Boston College vs Michigan State Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 06)

Updated: 2025-08-30T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Boston College travels to East Lansing on September 6, 2025 for a high-profile ACC–Big Ten clash after routing Fordham 66–10 in their opener, powered by quarterback Dylan Lonergan’s four touchdown debut. Michigan State counters with a strong 23–6 win over Western Michigan, leaning on a physical defense and a balanced offense led by Aidan Chiles and running back Makhi Frazier.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 06, 2025

Start Time: 7:30 PM EST​

Venue: Spartan Stadium​

Spartans Record: (1-0)

Eagles Record: (1-0)

OPENING ODDS

BC Moneyline: +142

MICHST Moneyline: -170

BC Spread: +3.5

MICHST Spread: -3.5

Over/Under: 46

BC
Betting Trends

  • Boston College is 1–0 ATS after easily covering in their opener, as Lonergan threw for 268 yards and four scores while the Eagles’ defense added a pick-six to cap the blowout.

MICHST
Betting Trends

  • Michigan State is also 1–0 ATS, covering the spread with a 23–6 defensive showcase that held Western Michigan to minimal yardage while controlling tempo offensively.

MATCHUP TRENDS

  • Both teams are unbeaten ATS heading into this matchup, making this one of the more balanced lines on the Week 2 slate, with bettors split between Boston College’s explosive offense and Michigan State’s defensive physicality at home.

BC vs. MICHST
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Frazier under 62.5 Rushing Yards.

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Boston College vs Michigan State Prediction & Odds:
Free CFB Betting Insights for 9/6/25

The September 6 matchup between Boston College and Michigan State at Spartan Stadium has the makings of an early-season measuring stick for both programs, as each comes off dominant season-opening wins and now faces a step up in competition. Boston College looked explosive in its 66–10 rout of Fordham, led by quarterback Dylan Lonergan, whose 268-yard, four-touchdown performance energized the offense and confirmed why the Eagles view him as their answer at quarterback moving forward. His chemistry with receiver Lewis Bond, who racked up 138 yards and two scores, made the Eagles a dangerous aerial unit, while running back Turbo Richard provided balance on the ground. Defensively, Boston College forced turnovers, applied pressure, and even contributed directly to the scoreboard with a pick-six, showcasing a unit that may be underrated heading into ACC play. Michigan State, meanwhile, opened with a controlled 23–6 win over Western Michigan, the kind of performance that reinforced head coach Jonathan Smith’s vision of a team built on physicality, running the ball, and defense.

Quarterback Aidan Chiles made efficient throws to keep the chains moving, and running back Makhi Frazier’s 103-yard, one-touchdown effort highlighted the Spartans’ ground dominance. Defensively, Michigan State stifled the Broncos until a late defensive touchdown prevented the shutout, a testament to their depth and discipline in the front seven. Strategically, this game pits contrasting identities: Boston College will aim to spread the field, push tempo, and use Lonergan’s quick release to stretch Michigan State’s secondary, while the Spartans will look to control the line of scrimmage, establish the run, and rely on defensive pressure to disrupt rhythm. Special teams and hidden yardage could loom large in what may be a closer battle than either team’s opener suggested, particularly if turnovers swing momentum. From a betting perspective, both teams are 1–0 ATS, which makes this a line that could shift late depending on public sentiment, but ultimately the result will come down to which side imposes its style. If Boston College can hit explosive plays through the air and protect Lonergan, they have the weapons to challenge the Spartans on the road. But if Michigan State keeps control of tempo, wins in the trenches, and forces BC into uncomfortable down-and-distance scenarios, their physicality and home crowd should carry them to victory.

Get live CFB odds and precise AI CFB picks, predictions, and cover probabilities.

