Musketeers vs. Fighting Illini
Prediction, Odds & Props
Mar 21 | CBB AI Picks
Updated: 2025-03-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On March 21, 2025, the No. 6 seed Illinois Fighting Illini (21-12) will face the No. 11 seed Xavier Musketeers (22-11) in the first round of the NCAA Tournament at Fiserv Forum in Milwaukee, Wisconsin. Illinois is favored by 3.5 points, with an over/under set at 160.5 points.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Mar 21, 2025
Start Time: 9:45 PM EST​
Venue: Fiserv Forum​
Fighting Illini Record: (21-12)
Musketeers Record: (22-11)
OPENING ODDS
XAVIER Moneyline: +136
ILL Moneyline: -162
XAVIER Spread: +3.5
ILL Spread: -3.5
Over/Under: 160.5
XAVIER
Betting Trends
- Xavier has an 18-14 record against the spread (ATS) this season, demonstrating a solid performance in covering spreads.
ILL
Betting Trends
- Illinois holds a 16-17 ATS record this season, indicating challenges in consistently covering the spread.
MATCHUP TRENDS
- Historically, No. 11 seeds have been successful in the NCAA Tournament, with at least one No. 11 seed advancing past the first round each year since 2005. This trend highlights the potential for upsets in 6-11 matchups.
XAVIER vs. ILL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: R. Conwell over 17.5 Points
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Xavier vs Illinois Prediction & Odds:
Free CBB Betting Insights for 3/21/25
Defensively, the Musketeers excel in rebounding, particularly on the defensive glass, limiting opponents’ second-chance opportunities. Players like Marcus Foster have been pivotal in their success, with Foster’s exceptional performance and experience being vital to the team’s dynamics. From a betting perspective, Illinois is favored by 3.5 points, with the total set at 160.5 points. The Fighting Illini’s 16-17 record against the spread (ATS) this season indicates challenges in consistently covering the spread, while Xavier’s 18-14 ATS record demonstrates a more reliable performance in covering spreads. Additionally, the historical success of No. 11 seeds in the NCAA Tournament, with at least one No. 11 seed advancing past the first round each year since 2005, adds an interesting dimension to this matchup. The outcome of this game may hinge on several critical factors. Illinois’s ability to maintain shooting consistency and manage turnovers will be crucial against a disciplined Xavier defense. Conversely, Xavier’s reliance on three-point shooting could be challenged by Illinois’s perimeter defense. Rebounding will also play a significant role, as both teams have demonstrated strengths on the boards. In conclusion, this 6-versus-11 seed matchup epitomizes the excitement and unpredictability of March Madness. While Illinois’s offensive firepower and higher seeding position them as favorites, Xavier’s efficient shooting, rebounding prowess, and recent momentum suggest they are well-equipped to challenge the Illini. Fans can anticipate a high-energy game that showcases contrasting styles and strategic adjustments, with the winner advancing to face either Kentucky or Troy in the second round.
Round of 64 🔜#LetsGoX | ALL IN pic.twitter.com/LvSedwZC03
— Xavier Basketball (@XavierMBB) March 20, 2025
Xavier Musketeers CBB Preview
The Xavier Musketeers enter the 2025 NCAA Tournament as the No. 11 seed in the Midwest Region with a 22-11 overall record and a wave of momentum after winning a high-octane First Four play-in game against Texas, 86-80, a result that not only extended their season but also reinforced their status as a dangerous mid-major capable of pulling off a classic 6-11 upset against the Illinois Fighting Illini, especially under the guidance of head coach Sean Miller, who brings extensive March experience and eight career Sweet 16 appearances to a program looking to make another deep tournament run. Xavier’s identity centers around efficient, perimeter-oriented offense, a methodical tempo, and disciplined ball movement that emphasizes high-percentage looks both at the rim and beyond the arc, and the team currently ranks in the top 20 nationally in three-point percentage, shooting 39.1% from deep while averaging 78.4 points per game overall. The Musketeers are led by senior guard Marcus Foster, a dynamic and composed floor leader who averages 17.6 points and 5.2 assists per game while operating as the team’s offensive initiator and emotional anchor, combining veteran savvy with the ability to create shots in isolation, break down defenders off the bounce, and hit clutch threes under pressure. Foster’s court vision and poise are particularly valuable in March, where possessions are tighter and defensive pressure is ramped up, and he has a proven ability to dictate tempo and make sound decisions in crunch time. Flanking him is sharpshooter Trey Green, who knocks down threes at a 42% clip and opens up the floor with his gravity and quick release, creating spacing for Xavier’s bigs to operate inside. In the frontcourt, forward Zach Freemantle has returned from injury to provide a physical presence in the paint, contributing 12.1 points and 6.8 rebounds per game while also serving as a capable passer from the high post, allowing Xavier to initiate offense from multiple levels.
