Eagles vs. Spartans
Prediction, Odds & Props
Sep 06 | CFB AI Picks

Updated: 2025-08-30T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Boston College travels to East Lansing on September 6, 2025 for a high-profile ACC–Big Ten clash after routing Fordham 66–10 in their opener, powered by quarterback Dylan Lonergan’s four touchdown debut. Michigan State counters with a strong 23–6 win over Western Michigan, leaning on a physical defense and a balanced offense led by Aidan Chiles and running back Makhi Frazier.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 06, 2025

Start Time: 7:30 PM EST​

Venue: Spartan Stadium​

Spartans Record: (1-0)

Eagles Record: (1-0)

OPENING ODDS

BC Moneyline: +142

MICHST Moneyline: -170

BC Spread: +3.5

MICHST Spread: -3.5

Over/Under: 46

BC
Betting Trends

  • Boston College is 1–0 ATS after easily covering in their opener, as Lonergan threw for 268 yards and four scores while the Eagles’ defense added a pick-six to cap the blowout.

MICHST
Betting Trends

  • Michigan State is also 1–0 ATS, covering the spread with a 23–6 defensive showcase that held Western Michigan to minimal yardage while controlling tempo offensively.

MATCHUP TRENDS

  • Both teams are unbeaten ATS heading into this matchup, making this one of the more balanced lines on the Week 2 slate, with bettors split between Boston College’s explosive offense and Michigan State’s defensive physicality at home.

BC vs. MICHST
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Frazier under 62.5 Rushing Yards.

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Boston College vs Michigan State Prediction & Odds:
Free CFB Betting Insights for 9/6/25

The September 6 matchup between Boston College and Michigan State at Spartan Stadium has the makings of an early-season measuring stick for both programs, as each comes off dominant season-opening wins and now faces a step up in competition. Boston College looked explosive in its 66–10 rout of Fordham, led by quarterback Dylan Lonergan, whose 268-yard, four-touchdown performance energized the offense and confirmed why the Eagles view him as their answer at quarterback moving forward. His chemistry with receiver Lewis Bond, who racked up 138 yards and two scores, made the Eagles a dangerous aerial unit, while running back Turbo Richard provided balance on the ground. Defensively, Boston College forced turnovers, applied pressure, and even contributed directly to the scoreboard with a pick-six, showcasing a unit that may be underrated heading into ACC play. Michigan State, meanwhile, opened with a controlled 23–6 win over Western Michigan, the kind of performance that reinforced head coach Jonathan Smith’s vision of a team built on physicality, running the ball, and defense.

Quarterback Aidan Chiles made efficient throws to keep the chains moving, and running back Makhi Frazier’s 103-yard, one-touchdown effort highlighted the Spartans’ ground dominance. Defensively, Michigan State stifled the Broncos until a late defensive touchdown prevented the shutout, a testament to their depth and discipline in the front seven. Strategically, this game pits contrasting identities: Boston College will aim to spread the field, push tempo, and use Lonergan’s quick release to stretch Michigan State’s secondary, while the Spartans will look to control the line of scrimmage, establish the run, and rely on defensive pressure to disrupt rhythm. Special teams and hidden yardage could loom large in what may be a closer battle than either team’s opener suggested, particularly if turnovers swing momentum. From a betting perspective, both teams are 1–0 ATS, which makes this a line that could shift late depending on public sentiment, but ultimately the result will come down to which side imposes its style. If Boston College can hit explosive plays through the air and protect Lonergan, they have the weapons to challenge the Spartans on the road. But if Michigan State keeps control of tempo, wins in the trenches, and forces BC into uncomfortable down-and-distance scenarios, their physicality and home crowd should carry them to victory.

Boston College Eagles CFB Preview

Boston College enters its Week 2 trip to Michigan State flying high after a 66–10 thrashing of Fordham in which their offense looked unstoppable and their defense turned opportunistic plays into points, but the challenge in East Lansing will be proving that such dominance can translate against a tougher, Big Ten-caliber opponent. The breakout star of the opener was quarterback Dylan Lonergan, who threw for 268 yards and four touchdowns while showing poise and command in his first start, and his connection with wideout Lewis Bond, who finished with 11 receptions for 138 yards and two scores, immediately became the focal point of the passing attack. Running back Turbo Richard added balance with steady production on the ground, giving the Eagles an offense that can hurt defenses in multiple ways if given time and space. Defensively, Boston College forced Fordham into mistakes, capitalized with a pick-six, and controlled the line of scrimmage throughout, but the real test will come in trying to stop Michigan State’s ground game, led by Makhi Frazier and a physical offensive line that thrives on wearing down opponents.

