Boston College vs Michigan State Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 06)

Updated: 2025-08-30T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Boston College travels to East Lansing on September 6, 2025 for a high-profile ACC–Big Ten clash after routing Fordham 66–10 in their opener, powered by quarterback Dylan Lonergan’s four touchdown debut. Michigan State counters with a strong 23–6 win over Western Michigan, leaning on a physical defense and a balanced offense led by Aidan Chiles and running back Makhi Frazier.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 06, 2025

Start Time: 7:30 PM EST​

Venue: Spartan Stadium​

Spartans Record: (1-0)

Eagles Record: (1-0)

OPENING ODDS

BC Moneyline: +142

MICHST Moneyline: -170

BC Spread: +3.5

MICHST Spread: -3.5

Over/Under: 46

BC
Betting Trends

  • Boston College is 1–0 ATS after easily covering in their opener, as Lonergan threw for 268 yards and four scores while the Eagles’ defense added a pick-six to cap the blowout.

MICHST
Betting Trends

  • Michigan State is also 1–0 ATS, covering the spread with a 23–6 defensive showcase that held Western Michigan to minimal yardage while controlling tempo offensively.

MATCHUP TRENDS

  • Both teams are unbeaten ATS heading into this matchup, making this one of the more balanced lines on the Week 2 slate, with bettors split between Boston College’s explosive offense and Michigan State’s defensive physicality at home.

BC vs. MICHST
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Frazier under 62.5 Rushing Yards.

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Boston College vs Michigan State Prediction & Odds:
Free CFB Betting Insights for 9/6/25

The September 6 matchup between Boston College and Michigan State at Spartan Stadium has the makings of an early-season measuring stick for both programs, as each comes off dominant season-opening wins and now faces a step up in competition. Boston College looked explosive in its 66–10 rout of Fordham, led by quarterback Dylan Lonergan, whose 268-yard, four-touchdown performance energized the offense and confirmed why the Eagles view him as their answer at quarterback moving forward. His chemistry with receiver Lewis Bond, who racked up 138 yards and two scores, made the Eagles a dangerous aerial unit, while running back Turbo Richard provided balance on the ground. Defensively, Boston College forced turnovers, applied pressure, and even contributed directly to the scoreboard with a pick-six, showcasing a unit that may be underrated heading into ACC play. Michigan State, meanwhile, opened with a controlled 23–6 win over Western Michigan, the kind of performance that reinforced head coach Jonathan Smith’s vision of a team built on physicality, running the ball, and defense.

Quarterback Aidan Chiles made efficient throws to keep the chains moving, and running back Makhi Frazier’s 103-yard, one-touchdown effort highlighted the Spartans’ ground dominance. Defensively, Michigan State stifled the Broncos until a late defensive touchdown prevented the shutout, a testament to their depth and discipline in the front seven. Strategically, this game pits contrasting identities: Boston College will aim to spread the field, push tempo, and use Lonergan’s quick release to stretch Michigan State’s secondary, while the Spartans will look to control the line of scrimmage, establish the run, and rely on defensive pressure to disrupt rhythm. Special teams and hidden yardage could loom large in what may be a closer battle than either team’s opener suggested, particularly if turnovers swing momentum. From a betting perspective, both teams are 1–0 ATS, which makes this a line that could shift late depending on public sentiment, but ultimately the result will come down to which side imposes its style. If Boston College can hit explosive plays through the air and protect Lonergan, they have the weapons to challenge the Spartans on the road. But if Michigan State keeps control of tempo, wins in the trenches, and forces BC into uncomfortable down-and-distance scenarios, their physicality and home crowd should carry them to victory.

