Musketeers vs. Fighting Illini
Prediction, Odds & Props
Mar 21 | CBB AI Picks

Updated: 2025-03-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On March 21, 2025, the No. 6 seed Illinois Fighting Illini (21-12) will face the No. 11 seed Xavier Musketeers (22-11) in the first round of the NCAA Tournament at Fiserv Forum in Milwaukee, Wisconsin. Illinois is favored by 3.5 points, with an over/under set at 160.5 points.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 21, 2025

Start Time: 9:45 PM EST​

Venue: Fiserv Forum​

Fighting Illini Record: (21-12)

Musketeers Record: (22-11)

OPENING ODDS

XAVIER Moneyline: +136

ILL Moneyline: -162

XAVIER Spread: +3.5

ILL Spread: -3.5

Over/Under: 160.5

XAVIER
Betting Trends

  • Xavier has an 18-14 record against the spread (ATS) this season, demonstrating a solid performance in covering spreads.

ILL
Betting Trends

  • Illinois holds a 16-17 ATS record this season, indicating challenges in consistently covering the spread.

MATCHUP TRENDS

  • Historically, No. 11 seeds have been successful in the NCAA Tournament, with at least one No. 11 seed advancing past the first round each year since 2005. This trend highlights the potential for upsets in 6-11 matchups.

XAVIER vs. ILL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Conwell over 17.5 Points

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Xavier vs Illinois Prediction & Odds:
Free CBB Betting Insights for 3/21/25

The NCAA Tournament’s first-round matchup between the No. 6 seed Illinois Fighting Illini and the No. 11 seed Xavier Musketeers on March 21, 2025, at Fiserv Forum in Milwaukee, Wisconsin, presents an intriguing contest between two programs with contrasting styles and season narratives. Illinois, under the guidance of head coach Brad Underwood, enters the tournament with a 21-12 record, reflecting a season of both impressive victories and puzzling inconsistencies. The Fighting Illini have showcased offensive prowess, leading the Big Ten with an average of 83.8 points per game and a shooting percentage of 45.0%. Their offensive strategy emphasizes a fast-paced tempo, with quick transitions and a focus on perimeter shooting. However, this approach has sometimes led to volatility, as cold shooting spells have contributed to unexpected losses. Defensively, Illinois has been formidable, utilizing a combination of man-to-man and zone defenses to disrupt opponents’ rhythms. Their ability to force turnovers and convert them into transition points has been a hallmark of their success. Key players such as forward Will Riley have been instrumental in both scoring and defensive efforts, providing leadership and versatility on the court. Despite their strengths, the Illini’s inconsistency has been a point of concern, as evidenced by their recent 88-65 loss to Maryland in the Big Ten Conference Tournament. On the other side, the Xavier Musketeers come into the tournament with a 22-11 record, having secured their spot by defeating Texas 86-80 in an NCAA play-in game. Head coach Sean Miller, who has eight appearances in the Sweet 16, brings a wealth of tournament experience to the team. Xavier’s offensive strategy is characterized by efficient three-point shooting, ranking second in the Big East with a 39.1% success rate from beyond the arc. This perimeter-oriented approach stretches defenses and creates driving lanes for their guards.

Defensively, the Musketeers excel in rebounding, particularly on the defensive glass, limiting opponents’ second-chance opportunities. Players like Marcus Foster have been pivotal in their success, with Foster’s exceptional performance and experience being vital to the team’s dynamics. From a betting perspective, Illinois is favored by 3.5 points, with the total set at 160.5 points. The Fighting Illini’s 16-17 record against the spread (ATS) this season indicates challenges in consistently covering the spread, while Xavier’s 18-14 ATS record demonstrates a more reliable performance in covering spreads. Additionally, the historical success of No. 11 seeds in the NCAA Tournament, with at least one No. 11 seed advancing past the first round each year since 2005, adds an interesting dimension to this matchup. The outcome of this game may hinge on several critical factors. Illinois’s ability to maintain shooting consistency and manage turnovers will be crucial against a disciplined Xavier defense. Conversely, Xavier’s reliance on three-point shooting could be challenged by Illinois’s perimeter defense. Rebounding will also play a significant role, as both teams have demonstrated strengths on the boards. In conclusion, this 6-versus-11 seed matchup epitomizes the excitement and unpredictability of March Madness. While Illinois’s offensive firepower and higher seeding position them as favorites, Xavier’s efficient shooting, rebounding prowess, and recent momentum suggest they are well-equipped to challenge the Illini. Fans can anticipate a high-energy game that showcases contrasting styles and strategic adjustments, with the winner advancing to face either Kentucky or Troy in the second round.