The Eagles will need their defensive front to hold up against the run and avoid getting pushed around, while the secondary must be ready for play-action shots that could catch them off balance if they overcommit to the box. Offensively, the key will be protecting Lonergan against a Spartan pass rush that has the ability to collapse the pocket quickly; if he has time, he’s shown the accuracy and decision-making to exploit holes in coverage, but if pressured consistently, the risk of turnovers rises significantly. Special teams execution will also be crucial, as hidden yardage could prove decisive in what may be a lower-scoring, grind-it-out type of game compared to BC’s opener. From a betting perspective, Boston College is 1–0 ATS after covering with ease against Fordham, but their true test comes here, and oddsmakers have positioned them as narrow underdogs due to Michigan State’s home-field advantage and defensive strengths. For head coach Bill O’Brien, the mission is clear: keep the offense balanced, stay disciplined defensively, and avoid the types of mistakes that Spartan Stadium’s crowd thrives on magnifying. If the Eagles can replicate their Week 1 sharpness, sustain drives through Lonergan’s passing and Richard’s rushing, and prevent Michigan State from dictating tempo with their run game, they have a legitimate chance to notch a signature road win early in the season. A victory here would not only boost their national profile but also send a strong message that Boston College is prepared to compete at a higher level this year, making them a dangerous team in the ACC race.

Boston College travels to East Lansing on September 6, 2025 for a high-profile ACC–Big Ten clash after routing Fordham 66–10 in their opener, powered by quarterback Dylan Lonergan’s four touchdown debut. Michigan State counters with a strong 23–6 win over Western Michigan, leaning on a physical defense and a balanced offense led by Aidan Chiles and running back Makhi Frazier. Boston College vs Michigan State AI Prediction: Free CFB Betting Insights for Sep 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Michigan State Spartans CFB Preview

Michigan State comes into its Week 2 matchup against Boston College with the confidence of a 23–6 win over Western Michigan, a game that may not have been flashy but reflected the exact formula head coach Jonathan Smith wants to define Spartan football—efficiency on offense, dominance in the trenches, and suffocating defense. Quarterback Aidan Chiles managed the game well, making smart throws and avoiding mistakes while keeping the offense balanced, but the real star was running back Makhi Frazier, who rushed for 103 yards and a touchdown and consistently moved the chains against an overmatched Broncos defense. The offensive line did its job in creating lanes for the running game and giving Chiles enough time to work, though tougher tests are on the horizon, and Boston College’s defensive front will be a significant step up in speed and physicality. Defensively, the Spartans were as disciplined as ever, holding Western Michigan to minimal yardage, generating pressure in the backfield, and tackling efficiently in space, with the only blemish being a pick-six allowed late that spoiled what could have been a shutout. The front seven’s ability to control the line of scrimmage will be vital against a Boston College team that showed in Week 1 how dangerous its offense can be, particularly with Lonergan’s chemistry with Lewis Bond and the versatility of Turbo Richard.

For Michigan State, the defensive strategy will likely center around collapsing the pocket quickly, forcing Lonergan into rushed throws, and containing BC’s receivers after the catch. Special teams also played clean in the opener, and Smith will expect the same in what could be a tighter, more physical contest where field position matters. From a betting perspective, Michigan State is 1–0 ATS after handling business in Week 1, and at home they are viewed as a slight favorite thanks to the advantage of Spartan Stadium and a defense that should test BC’s offensive rhythm more than Fordham ever could. The keys to victory are clear: run the football with consistency, protect Chiles from unnecessary pressure, limit explosive plays defensively, and avoid turnovers that could swing momentum. If the Spartans accomplish these goals, they not only have an excellent chance to win but also to further validate their identity as a Big Ten program built to grind out wins against quality opponents. A victory over Boston College would reinforce Smith’s blueprint for success, give the Spartans momentum heading into conference play, and serve as a reminder that while they may not win with flash, they can beat opponents with toughness, efficiency, and control.

