Boilermakers vs. Cougars
Prediction, Odds & Props
Mar 28 | CBB AI Picks

Updated: 2025-03-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On March 28, 2025, the Purdue Boilermakers will face the Houston Cougars in the Sweet 16 of the NCAA Men’s Basketball Tournament. Houston, the No. 1 seed in the Midwest Region, boasts a 32-4 record, while Purdue, the No. 4 seed, holds a 24-11 record. The game is scheduled to tip off at approximately 9:09 p.m. at Lucas Oil Stadium in Indianapolis, offering Purdue a home-court advantage given its proximity to their campus.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 28, 2025

Start Time: 10:09 PM EST​

Venue: Lucas Oil Stadium​

Cougars Record: (32-4)

Boilermakers Record: (24-11)

OPENING ODDS

PURDUE Moneyline: +293

HOU Moneyline: -373

PURDUE Spread: +7.5

HOU Spread: -7.5

Over/Under: 132.5

PURDUE
Betting Trends

  • Specific recent Against The Spread (ATS) statistics for Purdue are not available in the provided sources.

HOU
Betting Trends

  • Specific recent ATS statistics for Houston are not available in the provided sources.

MATCHUP TRENDS

  • Despite being the lower seed, Purdue’s proximity to the game venue may influence betting lines, potentially narrowing the spread due to their quasi-home-court advantage.

PURDUE vs. HOU
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Roberts under 19.5 PTS+REB+AST

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Purdue vs Houston Prediction & Odds:
Free CBB Betting Insights for 3/28/25

The upcoming Sweet 16 matchup between the Purdue Boilermakers and the Houston Cougars on March 28, 2025, is set to be a thrilling contest that pits two formidable programs against each other. Houston, entering as the No. 1 seed in the Midwest Region, has demonstrated exceptional consistency throughout the season, culminating in a 32-4 record. Their journey to this stage has been marked by a 13-game winning streak, including a significant victory over Arizona in the Big 12 tournament. The Cougars’ defense has been particularly noteworthy, allowing an average of only 58.1 points per game, making them one of the most stifling defensive units in the nation. Offensively, Houston is led by standout players such as Oklahoma transfer Milos Uzan and scoring guard Tre Johnson. Uzan’s versatility and Johnson’s scoring prowess have provided the Cougars with a balanced attack capable of adapting to various defensive schemes. Their ability to control the tempo and execute in half-court sets has been a hallmark of their success this season. On the other hand, the Purdue Boilermakers, holding a 24-11 record, have showcased resilience and depth. Their season has been characterized by significant victories, including a dominant 87-78 win over Alabama earlier in the year. Purdue’s offense is orchestrated by standout player Braden Smith, whose leadership and playmaking abilities have been instrumental in guiding the Boilermakers through challenging matchups.

Defensively, Purdue has emphasized a physical style of play, focusing on controlling the paint and limiting second-chance opportunities for opponents. Their rebounding efficiency and ability to contest shots without fouling have been critical components of their defensive strategy. The venue for this matchup, Lucas Oil Stadium in Indianapolis, is located approximately 70 miles from Purdue’s campus, effectively providing the Boilermakers with a home-court advantage. This proximity is expected to result in a substantial turnout of Purdue supporters, potentially influencing the game’s atmosphere and momentum. From a betting perspective, Houston’s status as the No. 1 seed and their defensive dominance may position them as the favorites. However, Purdue’s quasi-home-court advantage and their proven ability to compete against top-tier teams could impact the spread and betting dynamics. Bettors may find value in considering Purdue’s familiarity with the venue and the potential boost from their fan base. In summary, this Sweet 16 clash between Houston and Purdue promises to be a compelling encounter. Houston’s defensive tenacity and balanced offense will be tested against Purdue’s resilience, physicality, and home-court advantage. The outcome may hinge on which team can impose its style of play more effectively and handle the high-pressure environment of the NCAA Tournament. Fans can anticipate a high-stakes battle that epitomizes the excitement and unpredictability of March Madness.

