proven capable of sustaining drives and punching in red-zone opportunities. The wide receiver group gives Pitt versatility, with reliable hands, route precision, and the speed needed to create explosive plays, making them difficult to contain for secondaries that lack depth. Defensively, the Panthers boast one of the most aggressive fronts in the ACC, a unit that smothered Duquesne’s run game and lived in the backfield, and they will look to repeat that performance by overwhelming Central Michigan’s offensive line and limiting the Chippewas’ ability to sustain long drives.

Pitt’s linebackers and secondary will also play a crucial role in ensuring discipline against Central Michigan’s run-first attack, and they will be tasked with closing gaps quickly and preventing short plays from turning into chain-moving gains. Special teams provide another edge, as Pitt’s return units have the explosiveness to flip field position, while the kicking game remains consistent enough to turn drives into points when the offense stalls. From a betting perspective, Pittsburgh’s 1–0 ATS start and their commanding early-season win reflect a team meeting expectations, while the line of 21.5 points underscores the level of dominance oddsmakers believe they can exert in this contest, though their focus must remain sharp to avoid lapses that could allow Central Michigan to hang within the number. The keys for the Panthers are straightforward: establish dominance in the trenches, keep Veilleux comfortable with strong pass protection, sustain balance offensively to prevent predictability, and maintain defensive pressure that forces Central Michigan into third-and-long situations where mistakes are most likely. If they execute in those areas, the Panthers not only have the tools to cover but also to build further confidence before entering the grind of ACC play. More broadly, this matchup offers Pitt a chance to reinforce its identity as a program that handles business against lower-conference opponents, and a decisive win would serve as both a confidence-builder and a reminder that the Panthers possess the physicality, depth, and consistency to compete for positioning at the top of their league.

Central Michigan vs. Pittsburgh Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each line. In fact, anytime the Chippewas and Panthers play there’s always several intriguing angles to key in on. Not to mention games played at Acrisure Stadium in Sep seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Hicks under 49.5 Receiving Yards.

Central Michigan vs. Pittsburgh Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every past game between the Chippewas and Panthers and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the trending emphasis emotional bettors tend to put on player performance factors between a Chippewas team going up against a possibly deflated Panthers team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Central Michigan vs Pittsburgh picks, computer picks Chippewas vs Panthers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Chippewas Betting Trends

Central Michigan starts the season 1–0 ATS, having covered as underdogs in their opener behind a disciplined and balanced performance that provided early-season confidence.

Panthers Betting Trends

Pittsburgh is also 1–0 ATS, earning a cover in their opener with a resounding 61–9 win over Duquesne, driven by explosive offense and opportunistic defense.

Chippewas vs. Panthers Matchup Trends

Despite Pittsburgh’s imposing favorite status, 39% of spread bets currently back Central Michigan—indicating that a sizable portion of bettors see value in the Chippewas keeping the game within reach.

Central Michigan vs. Pittsburgh Game Info

Central Michigan vs Pittsburgh starts on September 06, 2025 at 12:00 PM EST.

Spread: Pittsburgh -21.5
Moneyline: Central Michigan +1002, Pittsburgh -1961
Over/Under: 52.5

Central Michigan: (1-0)  |  Pittsburgh: (1-0)

Remi's searched hard and found the best prop for this matchup: C. Hicks under 49.5 Receiving Yards.. Prices move—always shop for the best number.

Despite Pittsburgh’s imposing favorite status, 39% of spread bets currently back Central Michigan—indicating that a sizable portion of bettors see value in the Chippewas keeping the game within reach.

CMICH trend: Central Michigan starts the season 1–0 ATS, having covered as underdogs in their opener behind a disciplined and balanced performance that provided early-season confidence.

PITT trend: Pittsburgh is also 1–0 ATS, earning a cover in their opener with a resounding 61–9 win over Duquesne, driven by explosive offense and opportunistic defense.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Central Michigan vs. Pittsburgh Odds

AI algorithm Remi is pouring through loads of data on each team. In fact, anytime the Central Michigan vs Pittsburgh trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude can often follow normal, predictable betting trends.

Central Michigan vs Pittsburgh Opening Odds

CMICH Moneyline: +1002
PITT Moneyline: -1961
CMICH Spread: +21.5
PITT Spread: -21.5
Over/Under: 52.5

Central Michigan vs Pittsburgh Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+188
-6.5 (-110)
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O 56.5 (-106)
U 56.5 (-114)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1500
-27.5 (-102)
+27.5 (-120)
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Oct 24, 2025 7:30PM EDT
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Virginia Tech Hokies
10/24/25 7:30PM
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VATECH
+160
-190
+4.5 (-110)
-4.5 (-110)
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U 50.5 (-115)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+980
-21.5 (-105)
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U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-430
+330
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U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
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Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
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-135
+115
-2.5 (-110)
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Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+168
-5.5 (-110)
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Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1600
-4500
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Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
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Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-450
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Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+140
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U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+610
-950
+17.5 (-115)
-17.5 (-105)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-610
 
-14.5 (-105)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+172
-210
+4.5 (-105)
-4.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+122
-146
+2.5 (+100)
-2.5 (-122)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-110
-110
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-1.5 (-105)
O 57.5 (-105)
U 57.5 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-375
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O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-400
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O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+122
-146
+2.5 (-102)
-2.5 (-120)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
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IOWA
+275
-350
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-8.5 (-110)
O 38.5 (-115)
U 38.5 (-105)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-520
+385
-11.5 (-118)
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Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+122
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Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
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O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+176
-215
+5.5 (-110)
-5.5 (-110)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
+104
-125
+1.5 (-105)
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O 46.5 (-114)
U 46.5 (-106)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+480
-670
+15.5 (-110)
-15.5 (-110)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+146
-176
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-4.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-720
 
-15.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-146
+122
-2.5 (-122)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-138
+2.5 (-106)
-2.5 (-114)
O 52.5 (-110)
U 52.5 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+195
-240
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+106
 
+2.5 (-115)
 
O 41.5 (-110)
U 41.5 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+310
 
+11.5 (-115)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+37.5 (-108)
-37.5 (-112)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+152
-184
+4.5 (-115)
-4.5 (-105)
O 67.5 (-105)
U 67.5 (-115)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-285
+230
-7.5 (-102)
+7.5 (-120)
O 44.5 (-120)
U 44.5 (-102)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+470
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O 55.5 (-106)
U 55.5 (-114)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-106)
-33.5 (-114)
O 44.5 (-108)
U 44.5 (-112)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
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-9.5 (-110)
O 47.5 (-112)
U 47.5 (-108)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-104)
U 45.5 (-118)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+106
-128
+1.5 (-105)
-1.5 (-115)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-630
+450
-14.5 (-105)
+14.5 (-115)
O 48.5 (-105)
U 48.5 (-115)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-144
+120
-2.5 (-120)
+2.5 (-102)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 55.5 (-104)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+184
-225
+5.5 (-104)
-5.5 (-118)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+270
-9.5 (-110)
+9.5 (-110)
O 53.5 (-118)
U 53.5 (-104)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+220
-275
+7.5 (-120)
-7.5 (-102)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+375
-500
+13.5 (-110)
-13.5 (-110)
O 49.5 (-115)
U 49.5 (-105)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Central Michigan Chippewas vs. Pittsburgh Panthers on September 06, 2025 at Acrisure Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN