James Madison vs Louisville Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 05)

Updated: 2025-08-29T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The James Madison Dukes travel to face the Louisville Cardinals on September 5, 2025, in a non-conference matchup that gives the Dukes a chance to prove their rising national profile against a ranked ACC opponent. Louisville enters as 13.5-point favorites with the total set at 58.5, reflecting expectations of offensive fireworks and a test of discipline on both sides.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 05, 2025

Start Time: 7:00 PM EST​

Venue: L&N Federal Credit Union Stadium​

Cardinals Record: (1-0)

Dukes Record: (1-0)

OPENING ODDS

JMAD Moneyline: +418

LVILLE Moneyline: -575

JMAD Spread: +13.5

LVILLE Spread: -13.5

Over/Under: 58.5

JMAD
Betting Trends

  • James Madison covered in seven of its final 11 games last season, showing bettors that the Dukes often exceeded expectations against stronger opponents.

LVILLE
Betting Trends

  • Louisville ended 2024 with a 9-4 record ATS, continuing a trend of reliability under Jeff Brohm whenever oddsmakers set them as double-digit home favorites.

MATCHUP TRENDS

  • While Louisville has covered in 60 percent of games as a double-digit favorite over the past two seasons, James Madison has gone 5-2 ATS in its last seven non-conference road games, making this matchup an intriguing clash of reliable betting profiles.

JMAD vs. LVILLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Lacy over 52.5 Receiving Yards.

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James Madison vs Louisville Prediction & Odds:
Free CFB Betting Insights for 9/5/25

The September 5, 2025 matchup between the James Madison Dukes and the Louisville Cardinals at L&N Federal Credit Union Stadium in Louisville offers one of the most compelling early-season non-conference showdowns, pitting a Group of Five program with legitimate national aspirations against an ACC program that continues to ascend under the steady leadership of Jeff Brohm, and oddsmakers have given Louisville a 13.5-point edge with the total set at 58.5, reflecting both the confidence in the Cardinals’ talent and the expectation that James Madison’s offense can generate points even in a hostile road environment. James Madison arrives with momentum after a successful 2024 campaign in which their offense showed explosive potential and their defense consistently frustrated opponents, and they bring back quarterback Alonza Barnett, who has proven to be a dual-threat playmaker with the ability to attack defenses both through the air and on the ground. The Dukes also feature a dynamic backfield with Matthew Sluka and George Pettaway, who can provide balance, and a group of receivers capable of stretching the field, giving them multiple ways to challenge Louisville’s secondary. On the other side, Louisville counters with quarterback LaNorris Sellers, who has already established himself as one of the most dangerous dual-threat signal-callers in the ACC, supported by a strong offensive line and a versatile set of skill players that allow the Cardinals to attack in multiple ways.

The key matchup will likely come in the trenches, as Louisville’s defensive front will aim to disrupt Barnett and collapse the pocket, while James Madison’s offensive line must hold firm to allow their quarterback time to create opportunities. Defensively, the Dukes are known for their discipline and aggressiveness, and they will need to lean heavily on that identity to slow down Louisville’s balanced attack, which thrives on wearing down defenses and creating explosive plays in space. Special teams could also play an important role, particularly for James Madison, which will need to maximize every opportunity to flip field position and steal points in order to hang with a deeper opponent. From a betting perspective, both teams bring reliable ATS trends, with Louisville covering in nine of thirteen last year and James Madison rewarding backers in seven of their last eleven, making the spread particularly intriguing for bettors who see value in JMU’s ability to keep the game competitive. Ultimately, the outcome will hinge on whether Louisville can establish control early, dictate tempo, and leverage its home-field advantage, or whether James Madison can withstand the initial surge, generate turnovers, and turn the game into a second-half battle where pressure shifts back onto the favored Cardinals. Regardless of the result, the contest stands as a tone-setter for both programs, with Louisville looking to cement itself as a legitimate ACC contender and James Madison seeking to prove that it belongs in conversations beyond the Group of Five.

