Colo. State vs Memphis Prediction — AI Finds CAN'T MISS CBB Lines & Props (Mar 21)

Updated: 2025-03-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On March 21, 2025, the No. 12 seed Colorado State Rams (25-9) will face the No. 5 seed Memphis Tigers (29-5) in the first round of the NCAA Tournament’s West Region at Climate Pledge Arena in Seattle, Washington.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 21, 2025

Start Time: 2:00 PM EST​

Venue: Climate Pledge Arena​

Tigers Record: (29-5)

Rams Record: (25-9)

OPENING ODDS

COLOST Moneyline: -121

MEMP Moneyline: +102

COLOST Spread: -1.5

MEMP Spread: +1.5

Over/Under: 146.5

COLOST
Betting Trends

  • Colorado State has a 21-13-0 record against the spread (ATS) this season, including a 15-6 ATS record when favored by at least 1.5 points.

MEMP
Betting Trends

  • Memphis holds a 16-18-0 ATS record this season, with a 5-2 ATS record when playing as at least 1.5-point underdogs.

MATCHUP TRENDS

  • The over/under for this game is set at 147.5 points. In 11 of their 34 games this season, Colorado State and its opponents have scored more than this total, indicating a potential for a high-scoring affair.

COLOST vs. MEMP
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Rogers under 10.5 Points

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Colo. State vs Memphis Prediction & Odds:
Free CBB Betting Insights for 3/21/25

The upcoming NCAA Tournament first-round matchup between the No. 12 seed Colorado State Rams and the No. 5 seed Memphis Tigers on March 21, 2025, at Climate Pledge Arena in Seattle presents a compelling clash between two teams with contrasting styles and narratives. Colorado State, entering the tournament with a 25-9 record, has been on a remarkable 10-game winning streak, showcasing resilience and cohesion under the leadership of head coach Niko Medved. The Rams’ offense is orchestrated by senior guard Nique Clifford, who has been instrumental in their success, averaging 19.0 points, 9.7 rebounds, and 4.4 assists per game. Clifford’s versatility and ability to impact multiple facets of the game make him a focal point for opposing defenses. Complementing Clifford are key contributors like Jalen Lake and Kyan Evans, averaging 11.1 and 10.2 points per game, respectively, providing the Rams with a balanced scoring attack. Defensively, Colorado State has been effective in limiting opponents, utilizing a disciplined approach that emphasizes strong perimeter defense and effective rebounding. Their ability to control the tempo and dictate the pace of the game has been a significant factor in their recent success. On the other hand, the Memphis Tigers come into the tournament with a 29-5 record, reflecting a season marked by high-octane offense and athleticism under head coach Penny Hardaway. The Tigers’ offense is led by standout guard PJ Haggerty, who averages 21.8 points per game, showcasing his scoring prowess and ability to take over games. However, Memphis faces a significant challenge with the potential absence of star guard Tyrese Hunter, who suffered a foot injury in the AAC tournament semifinal against Tulane and has been in a walking boot since. Hunter’s status remains uncertain, and his absence could impact the Tigers’ backcourt depth and offensive efficiency. In Hunter’s stead, sophomore guard Baraka Okojie has stepped up, contributing four assists in 28 minutes during the AAC championship game against UAB, though he also committed four turnovers, indicating potential vulnerabilities under pressure.

