James Madison vs Louisville Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 05)
Updated: 2025-08-29T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The James Madison Dukes travel to face the Louisville Cardinals on September 5, 2025, in a non-conference matchup that gives the Dukes a chance to prove their rising national profile against a ranked ACC opponent. Louisville enters as 13.5-point favorites with the total set at 58.5, reflecting expectations of offensive fireworks and a test of discipline on both sides.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 05, 2025
Start Time: 7:00 PM EST
Venue: L&N Federal Credit Union Stadium
Cardinals Record: (1-0)
Dukes Record: (1-0)
OPENING ODDS
JMAD Moneyline: +418
LVILLE Moneyline: -575
JMAD Spread: +13.5
LVILLE Spread: -13.5
Over/Under: 58.5
JMAD
Betting Trends
- James Madison covered in seven of its final 11 games last season, showing bettors that the Dukes often exceeded expectations against stronger opponents.
LVILLE
Betting Trends
- Louisville ended 2024 with a 9-4 record ATS, continuing a trend of reliability under Jeff Brohm whenever oddsmakers set them as double-digit home favorites.
MATCHUP TRENDS
- While Louisville has covered in 60 percent of games as a double-digit favorite over the past two seasons, James Madison has gone 5-2 ATS in its last seven non-conference road games, making this matchup an intriguing clash of reliable betting profiles.
JMAD vs. LVILLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Lacy over 52.5 Receiving Yards.
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James Madison vs Louisville Prediction & Odds:
Free CFB Betting Insights for 9/5/25
The key matchup will likely come in the trenches, as Louisville’s defensive front will aim to disrupt Barnett and collapse the pocket, while James Madison’s offensive line must hold firm to allow their quarterback time to create opportunities. Defensively, the Dukes are known for their discipline and aggressiveness, and they will need to lean heavily on that identity to slow down Louisville’s balanced attack, which thrives on wearing down defenses and creating explosive plays in space. Special teams could also play an important role, particularly for James Madison, which will need to maximize every opportunity to flip field position and steal points in order to hang with a deeper opponent. From a betting perspective, both teams bring reliable ATS trends, with Louisville covering in nine of thirteen last year and James Madison rewarding backers in seven of their last eleven, making the spread particularly intriguing for bettors who see value in JMU’s ability to keep the game competitive. Ultimately, the outcome will hinge on whether Louisville can establish control early, dictate tempo, and leverage its home-field advantage, or whether James Madison can withstand the initial surge, generate turnovers, and turn the game into a second-half battle where pressure shifts back onto the favored Cardinals. Regardless of the result, the contest stands as a tone-setter for both programs, with Louisville looking to cement itself as a legitimate ACC contender and James Madison seeking to prove that it belongs in conversations beyond the Group of Five.
𝐆𝐀𝐌𝐄 2⃣ 𝐏𝐑𝐄𝐕𝐈𝐄𝐖 ⤵️
— JMU Football (@JMUFootball) September 2, 2025
Getting set for a Friday night clash at ACC foe Louisville on ESPN2.
📰 https://t.co/xu7Ogxdkt2 pic.twitter.com/apdEAblUJd
James Madison Dukes CFB Preview
The James Madison Dukes enter their September 5, 2025 showdown against the Louisville Cardinals with confidence, momentum, and the determination to show that they can compete at the highest levels of college football, and while they are listed as 13.5-point underdogs with the total set at 58.5, their recent performances suggest that they should not be dismissed lightly. James Madison finished 2024 as one of the more consistent Group of Five programs, demonstrating resilience, offensive creativity, and defensive toughness that allowed them to cover in seven of their final eleven games, giving bettors faith that they can punch above their weight even when facing stronger opponents. At the core of their identity is quarterback Alonza Barnett, a dynamic dual-threat signal-caller who can create plays with both his arm and his legs, and his presence ensures that the Dukes’ offense always has the potential to deliver explosive plays. Complementing him are running backs Matthew Sluka and George Pettaway, who provide balance and allow James Madison to dictate tempo when they are able to establish the ground game, while a talented group of receivers stretches defenses vertically and horizontally. The offensive line remains an area of focus, as they will need to hold their ground against Louisville’s aggressive defensive front in order to give Barnett the time and space necessary to operate effectively.