Boston College vs. Michigan State Prop Picks (AI)

Remi is pouring through tons of datapoints on each team. In fact, anytime the Eagles and Spartans play there’s always several intriguing observations to key in on. Not to mention games played at Spartan Stadium in Sep can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: M. Frazier under 62.5 Rushing Yards.

Boston College vs. Michigan State Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every simulation between the Eagles and Spartans and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the growing weight emotional bettors tend to put on player performance factors between a Eagles team going up against a possibly improved Spartans team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Boston College vs Michigan State picks, computer picks Eagles vs Spartans, best bets, model edges, confidence ratings.

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Eagles Betting Trends

Boston College is 1–0 ATS after easily covering in their opener, as Lonergan threw for 268 yards and four scores while the Eagles’ defense added a pick-six to cap the blowout.

Spartans Betting Trends

Michigan State is also 1–0 ATS, covering the spread with a 23–6 defensive showcase that held Western Michigan to minimal yardage while controlling tempo offensively.

Eagles vs. Spartans Matchup Trends

Both teams are unbeaten ATS heading into this matchup, making this one of the more balanced lines on the Week 2 slate, with bettors split between Boston College’s explosive offense and Michigan State’s defensive physicality at home.

Boston College vs. Michigan State Game Info

Boston College vs Michigan State starts on September 06, 2025 at 7:30 PM EST.

Spread: Michigan State -3.5
Moneyline: Boston College +142, Michigan State -170
Over/Under: 46

Boston College: (1-0)  |  Michigan State: (1-0)

Remi's searched hard and found the best prop for this matchup: M. Frazier under 62.5 Rushing Yards.. Prices move—always shop for the best number.

Both teams are unbeaten ATS heading into this matchup, making this one of the more balanced lines on the Week 2 slate, with bettors split between Boston College’s explosive offense and Michigan State’s defensive physicality at home.

BC trend: Boston College is 1–0 ATS after easily covering in their opener, as Lonergan threw for 268 yards and four scores while the Eagles’ defense added a pick-six to cap the blowout.

MICHST trend: Michigan State is also 1–0 ATS, covering the spread with a 23–6 defensive showcase that held Western Michigan to minimal yardage while controlling tempo offensively.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Boston College vs. Michigan State Odds

AI algorithm Remi is pouring through tons of data points on each team. In fact, anytime the Boston College vs Michigan State trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable betting trends.

Boston College vs Michigan State Opening Odds

BC Moneyline: +142
MICHST Moneyline: -170
BC Spread: +3.5
MICHST Spread: -3.5
Over/Under: 46

Boston College vs Michigan State Live Odds

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NC State Wolfpack
10/4/25 1PM
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Oct 4, 2025 1:00PM EDT
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10/4/25 3:30PM
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10/4/25 3:30PM
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Boise State Broncos
Notre Dame Fighting Irish
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Oregon State Beavers
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10/4/25 3:30PM
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FIU Panthers
UConn Huskies
10/4/25 3:30PM
FIU
UCONN
 
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Penn State Nittany Lions
UCLA Bruins
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UCLA
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Oct 4, 2025 4:00PM EDT
Kent State Golden Flashes
Oklahoma Sooners
10/4/25 4PM
KENT
OKLA
 
 
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Oct 4, 2025 4:00PM EDT
Michigan State Spartans
Nebraska Cornhuskers
10/4/25 4PM
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-450
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Arkansas State Red Wolves
10/4/25 4PM
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Mississippi State Bulldogs
Texas A&M Aggies
10/4/25 7:30PM
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TEXAM
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Oct 4, 2025 7:30PM EDT
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10/4/25 7:30PM
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Oct 4, 2025 8:00PM EDT
Tulsa Golden Hurricane
Memphis Tigers
10/4/25 8PM
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Oct 4, 2025 9:30PM EDT
Duke Blue Devils
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10/4/25 9:30PM
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Fresno State Bulldogs
10/4/25 10:30PM
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Oct 9, 2025 7:30PM EDT
East Carolina Pirates
Tulane Green Wave
10/9/25 7:30PM
ECAR
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South Florida Bulls
North Texas Mean Green
10/10/25 7:30PM
SFLA
NOTEX
 
