McNeese vs Purdue Prediction — AI Finds CAN'T MISS CBB Lines & Props (Mar 22)

Updated: 2025-03-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On March 22, 2025, the McNeese Cowboys (No. 12 seed) will face the Purdue Boilermakers (No. 4 seed) in the second round of the NCAA Tournament. McNeese aims to continue their Cinderella run after a stunning upset over Clemson, while Purdue looks to assert their dominance and advance to the Sweet 16.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 22, 2025

Start Time: 12:10 PM EST​

Venue: Amica Mutual Pavilion​

Boilermakers Record: (23-11)

Cowboys Record: (10-21)

OPENING ODDS

MCNSE Moneyline: +205

PURDUE Moneyline: -254

MCNSE Spread: +5.5

PURDUE Spread: -5.5

Over/Under: 143.5

MCNSE
Betting Trends

  • Specific against-the-spread (ATS) data for McNeese’s recent games is limited. However, their recent performance, including a significant upset over Clemson, suggests they have been outperforming expectations.

PURDUE
Betting Trends

  • Purdue has been strong ATS this season, particularly in non-conference play, reflecting their ability to cover spreads against various opponents.

MATCHUP TRENDS

  • Historically, No. 12 seeds have a reputation for upsetting No. 5 seeds in the NCAA Tournament, but McNeese’s advancement to face a No. 4 seed like Purdue is less common, making this matchup particularly intriguing for bettors.

MCNSE vs. PURDUE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: B. Smith under 18.5 Points

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McNeese vs Purdue Prediction & Odds:
Free CBB Betting Insights for 3/22/25

The NCAA Tournament’s second round on March 22, 2025, features a compelling matchup between the McNeese Cowboys and the Purdue Boilermakers. McNeese, under the guidance of coach Will Wade, has emerged as a Cinderella story following their narrow 69-67 victory over No. 5 seed Clemson. This win marked the program’s first-ever NCAA Tournament victory, propelling them into the national spotlight. The Cowboys’ aggressive defense was pivotal in stifling Clemson’s offense, showcasing their resilience and tactical acumen. Key contributors like Brandon Murray, who delivered 21 points off the bench, and Christian Shumate, who recorded a double-double, have been instrumental in McNeese’s success. Their ability to perform under pressure underscores the depth and versatility of the roster. Purdue enters this matchup with a strong season record, reflecting their consistent performance in both conference and non-conference play. The Boilermakers’ offense averages 77.8 points per game, outscoring opponents by an average margin of 6.9 points. This offensive efficiency is complemented by their defensive prowess, making them a formidable opponent. Players like Braden Smith and Trey Kaufman-Renn have been standout performers, collectively averaging 36.4 points per game. Their leadership and scoring ability are critical components of Purdue’s game plan. From a betting perspective, Purdue has demonstrated strength against the spread (ATS) this season, particularly in non-conference games.

This trend indicates their capability to meet or exceed expectations set by oddsmakers. Conversely, specific ATS data for McNeese is limited, but their recent performances, including the upset over Clemson, suggest they have been surpassing expectations. Bettors may find value in considering McNeese’s momentum and underdog status, which historically can be advantageous in tournament settings. The coaching dynamic adds another layer of intrigue to this matchup. Will Wade’s transparent approach regarding his future move to N.C. State has been a topic of discussion. His openness with his team about his career trajectory has been met with mixed reactions but has not detracted from the Cowboys’ focus and performance. This situation could serve as either a motivational factor or a distraction, depending on how the team channels this development. Purdue’s experience and higher seeding position them as the favorites in this contest. However, McNeese’s recent surge and the unpredictable nature of March Madness suggest that an upset is within the realm of possibility. The Cowboys’ defense will need to be relentless in containing Purdue’s key scorers, while their offense must capitalize on every opportunity to keep pace. For Purdue, maintaining composure and executing their game plan will be essential to avoid falling victim to the underdog narrative. In summary, this second-round matchup encapsulates the excitement and unpredictability that define the NCAA Tournament. McNeese’s Cinderella story faces a significant test against a seasoned Purdue squad. The outcome will hinge on execution, adaptability, and perhaps a touch of March Madness magic.