The Tigers’ frontcourt is anchored by players like DeAndre Williams, whose experience and versatility provide stability on both ends of the floor. Memphis thrives in transition, leveraging their athleticism to create fast-break opportunities and overwhelm opponents with their pace. From a betting perspective, Colorado State has been favorable against the spread (ATS), holding a 21-13-0 record this season, including a 15-6 ATS record when favored by at least 1.5 points. This suggests that the Rams have often exceeded expectations, particularly when entering games as favorites. Conversely, Memphis has a 16-18-0 ATS record, with a 5-2 ATS record when playing as at least 1.5-point underdogs, indicating a tendency to perform well in underdog situations. The over/under for this game is set at 147.5 points, and considering both teams’ offensive capabilities, there is potential for a high-scoring contest. In terms of strategy, Colorado State will likely aim to control the tempo, utilizing their disciplined defense to disrupt Memphis’s rhythm and prevent transition opportunities. Limiting turnovers and executing in the half-court offense will be crucial for the Rams to mitigate the Tigers’ athletic advantages. Memphis, meanwhile, will look to push the pace, capitalize on fast-break opportunities, and exploit mismatches with their athleticism. The potential absence of Tyrese Hunter necessitates that other players step up, particularly in ball-handling and perimeter defense, to counter Colorado State’s balanced attack. This matchup also highlights the classic 5 vs. 12 seed dynamic, where historically, No. 12 seeds have been known to upset No. 5 seeds, adding an extra layer of intrigue to the contest. Both teams have the talent and coaching acumen to advance, making this one of the more anticipated games in the tournament’s opening round. Fans can expect a hard-fought battle, with the outcome potentially hinging on key performances from star players and the ability of each team to execute their game plan under the tournament’s pressure-packed environment.

Colo. State Rams CBB Preview

The Colorado State Rams enter their March 21, 2025 NCAA Tournament first-round showdown against the Memphis Tigers with a 25-9 record and a full head of steam, riding a 10-game winning streak that includes a dominant run through the Mountain West Conference Tournament and positioning themselves as a dangerous No. 12 seed capable of making serious noise in March under the guidance of head coach Niko Medved, whose well-structured offensive sets, defensive discipline, and veteran leadership have made the Rams one of the most efficient and consistent mid-major programs this season. At the heart of Colorado State’s success is senior guard Nique Clifford, a versatile two-way star who has emerged as one of the most complete players in the country, averaging 19.0 points, 9.7 rebounds, and 4.4 assists per game while also serving as the team’s defensive anchor and emotional leader; his ability to create offense off the dribble, rebound aggressively from the guard position, and switch defensively across multiple assignments allows the Rams to remain competitive in all phases of the game. Alongside Clifford, guards Jalen Lake and freshman Kyan Evans provide balance and secondary scoring, with Lake averaging 11.1 points per game while shooting over 37% from three-point range and Evans contributing 10.2 points and giving the team a youthful spark with his quickness and composure beyond his years. The Rams pride themselves on execution, particularly in the half court, where they use off-ball movement, backdoor cuts, and crisp passing to break down opposing defenses, ranking among the national leaders in assist-to-turnover ratio and field goal percentage.

Defensively, Colorado State is methodical and disciplined, rarely gambling for steals but instead focusing on contesting shots, limiting fouls, and securing defensive rebounds to prevent second-chance opportunities, a strategy that will be crucial against a Memphis team that thrives on transition buckets and offensive rebounds. From a betting perspective, the Rams have been one of the most profitable teams in the nation, covering the spread in 21 of their 34 games, including a 15-6 ATS record when favored by 1.5 points or more—though in this matchup, they enter as slight underdogs, a role in which they’ve also performed admirably during their late-season surge. While not the most athletic team in the tournament, Colorado State compensates with high basketball IQ, cohesion, and an unselfish brand of basketball that forces opponents to beat them through sustained execution rather than sheer talent alone. Their 10-game win streak includes several impressive victories over top-tier Mountain West programs, and their ability to lock in defensively in big moments and generate high-percentage looks has given them the poise and confidence needed to pull off an upset against a Memphis team with more size and athleticism but also more volatility, especially with the potential absence of Tyrese Hunter. Medved’s experience and tactical savvy give Colorado State a coaching edge in preparation and in-game adjustments, and if the Rams can control the pace, keep Memphis out of transition, and continue shooting efficiently from the perimeter while Clifford dominates both ends, they have all the ingredients for a classic 12-over-5 tournament upset, fueled by momentum, structure, and a collective belief that they belong on the big stage.