Boston College Eagles CFB Preview

Boston College enters its Week 2 trip to Michigan State flying high after a 66–10 thrashing of Fordham in which their offense looked unstoppable and their defense turned opportunistic plays into points, but the challenge in East Lansing will be proving that such dominance can translate against a tougher, Big Ten-caliber opponent. The breakout star of the opener was quarterback Dylan Lonergan, who threw for 268 yards and four touchdowns while showing poise and command in his first start, and his connection with wideout Lewis Bond, who finished with 11 receptions for 138 yards and two scores, immediately became the focal point of the passing attack. Running back Turbo Richard added balance with steady production on the ground, giving the Eagles an offense that can hurt defenses in multiple ways if given time and space. Defensively, Boston College forced Fordham into mistakes, capitalized with a pick-six, and controlled the line of scrimmage throughout, but the real test will come in trying to stop Michigan State’s ground game, led by Makhi Frazier and a physical offensive line that thrives on wearing down opponents.

The Eagles will need their defensive front to hold up against the run and avoid getting pushed around, while the secondary must be ready for play-action shots that could catch them off balance if they overcommit to the box. Offensively, the key will be protecting Lonergan against a Spartan pass rush that has the ability to collapse the pocket quickly; if he has time, he’s shown the accuracy and decision-making to exploit holes in coverage, but if pressured consistently, the risk of turnovers rises significantly. Special teams execution will also be crucial, as hidden yardage could prove decisive in what may be a lower-scoring, grind-it-out type of game compared to BC’s opener. From a betting perspective, Boston College is 1–0 ATS after covering with ease against Fordham, but their true test comes here, and oddsmakers have positioned them as narrow underdogs due to Michigan State’s home-field advantage and defensive strengths. For head coach Bill O’Brien, the mission is clear: keep the offense balanced, stay disciplined defensively, and avoid the types of mistakes that Spartan Stadium’s crowd thrives on magnifying. If the Eagles can replicate their Week 1 sharpness, sustain drives through Lonergan’s passing and Richard’s rushing, and prevent Michigan State from dictating tempo with their run game, they have a legitimate chance to notch a signature road win early in the season. A victory here would not only boost their national profile but also send a strong message that Boston College is prepared to compete at a higher level this year, making them a dangerous team in the ACC race.

Boston College travels to East Lansing on September 6, 2025 for a high-profile ACC–Big Ten clash after routing Fordham 66–10 in their opener, powered by quarterback Dylan Lonergan’s four touchdown debut. Michigan State counters with a strong 23–6 win over Western Michigan, leaning on a physical defense and a balanced offense led by Aidan Chiles and running back Makhi Frazier. Boston College vs Michigan State AI Prediction: Free CFB Betting Insights for Sep 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Michigan State Spartans CFB Preview

Michigan State comes into its Week 2 matchup against Boston College with the confidence of a 23–6 win over Western Michigan, a game that may not have been flashy but reflected the exact formula head coach Jonathan Smith wants to define Spartan football—efficiency on offense, dominance in the trenches, and suffocating defense. Quarterback Aidan Chiles managed the game well, making smart throws and avoiding mistakes while keeping the offense balanced, but the real star was running back Makhi Frazier, who rushed for 103 yards and a touchdown and consistently moved the chains against an overmatched Broncos defense. The offensive line did its job in creating lanes for the running game and giving Chiles enough time to work, though tougher tests are on the horizon, and Boston College’s defensive front will be a significant step up in speed and physicality. Defensively, the Spartans were as disciplined as ever, holding Western Michigan to minimal yardage, generating pressure in the backfield, and tackling efficiently in space, with the only blemish being a pick-six allowed late that spoiled what could have been a shutout. The front seven’s ability to control the line of scrimmage will be vital against a Boston College team that showed in Week 1 how dangerous its offense can be, particularly with Lonergan’s chemistry with Lewis Bond and the versatility of Turbo Richard.