 
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Oct 11, 2025 12:00PM EDT
Florida Gators
Texas A&M Aggies
10/11/25 12PM
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Alabama Crimson Tide
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10/11/25 12PM
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Ohio State Buckeyes
Illinois Fighting Illini
10/11/25 12PM
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-780
+530
-15.5 (-110)
+15.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 11, 2025 12:45PM EDT
Georgia Bulldogs
Auburn Tigers
10/11/25 12:45PM
UGA
AUBURN
-172
+142
-3.5 (-114)
+3.5 (-106)
O 47.5 (-110)
U 47.5 (-110)
Oct 11, 2025 3:30PM EDT
Indiana Hoosiers
Oregon Ducks
10/11/25 3:30PM
IND
OREG
+300
-385
+10.5 (-112)
-10.5 (-108)
O 52.5 (-110)
U 52.5 (-110)
Oct 11, 2025 3:30PM EDT
Oklahoma Sooners
Texas Longhorns
10/11/25 3:30PM
OKLA
TEXAS
 
 
+3.5 (-110)
-3.5 (-110)
Oct 11, 2025 4:15PM EDT
Arkansas Razorbacks
Tennessee Volunteers
10/11/25 4:15PM
ARK
TENN
+350
-465
+12.5 (-110)
-12.5 (-110)
O 67.5 (-110)
U 67.5 (-110)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston College Eagles vs. Michigan State Spartans on September 06, 2025 at Spartan Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN
UNC@UCF UCF -6.5 54.4% 4 WIN
ARKST@KENSAW KENSAW +4.5 54.5% 4 WIN
ILL@IND IND -6 53.2% 3 WIN
SELOU@LSU LSU -47.5 55.3% 5 LOSS
TNMART@MIZZST MIZZST -14.5 56.2% 6 WIN
FRESNO@HAWAII HAWAII +3 56.6% 6 WIN
MRSHL@MTSU MTSU +2.5 56.8% 6 LOSS
MICH@NEB NEB +1.5 57.3% 7 LOSS
WASH@WASHST DENZEL BOSTON UNDER 69.5 RECV YDS 56.2% 6 LOSS
IOWA@RUT ANTWAN RAYMOND OVER 0.5 TOUCHDOWNS 54.4% 4 WIN
GEORGIA@TENN UNDER 50.5 55.5% 6 LOSS
ARK@OLEMISS MISS -225 72.0% 9 WIN
DUKE@TULANE TULANE -120 56.5% 4 WIN
ARK@OLEMISS MISS -6.5 53.9% 3 LOSS
AKRON@UAB UAB -11 54.7% 4 LOSS
UCONN@DEL DEL +9.5 55.0% 5 WIN
APLST@USM USM +4 55.3% 6 WIN
MERIMK@KENSAW KENSAW -13.5 56.2% 7 WIN
UMASS@IOWA IOWA -34.5 56.4% 7 WIN
UMASS@IOWA JAZIUN PATTERSON UNDER 0.5 RUSH TDS 54.8% 4 WIN
NMEX@UCLA NICO IAMALEAVA UNDER 31.5 PASS ATT 53.4% 3 LOSS
KSTATE@ARIZ ARIZ +1.5 56.1% 6 WIN
BC@MICHST NICK MARSH OVER 47.5 RCV YDS 53.6% 3 WIN
ARIZST@MISSST MISSST +7 54.2% 4 WIN
TULSA@NMEXST NMEXST +3.5 56.9% 6 WIN
UCLA@UNLV OVER 54.5 56.2% 6 LOSS
FRESNO@OREGST FRESNO +1.5 54.7% 4 WIN
VANDY@VATECH VANDY +2.5 55.8% 5 WIN
JMAD@LVILLE LVILLE -14.5 54.0% 3 LOSS
TCU@UNC JOSEPH MANJACK OVER 37.5 RECV YDS 53.8% 3 LOSS
ND@MIAMI MIAMI +3 55.2% 6 WIN
MISSST@USM USM +14.5 56.0% 6 LOSS
UTAH@UCLA UCLA +5.5 56.2% 6 LOSS
CAL@OREGST OREGST +1.5 55.1% 5 LOSS
FAU@MD MD -13.5 55.2% 5 WIN
GAS@FRESNO FRESNO +2 55.2% 5 WIN
TOLEDO@UK UK -9.5 56.2% 6 LOSS
AUSTPEAY@MTSU PEAY +12.5 56.2% 6 WIN