On March 21, 2025, the No. 12 seed Colorado State Rams (25-9) will face the No. 5 seed Memphis Tigers (29-5) in the first round of the NCAA Tournament’s West Region at Climate Pledge Arena in Seattle, Washington. Colo. State vs Memphis AI Prediction: Free CBB Betting Insights for Mar 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Memphis Tigers CBB Preview

The Memphis Tigers enter the NCAA Tournament as the No. 5 seed in the West Region, boasting a 29-5 record that reflects a season characterized by explosive offense, athleticism, and a relentless pace under the guidance of head coach Penny Hardaway, whose leadership has been instrumental in returning the program to national prominence. The Tigers’ offensive attack is spearheaded by dynamic guard PJ Haggerty, who leads the team with an impressive 21.8 points per game, showcasing his ability to score from all three levels, facilitate for teammates, and deliver in clutch moments, making him a focal point for opposing defenses. Complementing Haggerty is veteran forward DeAndre Williams, whose versatility allows him to stretch the floor with perimeter shooting, attack the basket with agility, and provide a strong defensive presence in the paint, averaging 15.3 points and 6.8 rebounds per game while serving as the emotional leader of the team. Williams’ experience in high-pressure games, combined with his ability to guard multiple positions, gives Memphis an edge in matchups that require defensive versatility and physical toughness. However, the Tigers face a significant variable heading into their first-round clash with Colorado State: the health status of star guard Tyrese Hunter, who suffered a foot injury in the AAC Tournament semifinal against Tulane and has been seen in a walking boot since. His absence, if confirmed, will undoubtedly impact Memphis’s guard depth, shot creation, and perimeter defense—areas where Hunter has been essential all season, averaging 12.7 points, 5.1 assists, and 1.6 steals per game. In response, sophomore guard Baraka Okojie has stepped into a larger role, and while he has shown promise, including dishing out four assists in the AAC title game against UAB, his four turnovers in that contest also highlighted growing pains and the high stakes of tournament play. Memphis will likely rely on a guard-by-committee approach to fill Hunter’s void, with Jaykwon Walton and Jonathan Pierre expected to provide scoring and floor spacing from the wings, while backup point guards will need to manage tempo and protect the ball against a disciplined Colorado State defense.

The Tigers thrive in transition, ranking among the nation’s best in fast-break points and offensive tempo, and their ability to turn defense into offense is powered by active hands on the perimeter and strong rebounding from the wings. Their 16-18 record against the spread (ATS) this season reflects some volatility in meeting betting expectations, but they are 5-2 ATS when entering as underdogs of 1.5 points or more—an indication that they respond well when counted out or facing adversity. Memphis’s defensive philosophy focuses on pressure, denying clean entry passes and forcing turnovers, but the challenge against Colorado State will be sustaining that pressure without overcommitting, especially against a team that is methodical, well-coached, and less prone to unforced errors. Inside, the Tigers will need big efforts from Malcolm Dandridge and Jordan Brown to contain Colorado State’s interior scoring and keep the rebounding battle competitive, as second-chance points and paint touches will be vital in a game where tempo may be dictated by the Rams’ deliberate style. Coach Hardaway, a veteran of NCAA Tournament atmospheres both as a player and coach, will stress poise, execution, and urgency to his squad, particularly in light of Memphis’s recent struggles in past tournaments where early exits have shadowed their strong regular-season campaigns. With an elite scorer in Haggerty, a savvy leader in Williams, and enough depth to survive short-term adversity, Memphis remains a serious threat to make noise in the tournament, but they will need to start strong, play smart, and avoid costly fouls or turnovers to advance. This opening round is about more than just a win—it’s an opportunity for the Tigers to show they can withstand pressure, execute their up-tempo identity in a disciplined setting, and begin what they hope is a deep March run that lives up to the immense talent and expectations surrounding the program.