For Michigan State, the defensive strategy will likely center around collapsing the pocket quickly, forcing Lonergan into rushed throws, and containing BC’s receivers after the catch. Special teams also played clean in the opener, and Smith will expect the same in what could be a tighter, more physical contest where field position matters. From a betting perspective, Michigan State is 1–0 ATS after handling business in Week 1, and at home they are viewed as a slight favorite thanks to the advantage of Spartan Stadium and a defense that should test BC’s offensive rhythm more than Fordham ever could. The keys to victory are clear: run the football with consistency, protect Chiles from unnecessary pressure, limit explosive plays defensively, and avoid turnovers that could swing momentum. If the Spartans accomplish these goals, they not only have an excellent chance to win but also to further validate their identity as a Big Ten program built to grind out wins against quality opponents. A victory over Boston College would reinforce Smith’s blueprint for success, give the Spartans momentum heading into conference play, and serve as a reminder that while they may not win with flash, they can beat opponents with toughness, efficiency, and control.

Boston College vs. Michigan State Prop Picks (AI)

Remi is pouring through tons of stats on each player. In fact, anytime the Eagles and Spartans play there’s always several intriguing angles to key in on. Not to mention games played at Spartan Stadium in Sep can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: M. Frazier under 62.5 Rushing Yards.

Boston College vs. Michigan State Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every angle between the Eagles and Spartans and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Remi has been most keyed in on the linear correlation of emphasis human bettors often put on Boston College’s strength factors between a Eagles team going up against a possibly strong Spartans team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Boston College vs Michigan State picks, computer picks Eagles vs Spartans, best bets, model edges, confidence ratings.

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Eagles Betting Trends

Boston College is 1–0 ATS after easily covering in their opener, as Lonergan threw for 268 yards and four scores while the Eagles’ defense added a pick-six to cap the blowout.

Spartans Betting Trends

Michigan State is also 1–0 ATS, covering the spread with a 23–6 defensive showcase that held Western Michigan to minimal yardage while controlling tempo offensively.

Eagles vs. Spartans Matchup Trends

Both teams are unbeaten ATS heading into this matchup, making this one of the more balanced lines on the Week 2 slate, with bettors split between Boston College’s explosive offense and Michigan State’s defensive physicality at home.

Boston College vs. Michigan State Game Info

Boston College vs Michigan State starts on September 06, 2025 at 7:30 PM EST.

Spread: Michigan State -3.5
Moneyline: Boston College +142, Michigan State -170
Over/Under: 46

Boston College: (1-0)  |  Michigan State: (1-0)

Remi's searched hard and found the best prop for this matchup: M. Frazier under 62.5 Rushing Yards.. Prices move—always shop for the best number.

Both teams are unbeaten ATS heading into this matchup, making this one of the more balanced lines on the Week 2 slate, with bettors split between Boston College’s explosive offense and Michigan State’s defensive physicality at home.

BC trend: Boston College is 1–0 ATS after easily covering in their opener, as Lonergan threw for 268 yards and four scores while the Eagles’ defense added a pick-six to cap the blowout.

MICHST trend: Michigan State is also 1–0 ATS, covering the spread with a 23–6 defensive showcase that held Western Michigan to minimal yardage while controlling tempo offensively.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Boston College vs. Michigan State Odds

AI algorithm Remi is pouring through tons of data points on each team. In fact, anytime the Boston College vs Michigan State trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.

Boston College vs Michigan State Opening Odds

BC Moneyline: +142
MICHST Moneyline: -170
BC Spread: +3.5
MICHST Spread: -3.5
Over/Under: 46