Boston College Eagles CFB Preview

Boston College enters its Week 2 trip to Michigan State flying high after a 66–10 thrashing of Fordham in which their offense looked unstoppable and their defense turned opportunistic plays into points, but the challenge in East Lansing will be proving that such dominance can translate against a tougher, Big Ten-caliber opponent. The breakout star of the opener was quarterback Dylan Lonergan, who threw for 268 yards and four touchdowns while showing poise and command in his first start, and his connection with wideout Lewis Bond, who finished with 11 receptions for 138 yards and two scores, immediately became the focal point of the passing attack. Running back Turbo Richard added balance with steady production on the ground, giving the Eagles an offense that can hurt defenses in multiple ways if given time and space. Defensively, Boston College forced Fordham into mistakes, capitalized with a pick-six, and controlled the line of scrimmage throughout, but the real test will come in trying to stop Michigan State’s ground game, led by Makhi Frazier and a physical offensive line that thrives on wearing down opponents.

The Eagles will need their defensive front to hold up against the run and avoid getting pushed around, while the secondary must be ready for play-action shots that could catch them off balance if they overcommit to the box. Offensively, the key will be protecting Lonergan against a Spartan pass rush that has the ability to collapse the pocket quickly; if he has time, he’s shown the accuracy and decision-making to exploit holes in coverage, but if pressured consistently, the risk of turnovers rises significantly. Special teams execution will also be crucial, as hidden yardage could prove decisive in what may be a lower-scoring, grind-it-out type of game compared to BC’s opener. From a betting perspective, Boston College is 1–0 ATS after covering with ease against Fordham, but their true test comes here, and oddsmakers have positioned them as narrow underdogs due to Michigan State’s home-field advantage and defensive strengths. For head coach Bill O’Brien, the mission is clear: keep the offense balanced, stay disciplined defensively, and avoid the types of mistakes that Spartan Stadium’s crowd thrives on magnifying. If the Eagles can replicate their Week 1 sharpness, sustain drives through Lonergan’s passing and Richard’s rushing, and prevent Michigan State from dictating tempo with their run game, they have a legitimate chance to notch a signature road win early in the season. A victory here would not only boost their national profile but also send a strong message that Boston College is prepared to compete at a higher level this year, making them a dangerous team in the ACC race.

Boston College travels to East Lansing on September 6, 2025 for a high-profile ACC–Big Ten clash after routing Fordham 66–10 in their opener, powered by quarterback Dylan Lonergan’s four touchdown debut. Michigan State counters with a strong 23–6 win over Western Michigan, leaning on a physical defense and a balanced offense led by Aidan Chiles and running back Makhi Frazier. Boston College vs Michigan State AI Prediction: Free CFB Betting Insights for Sep 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Michigan State Spartans CFB Preview

Michigan State comes into its Week 2 matchup against Boston College with the confidence of a 23–6 win over Western Michigan, a game that may not have been flashy but reflected the exact formula head coach Jonathan Smith wants to define Spartan football—efficiency on offense, dominance in the trenches, and suffocating defense. Quarterback Aidan Chiles managed the game well, making smart throws and avoiding mistakes while keeping the offense balanced, but the real star was running back Makhi Frazier, who rushed for 103 yards and a touchdown and consistently moved the chains against an overmatched Broncos defense. The offensive line did its job in creating lanes for the running game and giving Chiles enough time to work, though tougher tests are on the horizon, and Boston College’s defensive front will be a significant step up in speed and physicality. Defensively, the Spartans were as disciplined as ever, holding Western Michigan to minimal yardage, generating pressure in the backfield, and tackling efficiently in space, with the only blemish being a pick-six allowed late that spoiled what could have been a shutout. The front seven’s ability to control the line of scrimmage will be vital against a Boston College team that showed in Week 1 how dangerous its offense can be, particularly with Lonergan’s chemistry with Lewis Bond and the versatility of Turbo Richard.