Colo. State vs. Memphis Prop Picks (AI)

Remi is pouring through tons of datapoints on each line. In fact, anytime the Rams and Tigers play there’s always several intriguing observations to key in on. Not to mention games played at Climate Pledge Arena in Mar seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Rogers under 10.5 Points

Colo. State vs. Memphis Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every simulation between the Rams and Tigers and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

The Algorithm has been most keyed in on the trending weight human bettors regularly put on Memphis’s strength factors between a Rams team going up against a possibly improved Tigers team. It appears the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CBB AI picks for FREE now.

Below is our current AI Colo. State vs Memphis picks, computer picks Rams vs Tigers, best bets, model edges, confidence ratings.

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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CBB schedule.

Rams Betting Trends

Colorado State has a 21-13-0 record against the spread (ATS) this season, including a 15-6 ATS record when favored by at least 1.5 points.

Tigers Betting Trends

Memphis holds a 16-18-0 ATS record this season, with a 5-2 ATS record when playing as at least 1.5-point underdogs.

Rams vs. Tigers Matchup Trends

The over/under for this game is set at 147.5 points. In 11 of their 34 games this season, Colorado State and its opponents have scored more than this total, indicating a potential for a high-scoring affair.

Colo. State vs. Memphis Game Info

Colo. State vs Memphis starts on March 21, 2025 at 2:00 PM EST.

Venue: Climate Pledge Arena.

Spread: Memphis +1.5
Moneyline: Colo. State -121, Memphis +102
Over/Under: 146.5

Colo. State: (25-9)  |  Memphis: (29-5)

Remi's searched hard and found the best prop for this matchup: C. Rogers under 10.5 Points. Prices move—always shop for the best number.

The over/under for this game is set at 147.5 points. In 11 of their 34 games this season, Colorado State and its opponents have scored more than this total, indicating a potential for a high-scoring affair.

COLOST trend: Colorado State has a 21-13-0 record against the spread (ATS) this season, including a 15-6 ATS record when favored by at least 1.5 points.

MEMP trend: Memphis holds a 16-18-0 ATS record this season, with a 5-2 ATS record when playing as at least 1.5-point underdogs.

See our latest CBB picks and odds pages for 2025 to compare prices before you bet.

Colo. State vs. Memphis Odds

Remi is pouring through mountains of stats on each team. In fact, anytime the Colo. State vs Memphis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.

Colo. State vs Memphis Opening Odds

COLOST Moneyline: -121
MEMP Moneyline: +102
COLOST Spread: -1.5
MEMP Spread: +1.5
Over/Under: 146.5

Colo. State vs Memphis Live Odds

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O 148.5 (-118)
U 148.5 (-110)
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Delaware State Hornets
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NIAGRA
6
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O 139.5 (-115)
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O 137.5 (-110)
U 137.5 (-110)
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Eastern Michigan Eagles
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Presbyterian College Blue Hose
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Indiana State Sycamores
SIU-Edwardsville Cougars
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INDST
SIUE
 
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UNC Wilmington Seahawks
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+125
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11/10/25 7PM
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NCAT
 
-155
 
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O 159.5 (-105)
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-125
+105
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O 162.5 (-105)
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-2.5 (-110)
 
O 145.5 (-110)
U 145.5 (-110)
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ARKLR
MILW
 