Boston College vs Michigan State Live Odds

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Nov 11, 2025 7:30PM EST
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11/11/25 8PM
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11/12/25 7PM
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Nov 13, 2025 7:30PM EST
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11/14/25 7:30PM
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11/14/25 9PM
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Nov 15, 2025 12:00PM EST
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11/15/25 12PM
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Northwestern Wildcats
11/15/25 12PM
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Nov 15, 2025 12:00PM EST
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11/15/25 12PM
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11/15/25 12PM
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11/15/25 12PM
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11/15/25 12PM
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Nov 15, 2025 12:00PM EST
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Pittsburgh Panthers
11/15/25 12PM
ND
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Nov 15, 2025 12:00PM EST
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Texas A&M Aggies
11/15/25 12PM
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Nov 15, 2025 12:00PM EST
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Indiana Hoosiers
11/15/25 12PM
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IND
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Nov 15, 2025 12:00PM EST
Kansas State Wildcats
Oklahoma State Cowboys
11/15/25 12PM
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Nov 15, 2025 12:45PM EST
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LSU Tigers
11/15/25 12:45PM
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Nov 15, 2025 1:00PM EST
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Tulsa Golden Hurricane
11/15/25 1PM
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Nov 15, 2025 1:00PM EST
West Virginia Mountaineers
Arizona State Sun Devils
11/15/25 1PM
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Nov 15, 2025 1:30PM EST
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Kentucky Wildcats
11/15/25 1:30PM
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UK
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Nov 15, 2025 2:00PM EST
Marshall Thundering Herd
Georgia State Panthers
11/15/25 2PM
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11/15/25 2PM
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Nov 15, 2025 3:00PM EST
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Missouri State Bears
11/15/25 3PM
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New Mexico Lobos
11/15/25 3PM
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San Jose State Spartans
Nevada Wolf Pack
11/15/25 3:30PM
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UL Monroe Warhawks
11/15/25 3:30PM
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Nov 15, 2025 3:30PM EST
UCF Knights
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11/15/25 3:30PM
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11/15/25 3:30PM
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11/15/25 3:30PM
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11/15/25 3:30PM
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Penn State Nittany Lions
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11/15/25 3:30PM
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MTSU Blue Raiders
Western Kentucky Hilltoppers
11/15/25 3:30PM
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WKY
 
