Ole Miss vs Mich. State Prediction — AI Finds CAN'T MISS CBB Lines & Props (Mar 28)

Updated: 2025-03-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Sweet 16 matchup between the Ole Miss Rebels and the Michigan State Spartans is set for March 28, 2025, at State Farm Arena in Atlanta, Georgia. This game features the No. 6 seed Rebels, who have made a remarkable run through the tournament, against the No. 2 seed Spartans, a team with a storied history of postseason success.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 28, 2025

Start Time: 7:09 PM EST​

Venue: State Farm Arena​

Spartans Record: (29-6)

Rebels Record: (24-11)

OPENING ODDS

MISS Moneyline: +135

MICHST Moneyline: -161

MISS Spread: +3.5

MICHST Spread: -3.5

Over/Under: 143.5

MISS
Betting Trends

  • Ole Miss has demonstrated resilience against the spread (ATS) this season, particularly in high-stakes games. Notably, they covered the spread in their recent upset victory over Iowa State, showcasing their ability to perform under pressure.

MICHST
Betting Trends

  • Michigan State has been consistent ATS, especially when favored. In their recent matchup against New Mexico, the Spartans were favored and secured a victory, covering the spread and reinforcing their reliability in tournament play.

MATCHUP TRENDS

  • Historically, Michigan State has excelled in the Sweet 16 under Coach Tom Izzo, often covering the spread in these critical matchups. This trend highlights their preparedness and performance in high-pressure tournament situations.

MISS vs. MICHST
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Davis under 17.5 PTS+REB+AST

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Ole Miss vs Mich. State Prediction & Odds:
Free CBB Betting Insights for 3/28/25

The upcoming Sweet 16 clash between the Ole Miss Rebels and the Michigan State Spartans promises to be a compelling contest, pitting the underdog spirit of Ole Miss against the seasoned prowess of Michigan State. The Rebels, seeded sixth, have embarked on an impressive tournament journey, highlighted by a significant upset over the third-seeded Iowa State Cyclones. In that game, senior guard Sean Pedulla led the charge with a 20-point performance, exemplifying the team’s offensive capabilities. On the other side, the Spartans, holding the second seed, have showcased their tournament mettle with decisive victories, including a notable comeback win against New Mexico. Averaging 78.2 points and 40.1 rebounds per game, Michigan State demonstrates a balanced approach that combines offensive efficiency with defensive tenacity. Betting lines have established Michigan State as a 3.5-point favorite in this matchup.

This reflects the confidence in their consistent performance and experience in tournament settings. However, Ole Miss’s recent success against higher-seeded teams suggests that they are more than capable of defying expectations. The key to this game will likely hinge on the battle between Ole Miss’s dynamic offense and Michigan State’s disciplined defense. The Rebels will need to maintain their offensive rhythm and capitalize on scoring opportunities, particularly from beyond the arc. Conversely, the Spartans will aim to control the tempo, leveraging their rebounding strength to limit second-chance points and disrupt Ole Miss’s offensive flow. In conclusion, this Sweet 16 matchup offers a classic narrative of an underdog seeking to topple a tournament heavyweight. While Michigan State’s experience and balanced play make them the favorites, Ole Miss’s recent performances indicate that they possess the talent and determination to challenge the Spartans effectively. Fans can anticipate a thrilling encounter as both teams vie for a coveted spot in the Elite Eight.