The Musketeers pride themselves on their half-court execution and unselfishness, averaging 15.9 assists per game, and their ability to score from multiple positions makes them difficult to scout and defend. Defensively, Xavier is solid if not elite, giving up 70.1 points per game but making up for any deficiencies with smart positioning, help-side awareness, and strong defensive rebounding that limits second-chance opportunities. Their defense will face a stiff test against Illinois’ aggressive pace and perimeter shooting, but Xavier has shown the ability to contain explosive offenses by slowing the game down and forcing teams into contested shots late in the shot clock. From a betting standpoint, the Musketeers have been reliable, going 18-14 against the spread (ATS) this season, and with momentum on their side, the tournament-tested leadership of Coach Miller, and a perimeter-oriented offense that matches up well against Illinois’ occasionally porous three-point defense, Xavier is well-positioned to not only keep the game close but potentially pull off the upset. If Foster can continue his strong play, the shooters stay hot, and the defense can neutralize Will Riley’s impact, the Musketeers have all the tools necessary to extend their postseason and keep the long-standing tradition of 11-seed success in March very much alive.

Credit: USA TODAY/IMAGN
Illinois Fighting Illini CBB Preview
The Illinois Fighting Illini, under the leadership of head coach Brad Underwood, enter the 2025 NCAA Tournament as the No. 6 seed in the Midwest Region, boasting a 21-12 record that reflects a season marked by both impressive triumphs and challenging setbacks. Offensively, the Illini have been a force to reckon with, leading the Big Ten Conference by averaging 83.8 points per game and maintaining a shooting accuracy of 45.0%. Their offensive strategy is characterized by a fast-paced tempo, emphasizing quick transitions and a high volume of three-point attempts. This approach has allowed them to outpace opponents and capitalize on defensive mismatches. Key to Illinois’ offensive success is senior forward Will Riley, who has emerged as the Illini’s most consistent and dynamic scoring option, averaging 18.4 points and 7.3 rebounds per game while serving as a versatile inside-out threat who can score on the block, hit midrange jumpers, and stretch the floor from beyond the arc. Riley’s leadership and poise in late-game situations have been essential in securing key wins throughout the season, including notable victories over Michigan State, Purdue, and Wisconsin. Complementing Riley is point guard Ty Rodgers, a strong, athletic floor general who pushes the pace in transition and uses his vision and defensive instincts to control the tempo on both ends of the floor. Rodgers averages 11.9 points and 6.1 assists per game, and his ability to get into the paint and draw help defenders opens up clean looks for shooters like Luke Goode and Justin Harmon, both of whom shoot above 37% from three-point range. Defensively, Illinois employs a hybrid approach, often switching between man and zone to keep opponents off balance, while using their length and athleticism to close out on shooters and protect the rim. Center Dain Dainja plays a crucial role in anchoring the paint, averaging 1.8 blocks and 6.9 rebounds, and his physicality will be vital in combating Xavier’s post presence and limiting second-chance points.
However, despite their strong metrics, Illinois has struggled with consistency, particularly on the defensive end where lapses in rotations and overhelping have allowed efficient three-point shooting teams to exploit them—something that could be problematic against a Xavier team that ranks among the nation’s top 20 in three-point efficiency. Another area of concern is ball security, as the Illini have had games where careless turnovers disrupted offensive rhythm and led to transition points for opponents. Still, when clicking, Illinois can be one of the most explosive and difficult teams to guard in the country, especially when their shooters are connecting and their defense is active and engaged. In tournament play, the Illini have a mixed recent history, and Coach Underwood enters this March with the weight of expectations, looking to guide Illinois past the first weekend for the first time in over a decade. Playing in Milwaukee may give them a mild regional advantage with fans expected to travel in strong numbers, and the team’s depth—featuring valuable minutes from reserves like Terrence Shannon Jr. and Sencire Harris—gives Underwood flexibility in matchups and defensive alignments. From a betting perspective, Illinois’ 16-17 record against the spread (ATS) reflects their up-and-down nature, though their offensive ceiling gives them the ability to blow games open when their shooting is on point. To advance, the Illini must limit Xavier’s three-point looks, dominate the glass, and execute efficiently in half-court sets, especially late in the shot clock where mistakes are magnified in March. If Riley sets the tone early and the defense tightens up, Illinois has all the ingredients to justify their seeding and make a statement in the tournament opener against a capable, confident Xavier squad.