Xavier Musketeers CBB Preview

The Xavier Musketeers enter the 2025 NCAA Tournament as the No. 11 seed in the Midwest Region with a 22-11 overall record and a wave of momentum after winning a high-octane First Four play-in game against Texas, 86-80, a result that not only extended their season but also reinforced their status as a dangerous mid-major capable of pulling off a classic 6-11 upset against the Illinois Fighting Illini, especially under the guidance of head coach Sean Miller, who brings extensive March experience and eight career Sweet 16 appearances to a program looking to make another deep tournament run. Xavier’s identity centers around efficient, perimeter-oriented offense, a methodical tempo, and disciplined ball movement that emphasizes high-percentage looks both at the rim and beyond the arc, and the team currently ranks in the top 20 nationally in three-point percentage, shooting 39.1% from deep while averaging 78.4 points per game overall. The Musketeers are led by senior guard Marcus Foster, a dynamic and composed floor leader who averages 17.6 points and 5.2 assists per game while operating as the team’s offensive initiator and emotional anchor, combining veteran savvy with the ability to create shots in isolation, break down defenders off the bounce, and hit clutch threes under pressure. Foster’s court vision and poise are particularly valuable in March, where possessions are tighter and defensive pressure is ramped up, and he has a proven ability to dictate tempo and make sound decisions in crunch time. Flanking him is sharpshooter Trey Green, who knocks down threes at a 42% clip and opens up the floor with his gravity and quick release, creating spacing for Xavier’s bigs to operate inside. In the frontcourt, forward Zach Freemantle has returned from injury to provide a physical presence in the paint, contributing 12.1 points and 6.8 rebounds per game while also serving as a capable passer from the high post, allowing Xavier to initiate offense from multiple levels.

The Musketeers pride themselves on their half-court execution and unselfishness, averaging 15.9 assists per game, and their ability to score from multiple positions makes them difficult to scout and defend. Defensively, Xavier is solid if not elite, giving up 70.1 points per game but making up for any deficiencies with smart positioning, help-side awareness, and strong defensive rebounding that limits second-chance opportunities. Their defense will face a stiff test against Illinois’ aggressive pace and perimeter shooting, but Xavier has shown the ability to contain explosive offenses by slowing the game down and forcing teams into contested shots late in the shot clock. From a betting standpoint, the Musketeers have been reliable, going 18-14 against the spread (ATS) this season, and with momentum on their side, the tournament-tested leadership of Coach Miller, and a perimeter-oriented offense that matches up well against Illinois’ occasionally porous three-point defense, Xavier is well-positioned to not only keep the game close but potentially pull off the upset. If Foster can continue his strong play, the shooters stay hot, and the defense can neutralize Will Riley’s impact, the Musketeers have all the tools necessary to extend their postseason and keep the long-standing tradition of 11-seed success in March very much alive.

On March 21, 2025, the No. 6 seed Illinois Fighting Illini (21-12) will face the No. 11 seed Xavier Musketeers (22-11) in the first round of the NCAA Tournament at Fiserv Forum in Milwaukee, Wisconsin. Illinois is favored by 3.5 points, with an over/under set at 160.5 points. Xavier vs Illinois AI Prediction: Free CBB Betting Insights for Mar 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Illinois Fighting Illini CBB Preview