McNeese Cowboys CBB Preview

The McNeese Cowboys head into their March 22, 2025 second-round NCAA Tournament matchup against the Purdue Boilermakers riding the high of a program-defining upset, having just stunned No. 5 seed Clemson 69-67 to earn the school’s first-ever tournament victory and firmly establish themselves as this year’s early Cinderella story, a narrative that’s been years in the making under head coach Will Wade, whose controversial but effective return to college basketball has transformed McNeese from a middling Southland program into a legitimate mid-major force that plays with swagger, defensive grit, and surprising depth. Wade, who has already announced he’ll be heading to NC State after this season, has managed to keep his players laser-focused despite the noise, a testament to his leadership and the maturity of a roster that features multiple high-major transfers and veterans unafraid of the moment. Leading the charge is guard Brandon Murray, a former LSU and Georgetown product who erupted for 21 points off the bench in the upset over Clemson, displaying elite shot-making and composure in clutch moments, while forward Christian Shumate continues to serve as the emotional and physical anchor of the team, grabbing 12 rebounds and playing suffocating interior defense that helped slow down Clemson’s post threats. The Cowboys have been defined by their ability to make timely defensive stops, capitalize on turnovers, and hit big shots, particularly from the perimeter where guards like Shahada Wells and Javohn Garcia provide spacing and slashing that keeps defenses off balance.

Offensively, McNeese runs a balanced attack that thrives on ball movement and tempo control, rarely playing rushed or undisciplined basketball, a style Wade has drilled into them all season. Defensively, they’re scrappy, switching often, helping early, and willing to play physical against bigger opponents despite often being undersized in the frontcourt, an effort that will be sorely tested against Purdue’s 7’4” Zach Edey, whose presence in the paint could alter the Cowboys’ approach on both ends. To compete, McNeese will need to double in the post, rotate quickly to contest perimeter shots, and box out consistently to avoid giving up second-chance points—a challenge given Purdue’s rebounding edge and interior efficiency. On the offensive end, McNeese will need to get creative, using high ball screens and isolation matchups to draw Purdue’s bigs away from the rim and create driving lanes for their guards, while also shooting well from beyond the arc to loosen up the Boilermakers’ typically compact defense. One X-factor is the Cowboys’ bench, which outscored Clemson’s 31-13 in the first round and could be critical in maintaining energy and scoring punch when the starters rest. With the pressure off and house money on their side, McNeese enters this game fearless and confident, playing with a belief that they belong among the best despite their underdog status. They’ll look to exploit any hint of complacency from a Purdue team that has previously been vulnerable to tournament upsets, and if they can recreate the defensive intensity and offensive execution that fueled their opening-round shocker, the Cowboys just might extend their magical run another game and rewrite March history yet again.

On March 22, 2025, the McNeese Cowboys (No. 12 seed) will face the Purdue Boilermakers (No. 4 seed) in the second round of the NCAA Tournament. McNeese aims to continue their Cinderella run after a stunning upset over Clemson, while Purdue looks to assert their dominance and advance to the Sweet 16. McNeese vs Purdue AI Prediction: Free CBB Betting Insights for Mar 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Purdue Boilermakers CBB Preview

The Purdue Boilermakers, entering the NCAA Tournament as a No. 4 seed, have demonstrated a season characterized by offensive efficiency and defensive resilience, culminating in a 77.8 points per game scoring average and a 6.9-point average margin over opponents. This performance reflects their strategic prowess and adaptability across various matchups. Central to Purdue’s success are standout players Braden Smith and Trey Kaufman-Renn, who collectively contribute 36.4 points per game, underscoring their pivotal roles in the team’s offensive schemes. Smith’s playmaking abilities and Kaufman-Renn’s versatility have been instrumental in navigating the competitive landscape of the Big Ten Conference. The Boilermakers’ non-conference record of 9-3 further attests to their capability to adjust and excel against diverse playing styles. Defensively, Purdue’s strategy focuses on limiting opponents’ scoring opportunities, a testament to their disciplined approach and cohesive team dynamics. The coaching staff’s emphasis on preparation and in-game adjustments has fortified the team’s resilience in high-pressure situations. As they prepare to face the McNeese Cowboys, Purdue will need to approach the matchup with the same intensity and focus that carried them through a highly competitive Big Ten schedule, especially given the unpredictable nature of March Madness and the momentum McNeese brings into this second-round clash. Purdue’s size and physicality give them a distinct advantage in the frontcourt, particularly with Zach Edey anchoring the post, where his dominance on the boards and shot-blocking presence can severely disrupt the Cowboys’ rhythm on both ends of the floor. While Braden Smith and Trey Kaufman-Renn provide the scoring punch, Edey’s ability to alter shots and command double teams opens up perimeter opportunities for sharpshooters like Fletcher Loyer and Lance Jones, both of whom are capable of stretching the floor and punishing sagging defenses.