-185
 
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O 157.5 (-110)
U 157.5 (-110)
Nov 10, 2025 8:00PM EST
Lindenwood Lions
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11/10/25 8PM
LINDEN
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+2500
-10000
+25.5 (-115)
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O 165.5 (-110)
U 165.5 (-110)
Nov 10, 2025 8:00PM EST
New Orleans Privateers
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+1400
-4000
+19.5 (-105)
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O 161 (-110)
U 161 (-110)
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+1200
-3000
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O 148.5 (-105)
U 148.5 (-115)
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Mississippi State Bulldogs
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Santa Clara Broncos
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+140
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O 155.5 (-110)
U 155.5 (-110)
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+1650
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O 155.5 (-110)
U 155.5 (-110)
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SE Louisiana Lions
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+2 (-110)
O 158 (-125)
U 158 (+105)
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Michigan Wolverines
11/11/25 6:30PM
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MICH
+600
-900
+12.5 (-105)
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O 162.5 (-115)
U 162.5 (-105)
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Ohio State Buckeyes
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O 148.5 (-105)
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O 146 (-110)
U 146 (-110)
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NOVA
 
 
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Notre Dame Fighting Irish
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ND
 
 
+22.5 (-105)
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O 144.5 (-115)
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BUFF
DEPAUL
 
 
+17 (-110)
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UL
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-5.5 (-115)
 
O 137 (-105)
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-112
 
pk
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O 151.5 (-115)
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AUBURN
 
 
+25 (-110)
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O 153 (-110)
U 153 (-110)
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+150
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Missouri State Bears
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MIZZST
 
 
pk
pk
O 150.5 (-115)
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MURRAY
SMU
 
 
 
-12 (-110)
O 164.5 (-105)
U 164.5 (-115)
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LVILLE
+140
-170
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Texas Tech Red Raiders
Illinois Fighting Illini
11/11/25 8:30PM
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ILL
+145
-175
+3.5 (-110)
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O 163.5 (-115)
U 163.5 (-105)
Nov 11, 2025 8:30PM EST
Ball State Cardinals
Wisconsin Badgers
11/11/25 8:30PM
BALLST
WISC
 
 
+25 (-110)
-25 (-110)
O 153.5 (-110)
U 153.5 (-110)
Nov 11, 2025 9:00PM EST
Northern Arizona Lumberjacks
Arizona Wildcats
11/11/25 9PM
NAU
ARIZ
 
 
+35 (-110)
-35 (-110)
O 164 (-110)
U 164 (-110)
Nov 11, 2025 9:00PM EST
Hampton Pirates
Virginia Cavaliers
11/11/25 9PM
HAMPT
UVA
 
 
+22 (-110)
-22 (-110)
O 147.5 (-114)
U 147.5 (-106)
Nov 11, 2025 9:00PM EST
Memphis Tigers
Ole Miss Rebels
11/11/25 9PM
MEMP
OLEMISS
+400
-550
+9.5 (-110)
-9.5 (-110)
O 156 (-110)
U 156 (-110)
Nov 11, 2025 9:30PM EST
Western Illinois Leathernecks
CSU Bakersfield Roadrunners
11/11/25 9:30PM
WILL
CSBAK
+195
-238
+6 (-110)
-6 (-110)
O 143.5 (-110)
U 143.5 (-110)
Nov 11, 2025 10:00PM EST
UC Santa Barbara Gauchos
Sacramento State Hornets
11/11/25 10PM
UCSB
SACST
 
 
-8.5 (-115)
 
O 161 (-105)
U 161 (-115)
Nov 11, 2025 10:00PM EST
Ohio Bobcats
Saint Mary's Gaels
11/11/25 10PM
OHIO
STMARY
 
 
+19 (-110)
-19 (-110)
O 145 (-110)
U 145 (-110)
Nov 11, 2025 10:00PM EST
Montana Grizzlies
UNLV Rebels
11/11/25 10PM
MONT
UNLV
 
 
+9.5 (-110)
-9.5 (-110)
O 156.5 (-110)
U 156.5 (-110)
Nov 11, 2025 10:00PM EST
Creighton Bluejays
Gonzaga Bulldogs
11/11/25 10PM
CREIGH
GONZAG
+425
-600
+10.5 (-105)
-10.5 (-115)
O 166.5 (-110)
U 166.5 (-110)