The Illinois Fighting Illini, under the leadership of head coach Brad Underwood, enter the 2025 NCAA Tournament as the No. 6 seed in the Midwest Region, boasting a 21-12 record that reflects a season marked by both impressive triumphs and challenging setbacks. Offensively, the Illini have been a force to reckon with, leading the Big Ten Conference by averaging 83.8 points per game and maintaining a shooting accuracy of 45.0%. Their offensive strategy is characterized by a fast-paced tempo, emphasizing quick transitions and a high volume of three-point attempts. This approach has allowed them to outpace opponents and capitalize on defensive mismatches. Key to Illinois’ offensive success is senior forward Will Riley, who has emerged as the Illini’s most consistent and dynamic scoring option, averaging 18.4 points and 7.3 rebounds per game while serving as a versatile inside-out threat who can score on the block, hit midrange jumpers, and stretch the floor from beyond the arc. Riley’s leadership and poise in late-game situations have been essential in securing key wins throughout the season, including notable victories over Michigan State, Purdue, and Wisconsin. Complementing Riley is point guard Ty Rodgers, a strong, athletic floor general who pushes the pace in transition and uses his vision and defensive instincts to control the tempo on both ends of the floor. Rodgers averages 11.9 points and 6.1 assists per game, and his ability to get into the paint and draw help defenders opens up clean looks for shooters like Luke Goode and Justin Harmon, both of whom shoot above 37% from three-point range. Defensively, Illinois employs a hybrid approach, often switching between man and zone to keep opponents off balance, while using their length and athleticism to close out on shooters and protect the rim. Center Dain Dainja plays a crucial role in anchoring the paint, averaging 1.8 blocks and 6.9 rebounds, and his physicality will be vital in combating Xavier’s post presence and limiting second-chance points.

However, despite their strong metrics, Illinois has struggled with consistency, particularly on the defensive end where lapses in rotations and overhelping have allowed efficient three-point shooting teams to exploit them—something that could be problematic against a Xavier team that ranks among the nation’s top 20 in three-point efficiency. Another area of concern is ball security, as the Illini have had games where careless turnovers disrupted offensive rhythm and led to transition points for opponents. Still, when clicking, Illinois can be one of the most explosive and difficult teams to guard in the country, especially when their shooters are connecting and their defense is active and engaged. In tournament play, the Illini have a mixed recent history, and Coach Underwood enters this March with the weight of expectations, looking to guide Illinois past the first weekend for the first time in over a decade. Playing in Milwaukee may give them a mild regional advantage with fans expected to travel in strong numbers, and the team’s depth—featuring valuable minutes from reserves like Terrence Shannon Jr. and Sencire Harris—gives Underwood flexibility in matchups and defensive alignments. From a betting perspective, Illinois’ 16-17 record against the spread (ATS) reflects their up-and-down nature, though their offensive ceiling gives them the ability to blow games open when their shooting is on point. To advance, the Illini must limit Xavier’s three-point looks, dominate the glass, and execute efficiently in half-court sets, especially late in the shot clock where mistakes are magnified in March. If Riley sets the tone early and the defense tightens up, Illinois has all the ingredients to justify their seeding and make a statement in the tournament opener against a capable, confident Xavier squad.

Xavier vs. Illinois Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Musketeers and Fighting Illini play there’s always several intriguing angles to key in on. Not to mention games played at Fiserv Forum in Mar rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: R. Conwell over 17.5 Points

Xavier vs. Illinois Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every past game between the Musketeers and Fighting Illini and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Interestingly enough, the data has been most focused on the growing emphasis knucklehead sportsbettors regularly put on coaching factors between a Musketeers team going up against a possibly strong Fighting Illini team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CBB AI picks for FREE now.

Below is our current AI Xavier vs Illinois picks, computer picks Musketeers vs Fighting Illini, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
ACTIVE PICKS LOCKED - SEE NOW

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CBB schedule.

Musketeers Betting Trends

Xavier has an 18-14 record against the spread (ATS) this season, demonstrating a solid performance in covering spreads.

Fighting Illini Betting Trends

Illinois holds a 16-17 ATS record this season, indicating challenges in consistently covering the spread.

Musketeers vs. Fighting Illini Matchup Trends

Historically, No. 11 seeds have been successful in the NCAA Tournament, with at least one No. 11 seed advancing past the first round each year since 2005. This trend highlights the potential for upsets in 6-11 matchups.

Xavier vs. Illinois Game Info

Xavier vs Illinois starts on March 21, 2025 at 9:45 PM EST.

Spread: Illinois -3.5
Moneyline: Xavier +136, Illinois -162
Over/Under: 160.5

Xavier: (22-11)  |  Illinois: (21-12)

Remi's searched hard and found the best prop for this matchup: R. Conwell over 17.5 Points. Prices move—always shop for the best number.

Historically, No. 11 seeds have been successful in the NCAA Tournament, with at least one No. 11 seed advancing past the first round each year since 2005. This trend highlights the potential for upsets in 6-11 matchups.

XAVIER trend: Xavier has an 18-14 record against the spread (ATS) this season, demonstrating a solid performance in covering spreads.

ILL trend: Illinois holds a 16-17 ATS record this season, indicating challenges in consistently covering the spread.