The Boilermakers also excel in ball security, ranking among the national leaders in assist-to-turnover ratio, a critical factor in postseason play where every possession is magnified. Head coach Matt Painter has instilled a methodical, efficient offensive system that emphasizes ball movement, high-percentage looks, and smart tempo control, allowing Purdue to avoid the chaotic stretches that often lead to upsets. Against McNeese’s aggressive, high-energy defense—which was pivotal in their upset over Clemson—Purdue’s discipline and patience in halfcourt sets will be essential in wearing down the Cowboys and exploiting mismatches. The Boilermakers’ bench, often overlooked, provides valuable depth with forwards like Mason Gillis and Caleb Furst offering physicality and rebounding that can maintain intensity when starters rest. Defensively, Purdue will likely focus on containing McNeese guard Shahada Wells, whose explosiveness and downhill attacking game are central to the Cowboys’ offense. Expect Purdue to switch defensively on the perimeter to challenge shot attempts and deny driving lanes, while packing the paint to limit second-chance points—an area where McNeese capitalized heavily in their first-round upset. Purdue’s experience in the tournament and battle-tested roster give them a clear edge in terms of preparation and poise, but their history of being upset in previous tournaments serves as a cautionary tale and motivation not to take any opponent lightly. With their offensive efficiency, rebounding strength, and commitment to defense, Purdue is positioned to neutralize the Cinderella narrative McNeese is hoping to extend, and with a trip to the Sweet 16 on the line, the Boilermakers will aim to assert their dominance early, control the pace, and execute their game plan with the kind of precision and urgency expected from a top-tier program. Ultimately, this matchup is less about talent disparity and more about who can impose their style of play and maintain composure under pressure—areas where Purdue has historically thrived when fully locked in and where they’ll need to be sharp to avoid becoming another footnote in McNeese’s improbable March Madness journey.

McNeese vs. Purdue Prop Picks (AI)

Remi is pouring through mountains of datapoints on each team. In fact, anytime the Cowboys and Boilermakers play there’s always several intriguing observations to key in on. Not to mention games played at Amica Mutual Pavilion in Mar rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: B. Smith under 18.5 Points

McNeese vs. Purdue Prediction (AI)

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Remi, our AI sports wizard, has been pouring over millions of data from every facet between the Cowboys and Boilermakers and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the unproportionally assigned weight emotional bettors regularly put on player performance factors between a Cowboys team going up against a possibly improved Boilermakers team. Trends look to say the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CBB AI picks for FREE now.

Below is our current AI McNeese vs Purdue picks, computer picks Cowboys vs Boilermakers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CBB schedule.

Cowboys Betting Trends

Specific against-the-spread (ATS) data for McNeese’s recent games is limited. However, their recent performance, including a significant upset over Clemson, suggests they have been outperforming expectations.

Boilermakers Betting Trends

Purdue has been strong ATS this season, particularly in non-conference play, reflecting their ability to cover spreads against various opponents.

Cowboys vs. Boilermakers Matchup Trends

Historically, No. 12 seeds have a reputation for upsetting No. 5 seeds in the NCAA Tournament, but McNeese’s advancement to face a No. 4 seed like Purdue is less common, making this matchup particularly intriguing for bettors.

McNeese vs. Purdue Game Info

McNeese vs Purdue starts on March 22, 2025 at 12:10 PM EST.

Venue: Amica Mutual Pavilion.

Spread: Purdue -5.5
Moneyline: McNeese +205, Purdue -254
Over/Under: 143.5

McNeese: (10-21)  |  Purdue: (23-11)

Remi's searched hard and found the best prop for this matchup: B. Smith under 18.5 Points. Prices move—always shop for the best number.

Historically, No. 12 seeds have a reputation for upsetting No. 5 seeds in the NCAA Tournament, but McNeese’s advancement to face a No. 4 seed like Purdue is less common, making this matchup particularly intriguing for bettors.

MCNSE trend: Specific against-the-spread (ATS) data for McNeese’s recent games is limited. However, their recent performance, including a significant upset over Clemson, suggests they have been outperforming expectations.

PURDUE trend: Purdue has been strong ATS this season, particularly in non-conference play, reflecting their ability to cover spreads against various opponents.