Ole Miss Rebels CBB Preview

The Ole Miss Rebels enter the Sweet 16 with a 24-11 record and the momentum of a team that refuses to be defined by seedings or expectations, having shocked the college basketball world with a thrilling upset over Iowa State in the Round of 32—a win that showcased both their competitive toughness and the strategic acumen of head coach Chris Beard, who has transformed this group into a dangerous postseason force. Known more in recent years for rebuilding than for deep March runs, the Rebels have emerged in this year’s tournament as a legitimate threat, blending gritty, physical defense with opportunistic scoring and timely execution, headlined by senior guard Sean Pedulla, who has been a stabilizing and explosive presence throughout the season, averaging 15.2 points and 4.9 assists per game while shooting 38% from three and orchestrating a high-efficiency, low-turnover offense that has found success even against elite defenses. Complementing him is Matthew Murrell, the team’s emotional leader and dynamic two-way guard, whose perimeter defense and slashing ability have proven critical in both transition and late-clock scenarios, while forward Jaemyn Brakefield provides spacing, rebounding, and stretch-four versatility that keeps opposing bigs honest and opens up the paint for driving lanes and ball reversals. Ole Miss plays a measured style, favoring half-court execution over pace, but is opportunistic in transition off steals and long rebounds, turning defense into offense behind their strong perimeter core and tenacity on the boards. The Rebels hold opponents to just under 68 points per game, fueled by tight man-to-man pressure, intelligent switching, and excellent closeouts that have frustrated even high-powered scoring units throughout the season.

On the glass, Ole Miss is relentless, with a top-50 national offensive rebounding rate and a team-wide commitment to boxing out and contesting every possession—a key element of their identity that could help neutralize Michigan State’s size and rebounding strength. Against the spread, Ole Miss has been a surprisingly solid performer, especially in games where they are underdogs of fewer than five points, covering in multiple high-leverage situations throughout the SEC schedule and again during this tournament run. Their 3.5-point underdog status in this matchup against the Spartans places them squarely in the territory where they’ve thrived, and their current level of confidence, chemistry, and discipline makes them more than capable of competing from tip to buzzer. Coach Beard’s ability to adapt game plans in real time has played a pivotal role in their postseason success, often switching between ball-screen coverages and using tactical timeouts to stop opposing runs while maximizing efficiency out of set plays. For Ole Miss to advance, they must continue to get high-level decision-making from Pedulla, capitalize on second-chance opportunities, and maintain their commitment to defensive rotation and contesting without fouling. If their perimeter shooting holds steady and they can slow the game to their preferred tempo, the Rebels’ combination of toughness, senior leadership, and underdog momentum could propel them past a storied Michigan State program and into the Elite Eight, rewriting expectations and extending one of the most impressive tournament runs in program history.

The Sweet 16 matchup between the Ole Miss Rebels and the Michigan State Spartans is set for March 28, 2025, at State Farm Arena in Atlanta, Georgia. This game features the No. 6 seed Rebels, who have made a remarkable run through the tournament, against the No. 2 seed Spartans, a team with a storied history of postseason success. Ole Miss vs Mich. State AI Prediction: Free CBB Betting Insights for Mar 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Mich. State Spartans CBB Preview

The Michigan State Spartans, entering the Sweet 16 with a formidable 29-6 record, exemplify tournament poise and seasoned execution, a hallmark of Tom Izzo-led teams that thrive under March pressure, as evidenced by their steady progression through the early rounds of the 2025 NCAA Tournament and a convincing win over New Mexico that featured both resilience and depth in critical stretches. Michigan State has long established itself as a postseason juggernaut, and this year is no exception, with a balanced offensive approach averaging 78.2 points per game and anchored by guard Jaden Akins, who leads the team in scoring with 12.7 points per game, alongside the steady leadership of Jeremy Fears Jr., a floor general who averages over 5 assists per contest and serves as the cerebral core of Izzo’s half-court system. The Spartans’ offensive rhythm is characterized by quick ball movement, unselfish play, and high-percentage shot creation, both in transition and the half court, supported by a deep rotation that includes productive frontcourt contributors like Jaxon Kohler, whose 7.6 rebounds per game anchor the Spartans’ glass dominance, enabling a strong second-chance game and swift transition opportunities. Michigan State’s defensive identity is equally crucial to their success; they are known for disciplined man-to-man schemes, timely help-side rotations, and the ability to clamp down late in games, all of which have kept opponents to modest shooting percentages and stifled perimeter-oriented teams throughout the season. On average, they allow under 66 points per game, a reflection of their relentless effort, conditioning, and execution.