Purdue Boilermakers CBB Preview

The Purdue Boilermakers enter the Sweet 16 matchup against the Houston Cougars with a 24-11 record and a chip on their shoulder, eager to prove they can not only compete with but defeat the nation’s elite. Coached by Matt Painter, Purdue has built its identity around physicality, execution, and toughness—qualities that will be tested to the limit against the No. 1 seed in the Midwest Region. However, the Boilermakers hold one critical advantage heading into this matchup: the game is being played at Lucas Oil Stadium in Indianapolis, effectively giving them a home-court edge with tens of thousands of black-and-gold-clad fans expected in the stands. That proximity to West Lafayette could provide an emotional lift as Purdue attempts to pull off a significant tournament upset and return to the Elite Eight for the first time since 2019. The heartbeat of this Purdue squad is sophomore point guard Braden Smith, a composed and cerebral floor general who leads the team in assists and serves as the offensive catalyst. Smith’s ability to manage tempo, make reads under pressure, and find open teammates is critical to Purdue’s offensive success. He’s complemented by a cast of versatile scorers, including sharp-shooting guard Fletcher Loyer and forward Mason Gillis, who brings physical rebounding and defensive grit. Together, they’ve powered a Boilermakers team that values ball control, high-efficiency shots, and relentless execution in the half-court. Though not built on explosive athleticism, Purdue’s offense functions like a machine when clicking—emphasizing screens, motion, and interior passing to generate open looks.

Their perimeter shooting, while sometimes inconsistent, has surged in recent weeks, opening up spacing for drives and post entries. When their guards are knocking down shots early, the Boilermakers become difficult to defend, forcing opponents to extend defensively and creating room in the lane. That inside-out dynamic is a staple of Painter’s system, and it will be vital against Houston’s pressure-heavy defense. Defensively, Purdue relies on structure, communication, and physicality. They are fundamentally sound, rarely gambling, and instead focusing on positioning and contesting shots without fouling. Tarris Reed Jr., a strong interior defender, anchors the paint and gives Purdue size against the Cougars’ active bigs. Purdue also prides itself on rebounding, often winning battles on the glass through sheer effort and discipline. In a matchup against one of the best offensive-rebounding teams in the nation, those fundamentals will be tested at every possession. The key for Purdue in this game will be limiting turnovers and controlling pace. Houston thrives on converting mistakes into points and forcing opponents into rushed possessions. Purdue’s methodical style, if maintained, can frustrate the Cougars by slowing the game down and forcing them into extended defensive sets. If Braden Smith can handle pressure, distribute efficiently, and maintain composure, Purdue has the tools to keep the game close and create opportunities to strike late. Ultimately, Purdue enters this Sweet 16 with the opportunity to redefine its season narrative. After enduring a tough Big Ten schedule and surviving tight early-round games, the Boilermakers are poised for a breakthrough. With a strategic coach, a confident point guard, and a building full of fans behind them, Purdue has every reason to believe they can out-execute and outlast the nation’s top seed—and keep their March dreams alive.

On March 28, 2025, the Purdue Boilermakers will face the Houston Cougars in the Sweet 16 of the NCAA Men’s Basketball Tournament. Houston, the No. 1 seed in the Midwest Region, boasts a 32-4 record, while Purdue, the No. 4 seed, holds a 24-11 record. The game is scheduled to tip off at approximately 9:09 p.m. at Lucas Oil Stadium in Indianapolis, offering Purdue a home-court advantage given its proximity to their campus. Purdue vs Houston AI Prediction: Free CBB Betting Insights for Mar 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Houston Cougars CBB Preview

The Houston Cougars have solidified their position as one of the premier programs in college basketball, entering the Sweet 16 of the NCAA Tournament with a remarkable 32-4 record. Under the astute leadership of head coach Kelvin Sampson, the Cougars have consistently demonstrated excellence on both ends of the court, earning them the No. 1 seed in the Midwest Region. Their journey to this stage has been characterized by a 13-game winning streak, underscoring their dominance and resilience. Defensively, Houston has been exceptional, allowing an average of only 58.1 points per game, which ranks among the best in the nation. This defensive prowess is a testament to their discipline, communication, and strategic execution. The Cougars employ a relentless man-to-man defense, characterized by aggressive on-ball pressure and swift rotations. Their ability to contest shots effectively and force opponents into low-percentage attempts has been a cornerstone of their success. Offensively, the Cougars exhibit a balanced and efficient attack, orchestrated by key players such as Milos Uzan and Tre Johnson. Uzan, a transfer from Oklahoma, has seamlessly integrated into Houston’s system, providing versatility and playmaking abilities. His court vision and decision-making have been instrumental in facilitating the offense. Johnson, known for his scoring prowess, has been a consistent offensive threat, capable of creating his own shot and stretching defenses with his perimeter shooting. The Cougars’ offensive philosophy emphasizes ball movement, spacing, and exploiting mismatches. They are adept at adjusting their game plan based on opponents’ defensive schemes which has allowed them to remain efficient even when facing elite defenses. Houston’s offense doesn’t rely on a singular star to carry the scoring load—instead, they utilize a committee approach that emphasizes unselfishness and decision-making. Players such as J’Wan Roberts and Emanuel Sharp have proven to be reliable contributors, with Roberts bringing physicality and rebounding inside, and Sharp serving as a lethal shooter from the perimeter when left unchecked. This multidimensional approach makes it difficult for opponents to key in on any one player, creating spacing and open looks that the Cougars capitalize on with discipline. What sets Houston apart from many other top teams is their toughness—both mental and physical. Coach Kelvin Sampson has instilled a culture of accountability, hard-nosed defense, and resilience.