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Duke Blue Devils
11/15/25 3:30PM
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App State Mountaineers
James Madison Dukes
11/15/25 3:30PM
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USM Golden Eagles
11/15/25 3:30PM
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Tulane Green Wave
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Memphis Tigers
East Carolina Pirates
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ECAR
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Tennessee Volunteers
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Nov 15, 2025 5:00PM EST
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FIU Panthers
11/15/25 5PM
LIB
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Coastal Carolina Chanticleers
Georgia Southern Eagles
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Utah State Aggies
UNLV Rebels
11/15/25 7PM
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Nov 15, 2025 7:00PM EST
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Ole Miss Rebels
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Delaware Blue Hens
Sam Houston State Bearkats
11/15/25 7PM
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Baylor Bears
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Purdue Boilermakers
Washington Huskies
11/15/25 7PM
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Nov 15, 2025 7:30PM EST
Virginia Tech Hokies
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11/15/25 7:30PM
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UCLA Bruins
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11/15/25 7:30PM
UCLA
OHIOST
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Mississippi State Bulldogs
Missouri Tigers
11/15/25 7:45PM
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Nov 15, 2025 8:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
11/15/25 8PM
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O 54 (-109)
U 54 (-110)
Nov 15, 2025 10:00PM EST
Louisiana Tech Bulldogs
Washington State Cougars
11/15/25 10PM
LATECH
WASHST
+250
-315
+7.5 (-106)
-7.5 (-114)
O 44.5 (-114)
U 44.5 (-106)
Nov 15, 2025 10:15PM EST
TCU Horned Frogs
BYU Cougars
11/15/25 10:15PM
TCU
BYU
+158
-190
+4.5 (-110)
-4.5 (-110)
O 52.5 (-110)
U 52.5 (-110)
Nov 15, 2025 10:30PM EST
Boise State Broncos
San Diego State Aztecs
11/15/25 10:30PM
BOISE
SDGST
+118
-140
+3 (-115)
-3 (-105)
O 41.5 (-110)
U 41.5 (-110)
Nov 15, 2025 10:30PM EST
Wyoming Cowboys
Fresno State Bulldogs
11/15/25 10:30PM
WYO
FRESNO
+140
-170
+3.5 (-112)
-3.5 (-108)
O 40.5 (-110)
U 40.5 (-110)
Dec 6, 2025 8:00PM EST
Ohio State Buckeyes
Indiana Hoosiers
12/6/25 8PM
OHIOST
IND
-225
+180
-5.5 (-122)
+5.5 (+100)
O 49.5 (-110)
U 49.5 (-110)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston College Eagles vs. Michigan State Spartans on September 06, 2025 at Spartan Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
JAXST@UTEP JAXST -105 57.0% 7 WIN
FSU@CLEM CLEM -118 57.1% 5 WIN
UNLV@COLOST UNLV -4 55.2% 5 WIN
OREG@IOWA IOWA +6.5 53.3% 2 WIN
NEB@UCLA NEB +1.5 55.8% 5 WIN
AUBURN@VANDY AUBURN +6.5 56.2% 6 LOSS
KENSAW@NMEXST NMEXST +10 56.5% 6 WIN
STNFRD@UNC STNFRD +7.5 53.8% 3 WIN
DUKE@UCONN UCONN +8.5 57.9% 7 WIN
NEVADA@UTAHST NEVADA +9.5 55.9% 5 LOSS
SAMST@OREGST SAMST +21 57.7% 7 WIN
NEB@UCLA NICO IAMALEAVA UNDER 180.5 PASS YDS 56.6% 6 LOSS
HOU@UCF HOU -112 58.0% 6 WIN
GASTHRN@APPST GASTHRN +180 36.5% 2 WIN
KENTST@BALLST BALLST -2.5 54.5% 4 WIN
WAKE@FSU WAKE +10.5 56.4% 6 LOSS
WYO@SDGST SDGST -10.5 56.7% 7 WIN
OKLA@TENN TENN -130 58.3% 5 LOSS
GATECH@NCST GATECH -5 56.4% 6 LOSS
MIAMI@SMU MIAMI -10 54.3% 4 LOSS
DEL@LIB DEL +3.5 57.6% 7 LOSS
NMEXST@WKY NMEXST +8.5 57.9% 7 LOSS
IND@MD MD +21.5 54.6% 4 LOSS
CINCY@UTAH CINCY +11 57.6% 7 LOSS
OLDDOM@LAMON LAMON +17 58.4% 8 LOSS
VANDY@TEXAS OVER 46.5 53.7% 2 WIN
MICHST@MINN MAKHI FRAZIER UNDER 52.5 RUSH YDS 55.2% 5 WIN
UNC@CUSE UNC +110 50.4% 2 WIN
MRSHL@COASTAL COASTAL +7 53.3% 3 WIN
FIU@MIZZST FIU +3.5 53.9% 3 LOSS
TEXAM@LSU MARCEL REED OVER 0.5 INT 55.5% 5 WIN
RUT@PURDUE RUT +103 54.0% 4 WIN
TOLEDO@WASHST TOLEDO -110 56.1% 6 LOSS
AUBURN@ARK ARK -128 60.5% 8 LOSS
NCST@PITT NCST +6.5 54.9% 4 LOSS
OHIO@EMICH EMICH +12 54.1% 4 WIN
TCU@WVU WVU +16.5 54.6% 4 WIN
COLO@UTAH COLO +14.5 57.7% 7 LOSS
HOU@ARIZST HOU +7.5 57.1% 7 WIN
UVA@UNC UNC +11.5 56.2% 6 WIN
MINN@IOWA MINN +9.5 57.3% 7 LOSS
UCONN@RICE RICE +10.5 57.1% 6 WIN
FAU@NAVY FAU +14.5 56.7% 6 WIN
LAMON@USM LAMON +13.5 56.4% 6 LOSS
BOISE@NEVADA NEVADA +21.5 56.8% 6 WIN
SALA@GAST GAST +6.5 54.3% 4 LOSS
MIZZST@NMEXST MIZZST -108 54.4% 4 WIN
KENSAW@FIU FIU +3 53.7% 3 LOSS
KENTST@TOLEDO KENTST +24.5 56.9% 6 LOSS
OLDDOM@JMAD JMAD -125 57.9% 7 WIN
TXTECH@ARIZST TXTECH -6.5 54.2% 4 LOSS