Defensively, James Madison prides itself on discipline and physicality, traits that will be tested against a Louisville offense led by LaNorris Sellers, whose mobility and unpredictability can stress even well-prepared units. The Dukes will need to generate pressure, win key battles at the line of scrimmage, and capitalize on any mistakes to keep themselves within striking distance. Special teams could prove to be a difference-maker, as flipping field position and stealing points in high-leverage moments will be essential for an underdog seeking to deliver an upset. From a betting perspective, James Madison’s track record in non-conference road games has been strong, with five covers in their last seven, suggesting they are comfortable in environments where expectations are lower and opportunities exist to shock bigger-name programs. For the Dukes, the formula for success is straightforward but demanding: limit turnovers, control tempo with a balanced offensive attack, and lean on their defense to frustrate Sellers enough to keep the game close into the second half. If they can execute on those fronts, James Madison has the potential to not only cover the spread but also challenge Louisville in a way that forces the Cardinals to respond under pressure. Regardless of the outcome, this game represents an invaluable chance for the Dukes to showcase their progress, measure themselves against a high-level ACC opponent, and continue building a reputation as a program that belongs in conversations well beyond the Group of Five.

Credit: USA TODAY/IMAGN
Louisville Cardinals CFB Preview
The Louisville Cardinals open their home slate on September 5, 2025, against the James Madison Dukes with high expectations following a 9-4 season in which they proved to be one of the most reliable teams in the ACC both on the field and at the betting window, and head coach Jeff Brohm has instilled a culture of discipline, offensive creativity, and defensive toughness that has resonated with both players and fans, leading oddsmakers to install the Cardinals as 13.5-point favorites in this contest with the over/under at 58.5. At the heart of Louisville’s success is quarterback LaNorris Sellers, whose dual-threat ability has transformed the offense into one of the more unpredictable units in the league, as he can stretch defenses vertically with his arm while also punishing opponents with designed runs and improvisational plays. Sellers is supported by a strong offensive line that provides protection and opens lanes for the running game, along with a collection of receivers and backs who give the Cardinals flexibility to attack in a variety of ways. On defense, Louisville prides itself on physicality, particularly up front, where a deep rotation of defensive linemen can generate pressure and disrupt opposing quarterbacks, and against James Madison they will be tasked with containing Alonza Barnett, a player whose mobility and ability to extend plays could stress even a disciplined unit.
The Cardinals’ secondary has been an area of focus, and improvement there will be critical against a JMU passing attack that has proven capable of explosive plays. Special teams also remain a strength, with reliable kicking and dynamic return potential giving Louisville the ability to tilt field position in their favor. From a betting standpoint, Louisville’s 9-4 ATS record last season underlines their consistency in meeting expectations, and their 60 percent cover rate as double-digit favorites over the past two years reinforces the trust bettors have in their ability to dominate games like this. The formula for victory is clear: establish tempo early, pressure Barnett into mistakes, and let Sellers orchestrate a balanced offensive attack that forces the Dukes to chase from behind. If they execute, Louisville not only secures a win but also makes a statement to the rest of the ACC that they are prepared to contend at the highest level. This game also carries the added weight of perception, as a dominant win over a strong Group of Five opponent helps bolster national credibility and sets the tone for the remainder of the season, giving Louisville both a practical and symbolic opportunity to reinforce their growing reputation.
.@ACCFootball Running Back of the Week 🤝
— Louisville Football (@LouisvilleFB) September 2, 2025
Details: https://t.co/y4EIkaN5JD#GoCards x @isaac6brown_ pic.twitter.com/OwEtGwRaWk
James Madison vs. Louisville Prop Picks (AI)
James Madison vs. Louisville Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every past game between the Dukes and Cardinals and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Remi has been most watching on the unproportionally assigned factor knucklehead sportsbettors tend to put on coaching factors between a Dukes team going up against a possibly healthy Cardinals team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI James Madison vs Louisville picks, computer picks Dukes vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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CFB | 10/21 | KENSAW@FIU | UNLOCK THIS PICK | 3 |
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CFB | 10/21 | WKY@LATECH | UNLOCK THIS PICK | 2 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
Dukes Betting Trends
James Madison covered in seven of its final 11 games last season, showing bettors that the Dukes often exceeded expectations against stronger opponents.