Their transition defense is among the nation’s best, forcing opponents into tough, contested looks while limiting easy buckets off turnovers or long rebounds. Rebounding remains a pillar of their identity, with the Spartans averaging over 40 boards per contest, often winning the battle of physicality and denying second-chance scoring. Coach Izzo’s ability to prepare his teams mentally and tactically for each game remains a distinct advantage, especially in the NCAA Tournament, where his track record of Sweet 16 success is among the best all-time. ATS, Michigan State has been consistent, especially when favored, as is the case in this 3.5-point line matchup against Ole Miss. Their experience and ability to perform in clutch situations have made them a trusted bet in the eyes of the market, and their current form reinforces the notion that they are more than capable of making a deep run. As they prepare to face an Ole Miss team riding high off an upset, Michigan State’s blueprint for success will be grounded in defensive pressure, control of the glass, and the poise to weather any early momentum shifts. If Akins and Fears can continue dictating the pace and the frontcourt holds steady against a physical Rebels squad, the Spartans’ combination of talent, structure, and tournament seasoning should give them the upper hand in advancing to the Elite Eight while reaffirming their place as one of college basketball’s most consistent postseason programs.

Ole Miss vs. Mich. State Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the Rebels and Spartans play there’s always several intriguing observations to key in on. Not to mention games played at State Farm Arena in Mar can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: D. Davis under 17.5 PTS+REB+AST

Ole Miss vs. Mich. State Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every simulation between the Rebels and Spartans and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most watching on the linear correlation of weight human bettors regularly put on Mich. State’s strength factors between a Rebels team going up against a possibly improved Spartans team. We’ve found the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CBB AI picks for FREE now.

Below is our current AI Ole Miss vs Mich. State picks, computer picks Rebels vs Spartans, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
ACTIVE PICKS LOCKED - SEE NOW

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CBB schedule.

Rebels Betting Trends

Ole Miss has demonstrated resilience against the spread (ATS) this season, particularly in high-stakes games. Notably, they covered the spread in their recent upset victory over Iowa State, showcasing their ability to perform under pressure.

Spartans Betting Trends

Michigan State has been consistent ATS, especially when favored. In their recent matchup against New Mexico, the Spartans were favored and secured a victory, covering the spread and reinforcing their reliability in tournament play.

Rebels vs. Spartans Matchup Trends

Historically, Michigan State has excelled in the Sweet 16 under Coach Tom Izzo, often covering the spread in these critical matchups. This trend highlights their preparedness and performance in high-pressure tournament situations.

Ole Miss vs. Mich. State Game Info

Ole Miss vs Mich. State starts on March 28, 2025 at 7:09 PM EST.

Spread: Mich. State -3.5
Moneyline: Ole Miss +135, Mich. State -161
Over/Under: 143.5

Ole Miss: (24-11)  |  Mich. State: (29-6)

Remi's searched hard and found the best prop for this matchup: D. Davis under 17.5 PTS+REB+AST. Prices move—always shop for the best number.

Historically, Michigan State has excelled in the Sweet 16 under Coach Tom Izzo, often covering the spread in these critical matchups. This trend highlights their preparedness and performance in high-pressure tournament situations.

MISS trend: Ole Miss has demonstrated resilience against the spread (ATS) this season, particularly in high-stakes games. Notably, they covered the spread in their recent upset victory over Iowa State, showcasing their ability to perform under pressure.

MICHST trend: Michigan State has been consistent ATS, especially when favored. In their recent matchup against New Mexico, the Spartans were favored and secured a victory, covering the spread and reinforcing their reliability in tournament play.

See our latest CBB picks and odds pages for 2025 to compare prices before you bet.

Ole Miss vs. Mich. State Odds

AI algorithm Remi is pouring through tons of stats on each team. In fact, anytime the Ole Miss vs Mich. State trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.