For Michigan State, the defensive strategy will likely center around collapsing the pocket quickly, forcing Lonergan into rushed throws, and containing BC’s receivers after the catch. Special teams also played clean in the opener, and Smith will expect the same in what could be a tighter, more physical contest where field position matters. From a betting perspective, Michigan State is 1–0 ATS after handling business in Week 1, and at home they are viewed as a slight favorite thanks to the advantage of Spartan Stadium and a defense that should test BC’s offensive rhythm more than Fordham ever could. The keys to victory are clear: run the football with consistency, protect Chiles from unnecessary pressure, limit explosive plays defensively, and avoid turnovers that could swing momentum. If the Spartans accomplish these goals, they not only have an excellent chance to win but also to further validate their identity as a Big Ten program built to grind out wins against quality opponents. A victory over Boston College would reinforce Smith’s blueprint for success, give the Spartans momentum heading into conference play, and serve as a reminder that while they may not win with flash, they can beat opponents with toughness, efficiency, and control.

Boston College vs Michigan State Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each team. In fact, anytime the Eagles and Spartans play there’s always several intriguing trends to key in on. Not to mention games played at Spartan Stadium in Sep rarely follow normal, predictable patterns.

Remi's searched hard and found the best prop for this matchup: M. Frazier under 62.5 Rushing Yards.

Boston College vs Michigan State Prediction (AI)

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Remi, our AI sports wizard, has been pouring over millions of data from every simulation between the Eagles and Spartans and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most watching on the linear correlation of weight human bettors regularly put on Michigan State’s strength factors between a Eagles team going up against a possibly strong Spartans team. It appears the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Boston College vs Michigan State picks, computer picks Eagles vs Spartans, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 12/5 NOTEX@TULANE UNLOCK THIS PICK 7 VAULT v4 Locked VAULT v4
CFB 12/5 UNLV@BOISE UNLOCK THIS PICK 6 VAULT v2 Locked VAULT v2
CFB 12/5 NOTEX@TULANE UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.

Boston College Betting Trends

Boston College is 1–0 ATS after easily covering in their opener, as Lonergan threw for 268 yards and four scores while the Eagles’ defense added a pick-six to cap the blowout.

Michigan State Betting Trends

Michigan State is also 1–0 ATS, covering the spread with a 23–6 defensive showcase that held Western Michigan to minimal yardage while controlling tempo offensively.

Eagles vs. Spartans Matchup Trends

Both teams are unbeaten ATS heading into this matchup, making this one of the more balanced lines on the Week 2 slate, with bettors split between Boston College’s explosive offense and Michigan State’s defensive physicality at home.

Boston College vs. Michigan State Game Info

September 06, 2025 • 7:30 PM EST • Spartan Stadium

Boston College vs. Michigan State Odds

AI algorithm Remi is pouring through mountains of data points on each line. In fact, anytime the Boston College vs Michigan State trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

Boston College vs Michigan State

Boston College vs Michigan State Live Odds

Games PTS ML SPR O/U
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
+1256
-3000
+24 (-105)
-24 (-115)
O 47 (-106)
U 47 (-114)
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
-150
+130
-3 (-110)
+3 (-110)
O 62 (-110)
U 62 (-110)
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
-125
+105
-1.5 (-110)
+1.5 (-110)
O 67 (-115)
U 67 (-105)
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
+191
-228
+6 (-110)
-6 (-110)
O 59.5 (-114)
U 59.5 (-106)
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
 
-125
 
-2 (-110)
O 43.5 (-110)
U 43.5 (-110)
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
+383
-500
+12.5 (-114)
-12.5 (-106)
O 49 (-110)
U 49 (-110)
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
-125
+105
-2 (-110)
+2 (-110)
O 48 (-110)
U 48 (-110)
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
+155
-190
+4 (-110)
-4 (-110)
O 57.5 (-110)
U 57.5 (-110)
Dec 6, 2025 8:00PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8PM
IND
OHIOST
+168
-193
+4 (-110)
-4 (-110)
O 47 (-110)
U 47 (-110)
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
+177
-205
+5 (-110)
-5 (-110)
O 38.5 (-110)
U 38.5 (-110)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston College Eagles vs. Michigan State Spartans on September 06, 2025 at Spartan Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