Cardinals Betting Trends
Louisville ended 2024 with a 9-4 record ATS, continuing a trend of reliability under Jeff Brohm whenever oddsmakers set them as double-digit home favorites.
Dukes vs. Cardinals Matchup Trends
While Louisville has covered in 60 percent of games as a double-digit favorite over the past two seasons, James Madison has gone 5-2 ATS in its last seven non-conference road games, making this matchup an intriguing clash of reliable betting profiles.
James Madison vs. Louisville Game Info
What time does James Madison vs Louisville start on September 05, 2025?
James Madison vs Louisville starts on September 05, 2025 at 7:00 PM EST.
Where is James Madison vs Louisville being played?
Venue: L&N Federal Credit Union Stadium.
What are the opening odds for James Madison vs Louisville?
Spread: Louisville -13.5
Moneyline: James Madison +418, Louisville -575
Over/Under: 58.5
What are the records for James Madison vs Louisville?
James Madison: (1-0) | Louisville: (1-0)
What is the AI best bet for James Madison vs Louisville?
Remi's searched hard and found the best prop for this matchup: C. Lacy over 52.5 Receiving Yards.. Prices move—always shop for the best number.
What are James Madison vs Louisville trending bets?
While Louisville has covered in 60 percent of games as a double-digit favorite over the past two seasons, James Madison has gone 5-2 ATS in its last seven non-conference road games, making this matchup an intriguing clash of reliable betting profiles.
What are James Madison trending bets?
JMAD trend: James Madison covered in seven of its final 11 games last season, showing bettors that the Dukes often exceeded expectations against stronger opponents.
What are Louisville trending bets?
LVILLE trend: Louisville ended 2024 with a 9-4 record ATS, continuing a trend of reliability under Jeff Brohm whenever oddsmakers set them as double-digit home favorites.
Where can I find AI Picks for James Madison vs Louisville?
See our latest CFB picks and odds pages for 2025 to compare prices before you bet.
James Madison vs. Louisville Odds
AI algorithm Remi is pouring through mountains of data points on each team. In fact, anytime the James Madison vs Louisville trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.
James Madison vs Louisville Opening Odds
JMAD Moneyline:
+418 LVILLE Moneyline: -575
JMAD Spread: +13.5
LVILLE Spread: -13.5
Over/Under: 58.5
James Madison vs Louisville Live Odds
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-395
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U 51.5 (-110)
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Oct 25, 2025 12:00PM EDT
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Oct 25, 2025 12:00PM EDT
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-135
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O 58.5 (-112)
U 58.5 (-108)
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Oct 25, 2025 12:00PM EDT
South Florida Bulls
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SFLA
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-205
+170
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O 63.5 (-108)
U 63.5 (-112)
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Oct 25, 2025 12:00PM EDT
UCLA Bruins
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+1400
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O 54.5 (-115)
U 54.5 (-105)
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Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
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NEB
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+230
-285
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+7 (-105)
-7 (-115)
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O 43.5 (-110)
U 43.5 (-110)
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Oct 25, 2025 12:00PM EDT
Ohio Bobcats
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O 59.5 (-110)
U 59.5 (-110)
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-180
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O 53.5 (-115)
U 53.5 (-105)
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+600
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O 53.5 (-110)
U 53.5 (-110)
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Oct 25, 2025 12:00PM EDT
