Bulldogs vs. Cougars
Prediction, Odds & Props
Mar 22 | CBB AI Picks

Updated: 2025-03-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On March 22, 2025, the No. 1 seed Houston Cougars (31-4) will face the No. 8 seed Gonzaga Bulldogs (26-8) in the second round of the NCAA Tournament at INTRUST Bank Arena. Houston is favored by 5.5 points, with the over/under set at 140.5 points.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 22, 2025

Start Time: 8:40 PM EST​

Venue: Intrust Bank Arena​

Cougars Record: (31-4)

Bulldogs Record: (26-8)

OPENING ODDS

GONZAG Moneyline: +185

HOU Moneyline: -224

GONZAG Spread: +5.5

HOU Spread: -5.5

Over/Under: 139.5

GONZAG
Betting Trends

  • Gonzaga holds a 15-15 record against the spread (ATS) this season, with the total going under in 16 of their 30 games.

HOU
Betting Trends

  • Houston has a 14-16 ATS record this season, with the total going over in 15 of their 30 games.

MATCHUP TRENDS

  • Gonzaga has covered the spread in five of their last seven games when playing as underdogs.

GONZAG vs. HOU
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Uzan under 14.5 Points

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Gonzaga vs Houston Prediction & Odds:
Free CBB Betting Insights for 3/22/25

The upcoming NCAA Tournament second-round matchup between the No. 1 seed Houston Cougars and the No. 8 seed Gonzaga Bulldogs on March 22, 2025, is poised to be a thrilling contest between two college basketball powerhouses with contrasting styles. Houston enters the game with a stellar 31-4 record, having dominated Southern Illinois-Edwardsville in the first round with a commanding 78-40 victory. Their season has been marked by defensive excellence, leading the nation in scoring defense by allowing just 58.3 points per game. Offensively, the Cougars are efficient, averaging 75.2 points per game, with guard L.J. Cryer being a pivotal contributor, ranking among the nation’s leaders in three-pointers made. Gonzaga, boasting a 26-8 record, showcased their offensive firepower in an 89-68 first-round win over Georgia. The Bulldogs are renowned for their high-octane offense, averaging 83.6 points per game, and have been a consistent presence in the NCAA Tournament, marking their 26th consecutive appearance. This game is anticipated to be a classic battle of Houston’s defensive tenacity against Gonzaga’s offensive prowess. Houston’s defense is anchored by forward J’Wan Roberts, who provides rim protection and rebounding strength. Their perimeter defense is equally formidable, often disrupting opponents’ shooting rhythms.

Offensively, the Cougars’ balanced attack features multiple players capable of scoring in double figures, with Cryer’s sharpshooting and Milos Uzan’s playmaking abilities being central to their strategy. Gonzaga’s offense is orchestrated by guard Ryan Nembhard, who leads the nation in assists, facilitating a fluid offense that emphasizes ball movement and spacing. Khalif Battle’s scoring versatility and Braden Huff’s interior presence add layers to their offensive schemes. Defensively, Gonzaga allows 69.6 points per game, employing a mix of man-to-man and zone defenses to adapt to various offensive threats. From a betting perspective, Houston is favored by 5.5 points, with the over/under set at 140.5 points. Gonzaga has a 15-15 ATS record, with the total going under in 16 of their games, while Houston holds a 14-16 ATS record, with the total going over in 15 of their games. An interesting betting angle is Gonzaga’s recent performance as underdogs, having covered the spread in five of their last seven such instances, indicating their resilience in challenging matchups. The game’s outcome may hinge on the battle between Houston’s defense and Gonzaga’s offense. If Houston can impose their defensive will and limit Gonzaga’s transition opportunities, they can control the game’s tempo. Conversely, if Gonzaga can speed up the game and exploit Houston’s defense with their ball movement and shooting, they stand a strong chance of advancing. Both teams’ ability to adapt their strategies during the game will be crucial in this high-stakes encounter.