Over 33 games, there will be ups and downs, wins and losses, bumps and bruises.
— Illinois Men's Basketball (@IlliniMBB) March 21, 2025
But over 33 games, we have kept one target in mind. pic.twitter.com/hsT96ql4nc
Xavier vs. Illinois Prop Picks (AI)
Xavier vs. Illinois Prediction (AI)

Remi, our AI sports genius, has been pouring over tons of data from every past game between the Musketeers and Fighting Illini and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.
Interestingly enough, the data has been most focused on the growing emphasis knucklehead sportsbettors regularly put on coaching factors between a Musketeers team going up against a possibly strong Fighting Illini team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
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Below is our current AI Xavier vs Illinois picks, computer picks Musketeers vs Fighting Illini, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CBB schedule.
Musketeers Betting Trends
Xavier has an 18-14 record against the spread (ATS) this season, demonstrating a solid performance in covering spreads.
Fighting Illini Betting Trends
Illinois holds a 16-17 ATS record this season, indicating challenges in consistently covering the spread.
Musketeers vs. Fighting Illini Matchup Trends
Historically, No. 11 seeds have been successful in the NCAA Tournament, with at least one No. 11 seed advancing past the first round each year since 2005. This trend highlights the potential for upsets in 6-11 matchups.
Xavier vs. Illinois Game Info
What time does Xavier vs Illinois start on March 21, 2025?
Xavier vs Illinois starts on March 21, 2025 at 9:45 PM EST.
Where is Xavier vs Illinois being played?
Venue: Fiserv Forum.
What are the opening odds for Xavier vs Illinois?
Spread: Illinois -3.5
Moneyline: Xavier +136, Illinois -162
Over/Under: 160.5
What are the records for Xavier vs Illinois?
Xavier: (22-11) Â |Â Illinois: (21-12)
What is the AI best bet for Xavier vs Illinois?
Remi's searched hard and found the best prop for this matchup: R. Conwell over 17.5 Points. Prices move—always shop for the best number.
What are Xavier vs Illinois trending bets?
Historically, No. 11 seeds have been successful in the NCAA Tournament, with at least one No. 11 seed advancing past the first round each year since 2005. This trend highlights the potential for upsets in 6-11 matchups.
What are Xavier trending bets?
XAVIER trend: Xavier has an 18-14 record against the spread (ATS) this season, demonstrating a solid performance in covering spreads.
What are Illinois trending bets?
ILL trend: Illinois holds a 16-17 ATS record this season, indicating challenges in consistently covering the spread.
Where can I find AI Picks for Xavier vs Illinois?
See our latest CBB picks and odds pages for 2025 to compare prices before you bet.
Xavier vs. Illinois Odds
AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Xavier vs Illinois trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.
Xavier vs Illinois Opening Odds
XAVIER Moneyline:
+136 ILL Moneyline: -162
XAVIER Spread: +3.5
ILL Spread: -3.5
Over/Under: 160.5
Xavier vs Illinois Live Odds
Games | PTS | ML | SPR | O/U |
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CBB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Xavier Musketeers vs. Illinois Fighting Illini on March 21, 2025 at Fiserv Forum.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CBB odds pages, and compare prices before you place a bet.