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O 62.5 (-115)
U 62.5 (-105)
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Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
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O 54.5 (-108)
U 54.5 (-112)
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U 56.5 (-105)
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-105
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O 56.5 (-112)
U 56.5 (-108)
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U 49.5 (-115)
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U 61.5 (-108)
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O 39.5 (-108)
U 39.5 (-112)
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O 47.5 (-108)
U 47.5 (-112)
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U 48.5 (-108)
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O 53.5 (-112)
U 53.5 (-108)
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Oct 25, 2025 3:30PM EDT
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O 41.5 (-105)
U 41.5 (-115)
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Oct 25, 2025 3:30PM EDT
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O 46.5 (-108)
U 46.5 (-112)
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+455
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U 62.5 (-108)
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O 53.5 (-115)
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-700
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O 46.5 (-115)
U 46.5 (-105)
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-155
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-3 (-110)
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O 47.5 (-115)
U 47.5 (-105)
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O 51.5 (-115)
U 51.5 (-105)
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O 56.5 (-110)
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+340
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O 50.5 (-112)
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–
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+2800
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O 56.5 (-108)
U 56.5 (-112)
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+154
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O 66.5 (-115)
U 66.5 (-105)
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Oct 25, 2025 4:15PM EDT
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–
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-270
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-7 (-105)
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O 44.5 (-115)
U 44.5 (-105)
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–
–
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-650
+470
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-15.5 (-110)
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O 54.5 (-118)
U 54.5 (-102)
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Wisconsin Badgers
Oregon Ducks
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OREG
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–
–
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+33.5 (-108)
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O 44.5 (-112)
U 44.5 (-108)
|
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Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
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UL
TROY
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–
–
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+280
-355
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+8.5 (-108)
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O 47.5 (-110)
U 47.5 (-110)
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Oct 25, 2025 7:00PM EDT
Stanford Cardinal
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10/25/25 7PM
STNFRD
MIAMI
|
–
–
|
+4000
-30000
|
+30.5 (-115)
-30.5 (-105)
|
O 45.5 (-105)
U 45.5 (-115)
|
|
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
|
–
–
|
+100
-120
|
+1.5 (-110)
-1.5 (-110)
|
O 63.5 (-105)
U 63.5 (-115)
|
|
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
|
–
–
|
-625
+455
|
-14.5 (-105)
+14.5 (-115)
|
O 47.5 (-115)
U 47.5 (-105)
|
|
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