Gonzaga Bulldogs CBB Preview

The Gonzaga Bulldogs enter their second-round NCAA Tournament matchup against the top-seeded Houston Cougars as a dangerous No. 8 seed with a 26-8 overall record, fresh off a dominant 89–68 victory over Georgia that served as a showcase of their offensive firepower and postseason pedigree, both of which have made them one of college basketball’s most consistent forces over the past two decades under head coach Mark Few. Despite a relatively down year by Gonzaga’s lofty standards, the Bulldogs appear to be peaking at the right time, having won nine of their last ten games and returning to their identity as an unselfish, high-scoring team with elite ball movement and inside-out balance that punishes both aggressive defenses and zones alike. The heart of Gonzaga’s offense lies in the hands of point guard Ryan Nembhard, a seasoned playmaker who leads the nation in assists and serves as the engine behind the team’s pace and flow—his ability to push the tempo, read pick-and-rolls, and find open shooters has revitalized Gonzaga’s transition game and opened up clean looks for perimeter scorers like Nolan Hickman and Ben Gregg. Khalif Battle, a transfer from Arkansas, brings a dynamic scoring punch on the wing and has emerged as one of the tournament’s most dangerous offensive weapons, capable of creating his own shot from virtually anywhere on the court while also attacking closeouts and finishing through contact. In the frontcourt, Braden Huff has provided Gonzaga with a reliable inside presence, averaging double figures while shooting over 55% from the field and playing with the kind of patience and touch that complements the fast-paced guard play around him.

Defensively, the Bulldogs have had their inconsistencies this season, giving up 69.6 points per game, but their ability to adapt in-game, shift between man-to-man and matchup zones, and compete on the defensive glass has improved significantly over the past month. One of the key challenges facing Gonzaga against Houston will be handling the Cougars’ physicality, particularly in the half court, where Houston excels at grinding down possessions and forcing teams into low-efficiency jumpers late in the shot clock. Gonzaga must use its superior ball movement and off-ball cutting to prevent stagnation and keep Houston’s defense in rotation, especially by targeting early offense opportunities before the Cougars are fully set. The Bulldogs are among the best teams in the tournament at limiting turnovers, averaging fewer than 10 per game, and this discipline will be vital in neutralizing Houston’s ability to convert live-ball turnovers into transition points. From a betting standpoint, Gonzaga holds a 15-15 record against the spread this season but has covered in five of their last seven games as underdogs, underscoring their capability to outperform expectations when counted out. Few’s experience in March and his ability to adjust strategically gives Gonzaga a fighting chance even against the nation’s best defense, and if Nembhard can control the game’s tempo, Battle and Hickman can find their rhythm from the perimeter, and Huff can stay out of foul trouble while finishing strong in the paint, the Bulldogs are well-positioned to challenge Houston and potentially pull off one of the tournament’s biggest upsets by leveraging their seasoned core, offensive versatility, and postseason toughness.

On March 22, 2025, the No. 1 seed Houston Cougars (31-4) will face the No. 8 seed Gonzaga Bulldogs (26-8) in the second round of the NCAA Tournament at INTRUST Bank Arena. Houston is favored by 5.5 points, with the over/under set at 140.5 points. Gonzaga vs Houston AI Prediction: Free CBB Betting Insights for Mar 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Houston Cougars CBB Preview

The Houston Cougars, entering the NCAA Tournament as a No. 1 seed with an impressive 31-4 record, have epitomized defensive excellence and balanced offense throughout the season under the guidance of head coach Kelvin Sampson. Their journey to the second round was marked by a dominant 78-40 victory over Southern Illinois-Edwardsville, showcasing their defensive prowess that has been a hallmark all season. Houston leads the nation in scoring defense, allowing just 58.3 points per game, a testament to their disciplined man-to-man defense and ability to force opponents into low-percentage shots. Offensively, the Cougars are efficient, averaging 75.2 points per game, with a balanced attack that features multiple scoring options. Guard L.J. Cryer has been instrumental, ranking among the nation’s leaders in three-pointers made, providing a consistent perimeter threat that stretches defenses. Milos Uzan’s playmaking abilities have been pivotal in orchestrating the offense, facilitating ball movement that often leads to high-percentage shots. Forward J’Wan Roberts anchors the interior, offering rim protection and rebounding strength that ignites fast-break opportunities. The Cougars’ ability to control the tempo of the game, dictating a pace that suits their defensive strengths, has been crucial in their success. Their resilience is evident in their 22-1 conference record, reflecting consistency and dominance in the Big 12. Houston’s depth allows for sustained defensive pressure, with bench players seamlessly integrating into the system without a drop in intensity. Their experience in close games, coupled with a strategic approach to neutralizing opponents’ strengths, positions them well in high-stakes tournament settings. As they prepare to face Gonzaga, a team known for its offensive firepower, Houston’s emphasis will likely be on disrupting the Bulldogs’ rhythm, contesting shots, and controlling the boards to limit second-chance opportunities. Houston’s defensive discipline is unmatched across college basketball this season, thanks in large part to their ability to switch seamlessly on the perimeter, hedge aggressively on screens, and recover without overcommitting, allowing them to neutralize dribble penetration and force tough shots late in the clock. J’Wan Roberts has emerged as the heart of their interior defense, averaging over 1.5 blocks and 7 rebounds per game, and his physical presence in the paint will be essential in containing Gonzaga’s Braden Huff, who is efficient around the rim and dangerous in pick-and-roll action.