See our latest CBB picks and odds pages for 2025 to compare prices before you bet.

McNeese vs. Purdue Odds

Remi is pouring through loads of stats on each line. In fact, anytime the McNeese vs Purdue trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

McNeese vs Purdue Opening Odds

MCNSE Moneyline: +205
PURDUE Moneyline: -254
MCNSE Spread: +5.5
PURDUE Spread: -5.5
Over/Under: 143.5

McNeese vs Purdue Live Odds

Games PTS ML SPR O/U

CBB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers McNeese Cowboys vs. Purdue Boilermakers on March 22, 2025 at Amica Mutual Pavilion.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CBB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
DRAKE@MIZZOU DRAKE +6.5 53.50% 2 WIN
XAVIER@TEXAS XAVIER -2.5 53.40% 2 WIN
UAB@MEMP MEMP -3.5 54.00% 2 WIN
LVILLE@DUKE LVILLE +6.5 53.10% 2 LOSS
ECU@UAB UAB -5 53.60% 2 WIN
PURDUE@MICH MICH +3 54.60% 3 WIN
CLEM@LVILLE CLEM -120 56.10% 3 LOSS
COL@HOU ANDREJ JAKIMOVSKI PTS + REB + AST - UNDER 15.5 53.70% 2 LOSS
FORD@GWASH FORD +7 53.80% 2 WIN
SEATTLE@ABIL ABIL +6 54.50% 3 WIN
BAMAST@TEXSOU BAMAST -110 55.40% 4 WIN
OHIO@TOLEDO TOLEDO +3 56.70% 4 WIN
UVA@GATECH GATECH +1.5 53.70% 2 WIN
COLO@WVU COLO +7.5 53.20% 2 WIN
USC@RUT USC -115 54.00% 2 WIN
TEXAS@VANDY VANDY -130 56.50% 3 LOSS
BUTLER@PROV BUTLER -115 55.20% 3 WIN
IDAHO@MONTANA MONTANA -6 53.50% 2 WIN
TROY@JMAD TROY -125 55.60% 2 WIN
BELMONT@DRAKE DRAKE -7.5 53.50% 2 LOSS
UCSD@UCDAV UCSD -12.5 53.40% 2 LOSS
SIUE@SEMO SEMO -2.5 54.80% 3 LOSS
ALCORN@ARKPB ARKPB +6.5 56.00% 4 WIN
NORFLK@HOWARD HOWARD +5.5 53.70% 2 LOSS
NKY@CLEVST NKY +4.5 54.40% 3 LOSS
STNFRD@ND STNFRD -125 56.40% 3 LOSS
TENN@OLEMISS OLEMISS +2.5 54.30% 3 WIN
LSALLE@GMASON GMASON -12 54.30% 3 LOSS
PITT@NCST NCST +2.5 56.70% 4 WIN
IND@OREG OREG -6.5 53.60% 2 WIN
FSU@UVA UVA -4 54.40% 3 LOSS
ARK@VANDY ARK +7.5 54.40% 3 WIN
SDGST@UNLV UNLV +2.5 54.10% 3 WIN
EKTY@JVILLE JVILLE -135 58.90% 3 WIN
MANHAT@NIAGARA MANHAT -115 54.70% 3 WIN
MEMP@UAB MEMP -115 54.90% 3 WIN
ILL@MICH MICH -2.5 56.00% 4 LOSS
OKLA@OLEMISS OKLA +7.5 54.50% 3 WIN
ARIZST@UTAH ARIZST +8.5 54.60% 3 LOSS
GC@SEATTLE GC -110 55.00% 3 WIN
PENN@CLMBIA CLMBIA -122 57.50% 4 LOSS
IONA@NIAGARA NIAGARA +1.5 54.30% 3 LOSS
MARIST@SACHRT SACHRT -120 55.40% 3 WIN
CLEVST@WRIGHT CLEVST +1.5 54.30% 3 LOSS
NDAK@STTHOM STTHOM -10 54.30% 3 WIN
USD@WASHST WASHST -12.5 55.20% 4 LOSS
CSBAK@LBEACH CSBAK -130 59.70% 4 WIN
BU@LEHIGH LEHIGH -135 57.70% 3 LOSS
DUQ@LSALLE DUQ -125 56.70% 3 WIN
BYU@ARIZST ARIZST +7.5 54.60% 3 LOSS
UTAHST@BOISE BOISE -4 55.50% 4 WIN