Ole Miss vs Mich. State Opening Odds

MISS Moneyline: +135
MICHST Moneyline: -161
MISS Spread: +3.5
MICHST Spread: -3.5
Over/Under: 143.5

Ole Miss vs Mich. State Live Odds

Games PTS ML SPR O/U

CBB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Ole Miss Rebels vs. Mich. State Spartans on March 28, 2025 at State Farm Arena.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CBB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
DRAKE@MIZZOU DRAKE +6.5 53.50% 2 WIN
XAVIER@TEXAS XAVIER -2.5 53.40% 2 WIN
UAB@MEMP MEMP -3.5 54.00% 2 WIN
LVILLE@DUKE LVILLE +6.5 53.10% 2 LOSS
ECU@UAB UAB -5 53.60% 2 WIN
PURDUE@MICH MICH +3 54.60% 3 WIN
CLEM@LVILLE CLEM -120 56.10% 3 LOSS
COL@HOU ANDREJ JAKIMOVSKI PTS + REB + AST - UNDER 15.5 53.70% 2 LOSS
FORD@GWASH FORD +7 53.80% 2 WIN
SEATTLE@ABIL ABIL +6 54.50% 3 WIN
BAMAST@TEXSOU BAMAST -110 55.40% 4 WIN
OHIO@TOLEDO TOLEDO +3 56.70% 4 WIN
UVA@GATECH GATECH +1.5 53.70% 2 WIN
COLO@WVU COLO +7.5 53.20% 2 WIN
USC@RUT USC -115 54.00% 2 WIN
TEXAS@VANDY VANDY -130 56.50% 3 LOSS
BUTLER@PROV BUTLER -115 55.20% 3 WIN
IDAHO@MONTANA MONTANA -6 53.50% 2 WIN
TROY@JMAD TROY -125 55.60% 2 WIN
BELMONT@DRAKE DRAKE -7.5 53.50% 2 LOSS
UCSD@UCDAV UCSD -12.5 53.40% 2 LOSS
SIUE@SEMO SEMO -2.5 54.80% 3 LOSS
ALCORN@ARKPB ARKPB +6.5 56.00% 4 WIN
NORFLK@HOWARD HOWARD +5.5 53.70% 2 LOSS
NKY@CLEVST NKY +4.5 54.40% 3 LOSS
STNFRD@ND STNFRD -125 56.40% 3 LOSS
TENN@OLEMISS OLEMISS +2.5 54.30% 3 WIN
LSALLE@GMASON GMASON -12 54.30% 3 LOSS
PITT@NCST NCST +2.5 56.70% 4 WIN
IND@OREG OREG -6.5 53.60% 2 WIN
FSU@UVA UVA -4 54.40% 3 LOSS
ARK@VANDY ARK +7.5 54.40% 3 WIN
SDGST@UNLV UNLV +2.5 54.10% 3 WIN
EKTY@JVILLE JVILLE -135 58.90% 3 WIN
MANHAT@NIAGARA MANHAT -115 54.70% 3 WIN
MEMP@UAB MEMP -115 54.90% 3 WIN
ILL@MICH MICH -2.5 56.00% 4 LOSS
OKLA@OLEMISS OKLA +7.5 54.50% 3 WIN
ARIZST@UTAH ARIZST +8.5 54.60% 3 LOSS
GC@SEATTLE GC -110 55.00% 3 WIN
PENN@CLMBIA CLMBIA -122 57.50% 4 LOSS
IONA@NIAGARA NIAGARA +1.5 54.30% 3 LOSS
MARIST@SACHRT SACHRT -120 55.40% 3 WIN
CLEVST@WRIGHT CLEVST +1.5 54.30% 3 LOSS
NDAK@STTHOM STTHOM -10 54.30% 3 WIN
USD@WASHST WASHST -12.5 55.20% 4 LOSS
CSBAK@LBEACH CSBAK -130 59.70% 4 WIN
BU@LEHIGH LEHIGH -135 57.70% 3 LOSS
DUQ@LSALLE DUQ -125 56.70% 3 WIN
BYU@ARIZST ARIZST +7.5 54.60% 3 LOSS
UTAHST@BOISE BOISE -4 55.50% 4 WIN