On the perimeter, Jamal Shead and L.J. Cryer form one of the most experienced and clutch backcourts in the tournament, with Shead controlling pace and Cryer spacing the floor with his deep shooting range and uncanny ability to knock down shots off the dribble or catch. While Houston’s identity is built on defense, their offensive execution often goes overlooked—they average 14.6 assists per game and commit fewer than 10 turnovers on average, allowing them to maintain composure in high-pressure situations and out-execute less disciplined teams. Kelvin Sampson’s coaching acumen adds another layer of confidence to this group, as he has consistently molded his teams into defensive juggernauts with postseason poise and mental toughness, and his familiarity with March Madness gives Houston a distinct advantage in terms of preparation, in-game adjustments, and late-game decision-making. One of Houston’s underrated strengths this season has been their ability to dominate the offensive glass, averaging 11.4 second-chance opportunities per game, which often breaks the back of opponents trying to mount a comeback or slow down the pace. This relentless rebounding effort, led by Roberts and freshman sensation Joseph Tugler, ensures that even on off-shooting nights, the Cougars can generate enough possessions to keep pressure on the opposing defense. Against Gonzaga, Houston’s main tactical focus will be denying the Bulldogs’ transition game, limiting open looks from three, and making them work deep into the shot clock—a game plan designed to disrupt Gonzaga’s rhythm and force them into playing a slower, more physical brand of basketball. With a 14–16 record against the spread this season, Houston hasn’t always covered big numbers, but in tight tournament matchups, their elite defense tends to prevail, and their controlled, mistake-free approach often wears opponents down over 40 minutes. The Cougars will look to assert themselves early, using their physicality to set the tone, while maintaining their typical suffocating pace that has held 20 opponents under 60 points this season. If Cryer and Shead are able to generate enough offense to complement their defense, and the frontcourt continues to crash the glass and protect the rim, Houston will be in an excellent position not only to defeat Gonzaga but also to make another deep NCAA Tournament run, driven by a formula of toughness, depth, and elite defensive precision that no other team in the nation replicates with such consistency and intensity.

Gonzaga vs. Houston Prop Picks (AI)

Remi is pouring through loads of data on each team. In fact, anytime the Bulldogs and Cougars play there’s always several intriguing trends to key in on. Not to mention games played at Intrust Bank Arena in Mar can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: M. Uzan under 14.5 Points

Gonzaga vs. Houston Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every angle between the Bulldogs and Cougars and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

The Algorithm has been most fixated on the growing weight emotional bettors tend to put on player performance factors between a Bulldogs team going up against a possibly unhealthy Cougars team. We’ve found the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CBB AI picks for FREE now.

Below is our current AI Gonzaga vs Houston picks, computer picks Bulldogs vs Cougars, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CBB schedule.

Bulldogs Betting Trends

Gonzaga holds a 15-15 record against the spread (ATS) this season, with the total going under in 16 of their 30 games.

Cougars Betting Trends

Houston has a 14-16 ATS record this season, with the total going over in 15 of their 30 games.

Bulldogs vs. Cougars Matchup Trends

Gonzaga has covered the spread in five of their last seven games when playing as underdogs.

Gonzaga vs. Houston Game Info

Gonzaga vs Houston starts on March 22, 2025 at 8:40 PM EST.

Venue: Intrust Bank Arena.

Spread: Houston -5.5
Moneyline: Gonzaga +185, Houston -224
Over/Under: 139.5

Gonzaga: (26-8)  |  Houston: (31-4)

Remi's searched hard and found the best prop for this matchup: M. Uzan under 14.5 Points. Prices move—always shop for the best number.

Gonzaga has covered the spread in five of their last seven games when playing as underdogs.

GONZAG trend: Gonzaga holds a 15-15 record against the spread (ATS) this season, with the total going under in 16 of their 30 games.