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   LEAN |    %WIN |    UNITS | RESULT |
---|---|---|---|---|
DRAKE@MIZZOU | DRAKE +6.5 | 53.50% | 2 | WIN |
XAVIER@TEXAS | XAVIER -2.5 | 53.40% | 2 | WIN |
UAB@MEMP | MEMP -3.5 | 54.00% | 2 | WIN |
LVILLE@DUKE | LVILLE +6.5 | 53.10% | 2 | LOSS |
ECU@UAB | UAB -5 | 53.60% | 2 | WIN |
PURDUE@MICH | MICH +3 | 54.60% | 3 | WIN |
CLEM@LVILLE | CLEM -120 | 56.10% | 3 | LOSS |
COL@HOU | ANDREJ JAKIMOVSKI PTS + REB + AST - UNDER 15.5 | 53.70% | 2 | LOSS |
FORD@GWASH | FORD +7 | 53.80% | 2 | WIN |
SEATTLE@ABIL | ABIL +6 | 54.50% | 3 | WIN |
BAMAST@TEXSOU | BAMAST -110 | 55.40% | 4 | WIN |
OHIO@TOLEDO | TOLEDO +3 | 56.70% | 4 | WIN |
UVA@GATECH | GATECH +1.5 | 53.70% | 2 | WIN |
COLO@WVU | COLO +7.5 | 53.20% | 2 | WIN |
USC@RUT | USC -115 | 54.00% | 2 | WIN |
TEXAS@VANDY | VANDY -130 | 56.50% | 3 | LOSS |
BUTLER@PROV | BUTLER -115 | 55.20% | 3 | WIN |
IDAHO@MONTANA | MONTANA -6 | 53.50% | 2 | WIN |
TROY@JMAD | TROY -125 | 55.60% | 2 | WIN |
BELMONT@DRAKE | DRAKE -7.5 | 53.50% | 2 | LOSS |
UCSD@UCDAV | UCSD -12.5 | 53.40% | 2 | LOSS |
SIUE@SEMO | SEMO -2.5 | 54.80% | 3 | LOSS |
ALCORN@ARKPB | ARKPB +6.5 | 56.00% | 4 | WIN |
NORFLK@HOWARD | HOWARD +5.5 | 53.70% | 2 | LOSS |
NKY@CLEVST | NKY +4.5 | 54.40% | 3 | LOSS |
STNFRD@ND | STNFRD -125 | 56.40% | 3 | LOSS |
TENN@OLEMISS | OLEMISS +2.5 | 54.30% | 3 | WIN |
LSALLE@GMASON | GMASON -12 | 54.30% | 3 | LOSS |
PITT@NCST | NCST +2.5 | 56.70% | 4 | WIN |
IND@OREG | OREG -6.5 | 53.60% | 2 | WIN |
FSU@UVA | UVA -4 | 54.40% | 3 | LOSS |
ARK@VANDY | ARK +7.5 | 54.40% | 3 | WIN |
SDGST@UNLV | UNLV +2.5 | 54.10% | 3 | WIN |
EKTY@JVILLE | JVILLE -135 | 58.90% | 3 | WIN |
MANHAT@NIAGARA | MANHAT -115 | 54.70% | 3 | WIN |
MEMP@UAB | MEMP -115 | 54.90% | 3 | WIN |
ILL@MICH | MICH -2.5 | 56.00% | 4 | LOSS |
OKLA@OLEMISS | OKLA +7.5 | 54.50% | 3 | WIN |
ARIZST@UTAH | ARIZST +8.5 | 54.60% | 3 | LOSS |
GC@SEATTLE | GC -110 | 55.00% | 3 | WIN |
PENN@CLMBIA | CLMBIA -122 | 57.50% | 4 | LOSS |
IONA@NIAGARA | NIAGARA +1.5 | 54.30% | 3 | LOSS |
MARIST@SACHRT | SACHRT -120 | 55.40% | 3 | WIN |
CLEVST@WRIGHT | CLEVST +1.5 | 54.30% | 3 | LOSS |
NDAK@STTHOM | STTHOM -10 | 54.30% | 3 | WIN |
USD@WASHST | WASHST -12.5 | 55.20% | 4 | LOSS |
CSBAK@LBEACH | CSBAK -130 | 59.70% | 4 | WIN |
BU@LEHIGH | LEHIGH -135 | 57.70% | 3 | LOSS |
DUQ@LSALLE | DUQ -125 | 56.70% | 3 | WIN |
BYU@ARIZST | ARIZST +7.5 | 54.60% | 3 | LOSS |
UTAHST@BOISE | BOISE -4 | 55.50% | 4 | WIN |