|
–
–
|
-142
+120
|
-2.5 (-115)
+2.5 (-105)
|
O 47.5 (-115)
U 47.5 (-105)
|
|
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
|
–
–
|
+1400
-3200
|
+25.5 (-110)
-25.5 (-110)
|
O 55.5 (-102)
U 55.5 (-118)
|
|
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
|
–
–
|
+180
-218
|
+5.5 (-110)
-5.5 (-110)
|
O 46.5 (-112)
U 46.5 (-108)
|
|
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
|
–
–
|
-345
+275
|
-9.5 (-108)
+9.5 (-112)
|
O 54.5 (-110)
U 54.5 (-110)
|
|
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
|
–
–
|
+230
-285
|
+7.5 (-115)
-7.5 (-105)
|
O 46.5 (-115)
U 46.5 (-105)
|
|
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
|
–
–
|
+410
-550
|
+13.5 (-110)
-13.5 (-110)
|
O 49.5 (-112)
U 49.5 (-108)
|
|
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
|
–
–
|
-275
+220
|
-7.5 (-104)
+7.5 (-118)
|
O 60.5 (-112)
U 60.5 (-108)
|
|
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
|
–
–
|
-200
+164
|
-5.5 (-110)
+5.5 (-110)
|
O 52.5 (-112)
U 52.5 (-108)
|
|
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
|
–
–
|
+660
-1050
|
+17.5 (-115)
-17.5 (-105)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
|
–
–
|
-430
+330
|
-10.5 (-110)
+10.5 (-110)
|
O 51.5 (-110)
U 51.5 (-110)
|
|
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
|
–
–
|
-105
-114
|
+1.5 (-114)
-1.5 (-106)
|
O 53.5 (-112)
U 53.5 (-108)
|
|
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
|
–
–
|
+150
-182
|
+3.5 (-106)
-3.5 (-114)
|
O 45.5 (-110)
U 45.5 (-110)
|
|
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
|
–
–
|
-300
+240
|
-7.5 (-110)
+7.5 (-110)
|
O 50.5 (-112)
U 50.5 (-108)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers James Madison Dukes vs. Louisville Cardinals on September 05, 2025 at L&N Federal Credit Union Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
FSU@STNFRD | STNFRD +18 | 56.6% | 6 | WIN |
WASHST@UVA | WASHST +17.5 | 58.8% | 8 | WIN |
NEVADA@NMEX | NEVADA +13.5 | 57.8% | 7 | WIN |
TEXAS@UK | ARCH MANNING UNDER 1.5 PASS TD | 56.1% | 6 | WIN |
ARMY@TULANE | ARMY +10 | 55.3% | 5 | WIN |
SJST@UTAHST | SJST +4 | 54.4% | 4 | LOSS |
LVILLE@MIAMI | LVILLE +12.5 | 56.5% | 6 | WIN |
LVILLE@MIAMI | CJ DANIELS UNDER 4.5 RECEPTIONS | 54.4 | 4 | LOSS |
DEL@JAXST | DEL -2.5 | 57.6% | 6 | LOSS |
UTEP@SAMST | UTEP -2.5 | 53.9% | 3 | WIN |
FIU@WKY | FIU +10.5 | 54.6% | 4 | WIN |
ARKST@SALA | ARKST +7.5 | 54.5% | 4 | WIN |
ARKST@SALA | JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP | 53.3% | 3 | WIN |
SJST@WYO | SJST -120 | 59.8% | 7 | LOSS |
UMASS@KENTST | KENTST -135 | 60.2% | 6 | WIN |
NOILL@EMICH | EMICH +2.5 | 53.9% | 3 | WIN |
BYU@ARIZ | ARIZ +2.5 | 54.2% | 3 | LOSS |
OKLA@TEXAS | OKLA +2.5 | 54.7% | 4 | LOSS |
NMEX@BOISE | NMEX +16.5 | 56.4% | 6 | WIN |
WAKE@OREGST | WAKE -2.5 | 56.7% | 6 | WIN |
ULMON@COASTAL | ULMON -2.5 | 56.8% | 6 | LOSS |
IOWA@WISC | WISC +4 | 54.8% | 4 | LOSS |
TOLEDO@BGREEN | TOLEDO -10 | 56.3% | 6 | LOSS |
SFLA@NOTEX | SFLA +2.5 | 54.3% | 4 | WIN |
FRESNO@COLOST | RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 | 54.4% | 4 | LOSS |
JAXST@SAMST | SAMST +7.5 | 55.3% | 5 | WIN |
USM@GAS | GAS +3.5 | 57.4% | 7 | WIN |
LIB@UTEP | UTEP +2 | 54.5% | 4 | LOSS |
SALA@TROY | SALA -118 | 55.2% | 4 | LOSS |
TULSA@MEMP | MEMP -20.5 | 53.8% | 3 | WIN |
JMAD@GAST | GAST +20.5 | 54.6% | 4 | WIN |
WAKE@VATECH | VATECH -5.5 | 56.6% | 6 | LOSS |
UNLV@WYO | WYO +4.5 | 55.5% | 5 | LOSS |
PSU@UCLA | PSU -24.5 | 56.3% | 6 | LOSS |
TXSTSM@ARKST | TXSTSM -13 | 56.7% | 6 | LOSS |
UVA@LVILLE | ISAAC BROWN OVER 70.5 RUSH YDS | 56.6% | 6 | LOSS |
WVU@BYU | WVU +20.5 | 54.7% | 4 | WIN |
SAMST@NMEXST | SAMST -1.5 | 54.1% | 3 | LOSS |
EMICH@CMICH | CMICH -148 | 62.8% | 7 | WIN |
SDGST@NOILL | SDGST -118 | 55.7% | 3 | WIN |
BAMA@GEORGIA | GEORGIA -125 | 58.7% | 7 | LOSS |
TENN@MISSST | MISSST +7.5 | 54.3% | 4 | WIN |
UK@SC | SC -5.5 | 54.8% | 4 | WIN |
WKY@MIZZST | MIZZST +4.5 | 55.6% | 6 | LOSS |
JAXST@USM | USM -3.5 | 56.0% | 5 | WIN |
NMEXST@NMEX | NMEX -14.5 | 56.9% | 6 | WIN |
ARIZ@IOWAST | ROCCO BECHT UNDER 1.5 PASS TDS | 55.5% | 5 | WIN |
TCU@ARIZST | JOSH HOOVER PASS YDS UNDER 287.5 | 53.4% | 3 | WIN |
ARIZST@BAYLOR | BAYLOR -130 | 58.4% | 6 | LOSS |
WYO@COLO | WYO +13.5 | 54.1% | 3 | LOSS |
TULANE@OLEMISS | MISS -11.5 | 54.3% | 4 | WIN |