See our latest CBB picks and odds pages for 2025 to compare prices before you bet.

Xavier vs. Illinois Odds

AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Xavier vs Illinois trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.

Xavier vs Illinois Opening Odds

XAVIER Moneyline: +136
ILL Moneyline: -162
XAVIER Spread: +3.5
ILL Spread: -3.5
Over/Under: 160.5

Xavier vs Illinois Live Odds

Games PTS ML SPR O/U

CBB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Xavier Musketeers vs. Illinois Fighting Illini on March 21, 2025 at Fiserv Forum.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CBB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
DRAKE@MIZZOU DRAKE +6.5 53.50% 2 WIN
XAVIER@TEXAS XAVIER -2.5 53.40% 2 WIN
UAB@MEMP MEMP -3.5 54.00% 2 WIN
LVILLE@DUKE LVILLE +6.5 53.10% 2 LOSS
ECU@UAB UAB -5 53.60% 2 WIN
PURDUE@MICH MICH +3 54.60% 3 WIN
CLEM@LVILLE CLEM -120 56.10% 3 LOSS
COL@HOU ANDREJ JAKIMOVSKI PTS + REB + AST - UNDER 15.5 53.70% 2 LOSS
FORD@GWASH FORD +7 53.80% 2 WIN
SEATTLE@ABIL ABIL +6 54.50% 3 WIN
BAMAST@TEXSOU BAMAST -110 55.40% 4 WIN
OHIO@TOLEDO TOLEDO +3 56.70% 4 WIN
UVA@GATECH GATECH +1.5 53.70% 2 WIN
COLO@WVU COLO +7.5 53.20% 2 WIN
USC@RUT USC -115 54.00% 2 WIN
TEXAS@VANDY VANDY -130 56.50% 3 LOSS
BUTLER@PROV BUTLER -115 55.20% 3 WIN
IDAHO@MONTANA MONTANA -6 53.50% 2 WIN
TROY@JMAD TROY -125 55.60% 2 WIN
BELMONT@DRAKE DRAKE -7.5 53.50% 2 LOSS
UCSD@UCDAV UCSD -12.5 53.40% 2 LOSS
SIUE@SEMO SEMO -2.5 54.80% 3 LOSS
ALCORN@ARKPB ARKPB +6.5 56.00% 4 WIN
NORFLK@HOWARD HOWARD +5.5 53.70% 2 LOSS
NKY@CLEVST NKY +4.5 54.40% 3 LOSS
STNFRD@ND STNFRD -125 56.40% 3 LOSS
TENN@OLEMISS OLEMISS +2.5 54.30% 3 WIN
LSALLE@GMASON GMASON -12 54.30% 3 LOSS
PITT@NCST NCST +2.5 56.70% 4 WIN
IND@OREG OREG -6.5 53.60% 2 WIN
FSU@UVA UVA -4 54.40% 3 LOSS
ARK@VANDY ARK +7.5 54.40% 3 WIN
SDGST@UNLV UNLV +2.5 54.10% 3 WIN
EKTY@JVILLE JVILLE -135 58.90% 3 WIN
MANHAT@NIAGARA MANHAT -115 54.70% 3 WIN
MEMP@UAB MEMP -115 54.90% 3 WIN
ILL@MICH MICH -2.5 56.00% 4 LOSS
OKLA@OLEMISS OKLA +7.5 54.50% 3 WIN
ARIZST@UTAH ARIZST +8.5 54.60% 3 LOSS
GC@SEATTLE GC -110 55.00% 3 WIN
PENN@CLMBIA CLMBIA -122 57.50% 4 LOSS
IONA@NIAGARA NIAGARA +1.5 54.30% 3 LOSS
MARIST@SACHRT SACHRT -120 55.40% 3 WIN
CLEVST@WRIGHT CLEVST +1.5 54.30% 3 LOSS
NDAK@STTHOM STTHOM -10 54.30% 3 WIN
USD@WASHST WASHST -12.5 55.20% 4 LOSS
CSBAK@LBEACH CSBAK -130 59.70% 4 WIN
BU@LEHIGH LEHIGH -135 57.70% 3 LOSS
DUQ@LSALLE DUQ -125 56.70% 3 WIN
BYU@ARIZST ARIZST +7.5 54.60% 3 LOSS
UTAHST@BOISE BOISE -4 55.50% 4 WIN