The Arizona Cardinals and Buffalo Bills will clash in a Week 1 matchup that sets the stage for an intriguing 2024 NFL season. The game will take place at Highmark Stadium, with both teams eager to make a statement. The Bills, coming off a strong season, are the favorites, boasting a well-rounded team led by quarterback Josh Allen. Known for their high-powered offense, the Bills will look to exploit the Cardinals’ defense, which struggled last year. The Cardinals, under quarterback Kyler Murray, aim to show significant improvements after a rebuilding season. Their offense, featuring dynamic weapons like wide receiver Marquise Brown and running back James Conner, will need to be at its best against a tough Buffalo defense. The Bills have made defensive adjustments in the offseason, including new strategies from their coaching staff, which could prove vital in containing Murray’s dual-threat capabilities. Both teams have shown different trends in their recent games. The Bills have been reliable at home and are expected to control the game tempo, leveraging their strong passing attack. Meanwhile, the Cardinals will aim to keep the score close and rely on their improved defensive scheme to force turnovers and create scoring opportunities.