The Cougars are known for their grueling practices and physical play, which has translated into on-court tenacity that wears down opponents. Houston ranks among the top in the nation in offensive rebounding percentage, constantly generating second-chance points and extra possessions that demoralize opposing defenses. Their guards crash the glass with the same intensity as their forwards, contributing to their dominance on the boards despite not always having a size advantage. In close games, Houston thrives because of their defense, free-throw shooting, and veteran poise. They shoot over 76% from the charity stripe as a team, with Uzan and Johnson consistently converting in clutch situations. Late-game execution has been a strength, and their ability to protect leads with sound decision-making and lockdown defense gives them a notable advantage in tournament play. Their pace is typically moderate—they don’t force transition opportunities unless they’re there—but they excel at maximizing each possession, rarely rushing or taking ill-advised shots. Heading into their Sweet 16 matchup with Purdue, Houston faces a unique challenge. Purdue brings size, physicality, and a semi-home atmosphere, with the game being played in Indianapolis just an hour from the Boilermakers’ campus. However, Houston’s road-tested group has already silenced several hostile environments this year, and they enter the game as battle-hardened and unfazed by crowd dynamics. The Cougars will aim to neutralize Purdue’s strength in the paint, likely focusing defensive pressure on Boilermakers star Braden Smith while attempting to limit entry passes and force Purdue’s supporting cast to beat them from outside. To advance to the Elite Eight, Houston must continue what has brought them to this point: elite defense, rebounding, and depth. Their adaptability, combined with their postseason experience and coaching, makes them a formidable No. 1 seed with national title aspirations. If their core players maintain their form, their bench contributes as it has all season, and they win the battle of physicality and composure, Houston will be in strong position to advance. With a balanced roster, hardened mentality, and one of the game’s most respected coaches on the sideline, the Cougars enter this Sweet 16 contest fully prepared and poised to continue their march toward another Final Four appearance.

Purdue vs. Houston Prop Picks (AI)

Remi is pouring through tons of data on each line. In fact, anytime the Boilermakers and Cougars play there’s always several intriguing angles to key in on. Not to mention games played at Lucas Oil Stadium in Mar can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Roberts under 19.5 PTS+REB+AST

Purdue vs. Houston Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every facet between the Boilermakers and Cougars and using recursive machine learning and impressive AI to analyze the data to a single cover probability.

The Algorithm has been most keyed in on the linear correlation of factor human bettors tend to put on coaching factors between a Boilermakers team going up against a possibly improved Cougars team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

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Below is our current AI Purdue vs Houston picks, computer picks Boilermakers vs Cougars, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CBB schedule.

Boilermakers Betting Trends

Specific recent Against The Spread (ATS) statistics for Purdue are not available in the provided sources.

Cougars Betting Trends

Specific recent ATS statistics for Houston are not available in the provided sources.

Boilermakers vs. Cougars Matchup Trends

Despite being the lower seed, Purdue’s proximity to the game venue may influence betting lines, potentially narrowing the spread due to their quasi-home-court advantage.

Purdue vs. Houston Game Info

Purdue vs Houston starts on March 28, 2025 at 10:09 PM EST.

Venue: Lucas Oil Stadium.

Spread: Houston -7.5
Moneyline: Purdue +293, Houston -373
Over/Under: 132.5

Purdue: (24-11)  |  Houston: (32-4)

Remi's searched hard and found the best prop for this matchup: J. Roberts under 19.5 PTS+REB+AST. Prices move—always shop for the best number.

Despite being the lower seed, Purdue’s proximity to the game venue may influence betting lines, potentially narrowing the spread due to their quasi-home-court advantage.

PURDUE trend: Specific recent Against The Spread (ATS) statistics for Purdue are not available in the provided sources.