CBB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Colo. State Rams vs. Memphis Tigers on March 21, 2025 at Climate Pledge Arena.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CBB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
DRAKE@MIZZOU DRAKE +6.5 53.50% 2 WIN
XAVIER@TEXAS XAVIER -2.5 53.40% 2 WIN
UAB@MEMP MEMP -3.5 54.00% 2 WIN
LVILLE@DUKE LVILLE +6.5 53.10% 2 LOSS
ECU@UAB UAB -5 53.60% 2 WIN
PURDUE@MICH MICH +3 54.60% 3 WIN
CLEM@LVILLE CLEM -120 56.10% 3 LOSS
COL@HOU ANDREJ JAKIMOVSKI PTS + REB + AST - UNDER 15.5 53.70% 2 LOSS
FORD@GWASH FORD +7 53.80% 2 WIN
SEATTLE@ABIL ABIL +6 54.50% 3 WIN
BAMAST@TEXSOU BAMAST -110 55.40% 4 WIN
OHIO@TOLEDO TOLEDO +3 56.70% 4 WIN
UVA@GATECH GATECH +1.5 53.70% 2 WIN
COLO@WVU COLO +7.5 53.20% 2 WIN
USC@RUT USC -115 54.00% 2 WIN
TEXAS@VANDY VANDY -130 56.50% 3 LOSS
BUTLER@PROV BUTLER -115 55.20% 3 WIN
IDAHO@MONTANA MONTANA -6 53.50% 2 WIN
TROY@JMAD TROY -125 55.60% 2 WIN
BELMONT@DRAKE DRAKE -7.5 53.50% 2 LOSS
UCSD@UCDAV UCSD -12.5 53.40% 2 LOSS
SIUE@SEMO SEMO -2.5 54.80% 3 LOSS
ALCORN@ARKPB ARKPB +6.5 56.00% 4 WIN
NORFLK@HOWARD HOWARD +5.5 53.70% 2 LOSS
NKY@CLEVST NKY +4.5 54.40% 3 LOSS
STNFRD@ND STNFRD -125 56.40% 3 LOSS
TENN@OLEMISS OLEMISS +2.5 54.30% 3 WIN
LSALLE@GMASON GMASON -12 54.30% 3 LOSS
PITT@NCST NCST +2.5 56.70% 4 WIN
IND@OREG OREG -6.5 53.60% 2 WIN
FSU@UVA UVA -4 54.40% 3 LOSS
ARK@VANDY ARK +7.5 54.40% 3 WIN
SDGST@UNLV UNLV +2.5 54.10% 3 WIN
EKTY@JVILLE JVILLE -135 58.90% 3 WIN
MANHAT@NIAGARA MANHAT -115 54.70% 3 WIN
MEMP@UAB MEMP -115 54.90% 3 WIN
ILL@MICH MICH -2.5 56.00% 4 LOSS
OKLA@OLEMISS OKLA +7.5 54.50% 3 WIN
ARIZST@UTAH ARIZST +8.5 54.60% 3 LOSS
GC@SEATTLE GC -110 55.00% 3 WIN
PENN@CLMBIA CLMBIA -122 57.50% 4 LOSS
IONA@NIAGARA NIAGARA +1.5 54.30% 3 LOSS
MARIST@SACHRT SACHRT -120 55.40% 3 WIN
CLEVST@WRIGHT CLEVST +1.5 54.30% 3 LOSS
NDAK@STTHOM STTHOM -10 54.30% 3 WIN
USD@WASHST WASHST -12.5 55.20% 4 LOSS
CSBAK@LBEACH CSBAK -130 59.70% 4 WIN
BU@LEHIGH LEHIGH -135 57.70% 3 LOSS
DUQ@LSALLE DUQ -125 56.70% 3 WIN
BYU@ARIZST ARIZST +7.5 54.60% 3 LOSS
UTAHST@BOISE BOISE -4 55.50% 4 WIN