HOU trend: Houston has a 14-16 ATS record this season, with the total going over in 15 of their 30 games.

See our latest CBB picks and odds pages for 2025 to compare prices before you bet.

Gonzaga vs. Houston Odds

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Gonzaga vs Houston trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

Gonzaga vs Houston Opening Odds

GONZAG Moneyline: +185
HOU Moneyline: -224
GONZAG Spread: +5.5
HOU Spread: -5.5
Over/Under: 139.5

Gonzaga vs Houston Live Odds

Games PTS ML SPR O/U

CBB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Gonzaga Bulldogs vs. Houston Cougars on March 22, 2025 at Intrust Bank Arena.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CBB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
DRAKE@MIZZOU DRAKE +6.5 53.50% 2 WIN
XAVIER@TEXAS XAVIER -2.5 53.40% 2 WIN
UAB@MEMP MEMP -3.5 54.00% 2 WIN
LVILLE@DUKE LVILLE +6.5 53.10% 2 LOSS
ECU@UAB UAB -5 53.60% 2 WIN
PURDUE@MICH MICH +3 54.60% 3 WIN
CLEM@LVILLE CLEM -120 56.10% 3 LOSS
COL@HOU ANDREJ JAKIMOVSKI PTS + REB + AST - UNDER 15.5 53.70% 2 LOSS
FORD@GWASH FORD +7 53.80% 2 WIN
SEATTLE@ABIL ABIL +6 54.50% 3 WIN
BAMAST@TEXSOU BAMAST -110 55.40% 4 WIN
OHIO@TOLEDO TOLEDO +3 56.70% 4 WIN
UVA@GATECH GATECH +1.5 53.70% 2 WIN
COLO@WVU COLO +7.5 53.20% 2 WIN
USC@RUT USC -115 54.00% 2 WIN
TEXAS@VANDY VANDY -130 56.50% 3 LOSS
BUTLER@PROV BUTLER -115 55.20% 3 WIN
IDAHO@MONTANA MONTANA -6 53.50% 2 WIN
TROY@JMAD TROY -125 55.60% 2 WIN
BELMONT@DRAKE DRAKE -7.5 53.50% 2 LOSS
UCSD@UCDAV UCSD -12.5 53.40% 2 LOSS
SIUE@SEMO SEMO -2.5 54.80% 3 LOSS
ALCORN@ARKPB ARKPB +6.5 56.00% 4 WIN
NORFLK@HOWARD HOWARD +5.5 53.70% 2 LOSS
NKY@CLEVST NKY +4.5 54.40% 3 LOSS
STNFRD@ND STNFRD -125 56.40% 3 LOSS
TENN@OLEMISS OLEMISS +2.5 54.30% 3 WIN
LSALLE@GMASON GMASON -12 54.30% 3 LOSS
PITT@NCST NCST +2.5 56.70% 4 WIN
IND@OREG OREG -6.5 53.60% 2 WIN
FSU@UVA UVA -4 54.40% 3 LOSS
ARK@VANDY ARK +7.5 54.40% 3 WIN
SDGST@UNLV UNLV +2.5 54.10% 3 WIN
EKTY@JVILLE JVILLE -135 58.90% 3 WIN
MANHAT@NIAGARA MANHAT -115 54.70% 3 WIN
MEMP@UAB MEMP -115 54.90% 3 WIN
ILL@MICH MICH -2.5 56.00% 4 LOSS
OKLA@OLEMISS OKLA +7.5 54.50% 3 WIN
ARIZST@UTAH ARIZST +8.5 54.60% 3 LOSS
GC@SEATTLE GC -110 55.00% 3 WIN
PENN@CLMBIA CLMBIA -122 57.50% 4 LOSS
IONA@NIAGARA NIAGARA +1.5 54.30% 3 LOSS
MARIST@SACHRT SACHRT -120 55.40% 3 WIN
CLEVST@WRIGHT CLEVST +1.5 54.30% 3 LOSS
NDAK@STTHOM STTHOM -10 54.30% 3 WIN
USD@WASHST WASHST -12.5 55.20% 4 LOSS
CSBAK@LBEACH CSBAK -130 59.70% 4 WIN
BU@LEHIGH LEHIGH -135 57.70% 3 LOSS
DUQ@LSALLE DUQ -125 56.70% 3 WIN
BYU@ARIZST ARIZST +7.5 54.60% 3 LOSS
UTAHST@BOISE BOISE -4 55.50% 4 WIN