HOU trend: Specific recent ATS statistics for Houston are not available in the provided sources.

See our latest CBB picks and odds pages for 2025 to compare prices before you bet.

Purdue vs. Houston Odds

AI algorithm Remi is pouring through mountains of data on each line. In fact, anytime the Purdue vs Houston trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps can often follow normal, predictable patterns.

Purdue vs Houston Opening Odds

PURDUE Moneyline: +293
HOU Moneyline: -373
PURDUE Spread: +7.5
HOU Spread: -7.5
Over/Under: 132.5

Purdue vs Houston Live Odds

Games PTS ML SPR O/U

CBB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Purdue Boilermakers vs. Houston Cougars on March 28, 2025 at Lucas Oil Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CBB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
DRAKE@MIZZOU DRAKE +6.5 53.50% 2 WIN
XAVIER@TEXAS XAVIER -2.5 53.40% 2 WIN
UAB@MEMP MEMP -3.5 54.00% 2 WIN
LVILLE@DUKE LVILLE +6.5 53.10% 2 LOSS
ECU@UAB UAB -5 53.60% 2 WIN
PURDUE@MICH MICH +3 54.60% 3 WIN
CLEM@LVILLE CLEM -120 56.10% 3 LOSS
COL@HOU ANDREJ JAKIMOVSKI PTS + REB + AST - UNDER 15.5 53.70% 2 LOSS
FORD@GWASH FORD +7 53.80% 2 WIN
SEATTLE@ABIL ABIL +6 54.50% 3 WIN
BAMAST@TEXSOU BAMAST -110 55.40% 4 WIN
OHIO@TOLEDO TOLEDO +3 56.70% 4 WIN
UVA@GATECH GATECH +1.5 53.70% 2 WIN
COLO@WVU COLO +7.5 53.20% 2 WIN
USC@RUT USC -115 54.00% 2 WIN
TEXAS@VANDY VANDY -130 56.50% 3 LOSS
BUTLER@PROV BUTLER -115 55.20% 3 WIN
IDAHO@MONTANA MONTANA -6 53.50% 2 WIN
TROY@JMAD TROY -125 55.60% 2 WIN
BELMONT@DRAKE DRAKE -7.5 53.50% 2 LOSS
UCSD@UCDAV UCSD -12.5 53.40% 2 LOSS
SIUE@SEMO SEMO -2.5 54.80% 3 LOSS
ALCORN@ARKPB ARKPB +6.5 56.00% 4 WIN
NORFLK@HOWARD HOWARD +5.5 53.70% 2 LOSS
NKY@CLEVST NKY +4.5 54.40% 3 LOSS
STNFRD@ND STNFRD -125 56.40% 3 LOSS
TENN@OLEMISS OLEMISS +2.5 54.30% 3 WIN
LSALLE@GMASON GMASON -12 54.30% 3 LOSS
PITT@NCST NCST +2.5 56.70% 4 WIN
IND@OREG OREG -6.5 53.60% 2 WIN
FSU@UVA UVA -4 54.40% 3 LOSS
ARK@VANDY ARK +7.5 54.40% 3 WIN
SDGST@UNLV UNLV +2.5 54.10% 3 WIN
EKTY@JVILLE JVILLE -135 58.90% 3 WIN
MANHAT@NIAGARA MANHAT -115 54.70% 3 WIN
MEMP@UAB MEMP -115 54.90% 3 WIN
ILL@MICH MICH -2.5 56.00% 4 LOSS
OKLA@OLEMISS OKLA +7.5 54.50% 3 WIN
ARIZST@UTAH ARIZST +8.5 54.60% 3 LOSS
GC@SEATTLE GC -110 55.00% 3 WIN
PENN@CLMBIA CLMBIA -122 57.50% 4 LOSS
IONA@NIAGARA NIAGARA +1.5 54.30% 3 LOSS
MARIST@SACHRT SACHRT -120 55.40% 3 WIN
CLEVST@WRIGHT CLEVST +1.5 54.30% 3 LOSS
NDAK@STTHOM STTHOM -10 54.30% 3 WIN
USD@WASHST WASHST -12.5 55.20% 4 LOSS
CSBAK@LBEACH CSBAK -130 59.70% 4 WIN
BU@LEHIGH LEHIGH -135 57.70% 3 LOSS
DUQ@LSALLE DUQ -125 56.70% 3 WIN
BYU@ARIZST ARIZST +7.5 54.60% 3 LOSS
UTAHST@BOISE BOISE -4 55.50% 4 WIN