James Madison Dukes CFB Preview

The James Madison Dukes enter their September 5, 2025 showdown against the Louisville Cardinals with confidence, momentum, and the determination to show that they can compete at the highest levels of college football, and while they are listed as 13.5-point underdogs with the total set at 58.5, their recent performances suggest that they should not be dismissed lightly. James Madison finished 2024 as one of the more consistent Group of Five programs, demonstrating resilience, offensive creativity, and defensive toughness that allowed them to cover in seven of their final eleven games, giving bettors faith that they can punch above their weight even when facing stronger opponents. At the core of their identity is quarterback Alonza Barnett, a dynamic dual-threat signal-caller who can create plays with both his arm and his legs, and his presence ensures that the Dukes’ offense always has the potential to deliver explosive plays. Complementing him are running backs Matthew Sluka and George Pettaway, who provide balance and allow James Madison to dictate tempo when they are able to establish the ground game, while a talented group of receivers stretches defenses vertically and horizontally. The offensive line remains an area of focus, as they will need to hold their ground against Louisville’s aggressive defensive front in order to give Barnett the time and space necessary to operate effectively.

Defensively, James Madison prides itself on discipline and physicality, traits that will be tested against a Louisville offense led by LaNorris Sellers, whose mobility and unpredictability can stress even well-prepared units. The Dukes will need to generate pressure, win key battles at the line of scrimmage, and capitalize on any mistakes to keep themselves within striking distance. Special teams could prove to be a difference-maker, as flipping field position and stealing points in high-leverage moments will be essential for an underdog seeking to deliver an upset. From a betting perspective, James Madison’s track record in non-conference road games has been strong, with five covers in their last seven, suggesting they are comfortable in environments where expectations are lower and opportunities exist to shock bigger-name programs. For the Dukes, the formula for success is straightforward but demanding: limit turnovers, control tempo with a balanced offensive attack, and lean on their defense to frustrate Sellers enough to keep the game close into the second half. If they can execute on those fronts, James Madison has the potential to not only cover the spread but also challenge Louisville in a way that forces the Cardinals to respond under pressure. Regardless of the outcome, this game represents an invaluable chance for the Dukes to showcase their progress, measure themselves against a high-level ACC opponent, and continue building a reputation as a program that belongs in conversations well beyond the Group of Five.

The James Madison Dukes travel to face the Louisville Cardinals on September 5, 2025, in a non-conference matchup that gives the Dukes a chance to prove their rising national profile against a ranked ACC opponent. Louisville enters as 13.5-point favorites with the total set at 58.5, reflecting expectations of offensive fireworks and a test of discipline on both sides. James Madison vs Louisville AI Prediction: Free CFB Betting Insights for Sep 05. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Louisville Cardinals CFB Preview

The Louisville Cardinals open their home slate on September 5, 2025, against the James Madison Dukes with high expectations following a 9-4 season in which they proved to be one of the most reliable teams in the ACC both on the field and at the betting window, and head coach Jeff Brohm has instilled a culture of discipline, offensive creativity, and defensive toughness that has resonated with both players and fans, leading oddsmakers to install the Cardinals as 13.5-point favorites in this contest with the over/under at 58.5. At the heart of Louisville’s success is quarterback LaNorris Sellers, whose dual-threat ability has transformed the offense into one of the more unpredictable units in the league, as he can stretch defenses vertically with his arm while also punishing opponents with designed runs and improvisational plays. Sellers is supported by a strong offensive line that provides protection and opens lanes for the running game, along with a collection of receivers and backs who give the Cardinals flexibility to attack in a variety of ways. On defense, Louisville prides itself on physicality, particularly up front, where a deep rotation of defensive linemen can generate pressure and disrupt opposing quarterbacks, and against James Madison they will be tasked with containing Alonza Barnett, a player whose mobility and ability to extend plays could stress even a disciplined unit.