LEAN %WIN UNITS RESULT
COLO@KSTATE COLO +17.5 54.0% 4 WIN
PSU@RUT RUT +14 52.8% 1 WIN
OHIOST@MICH MICH +10.5 56.4% 6 LOSS
VATECH@UVA VATECH +8 57.8% 7 LOSS
NWEST@ILL LUKE ALTMYER UNDER 19.5 PASS COMP 54.3% 4 WIN
ORE@WAS DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS 55.2% 5 WIN
MIAMI@VATECH VATECH +18.5 54.2% 4 WIN
GAST@TROY TROY -9.5 55.7% 5 WIN
DEL@WAKE DEL +18 56.7% 6 LOSS
NMEX@AF NMEX -3.5 56.1% 5 WIN
WASHST@JMAD WASHST +14.5 55.3% 5 WIN
ILL@WISC WISC +9 55.1% 5 WIN
WKY@LSU WKY +23.5 56.3% 6 WIN
WASH@UCLA DEMOND WILLIAMS UNDER 27.5 PASS ATT 56.3% 6 WIN
TCU@HOU AMARE THOMAS OVER 69.5 RECV YDS 55.2% 5 WIN
TEX@UGA NATE FRAZIER UNDER 65.5 RUSH + REC YDS 55.5% 5 WIN
PUR@WASH ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS 54.1% 4 WIN
OKLA@BAMA UNDER 46 52.4% 2 WIN
UVA@DUKE DUKE -3.5 54.7% 3 LOSS
OKLA@BAMA BAMA -6 54.5% 3 LOSS
OREGST@TULSA OREGST -120 55.6% 5 LOSS
UTEP@MIZZST MIZZST -5 54.3% 4 WIN
COLOST@NMEX NMEX -14 57.1% 6 LOSS
PSU@MICHST MICHST +7.5 56.5% 6 LOSS
MISSST@MIZZOU MISSST +7.5 57.2% 7 LOSS
FAU@TULANE FAU +17.5 56.0% 6 WIN
NCST@MIAMI NCST +15.5 57.1% 7 LOSS
KENTST@AKRON AKRON -6.5 55.4% 5 LOSS
JAXST@UTEP JAXST -105 57.0% 7 WIN
FSU@CLEM CLEM -118 57.1% 5 WIN
UNLV@COLOST UNLV -4 55.2% 5 WIN
OREG@IOWA IOWA +6.5 53.3% 2 WIN
NEB@UCLA NEB +1.5 55.8% 5 WIN
KENSAW@NMEXST NMEXST +10 56.5% 6 WIN
STNFRD@UNC STNFRD +7.5 53.8% 3 WIN
DUKE@UCONN UCONN +8.5 57.9% 7 WIN
NEVADA@UTAHST NEVADA +9.5 55.9% 5 LOSS
SAMST@OREGST SAMST +21 57.7% 7 WIN
NEB@UCLA NICO IAMALEAVA UNDER 180.5 PASS YDS 56.6% 6 LOSS
HOU@UCF HOU -112 58.0% 6 WIN
GASTHRN@APPST GASTHRN +180 36.5% 2 WIN
KENTST@BALLST BALLST -2.5 54.5% 4 WIN
WAKE@FSU WAKE +10.5 56.4% 6 LOSS
WYO@SDGST SDGST -10.5 56.7% 7 WIN
OKLA@TENN TENN -130 58.3% 5 LOSS
GATECH@NCST GATECH -5 56.4% 6 LOSS
MIAMI@SMU MIAMI -10 54.3% 4 LOSS
IND@MD MD +21.5 54.6% 4 LOSS
CINCY@UTAH CINCY +11 57.6% 7 LOSS
OLDDOM@LAMON LAMON +17 58.4% 8 LOSS
VANDY@TEXAS OVER 46.5 53.7% 2 WIN