The Week 3 Monday Night Football matchup between the Jacksonville Jaguars and Buffalo Bills is set to be a thrilling contest, with the Bills favored to continue their strong start to the season. Buffalo, led by quarterback Josh Allen, has averaged 32.5 points per game across their first two outings, showcasing a potent passing attack bolstered by the addition of large targets like Dalton Kincaid and Dawson Knox. Allen has been particularly effective in spreading the ball around, taking advantage of mismatches against smaller defensive backs. On the other side, the Jaguars have been inconsistent. Trevor Lawrence, while showing moments of brilliance, has struggled to connect on deep passes, completing only 51% of his throws so far this season.

Jacksonville’s ground game, led by Travis Etienne, has shown flashes, but the team has yet to establish the consistent offensive rhythm needed to challenge an elite defense like Buffalo’s. Defensively, the Bills have been rock solid, particularly against the pass. Buffalo’s pass rush has been effective, forcing turnovers and putting pressure on opposing quarterbacks. For Jacksonville, their defense will need to step up, especially against Buffalo’s balanced offensive approach. If the Jaguars can’t control the line of scrimmage and slow down Buffalo’s offense, they will have difficulty keeping pace. This game could be decided by whether Jacksonville can limit their mistakes and capitalize on their red zone opportunities. The Bills, meanwhile, will look to dominate through their defense and maintain offensive efficiency to secure a 3-0 start to the season.