The Cardinals’ secondary has been an area of focus, and improvement there will be critical against a JMU passing attack that has proven capable of explosive plays. Special teams also remain a strength, with reliable kicking and dynamic return potential giving Louisville the ability to tilt field position in their favor. From a betting standpoint, Louisville’s 9-4 ATS record last season underlines their consistency in meeting expectations, and their 60 percent cover rate as double-digit favorites over the past two years reinforces the trust bettors have in their ability to dominate games like this. The formula for victory is clear: establish tempo early, pressure Barnett into mistakes, and let Sellers orchestrate a balanced offensive attack that forces the Dukes to chase from behind. If they execute, Louisville not only secures a win but also makes a statement to the rest of the ACC that they are prepared to contend at the highest level. This game also carries the added weight of perception, as a dominant win over a strong Group of Five opponent helps bolster national credibility and sets the tone for the remainder of the season, giving Louisville both a practical and symbolic opportunity to reinforce their growing reputation.

James Madison vs. Louisville Prop Picks (AI)

Remi is pouring through mountains of datapoints on each line. In fact, anytime the Dukes and Cardinals play there’s always several intriguing angles to key in on. Not to mention games played at L&N Federal Credit Union Stadium in Sep almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Lacy over 52.5 Receiving Yards.

James Madison vs. Louisville Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every past game between the Dukes and Cardinals and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Remi has been most watching on the unproportionally assigned factor knucklehead sportsbettors tend to put on coaching factors between a Dukes team going up against a possibly healthy Cardinals team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI James Madison vs Louisville picks, computer picks Dukes vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Dukes Betting Trends

James Madison covered in seven of its final 11 games last season, showing bettors that the Dukes often exceeded expectations against stronger opponents.

Cardinals Betting Trends

Louisville ended 2024 with a 9-4 record ATS, continuing a trend of reliability under Jeff Brohm whenever oddsmakers set them as double-digit home favorites.

Dukes vs. Cardinals Matchup Trends

While Louisville has covered in 60 percent of games as a double-digit favorite over the past two seasons, James Madison has gone 5-2 ATS in its last seven non-conference road games, making this matchup an intriguing clash of reliable betting profiles.

James Madison vs. Louisville Game Info

James Madison vs Louisville starts on September 05, 2025 at 7:00 PM EST.

Venue: L&N Federal Credit Union Stadium.

Spread: Louisville -13.5
Moneyline: James Madison +418, Louisville -575
Over/Under: 58.5

James Madison: (1-0)  |  Louisville: (1-0)

Remi's searched hard and found the best prop for this matchup: C. Lacy over 52.5 Receiving Yards.. Prices move—always shop for the best number.

While Louisville has covered in 60 percent of games as a double-digit favorite over the past two seasons, James Madison has gone 5-2 ATS in its last seven non-conference road games, making this matchup an intriguing clash of reliable betting profiles.

JMAD trend: James Madison covered in seven of its final 11 games last season, showing bettors that the Dukes often exceeded expectations against stronger opponents.

LVILLE trend: Louisville ended 2024 with a 9-4 record ATS, continuing a trend of reliability under Jeff Brohm whenever oddsmakers set them as double-digit home favorites.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

James Madison vs. Louisville Odds

AI algorithm Remi is pouring through mountains of data points on each team. In fact, anytime the James Madison vs Louisville trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.

James Madison vs Louisville Opening Odds

JMAD Moneyline: +418
LVILLE Moneyline: -575
JMAD Spread: +13.5
LVILLE Spread: -13.5
Over/Under: 58.5

James Madison vs Louisville Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-370
 
-9.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-225
+185
-6.5 (-110)
+6.5 (-110)
O 55.5 (-112)
U 55.5 (-108)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1600
-26.5 (-112)
+26.5 (-108)
O 61.5 (-105)
U 61.5 (-115)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+164
-198
+4.5 (-108)
-4.5 (-112)
O 49.5 (-115)
U 49.5 (-105)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+1000
-21 (-115)
+21 (-105)
O 50.5 (-112)
U 50.5 (-108)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-395
+310
-10.5 (-108)
+10.5 (-112)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-290
+235
-7.5 (-105)
+7.5 (-115)
O 48.5 (-108)
U 48.5 (-112)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+114
-2.5 (-115)
+2.5 (-105)
O 58.5 (-112)
U 58.5 (-108)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+170
-4.5 (-112)
+4.5 (-108)
O 63.5 (-108)
U 63.5 (-112)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1400
-3200
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+230
-285
+7 (-105)
-7 (-115)
O 43.5 (-110)
U 43.5 (-110)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-500
+380
-12.5 (-108)
+12.5 (-112)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-180
+150
-3.5 (-108)
+3.5 (-112)
O 53.5 (-115)
U 53.5 (-105)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+600
-900
+17.5 (-110)
-17.5 (-110)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-625
 
