The Indianapolis Colts and Jacksonville Jaguars will face off in a critical AFC South matchup that features two teams headed in opposite directions. The Colts, at 2-2, are coming off back-to-back wins and have started to build some momentum. Indianapolis has found success with a balanced offensive attack, as running back Jonathan Taylor leads the ground game, complemented by efficient play from quarterback Anthony Richardson. The Jaguars, meanwhile, are winless at 0-4 and are reeling after a heartbreaking loss to the Houston Texans.

Trevor Lawrence has struggled to find consistency, and the Jacksonville offense has been hampered by turnovers and a lack of third-down efficiency. The Jaguars’ defense, allowing 380 yards per game, has been one of the league’s worst, particularly against the pass. The key matchup will be whether Jacksonville’s defense can slow down the Colts’ run game, which averages 131.8 yards per game. If Taylor gets going early, it could be a long day for the Jaguars. Jacksonville needs to find a way to put points on the board early to keep the game close and put pressure on Indianapolis’ offense to respond. Expect a physical, divisional battle, with both teams looking to gain an edge in the AFC South standings.