-14.5 (-108)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+180
-218
+4.5 (-105)
-4.5 (-115)
O 54.5 (-108)
U 54.5 (-112)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+130
-155
+3 (-112)
-3 (-108)
O 56.5 (-115)
U 56.5 (-105)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-105
-115
+1.5 (-115)
-1.5 (-105)
O 56.5 (-112)
U 56.5 (-108)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+310
-395
+9.5 (-110)
-9.5 (-110)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-410
+320
-10.5 (-110)
+10.5 (-110)
O 49.5 (-105)
U 49.5 (-115)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+130
-155
+3 (-112)
-3 (-108)
O 61.5 (-112)
U 61.5 (-108)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-345
+9.5 (-112)
-9.5 (-108)
O 39.5 (-108)
U 39.5 (-112)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-485
+370
-12.5 (-110)
+12.5 (-110)
O 47.5 (-108)
U 47.5 (-112)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+124
-148
+2.5 (-102)
-2.5 (-118)
O 48.5 (-112)
U 48.5 (-108)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-238
+195
-6 (-112)
+6 (-108)
O 53.5 (-112)
U 53.5 (-108)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+180
-218
+5.5 (-112)
-5.5 (-108)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
-102
-118
+1.5 (-115)
-1.5 (-105)
O 46.5 (-108)
U 46.5 (-112)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+455
-625
+15.5 (-108)
-15.5 (-112)
O 62.5 (-112)
U 62.5 (-108)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+164
-198
+4.5 (-110)
-4.5 (-110)
O 53.5 (-115)
U 53.5 (-105)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-700
 
-16.5 (-108)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-155
+130
-3 (-110)
+3 (-110)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+114
-135
+2.5 (-110)
-2.5 (-110)
O 51.5 (-115)
U 51.5 (-105)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+205
-250
+6.5 (-108)
-6.5 (-112)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+102
 
+1.5 (-110)
 
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+340
 
+10.5 (-105)
 
O 50.5 (-112)
U 50.5 (-108)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+38.5 (-115)
-38.5 (-105)
O 56.5 (-108)
U 56.5 (-112)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+154
-185
+4.5 (-110)
-4.5 (-110)
O 66.5 (-115)
U 66.5 (-105)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-270
+220
-7 (-105)
+7 (-115)
O 44.5 (-115)
U 44.5 (-105)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-650
+470
-15.5 (-110)
+15.5 (-110)
O 54.5 (-118)
U 54.5 (-102)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-108)
-33.5 (-112)
O 44.5 (-112)
U 44.5 (-108)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+280
-355
+8.5 (-108)
-8.5 (-112)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-105)
U 45.5 (-115)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+100
-120
+1.5 (-110)
-1.5 (-110)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-625
+455
-14.5 (-105)
+14.5 (-115)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-142
+120
-2.5 (-115)
+2.5 (-105)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1400
-3200
+25.5 (-110)
-25.5 (-110)
O 55.5 (-102)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+180
-218
+5.5 (-110)
-5.5 (-110)
O 46.5 (-112)
U 46.5 (-108)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+275
-9.5 (-108)
+9.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+230
-285
+7.5 (-115)
-7.5 (-105)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+410
-550
+13.5 (-110)
-13.5 (-110)
O 49.5 (-112)
U 49.5 (-108)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers James Madison Dukes vs. Louisville Cardinals on September 05, 2025 at L&N Federal Credit Union Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN